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Prophylactic PEG placement in head and neck cancer:How many feeding tubes are unused (and unnecessary)?

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World Journal of Gastroenterology 2011年第8期17卷 1004-1008页

作者： mohammad f madhoun Matt M Blankenship Derek M Blankenship Greg A Krempl William M Tierney Section of Gastroenterology Department of Internal Medicine University of Oklahoma Health Sciences Center Department of Biostatistics Institute for Health Care Research and ImprovementBaylor Health care System Department of Otorhinolaryngology University of Oklahoma Health Sciences Center

AIM:To determine the rate of use and non-use of prophylactic percutaneous endoscopic gastrostomy(PEG) tubes among patients with head and neck cancer(HNC) ***:All patients with HNC undergoing PEG between January 01,2004 and June 30,2006 were ***(or their next-of-kin) were surveyed by phone and all available medical records and cancer registry data were *** PEG was def ined as placement in the absence of dysphagia and prior to radiation or *** patient with a prophylactic PEG was assessed for cancer diagnosis,type of therapy,PEG use,and complications related to ***:One hundred and three patients had PEG tubes placed for *** four patients(33%) could not be contacted for *** the 23(22.3%) patients with prophylactic PEG tubes,11/23(47.8%) either never used the PEG or used it for less than 2 *** association with PEG use vs non-use was observed for cancer diagnosis,stage,or specific cancer ***-use or limited use was observed in 3/6(50%) treated with radiation alone vs 8/17(47.1%) treated with chemoradiation(P = 1.0),and 3 of 10(30%) treated with surgery vs 8 of 13(62%) not treated with surgery(P = 0.21).Minor complications were reported in 5/23(21.7%).One(4.3%) major complication was ***:There is a high rate of unnecessary PEG placement when done prophylactically in patients with head and neck cancer.

关键词： Head and neck cancer Percutaneous gastrostomy tube Prophylactic

Patient prompting of their physician resulted in increased colon cancer screening referrals

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World Journal of Gastrointestinal Oncology 2014年第7期6卷 257-262页

作者： Vu Le Saqib Syed Kenneth J Vega Tushar Sharma mohammad f madhoun Nakumar Srinivasan Courtney W Houchen Division of Digestive Disease and Nutrition Univer-sity of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States College of Public Health University of Okla-homa Health Sciences Center Oklahoma City OK 73104 United States

AIM:To determine whether a communication instru-ment provided to patients prior to their primary carephysician(PCP)visit initiates a conversation with theirPCP about colorectal cancer screening(CRC-S),impact-ing screening referral rates in fully insured and underin-sured ***:A prospective randomized control studywas performed at a single academic center outpatient internal medicine(IRMC,underinsured)and fam-ily medicine(fMRC,insured)resident clinics prior to scheduled *** the intervention group,a pamphlet about the benefit of CRC-S and a reminder card were given to patients before the scheduled visit for prompt-ing of CRC-S referral by their *** main outcome measured was frequency of CRC-S referral in each clinic after ***:In the IRMC,148 patients participated,a control group of 72 patients(40f and 32M)and 76 patients(48f and 28M)in the intervention ***-ferrals for CRC-S occurred in 45/72(63%)of control vs 70/76(92%)in the intervention group(P≤0.001).In the fMRC,126 patients participated,66(39f:27M)con-trol and 60(33f:27M)in the intervention ***-S referrals occurred in 47/66(71%)of controls vs 56/60(98%)in the intervention group(P≤0.001).CONCLUSION:Patient initiated physician prompting produced a significant referral increase for CRC-S in un-derinsured and insured patient *** investigation aimed at increasing CRC-S acceptance is warranted.

关键词： Colon cancer Screening Primary care Physician patient relationship Referral

Higher dose of simethicone decreases colonic bubbles and increases prep tolerance and quality of bowel prep:Meta-analysis of randomized controlled trials

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World Journal of Meta-Analysis 2019年第3期7卷 110-119页

作者： mohammad f madhoun Maham Hayat Ijlal Akbar Ali Division of Digestive Diseases and Nutrition University of Oklahoma Health Sciences Center Veteran Affairs Medical Center

