检索结果-南通市图书馆

Factors associated with recurrence of clubfoot treated by the Ponseti method

World Journal of Clinical Cases 2016年第10期4卷 318-322页

作者： mohammad reza azarpira mohammad Jafar Emami Amir reza Vosoughi Keivan Rahbari Bone and Joint Diseases Research Center Shiraz University of Medical Sciences

AIM To assess several associated factors on the recurrence of clubfoot after successful correction by the Ponseti method. METHODS A total of 115 children with 196 clubfeet deformities, treated by the Ponseti method, were evaluated. Demographic data, family history of clubfoot in firstdegree relatives, maternal educational level and brace compliance were enquired. Based on their medical files, the characteristics of the patients at the time of presentation such as age, possible associated neuromuscular disease or especial syndrome, severity of the deformity according to the Dimeglio grade and Pirani score, residual deformity after previous Ponseti method and number of casts needed for the correction were *** There were 83 boys(72.2%) and 32 girls(27.8%) with a male to female ratio of 2.6. The mean age at the initiation of treatment was 5.4 d(range: 1 to 60 d). The average number of casts applied to achieve complete correction of all clubfoot deformities was 4.2. Follow-up range was 11 to 60 mo. In total, 39 feet had recurrence with a minimum Dimeglio grade of 1 or Pirani score of 0.5 at the follow-up visit. More recurrence was observed in non-idiopathic clubfoot deformities(P = 0.001), noncompliance to wear braces(P < 0.001), low educational level of mother(P = 0.033), increased number of casts(P < 0.001), and more follow-up periods(P < 0.001). No increase in the possibility of recurrence was observed when the previous unsuccessful casting was further treated using the Ponseti method(P = 0.091). Also, no significant correlation was found for variables of age(P = 0.763), Dimeglio grade(P = 0.875), and Pirani score(P = 0.624) obtaining at the beginning of the serial casting. CONCLUSION Using the Ponseti method, non-idiopathic clubfoot, noncompliance to wear braces, low educational level of mother, increased number of casts and more followup periods had more association to possible increase in recurrence rate after correction of clubfoot deformity.

关键词： Clubfoot Recurrence Cast Talipes equinovarus Ponseti

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function

引用

Liver Research 2021年第3期5卷 181-193页

作者： mohammad Mehdi Ommati Hanie Attari Asma Siavashpour Marzieh Shafaghat Negar azarpira Hasti Ghaffari Leila Moezi reza Heidari College of Life Sciences Shanxi Agricultural UniversityTaiguShanxiChina Department of Pharmacology and Toxicology School of PharmacyShiraz University of Medical SciencesShirazIran Transplant Research Center Shiraz University of Medical SciencesShirazIran Department of Veterinary Sciences Islamic Azad UniversityUrmia BranchUrmiaIran Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmacology School of MedicineShiraz University of Medical SciencesShirazIran

Background and aim:The liver is the primary organ affected by cholestasis,and complications such as renal injury,renal failure,and the need for renal transplantation are associated with cholestatic liver *** is substantial evidence indicating that reactive oxygen species(ROS)and mitochondrial impairment are fundamental mechanisms underlying cholestasis-induced hepatic and renal ***(EDV)is a potent radical scavenger and antioxidant that may prevent oxidative stress and improve impaired mitochondrial function in various *** study was performed to evaluate the effects and mechanisms of action of EDV on hepatic and renal injury in an animal model of ***:Rats subjected to bile duct ligation(BDL)were treated with EDV 1 or 10 mg/kg/day intraper-itoneally for 14 consecutive *** of oxidative stress and mitochondrial impairment in the liver and kidney were assessed in EDV-treated and untreated rats with ***:Significant increases in tissue ROS level,lipid peroxidation,protein carbonylation,and oxidized glutathione level were detected in rats subjected to ***,significant decreases in tissue glutathione level and antioxidant capacity were observed in the hepatic and renal tissues of rats with *** of mitochondrial impairment,including mitochondrial depolarization,lipid perox-idation,mitochondrial permeabilization,depleted adenosine triphosphate content,and decreased de-hydrogenase activity,were also detected in rats subjected to ***,portal inflammation,necrosis,and tissue fibrosis were detected in the liver and significant tubular atrophy and interstitial inflammation,as well as fibrotic lesions,were detected in the kidneys of rats with *** treatment significantly mitigated cholestasis-associated hepatic and renal ***:The antioxidative properties of EDV and its positive effects on the indices of mitochondrial function may be critical fac

