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The anti-neoplastic effects of metformin modulate the acquired phenotype of fbroblast cells in the breast cancer-normal fbroblast co-culture system

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Oncology Research 2024年第3期32卷 477-487页

作者： SAMANEH MOSTAFAVI ZUHAIR mohammad HASSAN Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Intracellular communications between breast cancer and fibroblast cells were reported to be involved in cancer proliferation,growth,and therapy *** hallmarks of cancer fibroblast interactions,consisting of caveolin 1(Cav1)and mono-carboxylate ransporter 4(MCT4)(metabolic coupling markers),along with IL-6,TGFB,and lactate secretion,are considered robust biomarkers predicting recurrence and *** order to promote a novel phenotype in normal fibroblasts,we predicted that breast cancer cells could be able to cause loss of Cavl and increase of MCT4,as well as elevate IL 6 and TGF in nearby nomal *** created a co culture model using breast cancer(4T1)and normal fibroblast(NIH3T3)cell lines cultured under specific experimental conditions in order to directly test our ***,we show that long-term co-culture of breast cancer cells and normal fibroblasts promotes loss of Cavl and gain of MCT4 in adjacent fibroblasts and increase lactate *** results were validated using the monoculture of each group separately as a *** this system,we show that me tformin inhibits IL-6 and TGFB secretion and re expresses Cavl in both ***,MCT4 and lactate stayed high after treatment with *** conclusion,our work shows that co-culture with breast cancer cells may cause signifcant alterations in the phenotype and secretion of normal ***,however,may change this state and affect fibroblasts'acquired ***,mitochondrial inhibition by metformin after 8 days of treatment,signi ficantly hinders tumor growth in mouse model of breast cancer.

关键词： Caveolin 1 Lactic acid Metformin NIH 3T3 cells Neoplasms

Wettability modification effects on relative permeability end-points:Comparative analysis of surfactant agents for enhanced oil recovery

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Petroleum Research 2024年第2期9卷 206-218页

作者： Erfan Hosseini Negar Hosseini mohammad Sarmadivaleh Exploration Directorate National Iranian Oil Company(NIOC)TehranIran Department of Petroleum Engineering Islamic Azad University(IAU)IlamIran WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWestern AustraliaAustralia

This research examines the impact of wettability alteration on the end points of relative permeability,a crucial property of fluids and porous media that influences the displacement processes of immiscible fluids through such *** estimation of the mobility ratio for oil recovery relies on these end points,which are influenced by connate water saturation and residual oil *** investigate this relationship,carbonate rock is generally subjected to wettability alteration using surfactant agents,and core flooding is employed to determine the relative permeability before and after the *** wettability of the rock is commonly assessed through contact angle *** surfactants,TritonX-100(Tx-100)and Cedar,were tested in reducing the wettability of the porous media for *** contact angle measurements revealed that Tx-100 was more effective for this purpose than ***,the relative permeability tests indicated that both surfactants decreased residual oil saturation,but Tx-100 also improved system *** contrast,Cedar reduced residual oil saturation but increased system pressure,possibly because of its high *** results also demonstrate that injecting Tx-100 leads to a 14%increase in ultimate oil recovery compared with water injection,while Cedar injection increased the recovery factor by 5%.This difference may be attributed to the incomplete coverage of the pore wall by Cedar or its weaker chemical structure than ***,in carbonate cores,neither non-ionic surfactant enhanced oil recovery.

关键词： Wettability alteration Relative permeability Core flooding Tx-100 Cedar Contact angle

High-fidelity model to predict heat transfer enhancement for liquid film boiling on uniform micro-structured wicking surfaces

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National Science Review 2024年第6期11卷 93-95页

作者： Vishwanath Ganesan mohammad Jalal Inanlu Nenad Miljkovic Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Materials Research Laboratory University of Illinois Urbana-Champaign International Institute for Carbon Neutral Energy Research (WPI-I2CNER) Kyushu University Institute for Sustainability Energy and Environment (iSEE)University of Illinois Urbana-Champaign

The field of thermal management in highpower electronic devices is a critical area of study, focusing on the efficient dissipation of heat to prevent device overheating and failure [1]. A key aspect of this field is understanding the dynamics of thin liquid film boiling, both on uniform and non-uniform micro-structured wicking surfaces, which can significantly enhance the heat transfer effectiveness[2].

