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Carbon mineralization in subtropical alluvial arable soils amended with sugarcane bagasse and rice husk biochars

Pedosphere 2022年第3期32卷 475-486页

作者： mohammad arifur rahman mohammad Abdul KADER mohammad JAHIRUDDIN mohammad Rafiqul ISLAM Zakaria mohammad SOLAIMAN Regional Agricultural Research Station(RARS) Bangladesh Agricultural Research Institute(BARI)Jamalpur 2000(Bangladesh) School of Agriculture GeographyEnvironmentOcean and Natural SciencesUniversity of South PacificApia 1343(Samoa) Department of Soil Science Bangladesh Agricultural University(BAU)Mymensingh 2202(Bangladesh) UWA School of Agriculture&Environment and the UWA Institute of Agriculture PerthWA 6009(Australia) School of Veterinary and Life Science Murdoch UniversityMurdochWA 6150(Australia)

Subtropical recent alluvial soils are low in organic carbon(C).Thus,increasing organic C is a major challenge to sustain soil *** amendment could be an option as biochar is a C-rich pyrolyzed material,which is slowly decomposed in *** investigated C mineralization(CO_(2)-C evolution)in two types of soils(recent and old alluvial soils)amended with two feedstocks(sugarcane bagasse and rice husk)(1%,weight/weight),as well as their biochars and aged biochars under a controlled environment(25±2℃)over 85 *** the recent alluvial soil(charland soil),the highest absolute cumulative CO_(2)-C evolution was observed in the sugarcane bagasse treatment(1140 mg CO_(2)-C kg^(-1)soil)followed by the rice husk treatment(1090 mg CO_(2)-C kg^(-1)soil);the lowest amount(150 mg CO_(2)-C kg^(-1)soil)was observed in the aged rice husk biochar ***,for the old alluvial soil(farmland soil),the highest absolute cumulative CO_(2)-C evolution(1290 mg CO_(2)-C kg^(-1)soil)was observed in the sugarcane bagasse treatment and then in the rice husk treatment(1270 mg CO_(2)-C kg^(-1)soil);the lowest amount(200 mg CO_(2)-C kg^(-1)soil)was in the aged rice husk biochar *** sugarcane bagasse and rice husk biochar treatments reduced absolute cumulative CO_(2)-C evolution by 10%and 36%,respectively,compared with unamended recent alluvial soil,and by 10%and 18%,respectively,compared with unamended old alluvial *** absolute and normalized C mineralization were similar between the sugarcane bagasse and rice husk treatments,between the biochar treatments,and between the aged biochar *** both soils,the feedstock treatments resulted in the highest cumulative CO_(2)-C evolution,followed by the biochar treatments and then the aged biochar *** absolute and normalized CO_(2)-C evolution and the mineralization rate constant of the stable C pool(K_(s))were lower in the recent alluvial soil compared with those in the old alluvial *** biochar

关键词： aged biochar biochar amendment charland CO_(2)emission CO_(2)-C evolution recent alluvial soil soil organic carboon soil organic matter

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Trace Metals Concentrations at the Atmosphere Particulate Matters in the Southeast Asian Mega City (Dhaka, Bangladesh)

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Open Journal of Air Pollution 2015年第2期4卷 86-98页

作者： Md. Faridul Islam Syada Sanjida Majumder Abdullah Al Mamun Md. Badiuzzaman Khan mohammad arifur rahman Abdus Salam Department of Chemistry University of Dhaka Dhaka Bangladesh Department of Chemistry University of Louisville Louisville USA Department of Environment Sciences Informatics and Statistics Cà Foscari University of Venice Venice Italy Department of Environment Science Bangladesh Agricultural University Mymensingh Bangladesh