关键词： Bile acids Cholestasis Cirrhosis Nephropathy Oxidative stress Renal failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function

引用

Liver Research 2021年第3期5卷 171-180页

作者： mohammad Mehdi Ommati Hamidreza mohammadi Khadijeh Mousavi Negar azarpira Omid Farshad Reyhaneh Dehghani Asma Najibi Sedigheh Kamran Hossein Niknahad reza Heidari College of Life Sciences Shanxi Agricultural UniversityTaiguShanxiChina Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmacology and Toxicology School of PharmacyShiraz University of Medical SciencesShirazIran Transplant Research Center Shiraz University of Medical SciencesShirazIran Department of Chemistry Payame Noor UniversityTehranIran

Background and aim:Cholestasis-associated renal injury or cholemic nephropathy(CN)is a serious clinical *** studies mentioned that oxidative stress and mitochondrial impairment play a role in *** is no specific pharmacological intervention for *** is an anti-diabetic drug administered for *** the other hand,novel pharmacological properties have emerged for this *** effect of metformin on oxidative stress parameters has been well-recognized in different experimental *** has also been found that metformin positively affected mitochondrial *** current study aimed to evaluate the effects of metformin in an animal model of ***:Rats underwent bile duct ligation(BDL)and were treated with metformin(250 and 500 mg/kg)for 14 consecutive *** weeks after the BDL operations,urine,serum,and kidney samples were collected and ***:Markers of oxidative stress,including reactive oxygen species(ROS)formation,lipid peroxida-tion,protein carbonylation,depleted antioxidant capacity,and decreased glutathione(GSH)levels were detected in BDL ***,mitochondrial indices,including adenosine triphosphate(ATP)level,dehydrogenase activity,mitochondrial membrane potential,and mitochondrial permeability,were impaired in the kidney of cholestatic *** histopathological alterations in cholestatic animals included tubular degeneration and interstitial inflammation,cast formation,and *** was found that metformin significantly alleviated oxidative stress and improved mitochondrial indices in the kidney of cholestatic *** histopathological alterations were also mitigated in metformin-treated ***:Metformin could be a candidate for managing *** nephroprotective role of metformin is primarily associated with its effects on oxidative stress parameters and mitochondrial function.

关键词： Metformin Bile acids Cholestasis Cirrhosis Oxidative stress Mitochondrial function Energy crisis Cholemic nephropathy(CN) Renal failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancing volumetric muscle loss(VML)recovery in a rat model using super durable hydrogels derived from bacteria

引用

Bioactive Materials 2024年第8期38卷 540-558页

作者： Seyyed Vahid Niknezhad Mehdi Mehrali Farinaz Riyahi Khorasgani reza Heidari Firoz Babu Kadumudi Nasim Golafshan Miguel Castilho Cristian Pablo Pennisi Masoud Hasany mohammadjavad Jahanshahi mohammad Mehrali Younes Ghasemi Negar azarpira Thomas L.Andresen Alireza Dolatshahi-Pirouz Burn and Wound Healing Research Center Shiraz University of Medical SciencesShiraz71987-54361Iran Department of Civil and Mechanical Engineering Technical University of Denmark2800Kgs LyngbyDenmark Department of Health Technology Technical University of Denmark2800Kongens LyngbyDenmark Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShirazIran Department of Orthopaedics University Medical Center UtrechtUtrecht3584 CXthe Netherlands Department of Biomedical Engineering Eindhoven University of Technologythe Netherlands Regenerative Medicine Group Department of Health Science and TechnologyAalborg University9260GistrupDenmark Department of Chemistry Faculty of ScienceUniversity of Jiroft***JiroftIran Faculty of Engineering Technology Department of Thermal and Fluid Engineering(TFE)University of Twente7500 AEEnschedethe Netherlands Transplant Research Center Shiraz University of Medical SciencesShirazIran Institute for Complex Molecular Systems Eindhoven University of TechnologyEindhoventhe Netherlands Department of Health Technology Section for Biotherapeutic Engineering and Drug TargetingTechnical University of Denmark2800Kongens LyngbyDenmark

