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Surveillance of Australian Hajj pilgrims for carriage of potentially pathogenic bacteria:Data from two pilot studies

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World Journal of Clinical Cases 2017年第3期5卷 102-111页

作者： mohammad irfan azeem Mohamed Tashani Al-Mamoon Badahdah Leon Heron Kristen Pedersen Neisha Jeoffreys Jen Kok Elizabeth Haworth Dominic E Dwyer Grant Hill-Cawthorne Harunor Rashid Robert Booy National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases Kids Research Institutethe Children’s Hospital at Westmead the Discipline of Child and Adolescent Health Sydney Medical Schoolthe University of Sydney Marie Bashir Institute for Infectious Diseases and Biosecurity the University of Sydney Department of Family and Community Medicine Faculty of Medicine in RabighKing Abdulaziz Uni-versity Centre for Infectious Diseases and Microbiology Laboratory Services Institute of Clinical Pathology and Medical ResearchPathology WestWestmead Hospital Menzies Research Institute Tasmania School of Public Health the University of Sydney World Health Organization Collaborating Centre for Mass Gatherings and High Consequence/High Visibility Events Flinders University

AIM To estimate the pharyngeal carriage rate of Neisseria meningitidis(N. meningitidis), Streptococcus pneumoniae(S. pneumoniae) and Staphylococcus aureus(S. aureus) among Australian Hajj *** In 2014, surveillance was conducted in two phases among Australian Hajj pilgrims: The first phase during Hajj in Mina, and the second phase soon after returning home to Australia. Nasopharyngeal or oropharyngeal swabs were taken from participants then tested, firstly by nucleic acid testing, and also by standard *** Of 183 participants recruited in the first phase, 26(14.2%) tested positive for S. pneumoniae; 4 had received pneumococcal conjugate vaccine(PCV13). Only one tested positive for N. meningitidis(W). Of 93 2^(nd) phase samples cultured, 17(18.3%) grew S. aureus, all methicillin sensitive, 2(2.2%) grew N. meningitidis(on subculture; one serotype B, one negative), and 1(1%), from an unvaccinated pilgrim, grew S. *** Relatively high carriage of S. pneumoniae and little meningococcal carriage was found. This indicates the importance of a larger study for improved infection surveillance and possible vaccine evaluation.

关键词： Carriage Conjugate vaccine Staphylococcus aureus Neisseria meningitidis Streptococcus pneumoniae Hajj

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Quintessence anisotropic stellar models in quadratic and Born-Infeld modified teleparallel Rastall gravity

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Chinese Physics B 2024年第3期33卷 179-189页

作者： Allah Ditta 夏铁成 irfan Mahmood Asif Mahmood Department of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai UniversityShanghai 200444China Centre for High Energy Physics University of the PunjabLahorePakistan College of Engineering Chemical Engineering DepartmentKing Saud University RiyadhSaudi Arabia

This study aims to discuss anisotropic solutions that are spherically symmetric in the quintessence field,which describe compact stellar objects in the modified Rastall teleparallel theory of *** achieve this goal,the Krori and Barua arrangement for spherically symmetric components of the line element is *** explore the field equations by selecting appropriate off-diagonal tetrad ***-Infeld function of torsion f(T)=β√λT+1-1 and power law form h(T)=δTn are *** Born-Infeld gravity was the first modified teleparallel gravity to discuss *** use the linear equation of state pr=ξρto separate the quintessence *** obtaining the field equations,we investigate different physical parameters that demonstrate the stability and physical acceptability of the stellar *** use observational data,such as the mass and radius of the compact star candidates PSRJ 1416-2230,Cen X-3,&4U 1820-30,to ensure the physical plausibility of our findings.