BACKGROUND Antifoaming agents,such as simethicone,may facilitate mucosal inspection during ***,conflicting results have been reported with regard to the impact of simethicone on quality of bowel preparation and adenoma detection rate(ADR).AIM To perform a meta-analysis of trials that have compared simethicone vs placebo during *** A reproducible literature search of multiple medical databases yielded eleven studies(n = 2605) for *** were compared for quality of bowel preparation,bubbles quality,ADR,and *** reviewers independently scored the identified studies for methodology and abstracted pertinent *** was conducted by both fixed-effects and random-effects *** risk(RR) estimates with a 95% confidence interval(CI) were *** was assessed by I-squared index(I2) *** Patients' demographic characteristics were comparable in all *** the 2605 patients,1300 were in the simethicone group,whereas 1305 were in the placebo *** bowel preparation was much lower in the simethicone group than in the placebo group [13% vs 24.6%; RR = 0.51(0.31-0.82); P ficant colonic bubbles than was the simethicone group [35% vs 8%; RR = 1.49(1.25-1.76); P = 0.0001].Use of simethicone resulted in a slight,statistically significant increase in ADR compared with the placebo group [26.6% vs 21.6%,RR = 1.07(1.01-1.13); P = 0.02].Higher doses of simethicone(> 478 mg) were more likely to result in significant reduction of inadequate bowel preparation,colonic bubbles,and to improve *** Adding simethicone improved the quality of bowel preparation,visualization,tolerability,and,eventually,ADR.

关键词： Simethicone Colonoscopy Bubbles Bowel preparation Adenoma detection rate

Teneligliptin:A potential therapeutic approach for diabetic cardiomyopathy

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World Journal of Diabetes 2024年第8期15卷 1654-1658页

作者： Ashraf Al madhoun Department of Genetics and Bioinformatics Dasman Diabetes InstituteDasman 15400Kuwait

In this editorial,we comment on the article by Zhang et *** mellitus is a chronic disorder associated with several complications like cardiomyopathy,neuropathy,and *** prevalence is increasing *** diabetes medications are prescribed based on individual patients’***,the exact mechanisms by which many of these drugs exert their protective effects remain *** et al elucidates molecular mechanisms undelaying cardioprotective effect of the dipeptidyl peptidase-IV inhibitor,***,teneligliptin alleviates the activation of NOD-like receptor protein 3 inflammasome,a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory *** of NOD-like receptor protein 3 inflammasome activity reduces the expression of cytokines,oxygen radicals and *** findings highlight teneligliptin as an anti-diabetic cardioprotective reagent.

关键词： Teneligliptin Diabetes mellitus NOD-like receptor protein 3 inflammasome Inflammation Cardiomyopathy

Glucokinase regulatory protein rs780094 polymorphism is associated with type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease, and nephropathy

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World Journal of Diabetes 2024年第5期15卷 814-817页

作者： Ashraf Al madhoun Department of Genetics and Bioinformatics Dasman Diabetes InstituteDasman 15400Kuwait

In this editorial,we comment on the article by Liu et al published in the recent issue of the World Journal of Diabetes(Relationship between GCKR gene rs780094 polymorphism and type 2 diabetes with albuminuria).Type 2 diabetes mellitus(T2DM)is a chronic disorder characterized by dysregulated glucose *** persistent elevated blood glucose level in T2DM significantly increases the risk of developing severe complications,including cardiovascular disease,re-tinopathy,neuropathy,and nephropathy.T2DM arises from a complex interplay between genetic,epigenetic,and environmental *** genomic studies have identified numerous genetic variations associated with an increased risk of ***,variations within the glucokinase regulatory protein(GCKR)gene have been linked to heightened susceptibility to T2DM and its associated *** clinical trial by Liu et al further elucidates the role of the GCKR rs780094 polymorphism in T2DM and nephropathy *** findings demonstrate that individuals carrying the CT or TT genotype at the GCKR rs780094 locus are at a higher risk of developing T2DM with albuminuria compared to those with the CC *** findings highlight the importance of genetic testing and risk assessment in T2DM to develop effective preventive strategies and personalized treatment plans.

关键词： Glucokinase regulatory protein rs780094 Type 2 diabetes mellitus Dyslipidemia Non-alcoholic fatty liver disease Nephropathy

MicroRNA-630:A potential guardian against inflammation in diabetic kidney disease

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World Journal of Diabetes 2024年第9期15卷 1837-1841页

作者： Ashraf Al madhoun Department of Genetics and Bioinformatics Dasman Diabetes InstituteDasman 15400Kuwait

In this editorial,we comment on the article by Wu et al published“MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4”.Diabetic kidney disease(DKD)stands as a significant complication occurring from diabetes mellitus,which contributes substantially to the morbidity and mortality rates *** tubular epithelial cell damage,often accompanied by inflammatory responses and mesenchymal transdifferentiation,plays a pivotal role in the progression of *** extensive research,the intricate molecular mechanisms underlying these processes remain to be *** et al remarkable work identifies microRNA-630(miR-630)as an emerging potential regulator of cell migration,apoptosis,and autophagy,prompting investigation into its association with DKD *** study endeavors to elucidate the impact of miR-630 on TEC injury and the inflammatory response in DKD *** role of miR-630 in human DKD will be of interest for future studies.