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Exploring Multi-Task Learning for Forecasting Energy-Cost Resource Allocation in IoT-Cloud Systems

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Computers, Materials & Continua 2024年第6期79卷 4603-4620页

作者： mohammad Aldossary Hatem A.Alharbi Nasir Ayub Department of Computer Engineering and Information College of EngineeringPrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir11991Saudi Arabia Department of Computer Engineering College of Computer Science and EngineeringTaibah UniversityMadinah42353Saudi Arabia Department of Creative Technologies Air University IslamabadIslamabad44000Pakistan

Cloud computing has become increasingly popular due to its capacity to perform computations without relying on physical infrastructure,thereby revolutionizing computer ***,the rising energy consumption in cloud centers poses a significant challenge,especially with the escalating energy *** paper tackles this issue by introducing efficient solutions for data placement and node management,with a clear emphasis on the crucial role of the Internet of Things(IoT)throughout the research *** IoT assumes a pivotal role in this study by actively collecting real-time data from various sensors strategically positioned in and around data *** sensors continuously monitor vital parameters such as energy usage and temperature,thereby providing a comprehensive dataset for *** data generated by the IoT is seamlessly integrated into the Hybrid TCN-GRU-NBeat(NGT)model,enabling a dynamic and accurate representation of the current state of the data center *** the incorporation of the Seagull Optimization Algorithm(SOA),the NGT model optimizes storage migration strategies based on the latest information provided by IoT *** model is trained using 80%of the available dataset and subsequently tested on the remaining 20%.The results demonstrate the effectiveness of the proposed approach,with a Mean Squared Error(MSE)of 5.33%and a Mean Absolute Error(MAE)of 2.83%,accurately estimating power prices and leading to an average reduction of 23.88%in power ***,the integration of IoT data significantly enhances the accuracy of the NGT model,outperforming benchmark algorithms such as DenseNet,Support Vector Machine(SVM),Decision Trees,and *** NGT model achieves an impressive accuracy rate of 97.9%,surpassing the rates of 87%,83%,80%,and 79%,respectively,for the benchmark *** findings underscore the effectiveness of the proposed method in optimizing energy efficiency and enhancing the predictive

关键词： Cloud computing energy efficiency data center optimization internet of things(IoT) hybrid models

Synchrotron X-ray micro-computed tomography imaging of solid bridges between potash particles near contact points

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Particuology 2024年第9期92卷 24-29页

作者： Mojtaba Nabipoor Hassankiadeh mohammad Mehdi Heydari Carter Blocka Lifeng Zhang Department of Chemical and Biological Engineering University of SaskatchewanSKS7N 5A9SaskatoonCanada

Chemical fertilizers,such as potash,have a strong tendency to cake when exposed to *** this work,a novel synchrotron-based X-ray tomography 3D-imaging technique was for the first time employed to investigate the solid bridge formation from 2D and 3D *** processing and a theoretical model were presented to demonstrate recrystallization near contact points between potash particles during a conventional drying *** effect of initial moisture content on the water activity of surface surrounding the contact points was *** results showed that by increasing the moisture content of particles(3%–5%),the dissolution of sylvite increased and the solid bridge length between potash particles was enlarged from 28μm to 44μm due to supersaturation *** addition,the external porosity of potash particles at the end of drying process decreased from 25.3%to 19.5%for 3%and 5%moisture content,respectively.

关键词： Potash fertilizer Solid bridge Recrystallization Synchrotron X-ray micro-CT imaging Drying process

Longitudinal vibration characteristics of a tapered pipe pile considering the vertical support of surrounding soil and construction disturbance

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 51-63页

作者： Li Zhenya Pan Yunchao He Xianbin Lv Chong mohammad Towhid Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China Geotechnical Research Institute Hohai UniversityNanjing 210098China MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China

This research is concentrated on the longitudinal vibration of a tapered pipe pile considering the vertical support of the surrounding soil and construction ***,the pile-soil system is partitioned into finite segments in the vertical direction and the Voigt model is applied to simulate the vertical support of the surrounding soil acting on the pile *** surrounding soil is divided into finite ring-shaped zones in the radial direction to consider the construction ***,the shear complex stiffness at the pile-soil interface is derived by solving the dynamic equilibrium equation for the soil from the outermost to innermost *** displacement impedance at the top of an arbitrary pile segment is obtained by solving the dynamic equilibrium equation for the pile and is combined with the vertical support of the surrounding soil to derive the displacement impedance at the bottom of the upper adjacent ***,the displacement impedance at the pile head is obtained based on the impedance function transfer ***,the reliability of the proposed solution is verified,followed by a sensitivity analysis concerning the coupling effect of the pile parameters,construction disturbance and the vertical support of the surrounding soil on the displacement impedance of the pile.

关键词： tapered pipe pile longitudinal vibration vertical support of the surrounding soil construction disturbance displacement impedance

Peer-to-Peer Trading in Distribution Systems with the Utility's Operation

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 629-638页

作者： Xuanyi Xiao Feng Wang mohammad Shahidehpour Yujia Zhai Quan Zhou Department of Electrical and Information Engineering Hunan UniversityChangshaChina Robert W.Galvin Center for Electricity Innovation Ilinois Institute of TechnologyChicagoIL60616USA

To realize a liberalized peer-to-peer (P2P) electricity market in distribution systems with network security, this paper develops a general framework for P2P trading in distribution systems with the utility's operation. The model is formulated as a bi-level programming. The utility's operation is an upper level problem, where a calculation method of network usage charges for P2P trading is also proposed. Peers' P2P trading is a lower level problem. An iterative algorithm based on analytical target cascading (ATC) is proposed to solve the model, where the interactions between utility and peers are presented. Numerical results on the IEEE 33-bus system demonstrate that the proposed method realizes a liberalized P2P market and ensures network security in distribution systems.

