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Regional variation of pediatric inflammatory bowel disease in Saudi Arabia: Results from a multicenter study

World Journal of Gastroenterology 2020年第4期26卷 416-423页

作者： mohammad i el mouzan Mohammed H AlEdreesi Mohammed Y Hasosah Abdulrahman A Al-Hussaini Ahmad A Al Sarkhy Asaad A Assiri Department of Pediatrics Gastroenterology UnitKing Saud UniversityRiyadh11461Saudi Arabia Specialty Pediatrics Division Pediatric GastroenterologyJohns Hopkins Aramco HealthcareDhahran 31311Saudi Arabia Department of Pediatrics Gastroenterology UnitKing Saud bin Abdulaziz University for Health SciencesJeddah 21423Saudi Arabia Children Hospital Gastroenterology DivisionKing Fahad Medical CityRiyadh 11525Saudi Arabia Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research Chair Gastroenterology UnitKing Saud UniversityRiyadh 11461Saudi Arabia

BACKGROUND incidence and severity variations of inflammatory bowel disease(iBD)have been reported from Western populations between continents and regions of the same ***,no data were available from other *** To investigate the regional differences in the iBD profiles of pediatric patients from the Kingdom of Saudi *** Data from a national multicenter iBD study were *** incidence,time trend,and clinical presentation of Crohn’s disease(CD)and ulcerative colitis(UC)in the Central region(CR),Western region(WR),and Eastern region(ER)were analyzed and *** analysis included Poisson regression analysis for incidence variation and Chi-square test for demographic and clinical parameters.A Pidered *** The prevalence of positive family history was lower in children with CD from the ER than the CR or the *** rate was higher in children with CD and UC from the CR and the ER,*** incidences and time trends of CD and UC were not significantly different between *** the ER,a significantly higher percentage of children with CD presented with abdominal pain(Pin stools(P=0.048),stricturing or penetrating disease(P=0.029),higher erythrocyte sedimentation rate(Pigher C-reactive protein(Pigher anemia(P=0.017),and lower albumin level(P=0.014).For children with UC from the ER,a significantly higher percentage presented with anemia(P=0.006)and a lower percentage with pancolitis(PiON The most important finding is the identification of significantly more severe presentation of CD in the ER of the Kingdom of Saudi *** studies are needed to explain such variations.

关键词： Crohn’s disease Ulcerative colitis Epidemiology Children Regional variation

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Fungal dysbiosis predicts the diagnosis of pediatric Crohn's disease

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World Journal of Gastroenterology 2018年第39期24卷 4510-4516页

作者： mohammad i el mouzan Kirill S Korolev mohammad A Al Mofarreh Rajita Menon Harland S Winter Ahmad A Al Sarkhy Scot E Dowd Ahmad M Al Barrag Asaad A Assiri Department of Pediatrics King Saud UniversityRiyadh 11461Saudi Arabia Department of Pediatrics Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research ChairKing Saud UniversityRiyadh 11461Saudi Arabia Bioinformatics Program Boston UniversityBostonMA 02215United States Al Mofarreh PolyClinic Riyadh 11423Saudi Arabia MassGeneral Hospital for Children BostonMA 02114United States MRDNA ShallowaterTX 79363United States Department of Microbiology King Saud UniversityRiyadh 11461Saudi Arabia