关键词： Diabetic kidney disease MicroRNA MicroRNA-630 Toll-like receptor 4 Inflammation

Review of single incision laparoscopic surgery in colorectal surgery

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World Journal of Gastroenterology 2015年第38期21卷 10824-10829页

作者： Nisreen madhoun Deborah S Keller Eric M Haas Colorectal Surgical Associates Division of Minimally Invasive Colorectal Surgery Department of SurgeryUniversity of Texas Medical School at Houston Houston Methodist Hospital

As surgical techniques continue to move towards less invasive techniques,single incision laparoscopic surgery(SILS),a hybrid between traditional multiport laparoscopy and natural orifice transluminal endoscopic surgery,was introduced to further the enhanced outcomes of multiport laparoscopy. The safety and feasibility of SILS for both benign and malignant colorectal disease has been proven. SILS provides the potential for improved cosmesis,postoperative pain,recovery time,and quality of life at the drawback of higher technical skill required. In this article,we review the history,describe the available technology and techniques,and evaluate the benefits and limitations of SILS for colorectal surgery in the published literature.

关键词： Laparoscopic colectomy Minimally invasive colorect

The Effects of Task-Based Mirror Therapy on the Upper Limb Motor function in Subacute Stroke Patients

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The Effects of Task-Based Mirror Therapy on the Upper Limb M...

作者： madhoun HAMZA Y R 重庆医科大学

学位级别：硕士

BACKGROUND: The improvement of the upper limb disability,which is mainly caused by stroke,is still one of the rehabilitation treatment ***,the effectiveness of Task-Based Mirror Therapy（TBMT）on subacute stroke with moderate and severe upper limb impairment has not been deeply ***: The purpose of this study is to investigate the effects of TBMT,in comparison to occupational therapy,in moderate and severe upper limb impairment by analyzing the motor function and activities of daily living in subacute stroke ***: 30 patients with moderate and severe subacute stroke recruited from the Second Affiliated Hospital of Chongqing Medical University have been randomly divided into two groups;the Task-Based Mirror Therapy group（N = 15）and the control group（N =15）.The first group received TBMT while the control group underwent only occupational therapy without a mirror *** into consideration that both groups received conventional *** intervention time was equal for both groups consisting of 25 minutes per day for 25 ***-Meyer Assessment（fMA）,Brunnstrom Assessment（BRS）,Modified Barthel Index（MBI）,and Modified Ashworth Scale（MAS）were used to assess the outcomes for this ***: After 25 sessions of treatment,the patients in both groups have shown improvement in the activates of daily living,motor recovery,and motor *** significant differences between the two groups were observed on BRS and ***,interestingly,the results of the TBMT group were significantly better than the control group in fMA（P ＜ 0.05）and certain aspects of MAS（elbow flexion,wrist flexion,wrist extension,and fingers extension with P＜ 0.05）.CONCLUSION: This study shows that the combination of conventional rehabilitation treatment and TBMT is an effective way to improve the functional recovery in the upper limb stroke patients.

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Restructuring nephrology services to combat COVID-19 pandemic:Report from a Middle Eastern country

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World Journal of Nephrology 2020年第2期9卷 9-17页

作者： Muhammad Asim Mohamad Alkadi Abdullah Hamad Muftah Othman Essa Abuhelaiqa Omar fituri IhabEl-madhoun Hassan Al-Malki Nephrology Division Department of MedicineHamad Medical CorporationDoha 3050Qatar

Coronavirus disease 2019 has spread across the world and has been classified as a *** has overwhelmed the healthcare ***,it has overstretched the intensive care units and renal replacement therapy services in many *** this paper,we discuss the reconfiguration of nephrology services in the State of Qatar during the current *** highlight the key strategies that have been implemented to ensure that renal replacement therapy capacity is not constrained in either the intensive care or ambulatory *** innovative approaches for the safe delivery of ambulatory care to dialysis and kidney transplant patients are also discussed.

关键词： Coronavirus COVID-19 Nephrology Pandemic Renal replacement therapy Infection control