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Effect of nanoparticle diameter on the forced convective heat transfer of nanofluid(water+Al_(2)O_(3))in the fully developed laminar region

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International Journal of Modeling, Simulation, and Scientific Computing 2014年第3期5卷 104-114页

作者： Seyyed Shahabeddin Azimi Mansour Kalbasi mohammad Hosain namazi Department of chemical Engineering Amirkabir University of Technology Hafez Avenue Tehran Iran

Nanofluid is a suspension of nanoparticles(solid particles with diameters below 100 nm)in a conventional base fluid with significantly improved heat transfer characteristics compared to the original *** heat transfer coefficient is a quantitative characteristic of the convective heat *** purpose of this paper is to study the effect of the nanoparticle size(diameter)on the heat transfer coefficient of forced convective heat transfer of nanofluid in the fully developed laminar region of a horizontal *** thermal conductivity model which is a function of the nanoparticle size,flow of a nanofluid(water+Al2O3)in a circular tube submitted to a constant wall temperature is numerically investigated with two particle sizes of 11 nm and 47 *** calculated results show that the nanoparticle size does not significantly affect the heat transfer coefficient,however,the heat transfer coefficient decreases as the particle size increases.

关键词： Nanoparticle volume fraction particle size heat transfer coefficient

The necessity for integrating traditional, complementary, and alternative medicine into medical education curricula in Iran

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Journal of Integrative Medicine 2019年第4期17卷 296-301页

作者： mohammad Hossein Ayati Ata Pourabbasi Nazli namazi Arman Zargaran Zahra Kheiry Amir Hooman Kazemi Bagher Larijani Department of Traditional Medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Department of History of Medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran ***Iran Diabetes Research Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran *** Iran Department of Traditional Pharmacy School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Idea Development and Innovation Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran *** Iran

Background: The use of traditional and complementary medicine (T&CM) is increasing in both developed and developing countries. The school of Persian medicine (PM) in Iran is a comprehensive medical school that is rich in history and has its own special principles, elements, philosophy, and diagnostic and treatment options. Many complementary therapy modalities are also popular and in demand among patients and physicians. The aim of this paper is to provide logic for the policymakers in Iranian medical education to make changes in medical education curricula, particularly on integrating T&CM. Methods: We reviewed the global experience in teaching T&CM to medical students, and highlighting the strengths of PM, described why it is necessary to integrate T&CM into general medicine curricula in Iran. Results: PM is a traditional system of medicine that dates back about 7000 years. Although there are few studies about the safety and effectiveness of PM, research into it has recently been accelerated. There is a suitable opportunity for integrating T&CM with conventional medicine. Physicians should be familiar with T&CM to avoid any contraindications, interactions, and unwanted effects. Conclusion: Traditional medicine is part of Iran's heritage and. thus, needs special attention. Familiarization of physicians with T&CM can help them choose the best treatment options for their patients. To integrate T&CM into the medical education curricula of Iran, a two-credit course has been proposed for implementation across the country.

关键词： Integrative medicine Traditional medicine Complementary medicine Medical education curriculum

Exploring the potential and safety of quantum dots in allergy diagnostics

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Microsystems & Nanoengineering 2023年第6期9卷 1-23页

作者： Milad Mohkam mohammad Sadraeian Antonio Lauto Ahmad Gholami Seyed Hesamodin Nabavizadeh Hossein Esmaeilzadeh Soheila Alyasin Allergy Research Center Shiraz University of Medical SciencesShirazIran Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia School of Science University of Western SydneyCampbelltownNSW2560Australia School of Medicine University of Western SydneyCampbelltownNSW2560Australia Biotechnology Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmaceutical Biotechnology School of PharmacyShiraz University of Medical SciencesShirazIran Department of Allergy and Clinical Immunology Namazi HospitalShiraz University of Medical SciencesShirazIran

Biomedical investigations in nanotherapeutics and nanomedicine have recently intensified in pursuit of new therapies with improved *** dots(QDs)are promising nanomaterials that possess a wide array of advantageous properties,including electronic properties,optical properties,and engineered biocompatibility under physiological *** to these characteristics,QDs are mainly used for biomedical labeling and theranostic(therapeutic-diagnostic)*** can be functionalized with ligands to facilitate their interaction with the immune system,specific IgE,and effector cell ***,undesirable side effects such as hypersensitivity and toxicity may occur,requiring further *** review systematically summarizes the potential uses of QDs in the allergy *** overview of the definition and development of QDs is provided,along with the applications of QDs in allergy studies,including the detection of allergen-specific IgE(sIgE),food allergens,and sIgE in cellular *** potential treatment of allergies with QDs is also described,highlighting the toxicity and biocompatibility of these ***,we discuss the current findings on the immunotoxicity of *** favorable points regarding the use of QDs for allergy diagnosis and treatment are noted.