Bacteria can be programmed to deliver natural materials with defined biological and mechanical properties for controlling cell growth and ***,we present an elastic,resilient and bioactive polysaccharide derived from the extracellular matrix of Pantoea *** ***,it was methacrylated to generate a new photo crosslinkable hydrogel that we coined Pantoan Methacrylate or put simply *** have used it for the first time as a tissue engineering hydrogel to treat VML injuries in *** crosslinked PAMA hydrogel was super elastic with a recovery nearing 100%,while mimicking the mechanical stiffness of native *** inclusion of thiolated gelatin via a Michaelis reaction with acrylate groups on PAMA we could also guide muscle progenitor cells into fused and aligned tubes-something reminiscent of mature muscle *** results were complemented by sarcomeric alpha-actinin immunostaining ***,the implanted hydrogels exhibited almost 2-fold more muscle formation and 50%less fibrous tissue formation compared to untreated rat *** vivo inflammation and toxicity assays likewise gave rise to positive results confirming the biocompatibility of this new biomaterial ***,our results demonstrate that programmable polysaccharides derived from bacteria can be used to further advance the field of tissue *** greater detail,they could in the foreseeable future be used in practical therapies against VML.

关键词： hydrogel simply fused

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration

引用

Bio-Design and Manufacturing 2021年第4期4卷 735-756页

作者： Haniyeh Najafi Mahboobeh Jafari Ghazal Farahavar Samira Sadat Abolmaali Negar azarpira Sedigheh Borandeh Raheleh Ravanfar Pharmaceutical Nanotechnology Department Shiraz University of Medical Sciences71345-1583 ShirazIran Center for Nanotechnology in Drug Delivery Shiraz University of Medical Sciences71345-1583 ShirazIran Transplant Research Center Shiraz University of Medical SciencesMohammad Rasoul-Allah Research Tower*** ShirazIran Polymer Technology Research Group Department of Chemical and Metallurgical EngineeringAalto University02152 EspooFinland Division of Chemistry and Chemical Engineering California Institute of TechnologyPasadenaCA 91125USA

The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance,especially in societies with a large elderly ***-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility,tunable mechanical stability,injectability,trigger capability,lack of immunogenic reactions,and the ability to load cells and active pharmaceutical agents for tissue ***-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals,which can mimic the extracellular ***,peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional *** review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration,including ionic self-complementary peptides,amphiphilic(surfactant-like)peptides,and triple-helix(collagen-like)*** attention is given to the main bioactive peptides,the role and importance of self-assembled peptide hydrogels,and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.

关键词： Self-assembled peptides Hydrogel Bone-repair material Dental regeneration Hard tissue engineering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatitis B virus genotypes in southwest Iran: Molecular, serological and clinical outcomes

引用

World Journal of Gastroenterology 2008年第10期14卷 1510-1513页

作者： Anahita Mojiri Abbas Behzad-Behbahani Mehdei Saberifirozi Maryam Ardabili Mahmood Beheshti Marjan Rahsaz Mehrdad Banihashemi Negar azarpira Bita Geramizadeh Baharak Khadang Afsaneh Moaddeb Mojgan Ghaedi Tahereh Heidari Ardeshir Torab Alireza Salah Saeid Amirzadeh Zahra Jowkar Davood Mehrabani Samad Amini-Bavil-Olyaee mohammad Ali Dehyadegari Gastroenterology and Hepatology Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Organ Transplant Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Department of Microbiology School of Medicine Shiraz University of Medical Sciences Shiraz Iran Iranian Blood Transfusion Organization Shiraz Iran Biotechnology Department PasteurInstitute of Iran Tehran Iran Professor Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran

AIM: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. RESULTS: Genotype D was the only type of HBV foundin different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV- infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals (P = 0.24). CONCLUSION: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.

关键词： Hepatitis B virus-D Cirrhosis Iran Anti-HBe Polymerase chain reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：