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Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 298-306页

作者： mohammad Hadi Zarei Sami Akbulut Maryam Zafari Elham Saghaei Zahra Lorigooini hossein AminiKhoei Somaye Khosravi Elham Bijad Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Liver Transplant Institute and Biostatistics Inonu University Faculty of Medicine44280MalatyaTurkey Student Research Committee Shahrekord University of Medical SciencesShahrekordIran Physiology and Pharmacology Department School of MedicineShahrekord University of Medical SciencesShahrekordIran Department of Anatomical Sciences School of MedicineShahrekord University of Medical SciencesShahrekordIran

Objective:To explore the effect of black radish(Raphanus sativus *** niger)root extract on liver enzymes,oxidative stress,and histopathological alterations in mice with sodium valproate-induced ***:Thirty-two mice were divided into four groups:the control group received drinking water by gavage,the second group was administered with 100 mg/kg of sodium valproate,the third group received 300 mg/kg of black radish root extract,and the fourth group was given both sodium valproate(100 mg/kg)and black radish root extract(300 mg/kg).After 28 days,the mice were euthanized,and serum levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and alkaline phosphatase(ALP),along with liver malondialdehyde(MDA),reactive oxygen species(ROS),mitochondrial parameters,tumor necrosis factor-alpha(TNF-α)gene expression,and histopathological changes were ***:Sodium valproate caused hepatic damage in mice,characterized by elevated serum levels of liver enzymes,increased MDA and ROS levels and TNF-αgene expression,as well as histopathological *** black radish root extract significantly alleviated sodium valproate-caused hepatic injury by decreasing the serum levels of ALT and AST,MDA,ROS,TNF-αgene expression,as well as mitochondrial impairment,but did not have a significant effect on sodium valproate-induced histopathological ***:The black radish root extract demonstrates protective effects against sodium valproate-induced liver injury,possibly through mitigating oxidative stress,mitochondrial impairment,and inflammatory mediator expression.

关键词： Black radish Raphanus sativus Sodium valproate Hepatotoxicity Oxidative stress Anti-inflammation

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3D打印和电沉积多层超轻夹层板的力学性能和能量吸收性能

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Transactions of Nonferrous Metals Society of China 2024年第1期34卷 255-264页

作者： Mehrnoosh hosseinPOUR Salar ROHANI NEJAD Seyed mohammad hossein MIRBAGHERI Department of Materials and Metallurgical Engineering Amirkabir University of TechnologyHafez St.Tehran15875-4413Iran

研究由开孔聚合物和金属/聚合物泡沫芯制成的轻质夹层板的力学性能和能量吸收性能。通过结合聚合物树脂的增材制造和三层金属(Ni/Ni-Cu/Ni)的电沉积制备多层夹层板,每英寸孔数(PPI)为4、5和6。测试样品在单轴压缩变形过程中的屈服强度,... 详细信息

研究由开孔聚合物和金属/聚合物泡沫芯制成的轻质夹层板的力学性能和能量吸收性能。通过结合聚合物树脂的增材制造和三层金属(Ni/Ni-Cu/Ni)的电沉积制备多层夹层板,每英寸孔数(PPI)为4、5和6。测试样品在单轴压缩变形过程中的屈服强度,计算其能量吸收密度、互补能和比吸收能(SEA)。结果表明,与相同厚度的纯Ni和Cu夹层板相比,复合夹层板的性能有明显改善。增加PPI和金属层可提高力学性能和能量吸收性能,当PPI为6时,屈服强度(能量吸收密度)由聚合物夹层板的0.12 MPa(0.12MJ/m^(3))提高到三层金属夹层板的1.83MPa(0.67 MJ/m^(3))。对夹层板结构归一化能量的研究表明,夹层板具有可预测的塑性变形行为,多金属层改善了新型夹层板的力学性能。其能量吸收性能的显著增强可保证材料在不同行业的独特应用。

关键词：夹层板能量吸收金属泡沫 Voronoi结构增材制造金属电层级

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The global,prevalence,and risk factors of postoperative fever after percutaneous nephrolithotomy:A systematic review and meta-analysis

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Asian Journal of Urology 2024年第2期11卷 253-260页

作者： Reza Falahatkar Siavash Falahatkar mohammad Amin Khajavi Gaskarei Masoomeh Afzalipoor Ali Mojtahedi Neda Aligolighasemabadi Ahmad Deilami Samaneh Mirzaei Dahka mohammad-hossein Keivanlou Alireza Jafari Urology Research Center Guilan University of Medical SciencesGuilanRashtIran Department of Surgery University of SaskatchewanSaskatoonCanada Microbiology Department School of MedicineGuilan University of Medical SciencesRashtIran Department of Internal Medicine School of MedicineGuilan University of Medical SiencesRashtIran School of Nursing and Midwifery Guilan University of Medical SciencesGuilanRashtIran

