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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 517-520页

作者： hossein Hamidinejat mohammad hossein razi jalali Ramezan Ali Jafari Kiomars Nourmohammadi Department of Pathobiology Veterinary FacultyShahid Chamran University Department of Clinical Sciences Veterinary FacultyShahid Chamran University MSc Student of Parasitology Shahid Chamran University

Objective:To identify the genotypes of prevalent Cryptosporidia in broiler chickens in Lorestan province,***:A total of 1 000 fecal and 1 000 trachea samples were collected from *** from both fecal and tracheal samples were stained with modified ZiehlNeelsen method and nested PCR-RFTP according to amplification of 18S rRNA gene using Ssp1 and Vsp 1 restriction enzymes and DNA ***:From the examined chickens0.7%was positive for Cryptosporidium,Infection was present in 0.3%fecal samples and also in0.5%*** 0.3%of simultaneous infections in fecal and tracheal samples were *** PCR of our isolates demonstrated Cryptosporidium ***:In our work,low rate of Cryptosporidium baileyi infection was detected,but in critical situations and our poor management circumstances,cryptosporidiosis occurs in serious feature especially in immune suppressed individuals.

关键词： Cryptosporidium Prevalence PCR-RFLP Sequencing Chicken Iran

Effect of Zataria multiflora Extract on Total and Differential White Blood Cell Count and Endothelin Level in Blood of Ovalbumin Sensitized Guinea Pigs

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Chinese Journal of Integrative Medicine 2020年第8期26卷 604-608页

作者： mohammad hossein Boskabady Sediqeh jalali Neurogenic Inflammation Research Center and Department of Physiology School of MedicineMashhadIran Department of Biology Payam Noor UniversityTehranIran

Objective:To investigate the effect of hydro-ethanolic extract of Zataria multiflora(***)on endothelin level,total and differential white blood cells(WBC)count of sensitized guinea ***:Five groups of guinea pigs sensitized to ovalbumin(OA)were given drinking water alone(group S),drinking water containing three concentrations of ***(0.2,0.4 and 0.8 mg/mL as groups S+Z1,S+Z2 and S+Z3)and dexamethasone(group S+D),n=6 for each *** endothelin levels as well as total and differential WBC count in blood of sensitized and control guinea pigs were evaluated using enzyme linked immunosorbent assay method,and hemocytometer and Wright-Giemsa’s staining of blood sample smear ***:Blood endothelin levels,total and most differential WBC count were increased but lymphocytes decreased in sensitized animals compared to controls(all P<0.01).In groups S+D,S+Z2 and S+Z3 endothelin level,total and differential WBC counts were significantly improved compared with group S(P<0.01).Although,all measured parameters in group S+Z1 was lower than group S+D(P<0.01),some parameters in group S+Z3 were greater than in group S+D(P<0.05 to P<0.01).Conclusion:The results showed an anti-inflammatory effect of *** extract in sensitized guinea pigs,which may suggest a therapeutic potential for the plant on asthma.

关键词： Zataria multiflora asthma endothelin level white blood cell sensitization

Extractive Spectrophotometric Determination of Fluconazole by Ion-pair Complex Formation with Bromocresol Green

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Chinese Journal of Chemistry 2007年第9期25卷 1300-1303页

作者： jalali, Fahimeh RAJABI, mohammad J. Department of Chemistry Faculty of Science Razi University Kermanshah Iran

An extraction-spectrophotometric method for the determination of trace amounts of fluconazole was described. Fluconazole was effectively extracted as a 1 ： 1 ion-pair complex with bromocresole green （BCG） at pH 3.0 into chloroform, followed by spectrophotometric determination at 420 nm. Beer＇s law was obeyed over the range of 4-50 μ***^-1 of fluconazole with a detection limit of 3.7 μ***^-1 . The method is simple, rapid and sensitive. The procedure was applied to the determination of fluconazole in pharmaceutical preparations as well as its recovery from a blood serum sample.

