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Cutaneous Manifestations of HIV/AIDS in the Era of Highly Active Antiretroviral Therapy: Evidence from Bangladesh

International Journal of Dermatology and Venereology 2022年第1期5卷 8-14页

作者： mohammad rafiqul mowla Mohammed Abul Manchur A Q M Serajul Islam Toby Maurer Department of Dermatology and Venereology Chittagong Medical CollegeChittagong 4203Bangladesh Department of Microbiology University of ChittagongChittagong 4331Bangladesh Department of Dermatology Indiana UniversityBloomingtonIN 47405USA Institute for Global Health University of CaliforniaSan FranciscoCA 94110USA

Objective:Skin diseases are common and striking features of patients with human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)and may vary considerably by ethnic and geographic regions and by the influence of highly active antiretroviral therapy(HAART).However,little information exists regarding the cutaneous manifestations of patients with HIV/AIDS in *** study was performed to elucidate the spectrum of cutaneous disorders in patients with HIV/AIDS in the era of ***:This descriptive cross-sectional study was carried out in Chittagong Medical College Hospital,Bangladesh from January 2017 and December *** case of HIV/AIDS for HAART therapy and all cases of HIV/AIDS who are already on HAART therapy were included in this *** statistical analysis was carried out by using frequencies and ***:Of 40 patients with HIV/AIDS,22(55.0%)were male and 18(45.0%)were *** patients ranged in age from 8 to 60 years,with a mean age of 38±0.966 *** all age groups,the highest 19(47.5%)patients were in the 31-to 40-year age *** of the patients were migrant workers[22/40(55.0%)]with low socioeconomic status[32/40(80.0%)],and the most common transmission mode was heterosexual activity[36/40(90.0%)].Most of the patients[32/40(80.0%)]had mucocutaneous disorders,30/40(75.0%)had infective dermatoses,and 21/40(52.5%)had non-infective inflammatory *** of forty(20.0%)patients presented with three or more skin *** most common infective dermatoses were fungal infections[15/40(37.5%)],followed by viral infections[8/40(20.0%)],bacterial infections[4/40(10.0%)],and scabies[3/40(7.5%)].The most common non-infective dermatosis was generalized pruritus[6/40(15.0%)],followed by prurigo simplex[4/40(10.0%)],psoriasis[4/40(10.0%)],eczema[3/40(7.5%)],pruritic papular eruption[1/40(2.5%)],seborrheic dermatitis[1/40(2.5%)],urticaria[1/40(2.5%)],and xerosis[1/40(2.5%)].Patients treat

关键词： Bangladesh Chittagong cutaneous highly active antiretroviral therapy(HAART) human immunodefi-ciency virus/acquired immunodeficiency syndrome(HIV/AIDS)

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Efficacy and Safety of Prednisolone Monotherapy Versus Prednisolone Plus Methotrexate in Erythema Nodosum Leprosum (Type 2 Lepra Reaction)

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International Journal of Dermatology and Venereology 2020年第4期3卷 205-210页

作者： Hasan Zahidul mowla mohammad rafiqul Angkur Debashish Mondol Khan Md. Ismail Department of Dermatology and Venereology Chittagong Medical CollegeChittagong 4203Bangladesh Department of Pharmacology Chittagong Medical UniversityChittagong 4203Bangladesh

Objective:This study was performed to compare the efficacy and safety of methotrexate(MTX)plus prednisolone versus prednisolone monotherapy in patients with erythema nodosum leprosum(ENL).Methods:This comparative clinical study was performed in the Chittagong Medical College Hospital,Bangladesh from June 2018 to December *** patients were selected according to inclusion criteria and randomly allocated to either the MTX plus prednisolone group(Group A,n=10)or the prednisolone monotherapy group(Group B,n=9).All patients were followed up until the end of the 6-month duration of therapy to observe the clinical outcomes and adverse ***:All patients in both groups showed significant improvement(P=0.005 and P=0.008 in Group A and B,respectively).However,prednisolone-related adverse events were more frequent in Group ***:The present study has demonstrated that a combination of prednisolone and MTX is a safer and more effective treatment than steroid monotherapy in ENL patients including the healing of ***,this combination therapy did not appear to have a significant steroid-sparing effect,possibly because of the small sample size and short study ***,a well-designed multicenter randomized controlled trial is recommended for validation of MTX with prednisolone for the management of ENL.