关键词： anisotropic spheres quintessence field modified Rastall teleparallel gravity equation of state(EoS) f(T)gravity

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Design and engineering of logic genetic-enzymatic gates based on the activity of the human CYP2C9 enzyme in permeabilized Saccharomyces cerevisiae cells

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Synthetic and Systems Biotechnology 2024年第3期9卷 406-415页

作者： Rana azeem Ashraf Matthias Bureik Mario Andrea Marchisio School of Pharmaceutical Science and Technology Tianjin University300072TianjinChina

Gene circuits allow cells to carry out complex functions such as the precise regulation of biological metabolic *** this study,we combined,in the yeast ***,genetic regulatory elements with the enzymatic reactions of the human CYP2C9 and its redox partner CPR on luciferin substrates and *** cells were permeabilized and used as enzyme bags in order to host these metabolic *** engineered three different(genetic)-enzymatic basic Boolean gates(YES,NOT,and N-IMPLY).In the YES and N-IMPLY gates,human CYP2C9 was expressed under the galactose-inducible GAL1 *** carbon monoxide releasing molecule CORM-401 was used as an input in the NOT and N-IMPLY gates to impair CYP2C9 activity through inhibition of the Fe+2-heme prosthetic group in the active site of the human *** study provides a new approach in designing synthetic bio-circuits and optimizing experimental conditions to favor the heterologous expression of human drug metabolic enzymes over their endogenous *** new approach will help study precise metabolic attributes of human P450s.

关键词： Cytochrome P450 Drug metabolism Budding yeast Diclofenac Synthetic biology CORM-401 Boolean gates

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Isolation and Characterization of Cellulose Nanofiber(CNF)from Kenaf(Hibiscus cannabinus)Bast through the Chemo-Mechanical Process

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Journal of Renewable Materials 2024年第6期12卷 1057-1069页

作者： Rudi Dungani mohammad irfan Bakshi Tsabita Zahra Hanifa Mustika Dewi Firda A.Syamani Melbi Mahardika Widya Fatriasari School of Life Sciences and Technology Institut Teknologi BandungBandung40132Indonesia Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Cibinong16911Indonesia

The present work emphasizes the isolation of cellulose nanofiber(CNF)from the kenaf(Hibiscus cannabinus)bast through a chemo-mechanical *** order to develop high CNF yield with superior properties of CNF for improving compatibility in varied applications this method is *** fiber purification involved pulping and bleaching treatments,whereas mechanical treatment was performed by grinding and high-pressure *** kraft pulping as a delignification method followed by bleaching has successfully removed almost 99%lignin in the fiber with high pulp yield and delignification *** morphology of the fibers was characterized by scanning electron microscopy,which showed a smooth surface,fiber bundles,gel-shaped nanofiber,and an average size of 94.05 nm with 69%of CNF in 34–100 nm *** chemo-mechanical process exhibited a more crystalline nature in CNF than pulp *** low zeta potential values exhibit the distribution of fibrils and colloidal suspension stability without any further agglomeration.A lower concentration of CNF is less stable exhibiting the product ***,the chemo-mechanical process for the isolation of CNF(Hibiscus cannabinus)from kenaf involves sustainable,low-cost,non-toxic,and cheap alternatives than other traditional methods.

关键词： Kenaf bast fiber kraft delignification and bleaching ultrafine grinder chemo-mechanical properties CNF

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A geochemical perspective on the genesis of Cenozoic basic volcanism in northeastern Turkey:an overview of metasomatism and heterogeneity of the sub-continental lithospheric mantle in a post-collisional setting

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Acta Geochimica 2024年第3期43卷 489-506页

作者： Mehmet Arslan irfan Temizel Department of Geological Engineering Karadeniz Technical University61080 TrabzonTurkey

The post-collisional Cenozoic basic volcanic rocks in NE Turkey show temporal variations in whole-rock lithophile element and highly siderophile element(HSE)systematics that are mainly associated with the nature of sub-continental lithospheric mantle(SCLM)sources and parental melt *** far,the traditional whole-rock lithophile geochemical data of these basic volcanic rocks have provided important constraints on the nature of SCLM *** lithophile element and HSE geochemical data of these basic volcanic rocks also reveal the heterogeneity of the SCLM source,which is principally related to variable metasomatism resulting from previous subduction(s)and post-collisional mantle-crust interactions in an extensional *** element geochemical features suggest that the parental magmas have derived from metasomatized spinel-to garnet-bearing SCLM sources for Eocene and Miocene basic volcanic rocks with subduction signatures whereas originated from spinel-to garnet-bearing SCLM sources for Mio-Pliocene and Plio-Quaternary basaltic volcanic rocks without the subduction *** element and HSE geo-chemistry also reveal that Eocene and Miocene basic vol-canic rocks were affected by more pronounced crustal contamination than the basaltic volcanic rocks of Mio-Pliocene and ***,the integrated lithophile element and HSE compositions of these basic volcanic rocks,together with the regional asymmetric lithospheric delamination model,reveal that the compositional variation(especially due to metasomatism)was significant temporally in the heterogeneity of the SCLM sources from which parental magmas formed during the Cenozoic era.