关键词： fluconazole solvent extraction spectrophotometry capsule blood serum

An Efficient Hybrid Model Based on Modified Whale Optimization Algorithm and Multilayer Perceptron Neural Network for Medical Classification Problems

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Journal of Bionic Engineering 2022年第5期19卷 1504-1521页

作者： Saeid raziani Sajad Ahmadian Seyed mohammad Jafar jalali Abdolah Chalechale Department of Computer Engineering Razi UniversityKermanshah ***Iran Faculty of Information Technology Kermanshah University of TechnologyKermanshah ***Iran Institute for Intelligent Systems Research and Innovation(IISRI) Deakin UniversityWaurn PondsMelbourne 3217Australia

Feedforward Neural Network(FNN)is one of the most popular neural network models that is utilized to solve a wide range of nonlinear and complex *** models such as stochastic gradient descent have been developed to train ***,they mainly suffer from falling into local optima leading to reduce the accuracy of ***,the convergence speed of training process depends on the initial values of weights and biases in ***,these values are randomly determined by most of the training *** deal with these issues,in this paper,we develop a novel evolutionary algorithm by modifying the original version of Whale Optimization Algorithm(WOA).To this end,a nonlinear function is introduced to improve the exploration and exploitation phases in the search process of ***,the modified WOA is applied to automatically obtain the initial values of weights and biases in FNN leading to reduce the probability of falling into local *** addition,the FNN model trained by the modified WOA is used to develop a classification approach for medical diagnosis *** medical diagnosis datasets are utilized to evaluate the efficiency of the proposed ***,four evaluation metrics including accuracy,AUC,specificity,and sensitivity are used in the experiments to compare the performance of classification *** experimental results demonstrate that the proposed method is better than other competing classification models due to achieving higher values of accuracy,AUC,specificity,and sensitivity metrics for the used datasets.

关键词： Feed forward neural network Meta-heuristic algorithm Whale optimization algorithm Optimization Classification Bionic algorithm

Dynamics and bifurcations of a host-parasite model

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International Journal of Biomathematics 2017年第6期10卷 301-316页

作者： Ali Atabaigi mohammad hossein Akrami Department of Mathematics razi University Kermanshah Iran Department of Mathematical Sciences Yazd University Yazd Iran

A two-parameter family of discrete models, consisting of two coupled nonlinear difference equations, describing a host-parasite interaction is considered. In particular, we prove that the model has at most one nontrivial interior fixed point which is stable for a certain range of parameter values and also undergoes a Neimark-Sacker bifurcation that produces an attracting invariant curve in some areas of the parameter.

关键词： Host-parasite Neimark-Sacker bifurcation local dynamics.

Prevalence and risk factors of avian influenza H9N2 among backyard birds in Iran in 2015

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Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 559-564页

作者： mohammad hossein Fallah Mehrabadi Arash Ghalyanchilangeroudi mohammad Hasan Rabiee Farshad Tehrani razi Vaccine and Serum Research Institute Agricultural ResearchEducation and Extension Organization(AREEO)TehranIran Department of Microbiology and Immunology Faculty of Veterinary MedicineUniversity of TehranTehranIran Division of Epidemiology&Zoonosis Department of Food Hygiene&Quality ControlFaculty of Veterinary MedicineUniversity of TehranTehranIran Department of Health and Management of Poultry Diseases Iranian Veterinary OrganizationTehranIran

Objective: To investigate the prevalence and the risk factors of H9 N2 avian influenza among backyard birds in Iran between October and November 2015. Methods: In this study, a total of 15 500 blood samples and 2 884 cloacal swab samples of backyard birds were collected in villages of Iran between October and November 2015. Then, serum samples were examined with the hemagluttination inhibition test and cloacal swab samples were pooled together and examined by RT-PCR. The samples that had serological titer ≥ 4(log2) and villages that had at least one seropositive sample were considered ***: Out of 559 villages, 526(94.10%) were seropositive for the infection. Among 15 500 serum samples, 7 468(48.18%) samples were seropositive for the infection. The seroprevalence according to species was 54.02% among chickens, 17.59 % among ducks, 18.73% among turkeys, 84.21% among pigeons and 12.15% among ostriches, partridges and pheasants. Based on molecular test, 3.04% villages were positive. The seroprevalence in hot and humid area was less than that in cold and humid area(P<0.05).Conclusions: H9 N2 avian influenza has high seroprevalence among backyard birds of Iran. Therefore, preventive measures such as biosecurity Practices and monitoring should be applied to reduce the prevalence.