Atmospheric particulate matters were collected on quartz fibre filters for 24 hours with a low volume sampler from January 2014 to March 2014 at the Southeast Asian mega city (Dhaka, Bangladesh). Particulate matters samples were analysed for eleven trace metals with inductively coupled plasma mass spectrometer (ICP-MS) at Cà Foscari University of Venice, Italy. Trace metals were extracted from filters with digestion method using a mixture of HNO3 and H2O2. The average concentration of the determined trace metals of As, Cd, Ni, Cu, Pb, Cr, Fe, Mn, Zn, Sband Se were 3.06, 6.28, 3.77, 11.98, 305.6, 9.2, 2057.0, 42.2, 303.3, 5.47 and 2.43 ng·mǅ, respectively. Arsenic concentration is much lower in the atmosphere of Dhaka, though Bangladesh has severe arsenic problem in the ground water. Lead and cadmium concentrations showed decreasing trend in Dhaka compared than previous measurements—but still they have very high levels compared than Europe and USA. There is very limited information for Mn, Sb and Se concentrations in Dhaka air. Correlation studies showed that several trace metals had potential joint sources of origin, e.g., manganese is highly correlated with iron (r2 = 0.97) and nickel (r2 = 0.84), copper (r2 = 0.86);lead with arsenic (r2 = 0.79) and antimony (r2 = 0.78). Enrichment factors analysis was also done with the data base for the respective metals in earth crust and coal fly ash. As and Cu both have combined sources, whereas Cd, Pb and Zn were from coal fly *** metals concentrations in Dhaka city air were much higher than Europe and USA but comparable or slightly lower than other south Asian countries. This is the first extensive study for the eleven trace metals with ICP-MS in Dhaka, Bangladesh.

关键词： Atmospheric Aerosol Particulate Matter Trace Metals Arsenic Lead and Cadmium

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Detecting anomalies in blockchain transactions using machine learning classifiers and explainability analysis

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Blockchain(Research and Applications) 2024年第3期5卷 106-122页

作者： mohammad Hasan mohammad Shahriar rahman Helge Janicke Iqbal H.Sarker Department of Computer Science and Engineering Premier University4000 ChitagongBangladesh Department of Computer Science and Engineering United International University1212 DhakaBangladesh Cyber Security Cooperative Research Centre 6027 PerthAustralia Centre for Securing Digital Futures Edith Cowan University6027 PerthAustralia

As the use of blockchain for digital payments continues to rise,it becomes susceptible to various malicious *** detecting anomalies within blockchain transactions is essential for bolstering trust in digital ***,the task of anomaly detection in blockchain transaction data is challenging due to the infrequent occurrence of illicit *** several studies have been conducted in the field,a limitation persists:the lack of explanations for the model’s *** study seeks to overcome this limitation by integrating explainable artificial intelligence(XAI)techniques and anomaly rules into tree-based ensemble classifiers for detecting anomalous Bitcoin *** shapley additive explanation(SHAP)method is employed to measure the contribution of each feature,and it is compatible with ensemble ***,we present rules for interpreting whether a Bitcoin transaction is anomalous or ***,we introduce an under-sampling algorithm named XGBCLUS,designed to balance anomalous and non-anomalous transaction *** algorithm is compared against other commonly used under-sampling and over-sampling ***,the outcomes of various tree-based single classifiers are compared with those of stacking and voting ensemble *** experimental results demonstrate that:(i)XGBCLUS enhances true positive rate(TPR)and receiver operating characteristic-area under curve(ROC-AUC)scores compared to state-of-the-art under-sampling and over-sampling techniques,and(ii)our proposed ensemble classifiers outperform traditional single tree-based machine learning classifiers in terms of accuracy,TPR,and false positive rate(FPR)scores.

关键词： Anomaly detection Blockchain Bitcoin transactions Data imbalance Data sampling Explainable AI Machine learning Decision tree Anomaly rules

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Intelligent Vehicle for Urban Road Traffic Recognition System Using Deep Learning Algorithm

Intelligent Vehicle for Urban Road Traffic Recognition Syste...