关键词： Distribution system peer-to-peer trading electricitymarket distributed energyresources(DERs) analytical target cascading(ATC)

Fatal cases in pediatric patients after post-exposure prophylaxis for rabies:A report of two cases

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 39-42页

作者： Hekmatollah Khoubfekr mohammad Jokar Vahid Rahmanian Hasan Blouch mohammad Reza Shirzadi Rouzbeh Bashar Department of Public Health Iranshahr University of Medical SciencesIranshahrIran Faculty of Veterinary Medicine Karaj BranchIslamic Azad UniversityKarajIran Department of Public Health Torbat Jam Faculty of Medical SciencesTorbat JamIran Center for Communicable Diseases Control Ministry of Health and Medical EducationTehranIran WHO Collaborating Center for Reference and Research on Rabies Virology DepartmentPasteur Institute of IranTehranIran

Rationale:Rabies is a zoonotic disease with a high mortality,primarily transmitted through the bite of infected mammals,particularly dogs and *** being a well-known disease since ancient times,it continues to cause a significant number of human deaths worldwide,with approximately 65000 fatalities reported *** concerns:We present two fatal cases of rabies in a 12-year-old immigrant boy and a 7-year-old *** first case was subject to a 24-hour delay in receiving appropriate medical attention and rabies preventive measures due to the lack of awareness among emergency hospital staff,leading to the administration of wound dressing *** second case received timely rabies immunoglobulin administration;however,there was a 4-day delay in administering the fourth dose of the rabies vaccine,despite presenting evident symptoms of ***:Postmortem examination of brain samples from both patients confirmed the presence of rabies ***:Post-exposure prophylaxis for ***:Both patients were admitted to the hospital after the manifestation of rabies-related symptoms,with the 12-year-old child seeking medical care 47 days after the animal bite and the 7-year-old child seeking medical care 58 days after the ***,the first patient died after 27 days and the second patient died after 40 days of ***:There is an urgent need for heightened awareness and education among both healthcare professionals and the public regarding the urgency of seeking immediate medical attention after potential rabies *** recognition and initiation of post-exposure prophylaxis are pivotal in preventing the progression of the *** surveillance and reporting systems,coupled with continuous training for healthcare professionals,can contribute to early detection and management of rabies cases.

关键词： Rabies Encephalitis Pediatric patients Rabies prophylaxis Public health awareness

Studying the effect of surfactant assisted low-salinity water flooding on clay-rich sandstones

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Petroleum 2024年第2期10卷 306-318页

作者： Saeed Khezerloo-ye Aghdam Alireza Kazemi mohammad Ahmadi Department of Petroleum Engineering Amirkabir University of Technology(AUT)TehranIran Department of Petroleum and Chemical Engineering College of EngineeringSultan Qaboos UniversityMuscatOman

Sandstone reservoirs often contain clay particles that can cause damage and reduce permeability during low-salinity water *** this study,the effect of surfactants on fine migration in clay-rich sandstones and its impact on oil recovery was ***,the impact of surfactants on interparticle forces in fine-matrix,fine-fine,and oil-matrix systems was *** results showed that both CTAB(cetyltrimethyl ammonium bromide)and QS(quillaja saponin)cause EDL compaction,weakening the repulsive ***,SDS(sodium dodecyl sulfate)and TX(triton X-100)do not affect the ***,the effect of surfactants on IFT reduction and wettability alteration was experimentally *** surfactants reduced IFT due to the surface excessive concentration *** wettability alteration experiment illustrated that although QS and CTAB compact EDL around oil and matrix particles leading to attraction force augmentation,they both alter wettability through adsorption on matrix and carboxylic groups present in crude oil,*** aqueous solutions were then injected into various clay-rich sandstone sanpacks,which resulted in increased oil ***,the mechanisms leading to enhanced oil recovery variedby surfactant *** increased recovery by 10%through IFT reduction and wettability alteration,while SDS and TX increased recovery by 12%and 9%,respectively,through wettability alteration and extreme fine *** contrast,partial fine migration in the QS flooding experiment reached a recovery increase of 18%.Permeability trends through experiments were also *** CTAB injection,permeability did not reduce,while QS aqueous solution reduced rock permeability to 5 m *** and TX reduced the magnitude of permeability to 2 m *** conclusion,this study demonstrates that surfactants can effectively improve oil recovery in clay-rich sandstones by altering the interparticle forces,reducing IFT,and changing *** results

关键词： Surfactant flooding Smart water Fine migration Recovery factor