关键词： Influenza H9N2 Iran Backyard birds

Adjuvant activity of Pasteurella multocida A strain,Pasteurella multocida B strain and Salmonella typhimurium bacterial DNA on cellular and humoral immunity responses against Pasteurella multocida specific strain infections in Balb/c mice

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Asian Pacific Journal of Tropical Medicine 2018年第5期11卷 336-341页

作者： Maryam Homayoon Yahya Tahamtan mohammad Kargar Seyed mohammad hossein hosseini Abbas Akhavan Sepahy Department of Biology Science and Research BranchIslamic Azad University Department of Microbiology Shiraz BranchRazi Vaccine and Serum Research InstituteAgriculture ResearchEducation and Extension Organization Department of Microbiology Jahrom Branch Islamic Azad University Department of Microbiology Tehran North BranchIslamic Azad University

Objective: To evaluate the effects of Pasteurella multocida(P. multocida) vaccines on the expression and release of antibodies, interleukin(IL)-6 and IL-12 by serum. Methods: Balb/c mice were immunized with two formalin and iron inactivated vaccine doses within 2 weeks. The vaccines were adjuvant with P. multocida A strain, P. multocida B strain and Salmonella typhimurium bacterial DNA(AbDNA, BbDNA and SbDNA for short, respectively). The animals were challenged 4 weeks after immunization. Blood of mice was collected to detect the change of specific antibody, IL-6, and IL-12 using ELISA. Results: The specific antibody and interleukins in the immunized group increased significantly compared to the control mice after vaccination and challenge(P<0.05). The highest release of these cytokines was obtained by *** inactivated with iron and adjuvant with AbDNA at a concentration of 25 μg/mL. The antibody titer peak was 0.447 in mice vaccinated with iron-killed whole-cell antigen adjunct with AbDNA. The time-courses of release showed that bacterial DNA was able to stimulate IL-6 and IL-12 production more than alum(P<0.05). Conclusions: Our findings introduce that bacterial DNA is capable of releasing an immunological response with several *** indicate that bacterial DNA entrapped with killed P. multocida antigen is a new and effective adjuvant to enhance specific immunity and resistance of animal against the infectious pathogen, which could simplify the development of highly promising strong adjuvant.

关键词： Pasteurella multocida Bacterial DNA Adjuvant activity Vaccine Immunity Balb/c mice

Comprehensive AIDS prevention programs in prisons:A review study

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Family Medicine and Community Health 2018年第4期6卷 200-207页

作者： Somayeh Zare Mehdi Kargar Jeyran Ostovarfar mohammad hossein Kaveh Health Education and Health Promotion Department Health SchoolRazi StreetShirazIran

Objective:Since prisoners may acquire AIDS and transmit HIV because of highly risky be-haviors,implementation of educational and therapeutic programs is important in decreasing the prevalence of AIDS and transmission of *** study was conducted to recognize different types of interventions and compare their effectiveness regarding prevention of AIDS and its control in ***:The ISI,PubMed,Google Scholar,databases were searched with use of“AIDS,”“prison,”“HIV,”and“incarceration”as keywords from January 2000 to March 2017,with ac-cess to free full text and English language as *** articles,including observational,epidemiological,case,and interventional studies,were extracted and those inconsistent with the study’s goals were ***:Forty-three studies were finally *** effectiveness of interventions related to AIDS prevention and control in prisons was ***:It seems that theory-based studies conducted with stakeholders participation and evaluated summatively are more successful,because they give a sense of *** addition,considering prison as a setting can lead to more success of these programs.