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作者： ASHIKUR rahman mohammad 重庆交通大学

学位级别：硕士

城市道路的目标识别和监测技术是计算机视觉领域的关键研究途径,在日常生活中得到了广泛应用。人类探测作为主要焦点,具有独特的特征,将目标的典型属性与无与伦比的可变性相结合。因此,与行人检测和跟踪相关的技术挑战超过了普通目标所... 详细信息

城市道路的目标识别和监测技术是计算机视觉领域的关键研究途径,在日常生活中得到了广泛应用。人类探测作为主要焦点,具有独特的特征,将目标的典型属性与无与伦比的可变性相结合。因此,与行人检测和跟踪相关的技术挑战超过了普通目标所面临的挑战,这使得这一主题变得特别复杂和苛刻。对这一主题的探索不仅具有科学研究意义,而且具有相当大的社会应用价值。智能汽车技术的快速发展导致了解决城市道路交通复杂性的范式转变。本文介绍了新能源智能汽车领域内交通识别系统的一种开创性方法,利用最先进的深度学习算法。本研究强调YOLO v8(You Only Look Once)和DETR(Detection Transformer)的融合,推动了物体检测的前沿,特别是在自动驾驶汽车的背景下。使用深度学习算法进行城市道路交通监测面临着一些挑战,包括高计算需求、实时处理要求、多样化和复杂的城市环境,以及对物体检测和分类的高精度要求。像Faster R-CNN这样的传统模型虽然准确,但计算密集且速度较慢,因此不太适合实时应用。DETR以其基于转换器的架构提供了稳健的特征提取,但可能会在速度和复杂性方面遇到困难。YOLO模型效率高、速度快,适用于实时检测,但它们可能会为速度牺牲一些准确性。所提出的DETR-YOLO v8n融合模型旨在通过将DETR的鲁棒特征提取的优势与YOLO v8n的实时检测能力相结合来解决这些问题。这种融合利用注意力机制来突出相关特征,在不显著影响速度的情况下提高准确性。通过集成这些方法,DETR-YOLO v8n Fusion模型提供了一个平衡的解决方案,可以提高检测精度,保持实时处理,并有效地导航城市道路环境的复杂性,从而改善整体交通监控和管理。这项研究错综复杂地探索了YOLO v8的细微改进,展示了其在城市道路交通场景中的卓越性能。细化的锚盒预测细化了空间定位,而特征金字塔网络增强了模型在不同尺度上辨别物体的能力。先进的主干架构增强了特征提取,从而增强了网络的整体辨别能力。所提出的系统以YOLO v8和DETR的融合为基础,强调了其在复杂交通环境中显著提高新能源智能汽车安全性和有效性的潜力。这项研究不仅有助于新兴的智能交通解决方案领域,而且有助于不断完善自动驾驶汽车的目标检测机制。这些发现强调了接受YOLO v8进化改进的关键性,为追求智能和响应能力强的城市交通系统的先进识别系统树立了新的基准。近年来,深度学习的出现在计算机视觉方面取得了重大进展,特别是在目标检测精度方面。然而,深度模型的复杂性阻碍了检测速度的提高,再加上硬件需求的提高,从而阻碍了其对行人检测和跟踪的适用性。因此,本文对行人检测与跟踪进行了全面的研究。这项研究的高潮涉及对峰值响应和目标损失之间相关性的检查。在本文中,我们使用最新的YOLO v8升级了这三项改进,用于城市道路的交通监控。*** v8引入了精细的锚盒预测,增强了空间定位,以更精确地识别对象位置。这一改进对于智能汽车在复杂城市环境中的精确导航至关重要。2.在YOLO v8中引入特征金字塔网络解决了多尺度检测中的挑战。这种增强使该模型能够有效地识别和分类不同大小的对象,确保在不同的交通场景中具有强大的检测能力。*** v8的高级骨干架构提高了特征提取效率,捕捉了复杂的细节和上下文信息。这一改进提高了模型的鉴别力,特别是在具有挑战性的城市道路交通条件下,从而提高了物体检测任务的整体性能。在我之前的研究中,我使用Tensor Flow深度学习框架,来完成网络模型的设计与训练。为了验证本文提出模型的可行性与检测效果,将本文算法的检测实验结果与当前常见的目标检测算法进行对比分析,对比的算法包括SSD、YOLO V3和GANet(Guided Attention Net Work),在相同数据集进行对比,检测准确率结果如下:SSD模型的平均查准率为68.2%,YOLO V3网络模型的平均查准率为73.8%,GANet网络模型的平均查准率为76.8%:而本文采用的Faster R-CNN平均查准率为86.3%。由此可知,Faster R-CNN网络模型在城市道路目标检测准确.在智能汽车自动驾驶道路智能识别实验中,本文改进了DETR(Detection Transformer)网络结构,并与其他常见的识别算法,如Faster R-CNN、YOLO(You Only Look Once)和SSD(Single Shot Multi Box Detector)进行了对比。在我之前的研究中,它的结果如下,以评价指标的数据说明:(1)准确率(Precision):指模型检测到的物体中真实物体的比例。综合了测试集上的准确率结果,DETR网络达到了90%的准确率,超过了Faster R-CNN和YOL