关键词： Basalt Lithospheric mantle Metasomatism Mantle heterogeneity Cenozoic volcanics NE Turkey

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Assessing Multidimensional Vulnerability of Rural Areas to Flooding:An Index‑Based Approach

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International Journal of Disaster Risk Science 2024年第1期15卷 88-106页

作者： Samavia Rasool irfan Ahmad Rana Hassam Bin Waseem Department of Urban and Regional Planning School of Civil and Environmental Engineering(SCEE)National University of Sciences and Technology(NUST)Islamabad 44000Pakistan

Vulnerability assessment is essential for understanding and launching effective flood risk reduction *** study aimed to examine the vulnerability of flood-prone rural communities in southern Punjab,Pakistan to external *** concept of vulnerability encompasses a range of dimensions,including physical,social,institutional,environmental,economic,and *** a composite index method,indices were developed for each dimension and combined to create a multidimensional measure of vulnerability.A sample of 365 communities was selected using the Yamane sampling technique,and data were collected through a questionnaire containing 65 indicators across all *** statistics and ANOVA tests were used to analyze the *** results show that communities near the Chenab River had higher attitudinal and institutional vulnerability compared to other *** attitudinal vulnerabilities were as sociated with poorly perceived flood risks and low preparedness measures,whereas institutional vulnerabilities were driven by conventional flood protection strategies,lack of institutional trust,and lack of flood risk *** research provides insights into the various components of vulnerability in flood-prone rural communities in Pakistan and demonstrates a useful methodology that can be applied to other disasters at different spatial scales.

关键词： Chenab River Flood hazard Indus River Pakistan-Rural areas:Vulnerability to flooding

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Auto-tuning PVT data using multi-objective optimization:Application of NSGA-II algorithm

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Petroleum 2024年第1期10卷 135-149页

作者： Abdolhadi Zarifi mohammad Madani mohammad Jafarzadegan Reservoir Engineering Systems Petroleum Engineering DepartmentMain Office Building of National Iranian South Oil Company(NISOC)AhvazIran Reservoir Engineering Division Petroleum Engineering DepartmentPetroleum Engineering and Development Company(PEDEC)TehranIran Combined Planning Management National Iranian Oil Company(NIOC)TehranIran

Reservoir simulation is known as perhaps the most widely used,accurate,and reliable method for field development in the petroleum *** integral part of a reliable reservoir simulation process is to consider robust and rigorous tuned EOS ***,EOS models are tuned iteratively through arduous workflows against experimental PVT ***,this comes with a number of drawbacks such as forcingly using weight factors,which upon alteration adversely affects the optimization *** objective of the current work is thus to introduce an auto-tune PVT matching tool using NSGA-II multi-objective *** order to illustrate the robustness of the presented technique,three different PVT samples are used,including two black-oil and one gas condensate *** utilize PengRobinson EOS during all the manual and auto-tuning *** of auto-tuned EOS-generated results with those of experimental and computed statistical error values for these samples clearly show that the proposed method is *** addition,the proposed method,contrary to the manual matching process,provides the engineer with several matched solutions,which allows them to select a match based on the engineering background to be best amenable to the problem at *** addition,the proposed technique is fast,and can output several solutions within less time compared to the traditional manual matching method.

关键词： Auto-tuning PVT Equation of state NSGA-II Multi-objective optimization

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Computational and bioinformatics tools for understanding disease mechanisms

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BIOCELL 2024年第6期48卷 935-944页

作者： MOHD ATHAR ANU MANHAS NISARG RANA AHMAD irfan Physics Department University of CagliariCittadella UniversitariaMonserrato(CA)09042Italy Department of Chemistry School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar382426India Department of Chemistry College of ScienceKing Khalid UniversityAbha61413Saudi Arabia

Computational methods have signiﬁcantly transformed biomedical research,offering a comprehensive exploration of disease mechanisms and molecular protein *** article reviews a spectrum of computational tools and network analysis databases that play a crucial role in identifying potential interactions and signaling networks contributing to the onset of disease *** utilization of protein/gene interaction and genetic variation databases,coupled with pathway analysis can facilitate the identiﬁcation of potential drug *** bridging the gap between molecular-level information and disease understanding,this review contributes insights into the impactful utilization of computational methods,paving the way for targeted interventions and therapeutic advancements in biomedical research.