关键词： AIDS prison intervention prevention

Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress,inflammation and apoptosis in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 242-249页

作者： Yosra raziani Kimia Karami Hamid Reza mohammadi hossein Mahmoudvand mohammad Nabi Moradi Javad Ghasemian Yadegari Nursing Department Al-Mustaqbal University College51001 HillahBabylonIraq razi Herbal Medicines Research Center Lorestan University of Medical SciencesKhorramabadIran Molecular and Cellular Laboratory School of Allied MedicineLorestan University of Medical SciencesKhorramabadIran

Objective:To assess the effect of oral treatment of methanolic extract of the aerial parts of Astragalus adscendens in streptozotocin-induced diabetic ***:In order to induce diabetes,rats intraperitoneally received streptozotocin at 65 mg/*** adult male Wistar rats were allocated into six groups(10 rats per each)including the healthy control group,the diabetic group as well as the diabetic group treated with Astragalus adscendens methanolic extract at 50,100,and 200 mg/kg per day or glibenclamide(0.6 mg/kg/day)for 28 *** effects of Astragalus adscendens methanolic extract on the levels of glucose,insulin,alanine aminotransferase,alkaline phosphatase,aspartate aminotransferase,bilirubin,creatinine,urea,uric acid,total protein,albumin,triglyceride,cholesterol,α-amylase,oxidant/antioxidant enzymes,and inflammatory cytokines were *** time-PCR was also used for measuring the gene expression of caspase-3,Bcl2,and ***:The levels of glucose,cholesterol,triglyceride,creatinine,urea,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,bilirubin,and malondialdehyde considerably declined(P<0.001)in diabetic rats after treatment with Astragalus adscendens methanolic extract especially at a dose of 200 mg/*** addition,treatment with Astragalus adscendens methanolic extract noticeably increased the level of insulin,total protein,and albumin as well as improved the activities of catalase,glutathione peroxidase,and superoxide dismutase,as well as the expression levels of TNF-α,IL-1β,caspase-3,Bcl2 and Bax(P<0.001)compared to the diabetic control *** extract also inhibitedα-amylase in a dose-dependent manner with an IC_(50)value of 19.6μg/***:Astragalus adscendens methanolic extract shows potent antidiabetic,anti-inflammatory,anti-apoptotic,and antioxidant effects in diabetic ***,more studies are needed to verify the underlying mechanism of the effect of this plant extract and test its effica

关键词： Herbal medicines Astragalus adscendens Diabetes Antioxidant Antidiabetes Streptozotocin Antiinflammation

Combination of sensitivity and uncertainty analyses for sediment transport modeling in sewer pipes

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International Journal of Sediment Research 2020年第2期35卷 157-170页

作者： Isa Ebtehaj hossein Bonakdari Mir Jafar Sadegh Safari Bahram Gharabaghi Amir hossein Zaji Hossien Riahi Madavar Zohreh Sheikh Khozani mohammad Sadegh Es-haghi Aydin Shishegaran Ali Danandeh Mehr Department of Civil Engineering Razi University Environmental Research Center Razi University Department of Civil Engineering Yasar University 4. School of EngineeringUniversity of Guelph 5. Department of Water EngineeringVali-e-Asr University of Rafsanjan 6. Smart and Sustainable Township Research CenterFaculty of Engineering&Built EnvironmentUniversiti Kebangsaan Malaysia 7. School of Civil EngineeringK.N.Toosi University of Technology 8. Department of Waterand EnvironmentalIran University of Science and Technology 9. Department of Civil EngineeringAntalya Bilim University

Mitigation of sediment deposition in lined open channels is an essential issue in hydraulic engineering ***,the limiting velocity should be determined to keep the channel bottom clean from sediment ***,sediment transport modeling using various artificial intelligence(AI) techniques has attracted the interest of many *** current integrated study highlights unique insight for modeling of sediment transport in sewer and urban drainage systems.A novel methodology based on the combination of sensitivity and uncertainty analyses with a machine learning technique is proposed as a tool for selection of the best input combination for modeling process at non-deposition conditions of sediment *** one to seven dimensionless parameters,127 models are developed in the current *** order to evaluate the different parameter co mbinations and select the training and te sting data,four strategies are *** the densimetric Froude number(Fr) as the dependent parameter,a model with independent parameters of volumetric sediment concentration(CV) and relative particle size(d/R) gave the best results with a mean absolute relative error(MARE) of 0.1 and a root means square error(RMSE) of *** analysis is applied with a machine learning technique to investigate the credibility of the proposed *** percentage of the observed sample data bracketed by95% predicted uncertainty bound(95 PPU) is computed to assess the uncertainty of the best models.

关键词： Non-deposition Sediment transport Sensitivity analysis Sewer Uncertainty analysis Urban drainage