关键词：深度学习 YOLOv8模型交通检测 DETR Faster R-CNN 自动驾驶

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Tracking of microplastics distribution patterns and their characterisation in deposited road dust from Dhaka city,Bangladesh

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Emerging Contaminants 2024年第3期10卷 386-399页

作者： mohammad Toha R-Rafiul rahman Sadia Sikder Md Ahedul Akbor Md Mostafizur rahman Department of Environmental Science Bangladesh University of ProfessionalsMirpurCantonmentDhaka1216Bangladesh Department of Environmental Sciences Jahangirnagar UniversitySavarDhaka1342Bangladesh Laboratory of Environmental Health and Ecotoxicology Department of Environmental SciencesJahangirnagar UniversitySavarDhaka1342Bangladesh Institute of National Analytical Research and Service(INARS) Bangladesh Council of Scientific and Industrial Research(BCSIR)DhanmondiDhaka1205Bangladesh

The widespread presence of microplastics(MPs)in road dust has considerable concern regarding their potential risks to ecosystems and human *** the massive production of plastic,the erudition of MPs distribution patterns in various sizes of deposited road dust is still limited around the ***,the aim of this research is to provide an unambiguous picture of MPs distributional pattern,identification,classification,quantification,and features from road dust in various zones and types of roadways in Dhaka,*** study examined MPs in road dust samples with particle sizes ranging from 300 to 150 mm(Group-A),149-75 mm(Group-B),andunpaved road(325 items/5 g)>soil samples(294 items/5 g),roadside dust samples(284 items/5 g),and mid-road(283 items/5 g).By taking into account all sizes of road dust samples,the MPs were classified as fiber(70.26%),fragment(26.12%),beads(0.66%),films(1.32%),and foams(1.58%).It was found that adults inhaled MPs an average of 1612 items/day,while they ingested an average of 880 items/*** had an inhalation rate of 1232 items/day and an ingestion rate of 10267 items/day,which was 4e17 times greater than in other *** study identified 22 MPs polymer types,and SEM results show that MPs surfaces are being weathered into nanoplastics,creating a more hazardous environment.