关键词： Interaction database Disease mechanisms Protein function Network analysis Bioinformatics Genetic variations Protein-protein interactions Signaling pathways

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Leveraging Augmented Reality,Semantic-Segmentation,and VANETs for Enhanced Driver’s Safety Assistance

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Computers, Materials & Continua 2024年第1期78卷 1443-1460页

作者： Sitara Afzal Imran Ullah Khan irfan Mehmood Jong Weon Lee Mixed Reality and Interaction Lab Department of SoftwareSejong UniversitySeoul05006Korea Faculty of Engineering and Digital Technologies School of Computer ScienceAI and ElectronicsUniversity of BradfordBradfordUK

Overtaking is a crucial maneuver in road transportation that requires a clear view of the road ***,limited visibility of ahead vehicles can often make it challenging for drivers to assess the safety of overtaking maneuvers,leading to accidents and *** this paper,we consider atrous convolution,a powerful tool for explicitly adjusting the field-of-view of a filter as well as controlling the resolution of feature responses generated by Deep Convolutional Neural Networks in the context of semantic image *** article explores the potential of seeing-through vehicles as a solution to enhance overtaking ***-through vehicles leverage advanced technologies such as cameras,sensors,and displays to provide drivers with a real-time view of the vehicle ahead,including the areas hidden from their direct line of *** address the problems of safe passing and occlusion by huge vehicles,we designed a see-through vehicle system in this study,we employed a windshield display in the back car together with cameras in both *** server within the back car was used to segment the car,and the segmented portion of the car displayed the video from the front *** see-through system improves the driver’s field of vision and helps him change lanes,cross a large car that is blocking their view,and safely overtake other *** network was trained and tested on the Cityscape dataset using semantic *** transparent technique will instruct the driver on the concealed traffic situation that the front vehicle has *** our findings,we have achieved 97.1% *** article also discusses the challenges and opportunities of implementing see-through vehicles in real-world scenarios,including technical,regulatory,and user acceptance factors.

关键词： Overtaking safety augmented reality VANET V2V deep learning

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Investigation of material composition,design,and performance of open-graded asphalt mixtures for semi-flexible pavement:A comprehensive experimental study

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 92-116页

作者： mohammad Taghipoor Abolfazl Hassani mohammad M.Karimi Department of Civil and Environmental Engineering Tarbiat Modares UniversityTehranIran

The primary goal of this study is the design and construction of semi-flexible pavement(SFP)mixture in accordance with the engineering and mechanical *** study involves the use of a range of gradation curves,air void contents,cellulose and synthesized fibers,and neat and modified asphalt binders to prepare the open-graded asphalt(OGA)*** analyze the characteristics of these mixtures,a variety of test,namely binder drainage,semi-circular bending(SCB),Cantabro,wheel tracking,indirect tensile strength(ITS),and permeability tests were ***,to analyze the prepared grouting material,flexural strength,compressive strength,and fluidity tests were *** the final stage,SFP was compared to HMA in terms of engineering characteristics and *** to the results,SFP was more resistant to skid,rutting,fire,and moisture damage,while HMA had a better performance in fracture tests,including SCB *** to the results of the mechanical performance tests conducted on OGA mixtures,the highest and lowest values for air void content to achieve the highest mechanical performance level were 30%-35%and 25%,***,based on the laboratory results,it was determined that the required void ratio for constructing OGA mixtures was 24%-26%based on the bitumen type and fibers amount in the ***,SFP mixture can be regarded as a viable alternative to common pavements thanks to its high resistance to rutting and moisture damage,long freezing-thawing fatigue life,and adequate fire and skid resistance.

关键词： Semi-flexible pavement mixture Open-graded asphalt mixture Engineering properties Cantabro test Hot mix asphalt

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