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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： mohammad M Khan Zaw ali Khan Mohsin ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Robust design of sliding mode control for airship trajectory tracking with uncertainty and disturbance estimation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 242-258页

作者： WASIM Muhammad ali Ahsan CHOUDHRY mohammad Ahmad SHAIKH Inam Ul Hasan SALEEM Faisal Department of Aeronautics and Astronautics Engineering Institute of Space TechnologyIslamabad 44000Pakistan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan Department of Measurements and Control Systems Silesian University of TechnologyGliwice 44-101Poland The Joint Doctoral School Silesian University of TechnologyGliwice 44-100Poland

The robotic airship can provide a promising aerostatic platform for many potential *** applications require a precise autonomous trajectory tracking control for *** has a nonlinear and uncertain *** is prone to wind disturbances that offer a challenge for a trajectory tracking control *** paper addresses the airship trajectory tracking problem having time varying reference path.A lumped parameter estimation approach under model uncertainties and wind disturbances is opted against distributed *** uses extended Kalman filter(EKF)for uncertainty and disturbance *** estimated parameters are used by sliding mode controller(SMC)for ultimate control of airship trajectory *** comprehensive algorithm,EKF based SMC(ESMC),is used as a robust solution to track airship *** proposed estimator provides the estimates of wind disturbances as well as model uncertainty due to the mass matrix variations and aerodynamic model *** stability and convergence of the proposed method are investigated using the Lyapunov stability *** simulation results show that the proposed method efficiently tracks the desired *** method solves the stability,convergence,and chattering problem of SMC under model uncertainties and wind disturbances.

关键词： airship chattering extended Kalman filter(EKF) model uncertainties estimation sliding mode controller(SMC)

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Multi-trial Vector-based Whale Optimization Algorithm

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Journal of Bionic Engineering 2024年第3期21卷 1465-1495页

作者： mohammad H.Nadimi-Shahraki Hajar Farhanginasab Shokooh Taghian ali Safaa Sadiq Seyedali Mirjalili Faculty of Computer Engineering Najafabad BranchIslamic Azad UniversityNajafabad***Iran Big Data Research Center Najafabad BranchIslamic Azad UniversityNajafabad***Iran Department of Computer Science Nottingham Trent UniversityNottinghamNG118NSUK Centre for Artificial Intelligence Research and Optimisation Torrens UniversityBrisbane4006Australia

The Whale Optimization Algorithm(WOA)is a swarm intelligence metaheuristic inspired by the bubble-net hunting tactic of humpback *** spite of its popularity due to simplicity,ease of implementation,and a limited number of parameters,WOA’s search strategy can adversely affect the convergence and equilibrium between exploration and exploitation in complex *** address this limitation,we propose a new algorithm called Multi-trial Vector-based Whale Optimization Algorithm(MTV-WOA)that incorporates a Balancing Strategy-based Trial-vector Producer(BS_TVP),a Local Strategy-based Trial-vector Producer(LS_TVP),and a Global Strategy-based Trial-vector Producer(GS_TVP)to address real-world optimization problems of varied degrees of ***-WOA has the potential to enhance exploitation and exploration,reduce the probability of being stranded in local optima,and preserve the equilibrium between exploration and *** the purpose of evaluating the proposed algorithm's performance,it is compared to eight metaheuristic algorithms utilizing CEC 2018 test ***,MTV-WOA is compared with well-stablished,recent,and WOA variant *** experimental results demonstrate that MTV-WOA surpasses comparative algorithms in terms of the accuracy of the solutions and convergence ***,we conducted the Friedman test to assess the gained results statistically and observed that MTV-WOA significantly outperforms comparative ***,we solved five engineering design problems to demonstrate the practicality of *** results indicate that the proposed MTV-WOA can efficiently address the complexities of engineering challenges and provide superior solutions that are superior to those of other algorithms.