Objective:This study aimed to explore the global,prevalence,and risk factors of fever after percutaneous nephrolithotomy(PCNL)by conducting a systematic review and ***:The high-sensitivity searching was conducted without time limitation until December 30,2020 in Web of Sciences,Scopus,and PubMed based on inclusion and exclusion ***:The prevalence rates of fever and sepsis among patient undergoing PCNL were estimated 9.5%(95%confidence interval[CI]:9.3%-9.7%),and 4.5%(95%CI:4.2%-4.8%),*** tube was used in 9.96%(95%CI:9.94%-9.97%)of *** mean preoperative white blood cells of patients were 6.401×109/L;18.3%and 4.55%of patients were considered as the positive urinary culture and pyuria,*** 20.4%of patients suffered from residual *** odds ratios(ORs)of fever in patients who suffering from diabetes mellitus,hydronephrosis,staghorn stones,and blood transfusion were 4.62(95%CI:2.95-7.26),1.04(95%CI:0.81-1.34),2.57(95%CI:0.93-7.11),and 2.65(95%CI:1.62-4.35),*** who underwent PCNL in prone position were more likely to develop fever(OR:1.23;95%CI:0.75-2.00)than patients in supine ***:The current study showed that patients who suffer from diabetes mellitus,hydronephrosis,staghorn stones,nephrostomy tube or double-J stent,blood transfusion,and also patients who underwent PCNL in prone position surgery are more likely to develop a postoperative fever after PCNL.

关键词： Percutaneous nephrolithotomy Fever Hydronephrosis Diabetes Meta-analysis

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Outcomes of surgical correction of Peyronie’s disease with plaque excision and grafting: Comparison of testicular tunica vaginalis graft versus bovine pericardium graft

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Asian Journal of Urology 2024年第3期11卷 497-503页

作者： Ali Eslahi Faisal Ahmed mohammad Reza Askarpour hossein-Ali Nikbakht Iman Shamohammadi Payam Ghasemi Hanieh Alimardani Bahareh Ebrahimi Department of Urology School of MedicineShiraz University of Medical SciencesShirazIran Shiraz Geriatric Research Center Shiraz University of Medical SciencesShirazIran Urology Research Center Al-Thora General HospitalDepartment of UrologySchool of MedicineIbb University of Medical SciencesIbbYemen Social Determinants of Health Research Center Health Research InstituteBabol University of Medical SciencesBabolIran

Objective:Peyronie’s disease(PD)is an abnormal wound healing in the penile tunica *** fibrotic plaque excision,different graft materials have been used to repair the defects,but the optimal graft remains *** study aimed to compare the functional outcomes of testicular tunica vaginalis grafts and bovine pericardium grafts in patients with severe ***:A retrospective comparative study was conducted on 33 PD patients undergoing partial plaque excision and grafting from September 2015 to May *** patients were divided into two groups depending on the type of graft *** 15 patients in Group B,testicular tunica vaginalis grafts were used to repair the defect,while for 18 patients in Group A,bovine pericardium grafts were *** of the patient’s age,comorbidities,sexual function,penile curvature,postoperative complications,need for further treatment,change in penile length,and satisfaction were gathered and compared between the *** function was evaluated using the 5-item version of the International Index of Erectile Function(IIEF-5),and a functional less than 20-degree penile curvature after surgery was considered a successful ***:There was no difference in age,comorbidities,degree of curvature,perioperative IIEF-5,operative time,plaque size,or complication *** surgery,a statistically significant improvement in curvature degree(p<0.05)and satisfactory penile appearance(p<0.05)were seen in both groups without any superiority between the two groups(p=0.423 and p=0.840,respectively).With a 30-month follow-up,the IIEF-5 was consistent in both groups,with no statistical significance between the groups(p=0.492).The main change in penile length during the operation was increased and still positive in the last follow-up in both groups without statistical significance(p=0.255 and p=0.101,respectively).Conclusion:Partial plaque excision and corporoplasty with both testicular tunica vaginalis or bovine pericard

关键词： Peyronie's disease Plaque excision Testicular tunica vaginalis graft Bovine pericardium graft

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Isoimperatorin alleviates acetic acid-induced colitis in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied Goodarzi Amir hossein Abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi Maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

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Special Column on Recent Advances in PCMs as Thermal Energy Storage in Energy Systems

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Journal of Thermal Science 2024年第2期33卷 395-395页

作者： mohammad hossein AHMADI Tingzhen MING Marc A.ROSEN S.A.SHERIF mohammad Mehdi RASHIDI Shahrood University of Technology Iran Wuhan University of Technology China University of Ontario Institute of Technology Canada University of Florida USA University of Electronic Science and Technology of China China

Thermal energy storage technology has the advantages of high energy storage density,small size,and high energy conversion *** is one of the key energy storage technologies and an important way to achieve carbon peaking and carbon neutrality *** change materials (PCMs) offer this opportunity to store high amount of energy and release it in the form of latent heat when needed,and therefore have the advantage of being capable to alleviate the intrinsic intermittency of renewable power production,especially in wind and solar farms.