关键词： allergy diagnosis potential

A simple multiplex PCR for assessing prevalence of extended-spectrumβ-lactamases producing Klebsiella pneumoniae in Intensive Care Units of a referral hospital in Shiraz,Iran

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 703-708页

作者： Younes Ghasemi Talieh Archin mohammad Kargar Milad Mohkam Parmaceutical Sciences Research Center School of PharmacyShiraz University of Medical Sciences Department of Pharmaceutical Biotechnology School of PharmacyShiraz University of Medical Sciences Department of Microbiology Jahrom BranchIslamic Azad University

Objective:To identify three common genes(bla_(TEM),bla_(SHV)and bla_(CTX-M)responsible for ESBL production in Klebsiella pneumnniae(***)isolated from Intensive Care Units of namazi Hospital,Shiraz,***:A total of 60 non-repetitive nosocomial isolates from 60patients were selected during *** phenotypic identification of ESBL production was confirmed by Double Disk Synergy Test(DDST)according to CLSI *** ESBL's genotype was then analyzed by multiplex PCR of bla_(TEM),bla_(SHV)and bla_(CTX-M)genes and DNA ***:The primary susceptibility tests of *** showed that among 10 examined antibiotics,the most resistant and susceptible antibiotics identified in this study were ampicillin and imipenem,*** phenotypic determination of ESBL by DDST showed that 60%(n=36)of isolates produced *** PCR of genes among *** isolates showed that 39%(n=18)of them have TEM,39%in=18)of then have both CTX-M and TEM and 13%(n=8)of them have TEM,SHV,***:Our findings reveal the high prevalence(60%)of ESBL prcxducing *** from ICL patients along with a new pattern of bla_(TEM)distribution differ from other countries.

关键词： Klebsiella pneumoniae ESBLs ICUs Multiplex PCR

Does delayed gastric emptying shorten the H pylori eradication period? A double blind clinical trial

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World Journal of Gastroenterology 2006年第39期12卷 6310-6315页

作者： mohammad Hassan Emami mohammad Mehdi Saberfiroozi Abbas Arj Ali Reza Taghavi Kamran Bagheri-Lankarani Najaf Dehbashi mohammad Reza Fattahi Mahvash Alizadeh mohammad Javad Kaviani Rahim Bahri-Najafi Bita Geramizadeh Abbas Esmaeili Gastroenterologist Isfahan University of Medical Sciences Poursina Hakim Research Institute Isfahan Iran Gastroenterologist Namazi University Hospital School of Medicine Shiraz University of Medical Sciences Isfahan Iran Gastroenterologist School of Medicine Kashan University of Medical Sciences Isfahan Iran Clinical Pharmacist Pharmaceutical School Shiraz University of Medical Sciences Shiraz Iran General Practitioner Poursina Hakim Research Institute Isfahan Iran

AIM: To evaluate the gastric emptying inhibitory effects of sugar and levodopa on H pylori eradication period. METHODS: A total of 139 consecutive patients were randomized into 6 groups. The participants with peptic ulcer disease or non-ulcer dyspepsia non-responding to other medications who were also H pylori-positive patients either with positive rapid urease test (RUT) or positive histology were included. All groups were pretreated with omeprazole for 2 d and then treated with quadruple therapy regimen (omeprazole, bismuth, tetracycline and metronidazole); all drugs were given twice daily. Groups 1 and 2 were treated for 3 d, groups 3, 4 and 5 for 7 d, and group 6 for 14 d. Groups 1 to 4 received sugar in the form of 10% sucrose syrup. Levodopa was prescribed for groups 1 and 3. Patients in groups 2 and 4 were given placebo for levodopa and groups 5 and 6 received placebos for both sugar and levodopa. Upper endoscopy and biopsies were carried out before treatment and two months after treatment. Eradication of H pylori was assessed by RUT and histology 8 wk ***: Thirty patients were excluded. Per-protocol analysis showed successful eradication in 53% in group 1, 56% in group 2, 58% in group 3, 33.3% in group 4, 28% in group 5, and 53% in group 6. Eradication rate, patient compliance and satisfaction were not significantly different between the groups. CONCLUSION: It seems that adding sugar or levodopa or both to anti H pylori eradication regimens may lead to shorter duration of treatment.