关键词： erythema nodosum leprosum type 2 lepra reaction methotrexate prednisolone Bangladesh

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How to manage rheumatoid arthritis according to classic biomarkers and polymorphisms？

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Frontiers in Biology 2017年第3期12卷 183-191页

作者： Karim mowla mohammad Amin Saki mohammad Taha Jalali Zeinab Deris Zayeri Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Sana Institute of Higher Education Mazandaran Sari Iran Department of Laboratory Sciences School of Para-medical science Jundishapur University of Medical Science Ahvaz Iran

OBJECTIVES： Single nucleotide polymorphisms （SNPs）, genetic background, and epigenetics play important roles in rheumatoid arthritis （RA）. These factors can be useful in RA diagnosis, prognosis, and treatment response evaluation, particularly with the growing trends in personalized medicine. Therefore, categorizing classic genes and SNPs in RA can present an appropriate guideline for RA management. DISCUSSION： Prognostic and diagnostic biomarkers play important roles in RA diagnosis and treatment. Categorizing SNPs is not an easy process yet, but selecting classic SNPs can be useful worldwide, according to basic similarities that exist in genomes. In this review, we compiled some of these RA-associated SNPs and biomarkers in a table, according to newly identified factors. The role of epigenetics in RA is undeniable; using epigenetic biomarkers like histone deacetylase （HDACs） can be useful in RA diagnosis and treatment, miRs such as miR-146a, miR-155, and miR-222 are useful in diagnosis and can be used in treatment by interfering with other factors＇ functions. Interleukins （ILs） seem to be good prognostic and diagnostic markers and can be targeted in RA treatment. CONCLUSION： Using multiple types of biomarkers, such as useful in RA management and treatment. PTPN22, HLA-DR genes, SNPs, and epigenetic biomarkers like HDACs can be polymorphisms, miRs, and HDACs are considerable in RA susceptibility; hence, they can be valuable biomarkers in future studies. This article gathered separate information from approximately 100 articles to present useful biomarkers and polymorphisms in one review.

关键词： polymorphism rheumatoid arthritis miRs HLA-DR epigenetics

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Threatening biomarkers in lupus pregnancy： Biochemistry and genetic challenges

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Frontiers in Biology 2018年第1期13卷 28-35页

作者： Karim mowla Elham Rajaei mohammad Taha Jalali Zeinab Deris Zayeri Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Hyperlipidemia Research Center Diabetes Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

OBJECTIVES： Using genetic markers and miRs work strongly beside other sensitive biomarkers in lupus management during sensitive period of pregnancy. METHOD： PubMed and Google Scholar databases were searched from 2000 to 2017 using the terms ＂lupus,＂＂lupus pregnancy, biomarkers,＂＂micro-RNA,＂＂polymorphisms,＂＂anti-phospholipid antibodies,＂ and ＂cluster differentiation markers,＂ DISCUSSION： Complement is a valuable biomarker in lupus pregnancy. However, the complement profile has ambiguous meaning because decreased levels of C3 and C4 reflect inflammation and because they are also prognostic biomarkers for abortion. Furthermore, increased C3 and C4 levels indicate hepatic protein synthesis in hepatocytes. Anti-phospholipid （APL） antibodies are present in 25% to 50% of lupus patients, and can lead to thrombotic and obstetric complications in some pregnancies and increase the risk of abortion, especially in a pregnant woman in the active phase of lupus. Several studies have associated APL with HELLP syndrome. However, other pregnancy complications have not been associated with APL. Autoantibodies against the major vault protein and anti-double strand DNA antibodies are valuable biomarkers in evaluating lupus activity. The expression pattern ofmicro-RNAs （miRs） differs in various diseases. Current studies have demonstrated the potential of miRs as diagnostic and prognostic biomarkers in various diseases; for example, the level of miR-126 is higher in lupus. CONCLUSION： miR-223-3p and miR-451 are informative biomarkers in estimating disease activity. TWEAK, BAFF, and APOL1 genes, and their polymorphisms are informative in estimating disease activity, especially renal effects, and in monitoring higher-risk pregnant women. Further studies of these genes and their relevant polymorphisms are needed.

关键词： lupus biomarker genetic micro-RNA anti-phospholipid antibodies

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