AiM To investigate the accuracy of fungal dysbiosis inmucosa and stool for predicting the diagnosis of Crohn's disease(CD). METHODS Children were prospectively enrolled in two medical centers: one university hospital and one private gastroenterology clinic in the city of Riyadh, Kingdom of Saudi Arabia. The children with confirmed diagnosis of CD by standard guidelines were considered cases, and the others were considered non-inflammatory bowel disease controls. Mucosal and stool samples were sequenced utilizing illumina MiSeq chemistry following the manufacturer's protocols, and abundance and diversity of fungal taxa in mucosa and stool were analyzed. Sparse logistic regression was used to predict the diagnosis of CD. The accuracy of the classifier was tested by computing the receiver operating characteristic curves with 5-fold stratified cross-validation under 100 permutations of the training data partition and the mean area under the curve(AUC) was calculated. RESULTS All the children were Saudi nationals. There were 15 children with CD and 20 controls. The mean age was 13.9(range: 6.7-17.8) years for CD children and 13.9(3.25-18.6) years for controls, and 10/15(67%) of the CD and 13/20(65%) of the control subjects were boys. CD locations at diagnosis were ileal(L1) in 4 and colonic(L3) in 11 children, while CD behavior was non-stricturing and non-penetrating(B1) in 12 and stricturing(B2) in 3 children. The mean AUC for the fungal dysbiosis classifier was significantly higher in stools(AUC = 0.85 ± 0.057) than in mucosa(AUC = 0.71 ± 0.067)(P ies were significantly more depleted in stools than mucosal samples, except for Saccharomyces cerevisiae and S. bayanus, which were significantly more abundant. Diversity was significantly more reduced in stools than in mucosa. CONCLUSiON We found high AUC of fungal dysbiosis in fecal samples of children with CD, suggesting high accuracy in predicting diagnosis of CD.

关键词： Fungiome Mycobiome Crohn’s disease inflammation Saudi children

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Gut microbiota predicts the diagnosis of ulcerative colitis in Saudi children

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World Journal of Clinical Pediatrics 2024年第1期13卷 118-124页

作者： mohammad el mouzan Ahmed Al Sarkhy Asaad Assiri Department of Pediatrics Gastroenterology UnitKing Saud UniversityRiyadh 11461Saudi Arabia

BACKGROUND Ulcerative colitis(UC)is an immune-mediated chronic inflammatory condition with a worldwide *** the etiology of this disease is still unknown,the understanding of the role of the microbiota is becoming increasingly *** To investigate the predictive power of the gut microbiota for the diagnosis of UC in a cohort of newly diagnosed treatment-naïve Saudi children with *** The study population included 20 children with a confirmed diagnosis of UC and 20 healthy *** DNA was extracted and sequenced,and shotgun metagenomic analysis was performed for bacteria and *** and bioinformatics demonstrated significant dysbiosis in the form of reduced alpha diversity,beta diversity,and significant difference of abundance of taxa between children with UC and control *** receiver operating characteristic curve,a probability curve,was used to determine the difference between the UC and control *** area under the curve(AUC)represents the degree of separability between the UC group and the control *** AUC was calculated for all identified bacterial species and for bacterial species identified by the random forest classification algorithm as important potential biomarkers of UC.A similar method of AUC calculation for all bacteriophages and important species was *** The median age and range were 14(0.5-21)and 12.9(6.8-16.3)years for children with UC and controls,respectively,and 40%and 35%were male for children with UC and controls,*** AUC for all identified bacterial species was 89.5%.However,when using the bacterial species identified as important by random forest classification algorithm analysis, the accuracy increased to 97.6%. Similarly, the AUC for all theidentified bacteriophages was 87.4%, but this value increased to 94.5% when the important bacteriophagebiomarkers were *** very high to excellent AUCs of fecal bacterial and viral species sugge

关键词： Ulcerative colitis Microbiota Area under the curve Children Saudi Arabia

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Suitability of SDN and MEC to facilitate digital twin communication over LTE-A

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Digital Communications and Networks 2024年第2期10卷 347-354页

作者： Hikmat Adhami mohammad Alja’afreh Mohamed Hoda Jiaqi Zhao Yong Zhou Abdulmotaleb el Saddik Mohamed bin Zayed University of Artificial intelligence Masdar CityAbu DhabiUnited Arab Emirates School of Computer Science and Technology China University of Mining and TechnologyXuzhou221116China School of electrical Engineering and Computer Science University of OttawaOttawaONK1N 6N5Canada

