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13th Asian Chemical Congress

作者： ADIBI HADI KHODAEI mohammad MEHDI alizadeh ABDOLHAMID PAKRAVAN NARGES RASHIDI ATEFEH MAJNOONI mohammad BAGHER ABIRI RAMIN NEMATOLLAHI DAVOOD Faculty of Pharmacy Kermanshah University of Medical SciencesKermanshahIran Faculty of of Chemistry Razi University Faculty of Medicine Kermanshah University of Medical SciencesKermanshahIran Faculty of Chemistry Bu-Ali Sina University

＜正＞Generation of reactive oxygen species（ROS）and free radicals in vivo is involved in a wide range of human ***,including superoxide anion,hydrogen peroxide and hydroxyl radical,are by products of a variety of pathways of aerobic *** catecholthioethers have become an important structural motif in biological *** report here the synthesis of a series of

关键词： Catecholthioethers Antioxidant Antimicrobial

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Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

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World Journal of Gastroenterology 2015年第47期21卷 13225-13239页

作者： Behzad Yeganeh Adel rezaei Moghadam Javad alizadeh Emilia Wiechec Seyed Moayed Alavian mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami Department of Physiology and Experimental Medicine Hospital for Sick Children Research Institute University of Toronto Young Researchers and Elite Club Ardabil Branch Islamic Azad University Department of Human Anatomy and Cell Science College of Medicine Faculty of Health Sciences University of Manitoba The Children's Hospital Research Institute of Manitoba University of Manitoba Department of Clinical and Experimental Medicine Division of Otorhinolaryngology Link?ping University Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL) Department of Clinical Biochemistry School of Medicine Zahedan University of Medical Sciences Department of Pathology and Organ Transplant Research Center Shiraz University of Medical Sciences Department of Biochemistry National University of Ireland Galway Health Policy Research Centre Shiraz University of Medical Sciences Manitoba Center for Proteomics and Systems Biology University of Manitoba Department of Medical Microbiology and Infectious Diseases The Children's Hospital Research Institute of Manitoba University of Manitoba

AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected ***: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy,

关键词： Cell fate Cell death Hepatocyte Viralinfection Endoplasmic reticulum stress

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