关键词： Microplastics Road dust SEM FTIR Health impact Distribution pattern

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Surface Morphology and Thermo-Electrical Energy Analysis of Polyaniline (PANI) Incorporated Cotton Fabric

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Energy Engineering 2024年第1期121卷 1-12页

作者： Md.Shohan Parvez Md.Mustafizur rahman Mahendran Samykano mohammad Yeakub Ali Automotive Engineering Research Group Faculty of Mechanical and Automotive Engineering TechnologyUniversiti Malaysia Pahang Al-Sultan AbdullahPekanMalaysia Department of Textile Engineering Khulna University of Engineering&Technology(KUET)KhulnaBangladesh Centre for Research in Advanced Fluid and Processes(CARIFF) Universiti Malaysia Pahang Al-Sultan AbdullahLebuhraya Tun RazakGambangMalaysia Mechanical Engineering Programme Area Faculty of EngineeringUniversiti Teknologi BruneiBruneiDarussalam

With the exponential development in wearable electronics,a significant paradigm shift is observed from rigid electronics to flexible wearable ***(PANI)is considered as a dominant material in this sector,as it is endowed with the optical properties of both metal and ***,its widespread application got delineated because of its irregular rigid form,level of conductivity,and precise choice of *** PANI in textile materials can generate promising functionality for wearable *** research work employed a straightforward in-situ chemical oxidative polymerization to synthesize PANI on Cotton fabric surfaces with varying dopant(HCl)***-treatment using NaOH is implemented to improve the conductivity of the fabric surface by increasing the monomer *** research explores the morphological and structural analysis employing SEM,FTIR and *** surface resistivity was measured using a digital multimeter,and thermal stability is measured using *** successful polymerization,a homogenous coating layer is *** is revealed that the simple pre-treatment technique significantly reduces the surface resistivity of Cotton fabric to 1.27 kΩ/cm with increasing acid concentration and thermal *** electro-thermal energy can also reach up to 38.2°C within 50 s with a deployed voltage of 15 *** modified fabric is anticipated to be used in thermal regulation,supercapacitor,sensor,UV shielding,antimicrobial and other prospective functional applications.

关键词： Polyaniline cotton in-situ polymerization SEM TGA heating fabric

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Urban Freight Consolidation Model for Post-Hauler Planning

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Journal of Transportation Technologies 2024年第2期14卷 255-272页

作者： mohammad Anwar rahman School of Engineering Science & Technology Central Connecticut State University New Britain USA

Freight transportation in urban areas has increased significantly in a shorter period due to the widespread use of e-commerce, fast delivery, and population growth. Recently, a noticeable government initiative aimed at creating an effective, acceptable, and sustainable city logistics policy. This paper examines freight consolidation as a transportation strategy for optimizing last-mile delivery costs. Freight consolidation involves combining smaller shipments from various origins into a single, larger shipment for more efficient transportation to a common destination. This approach is particularly beneficial for last-mile delivery, where frequent deliveries of smaller quantities are frequently visible. Finally, we provide an illustrative example targeting urban freight stakeholders for practicing possible consolidation methodology. The result in the illustrative example shows that freight with 3-day consolidation, despite the delay penalty, is cheaper than daily shipping, and both are cheaper than 2-day consolidated shipping. The study will benefit urban businesses and freight services.

关键词： Freight Consolidation Urban Transport Intermodal Last-Mile Delivery

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Choosing Multimodal Freight Mix: An Integrated Multi-Objective Multicriteria Approach

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Journal of Transportation Technologies 2024年第3期14卷 402-422页

作者： mohammad Anwar rahman School of Engineering Science & Technology Central Connecticut State University New Britain CT USA