Haptic is the modality that complements traditional multimedia,i.e.,audiovisual,to evolve the next wave of innovation at which the internet data stream can be exchanged to enable remote skills and control *** will require ultra-low latency and ultra-high reliability to evolve the mobile experience into the era of Digital Twin and Tactile *** the 5th generation of mobile networks is not yet widely deployed,Long-Term Evolution(LTE-A)latency remains much higher than the 1 ms requirement for the Tactile internet and therefore the Digital *** work investigates an interesting solution based on the incorporation of Software-defined networking(SDN)and Multi-access Mobile Edge Computing(MEC)technologies in an LTE-A network,to deliver future multimedia applications over the Tactile internet while overcoming the QoS *** network scenarios were designed and simulated using Riverbed modeler and the performance was evaluated using several time-related Key Performance indicators(KPis)such as throughput,End-2-End(E2E)delay,and *** best scenario possible is clearly the one integrating MEC and SDN approaches,where the overall delay,jitter,and throughput for haptics-attained 2 ms,0.01 ms,and 1000 packets per *** results obtained give clear evidence that the integration of,both SDN and MEC,in LTE-A indicates performance improvement,and fulfills the standard requirements in terms of the above KPis,for realizing a Digital Twin/Tactile internet-based system.

关键词： LTE-A 5G Digital twin Tactile internet KPis SDN MEC NFV Haptic

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Phosphoric Acid Pretreatment and Saccharification of Paper Sludge as a Renewable Material for Cellulosic Fibers

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Journal of Renewable Materials 2024年第9期12卷 1573-1591页

作者： Samar el-Mekkawi Wafaa Abou-elseoud Shaimaa Fadel Enas Hassan mohammad Hassan Chemical Engineering and Pilot Plant Department National Research CentreDokkiGiza12622Egypt Cellulose and Paper Department National Research CentreDokkiGiza12622Egypt

Recycling of paper sludge waste is crucial for establishing a sustainable green *** waste contains valuable sugars that can be converted into important chemicals such as ethanol,poly hydroxybutyrate,and lactic ***,the main challenge in obtaining sugars in high yield from paper sludge is the high crystallinity of cellulose,which hinders *** address this,pretreatment using phosphoric acid was optimized using response surface methodology to facilitate cellulose hydrolysis with minimal energy and *** created prediction model using the response surface method considered factors such as acid concentration(ranging from 60%to 85%),consistency(ranging from 4%to 10%),temperature(ranging from 25℃to 80℃),and time(ranging from 0.5 to 4 h).The results revealed that the model’s significant factors affecting the yield were acid concentration,reaction time,temperature,and the product of acid concentration and temperature,while the model’s significant factors affecting the crystallinity were the consistency,the temperature,and their *** results showed that the optimum conditions for pretreatment were using an acid concentration of 64%,temperature of 25℃,consistency of 10%,and time of 30 *** hydrolysis of the conditionally pretreated paper sludge resulted in a weight loss of 42%,compared to only 18%weight loss in non-pretreated paper ***,the optimized conditions led to low levels of furfurals and acetic acid,which are undesirable by-products that can interfere with sugar *** total sugar obtained under the optimized conditions was 0.43 g glucose/g sample(10.46 g/L),while the contents of methyl furfural,furfural,and acetic acid were 21.65,235.7,and 4.57 mg/L,*** study demonstrates the potential of phosphoric acid for pretreatment and hydrolysis of paper sludge,enabling efficient saccharification and the production of sugars with minimal undesired by-products.