关键词： efficiency store latent

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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi mohammad-Mahdi Salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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Etiology of Pancytopenia in Tabriz Shahid Ghazi Hospital:A Cross-sectional Study in Iran

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Proceedings of Anticancer Research 2024年第4期8卷 104-115页

作者： hossein Azari Bostanabad Safa Mousavi mohammad hossein hosseini Sadra Sarandili Ali Esfahani Babak Nejati Department of Hematology and Oncology Faculty of MedicineTabriz University of Medical SciencesTabrizIran Liqvan Health Center Tabriz University of Medical SciencesTabrizIran Hematology and Oncology Research Center Tabriz University of Medical SciencesTabrizIran Department of Health Sciences Curtin Medical SchoolCurtin UniversityPerthWAAustralia

Objective:Pancytopenia is characterized by a reduction in all three types of blood cells:erythrocytes,leukocytes,and *** is caused by a wide range of diseases,leading to diagnostic *** causes can range from drug reactions to life-threatening diseases such as aplastic anemia and *** study aims to investigate the causes of pancytopenia,specifically focusing on age and gender differences among ***:This cross-sectional study includes patients of all ages diagnosed with pancytopenia,as indicated by a CBC/H1 showing a WBC count less than 4,000/μL,platelet count less than 150,000/μL,and hemoglobin levels below 12 g/dL in women and less than 13 g/dL in *** study only included patients with pancytopenia who underwent bone marrow examination and were not subjected to chemotherapy or radiation ***:A total of 133 patients with pancytopenia were included in the *** average age was 47.35±17.62 years old,with 66%of the participants being male and 34%being *** leukemia,specifically acute myeloid leukemia(AML)and acute lymphoid leukemia(ALL),was identified as the primary cause of pancytopenia,accounting for 31.5%of *** anemia was the second most common cause,accounting for 30%of cases,followed by aplastic anemia at 7.5%.Conclusion:Pancytopenia,a condition marked by the decrease in both erythrocytes and leukocytes as well as thrombocytes,can arise from a myriad of *** main findings of this study revealed that megaloblastic anemia,acute myeloid leukemia(AML),and acute lymphoid leukemia(ALL)were the most common ***,a considerable proportion of cases of pancytopenia can be attributed to acute ***,expeditious and accurate diagnosis is imperative and has the potential to save lives in such cases.

关键词： Pancytopenia Leukemia Anemia Bone marrow Blood cells

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Enhanced Sensitivity and Stability in Gelatin-Based Fricke gel Dosimeters:Impact of Benzoic Acid on Low-Dose Radiation Measurements

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Instrumentation 2024年 23-29页

作者： Seyed Amir Saeedi-Sini Sedigheh Sina mohammad hossein Sadeghi Ebrahim Farajzadeh Nuclear Engineering Department School of Mechanical EngineeringShiraz University Radiation Research Center School of Mechanical EngineeringShiraz University Secondary Standard Dosimetry Laboratory(SSDL) Pars Isotope Co.

Fricke gel dosimetry is a critical technique for accurate radiation dose measurement,leveraging the radiation-induced oxidation of ferrous to ferric ions within a hydrogel *** study aimed to advance the field by preparing and evaluating seventy-one Fricke gel dosimeter (FGD) samples with varying chemical compositions,focusing on the incorporation of benzoic *** gelatin-based samples demonstrated superior sensitivity,particularly for low-dose *** findings indicated that the sample without benzoic acid exhibited a 1.75 times higher sensitivity compared to the sample containing benzoic acid,with lower limits of detection at 0.04 Gy and 0.1 Gy,*** tests revealed temperature-dependent responses,with better performance observed under refrigerated *** was confirmed through consistent calibration curves across multiple ***,the dosimeters'responses varied with different radiation types,underscoring the need for specific *** study concludes that while benzoic acid slightly reduces sensitivity,it provides consistent responses across various radiation energies,suggesting its potential as a beneficial additive in diverse clinical *** research contributes to the ongoing optimization of FGDs for precise radiation dose assessment.

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Myelopathy as a Presentation of Cervical Spine Metastasis: A Case Report

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Open Journal of Modern Neurosurgery 2024年第1期14卷 64-71页

作者： Ramin Shayan-Moghadam Mosayeb Soleymani Hassan Zolghadr mohammad hossein Nabian Saeed Reza Mehrpour Department of Orthopedic and Trauma Surgery Shariati Hospital Tehran University of Medical Sciences Tehran Iran Center for Orthopedic Trans-Deciplinary Applied Research Tehran University of Medical Sciences Tehran Iran

Cervical myelopathy is a consequence of spinal cord compression in the cervical spine. Degenerative cervical spondylosis, osteophytes, discosteophyte complex, degenerative spondylolisthesis and hypertrophy of ligamentum flavum are the main etiologies of cervical myelopathy. Metastasis to cervical spine could be a rare cause of cervical myelopathy. The present study is a case report;presented a 36-year-old male with severe pain in cervical region, gait disability and impairment in sensory and motor function of upper left extremity. The patient had a history of thyroidectomy and cervical lymph node dissection due to follicular thyroid carcinoma (FTC) with improper follow-ups. He was diagnosed with metastatic cervical myelopathy and underwent surgical treatment. Cervical myelopathy due to metastasis is a rare condition and only few cases have been reported so far. So myelopathies can be a complication of metastatic cancers, and it should be considered by health professionals.

关键词： Myelopathy Metastasis Thyroid Cancer

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