Multimodal freight transportation emerges as the go-to strategy for cost-effectively and sustainably moving goods over long distances. In a multimodal freight system, where a single contract includes various transportation methods, businesses aiming for economic success must make well-informed decisions about which modes of transport to use. These decisions prioritize secure deliveries, competitive cost advantages, and the minimization of environmental footprints associated with transportation-related pollution. Within the dynamic landscape of logistics innovation, various multicriteria decision-making (MCDM) approaches empower businesses to evaluate freight transport options thoroughly. In this study, we utilize a case study to demonstrate the application of the Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS) algorithm for MCDM decision-making in freight mode selection. We further enhance the TOPSIS framework by integrating the entropy weight coefficient method. This enhancement aids in assigning precise weights to each criterion involved in mode selection, leading to a more reliable decision-making process. The proposed model provides cost-effective and timely deliveries, minimizing environmental footprint and meeting consumers’ needs. Our findings reveal that freight carbon footprint is the primary concern, followed by freight cost, time sensitivity, and service reliability. The study identifies the combination of Rail/Truck as the ideal mode of transport and containers in flat cars (COFC) as the next best option for the selected case. The proposed algorithm, incorporating the enhanced TOPSIS framework, benefits companies navigating the complexities of multimodal transport. It empowers making more strategic and informed transportation decisions. This demonstration will be increasingly valuable as companies navigate the ever-growing trade within the global supply chains.

关键词： Multimodal Freight Transport MCDM TOPSIS Entropy Technique COFC

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Rhizobium Inoculation and Micronutrient Addition Influence the Growth,Yield,Quality and Nutrient Uptake of Garden Peas(Pisum sativum L.)

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 901-922页

作者： MdAbdul Quddus MdAtaur rahman Razu Ahmed mohammad Eyakub Ali Khokan Kumer Sarker MdAlamgir Siddiky Mohibur rahman Lamya Ahmed Alkeridis Samy Sayed Ahmed Gaber Akbar Hossain Horticulture Research Centre Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Soil Science Division Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Irrigation and Water Management Division Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Regional Agricultural Research Station Bangladesh Agricultural Research InstituteCumilla3500Bangladesh Department of Biology College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Science and Technology University College‑RanyahTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Economic Entomology and Pesticides Faculty of AgricultureCairo UniversityGiza12613Egypt Department of Genetics Faculty of AgricultureCairo UniversityGiza12613Egypt Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Division of Soil Science Bangladesh Wheat and Maize Research InstituteDinajpur5200Bangladesh

Garden pea productivity and qualities are hampered in zinc(Zn),boron(B),and molybdenum(Mo)deficient ***,the combination of micronutrients(i.e.,Zn,B,and Mo)and rhizobium is necessary to increase the productivity and quality of garden peas,since this management for garden peas is neglected in ***,the present study was made to assess the effectiveness of rhizobium inoculant singly or in combination with the micronutrients(i.e.,Zn,B,and Mo)on growth,yield,nutrient uptake,and quality of garden *** were:T_(1)=Control,T_(2)=Rhizobium inoculation at 50 g/kg seed,T_(3)=T_(2)+Zn_(3)Mo1,T_(4)=T_(2)+B_(2)Mo1,T_(5)=T_(2)+Zn_(3)B_(2),T_(6)=T_(2)+Zn_(3)B_(2)Mo1 and T_(7)=Zn_(3)B_(2)*** treatments were arranged in a randomized complete block design and repeated all treatments in three *** application of 3 kg Zn,2 kg B,and 1 kg Mo ha^(−1)with inoculation of Rhizobium at 50 g kg^(−1)seed(T_(6))facilitated to increase of 44.8%in the green pod and 29.7%seed yield over *** same treatment contributed to attaining the maximum nodulation(25.3 plant^(−1)),Vitamin C(43.5 mg 100 g^(−1)),protein content(22.2%),and nutrient uptake as well as accumulation in garden *** all treatment combinations,treatment T_(6)was found superior to others based on microbial activities,soil fertility,and *** results of the study found that the application of 3 kg Zn,2 kg B,and 1 kg Mo ha^(−1)in combination with Rhizobium inoculation(50 g kg^(−1)seed)can improve the yield and quality of garden *** results of the study have the potential for the areas,where there is no use of Rhizobium inoculant or Zn,B,and Mo fertilizer for cultivation of garden pea.

关键词： Nodulation nutrient content Pisum sativum L. profitability rhizobium Zn B Mo

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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi mohammad-Mahdi Salarabedi Syed Azizur rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi mohammad Ahmadvand Wael M Abdel-rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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