关键词： Waste valorization fermentable sugars response surface methodology acid hydrolysis cellulose crystallinity

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Thermodynamic Performance Analysis of Geothermal Power Plant Based on Organic Rankine Cycle (ORC) Using Mixture of Pure Working Fluids

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Energy Engineering 2024年第8期121卷 2023-2038页

作者： Abdul Sattar Laghari mohammad Waqas Chandio Laveet Kumar Mamdouh el Haj Assad Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoro76062Pakistan Department of Mechanical and industrial Engineering College of EngineeringQatar UniversityDoha00000Qatar Sustainable&Renewable Energy Engineering Department University of SharjahSharjah00000United Arab Emirates

The selection of working fluid significantly impacts the geothermal ORC’s *** a mixture as a working fluid is a strategy to improve the output of geothermal *** the current study,modelling and thermodynamic analysis of ORC,using geothermal as a heat source,is carried out at fixed operating *** model is simulated in the Engineering Equation Solver(EES).An environment-friendly mixture of fluids,i.e.,R245fa/R600a,with a suitable mole fraction,is used as the operating *** mixture provided the most convenient results compared to the pure working fluid under fixed operating *** impact of varying the evaporator pressure on the performance parameters,including energy efficiency,exergy efficiency and net power output is *** system provided the optimal performance once the evaporator pressure reached the maximum *** efficiencies:Energy and Exergy,and Net Power output of the system are 16.62%,64.08%and 2199 kW for the basic cycle and 20.72%,67.76%and 2326 kW respectively for the regenerative cycle.

关键词： Organic rankine cycle internal heat exchanger moderate-temperature geothermal source mixture of the fluid exergy

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Modern Mobile Malware Detection Framework Using Machine Learning and Random Forest Algorithm

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Computer Systems Science & Engineering 2024年第5期48卷 1171-1191页

作者： mohammad Ababneh Ayat Al-Droos Ammar el-Hassan School of Computing Sciences Princess Sumaya University for TechnologyAmman11941Jordan

With the high level of proliferation of connected mobile devices,the risk of intrusion becomes *** intelligence(Ai)and Machine Learning(ML)algorithms started to feature in protection software and showed effective *** algorithms are nonetheless hindered by the lack of rich datasets and compounded by the appearance of new categories of malware such that the race between attackers’malware,especially with the assistance of Artificial intelligence tools and protection solutions makes these systems and frameworks lose effectiveness *** this article,we present a framework for mobile malware detection based on a new dataset containing new categories of mobile *** focus on categories of malware that were not tested before by Machine Learning algorithms proven effective in malware *** carefully select an optimal number of features,do necessary preprocessing,and then apply Machine Learning algorithms to discover malicious code *** our experiments,we have found that the Random Forest algorithm is the best-performing algorithm with such mobile malware with detection rates of around 99%.We compared our results from this work and found that they are aligned well with our previous *** also compared our work with State-of-the-Art works of others and found that the results are very close and competitive.

关键词： Android malware detect prevent artificial intelligence machine learning mobile CiCMalDroid2020 CCCSCiC-AndMal-2020

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Landau quantization effects on damping Kawahara solitons in electron–positron–ion plasma in rotating ionized medium

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Communications in Theoretical Physics 2024年第10期76卷 143-152页

作者： E i el-Awady S Hussain N Akhtar Department of Physics Faculty of Science Port Said University Theoretical Physics Division (TPD) PINSTECH

For the dynamics of three-dimensional electron–positron–ion plasmas, a fluid quantum hydrodynamic model is proposed by considering Landau quantization effects in dense ***–neutral collisions in the presence of the Coriolis force are also considered. The application of the reductive perturbation technique produces a wave evolution equation represented by a damped Korteweg–de Vries equation. This equation, however, is insufficient for describing waves in our system at very low dispersion coefficients. As a result, we considered the highest-order perturbation, which resulted in the damped Kawahara equation. The effects of the magnetic field, Landau quantization, the ratio of positron density to electron density, the ratio of positron density to ion density, and the direction cosine on linear dispersion laws as well as soliton and conoidal solutions of the damped Kawahara equation are explored. The understanding from this research can contribute to the broader field of astrophysics and aid in the interpretation of observational data from white dwarfs.