关键词：胃排空幽门螺杆菌葡萄糖左旋多巴

Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level

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World Journal of Gastroenterology 2017年第7期23卷 1224-1232页

作者： Ahad Eshraghian mohammad Hadi Imanieh Seyed Mohsen Dehghani Saman Nikeghbalian Alireza Shamsaeefar Frouzan Barshans Kourosh Kazemi Bita Geramizadeh Seyed Ali Malek-Hosseini Transplant Research Center Shiraz University of Medical Sciences Gastroenterohepatology Research Center Namazi Hospital

AIM To investigate incidence and survival of post-transplant lymphoproliferative disorder(PTLD) patients after liver transplantation. METHODS A cross-sectional survey was conducted among patients who underwent liver transplantation at Shiraz Transplant Center(Shiraz, Iran) between August 2004 and March 2015. Clinical and laboratory data of patients were collected using a data gathering form. RESULTS There were 40 cases of PTLD in the pediatric age group and 13 cases in the adult group. The incidence of PTLD was 6.25% in pediatric patients and 1.18% in adult liver transplant recipients. The post-PTLD survival of patients at 6 mo was 75.1% ± 6%, at 1 year was 68.9% ± 6.5% and at 5 years was 39.2% ± 14.2%. Higher serum tacrolimus level was associated with lower post-PTLD survival in pediatric patients(OR = 1.07, 95%CI: 1.006-1.15, P = 0.032). A serum tacrolimus level over 11.1 ng/mL was predictive of post PTLD survival(sensitivity = 90%, specificity = 52%, area under the curve = 0.738, P = 0.035). CONCLUSION Incidence of PTLD in our liver transplant patients is comparable to other centers. Transplant physicians may consider adjustment of tacrolimus dose to maintain its serum level below this cutoff point.

关键词： transplant 以后 lymphoproliferative 混乱肝移植幸存 Tacrolimus Epstein-Barr 病毒

Role of cytomegalovirus on the maturation and function of monocyte derived dendritic cells of liver transplant patients

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World Journal of Transplantation 2016年第2期6卷 336-346页

作者： mohammad Hossein Karimi Afsoon Shariat Ramin Yaghobi Talat Mokhtariazad Seyed mohammad Moazzeni Shiraz Trans-plant Research Center Shiraz University of Medical Sciences Department of Microbiology Faculty of Basic SciencesKazerun BranchIslamic Azad University College of Basic Sciences Tehran Science and Research BranchIslamic Azad University Department of Virology School of Public HealthTehran University of Medical Sciences Department of Immunology Faculty of Medical SciencesTarbiat Modarres University

AIM: To study the impact of association between cytomegalovirus(CMV) pathogenesis with dendritic cell(DC) maturation and function was evaluated in CMV reactivated liver transplanted patients in comparing with non-reactivated ones, and healthy controls. METHODS: Monocyte derived dendritic cells(Mo DCs) was generated from collected ethylenediaminetetraacetic acid-treated blood samples from patient groups and controls. In these groups, expression rates and mean fluorescent intensity of DC markers were evaluated using flowcytometry technique. Secretion of cytokines including: interleukin(IL)-6, IL-12 and IL-23 were determined using enzyme-linked immunosorbent assay methods. The gene expression of toll-like receptor 2(TLR2), TLR4 and IL-23 were analyzed using in-house real-time polymerase chain reaction ***: Results have been shown significant decreases in: Expression rates of Mo DC markers including CD83, CD1 a and human leukocyte antigen DR(HLA-DR), the mean fluorescence intensitys for CD1 a and HLA-DR, and secretion of IL-12 in CMV reactivated comparedwith non-reactivated liver transplanted patients. On the other hand, significant increases have been shown in the secretions of IL-6 and IL-23 and gene expression levels of TLR2, TLR4 and IL-23 from Mo DCs in CMV reactivated compared with non-reactivated liver transplanted recipients. CONCLUSION: DC functional defects in CMV reactivated recipients, such as decrease in expression of DC maturation markers, increase in secretion of proinflammatory cytokines, and TLRs can emphasize on the importance of CMV infectivity in development of liver rejection in transplanted patients.

关键词： Cytomegalovirus Dendritic cells Liver transplantation

Hepatitis B virus genotypes in southwest Iran: Molecular, serological and clinical outcomes

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World Journal of Gastroenterology 2008年第10期14卷 1510-1513页

作者： Anahita Mojiri Abbas Behzad-Behbahani Mehdei Saberifirozi Maryam Ardabili Mahmood Beheshti Marjan Rahsaz Mehrdad Banihashemi Negar Azarpira Bita Geramizadeh Baharak Khadang Afsaneh Moaddeb Mojgan Ghaedi Tahereh Heidari Ardeshir Torab Alireza Salah Saeid Amirzadeh Zahra Jowkar Davood Mehrabani Samad Amini-Bavil-Olyaee mohammad Ali Dehyadegari Gastroenterology and Hepatology Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Organ Transplant Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Department of Microbiology School of Medicine Shiraz University of Medical Sciences Shiraz Iran Iranian Blood Transfusion Organization Shiraz Iran Biotechnology Department PasteurInstitute of Iran Tehran Iran Professor Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran

AIM: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. RESULTS: Genotype D was the only type of HBV foundin different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV- infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals (P = 0.24). CONCLUSION: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.

关键词：乙型肝炎病毒肝硬化聚合酶联反应基因型伊朗