关键词： Coriolis force Kawahara equation Landau quantization magnetoplasmas quantum plasma solitary and cnoidal waves

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impact of auditory stimulation nursing protocol on auditory response in cerebrovascular stroke patients

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Journal of integrative Nursing 2024年第2期6卷 111-116页

作者： Mohammed elSayed ZAKY Hanan Ahmed AL SEBAEE Nagat el Morsy iBRAHiEM Heba Ahmed MOHAMMED mohammad Edrees mohammad Department of Medical Surgical Nursing Faculty of NursingCairo UniversityCairoEgypt Department of Neurology Faculty of MedicineCairo UniversityCairoEgypt

Objectives:The objective of the study was to explore the impact of auditory stimulation protocol on auditory response in cerebrovascular stroke(CVS)*** and Methods:A pre-posttest nonequivalent control group quasi-experimental study was conducted at Al Mainal Hospital at Al Kars Einy Hospital,Cairo University,among 60 CVS patients,and the sample was randomly assigned through a coin to allocate subjects to study or control group(30 for each group).Auditory stimulation techniques were applied three times per week for the study group for two consecutive *** in the control group received only routine hospital care during the study *** Glasgow Coma Scale(GCS)score for assessing the neurological function and level of arousal and the auditory subscale score of Western Neuro Sensory Stimulation Profile(WNSSP)for assessing auditory response were recorded and compared between the two groups before and after the ***:There were statistically significant differences between the study group and the control group regarding third reading of GCS score(11.5±0.3 vs.10.6±0.9,t=4.676,P=0.000).The scores of all auditory subscales of WNSSP in the study groups increased after implementing the auditory stimulation protocol(Pion:Utilizing the auditory stimulation protocol by nurse proves to be an effective method for enhancing hearing responses in individuals with CVS.

关键词： Auditory stimulation techniques hearing response nursing management stroke

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Genetic Variability and Phenotypic Correlations Study among Grain Quality Traits and Mineral elements Concentrations in Colored and Non-Colored Rice (Oryza sativa L.)

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Phyton-international Journal of Experimental Botany 2024年第7期93卷 1733-1748页

作者： Adel A.Rezk Mohamed M.el-Malky Heba i.Mohamed Hossam S.el-Beltagi Agricultural Biotechnology Department College of Agricultural and Food ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Plant Pathology Research institute Agriculture Research CenterGiza12619Egypt Rice Research and Training Center Field Crop Research InstituteAgriculture Research Center33717Egypt Biological and Geological Sciences Department Faculty of EducationAin Shams UniversityCairo11511Egypt Biochemistry Department Faculty of AgricultureCairo UniversityGiza12613Egypt

Twenty-four rice genotypes were examined to assess genetic variability,heritability,and correlations for seven-grain quality traits,eight nutritional elements,and *** revealed signiﬁcant differences for the quality traits *** every trait under study,the phenotypic coefﬁcient of variation was higher than the correspon-dence genotypic coefﬁcient of *** in a broad sense varied from 29.75%for grain length to 98.31%for the elongation *** percentage recovery had a highly signiﬁcant positive correlation with milling and head rice ***,milling percentage had a highly positive correlation with head rice *** amylose percentage,all the genotypes belonged to low amylose except the Hassawi-1 variety,which had intermediate amylose *** nutrition contents of magnesium(Mg),sodium(Na),potas-sium(K),calcium(Ca),copper(Cu),manganese(Mn),zinc(Zn),iron(Fe),or protein percentage gave different variations for 24 rice genotypes under all the nutritional *** the 24 genotypes,ten rice genotypes–HighNutrient-1,HighNutrient-2,HighNutrient-9,HighNutrient-8,HighNutrient-3,Hassawi-2,HighNutrient-7,HighNutrient-6,Hassawi-1,and HighNutrient-4–had the highest heist value for all nutritional and protein con-tents,and could be used as a donor to improving new *** was a positive and signiﬁcant correlation between magnesium Mg,K,Zn and ***,K had a positive correlation with zinc Zn,Fe,and protein *** analysis was divided into two groups:theﬁrst group included all genotypes rich in nutri-ents,while the remaining genotypes with low nutritional content were included in the second group.

关键词： Amylose cluster analysis genotypes grain quality mineral nutrition rice

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