关键词： Swarm intelligence algorithms Metaheuristic algorithms Optimization Engineering design problems Whale optimization algorithm

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Innovative approach to boosting the chemical stability of AZ31 magnesium alloy using polymer-modified hybrid metal oxides

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Journal of Magnesium and Alloys 2024年第3期12卷 1068-1081页

作者： Mosab Kaseem Ananda Repycha Safira mohammad Aadil Tehseen Zehra Muhammad ali Khan Arash Fattah-alhosseini Corrosion and Electrochemistry Laboratory Department of Nanotechnology and Advanced Materials EngineeringSejong UniversitySeoul 05006Republic of Korea Department of Materials Engineering Bu-Ali Sina UniversityHamedan 65178-38695Iran

Meeting the demands of complex and advanced applications requires the development of high-performance hybrid materials with unique ***,the integration of polymeric frameworks with MgO/WO_(3) composite layers faces challenges due to the lack of understanding of the formation mechanism and the challenge of determining the impact of self-assembled architecture on anticorrosive *** this study,we aimed to enhance the corrosion resistance of the MgO layer produced by plasma electrolysis(PE)of AZ31 Mg alloy by incorporating WO_(3) with partially phosphorated poly(vinyl alcohol)(PPVA).Two types of porous MgO layers were produced using the PE process with an alkaline-phosphate electrolyte,one with and one without WO_(3) nanoparticles,which were subsequently immersed in an aqueous solution of *** PPVA into the WO_(3)-MgO layer resulted in hybrids being deposited in a fragmented manner,creating a“laminar reef-like structure”that sealed most of the structural defects in the *** PPVA-sealed WO_(3)-based coating exhibited superior corrosion resistance compared to the other *** analyses were employed to explore the mechanism underlying the formation of PPVA/WO_(3) hybrids on the MgO *** findings suggest that PPVA-WO_(3)-MgO hybrid coatings can potentially improve corrosion resistance in various fields.

关键词： Plasma electrolysis Poly(vinyl alcohol) Tungsten trioxide Sealing Corrosion DFT.

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Ionotropic receptors mediate olfactory learning and memory in Drosophila

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Insect Science 2024年第4期31卷 1249-1269页

作者： Md Zeeshan ali Anushree Aarif Ahsan mohammad Shamsul Ola Rizwanul Haque Jawaid Ahsan Department of Biotechnology Central University of South BiharGayaBiharIndia Department of Radiation Oncology University of MichiganAnn ArborMichiganUSA Department of Biochemistry College of ScienceKing Saud UniversityRiyadhSaudi Arabia

Phenylacetaldehyde(PAH),an aromatic compound,is present in a diverse range of fruits including overripe bananas and prickly pear cactus,the two major host fruits for Drosophila *** acts as a potent ligand for the ionotropic receptor 84a(IR84a)in the adult fruit fly and it is detected by the IR84a/IR8a heterotetrameric *** role in the male courtship behavior through IR84a as an environmental aphrodisiac is of additional *** ***,two distinct kinds of olfactory receptors,that is,odorant receptors(ORs)and ionotropic receptors(IRs),perceive the odorant *** display unique structural,molecular,and functional characteristics in addition to having different evolutionary ***,olfactory cues detected by the ORs such as ethyl acetate,1-butanol,isoamyl acetate,1-octanol,4-methylcyclohexanol,*** as aliphatic esters and alcohols have been employed in olfactory classical conditioning using fruit *** underlines the participation of OR-activated olfactory pathways in learning and memory *** study elucidates that likewise ethyl acetate(EA)(an OR-responsive odorant),PAH(an IR-responsive aromatic compound)too can form learning and memory when associated with an appetitive gustatory *** association of PAH with sucrose(PAH/SUC)led to learning and formation of the long-term memory(LTM).Additionally,the Orco^(1),Ir84a^(MI00501),and Ir8a^(1)mutant flies were used to confirm the exclusive participation of the IR84a/IR8a complex in PAH/SUC olfactory associative *** results highlight the involvement of IRs via an IR-activated pathway in facilitating robust olfactory behavior.

关键词： appetitive conditioning Drosophila melanogaster ethyl acetate ionotropic receptors learning and memory phenylacetaldehyde

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Social Media-Based Surveillance Systems for Health Informatics Using Machine and Deep Learning Techniques:A Comprehensive Review and Open Challenges

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1167-1202页

作者： Samina Amin Muhammad ali Zeb Hani Alshahrani Mohammed Hamdi mohammad Alsulami Asadullah Shaikh Institute of Computing Kohat University of Science and TechnologyKohat26000Pakistan Department of Computer Science College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Information System College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia

Social media(SM)based surveillance systems,combined with machine learning(ML)and deep learning(DL)techniques,have shown potential for early detection of epidemic *** review discusses the current state of SM-based surveillance methods for early epidemic outbreaks and the role of ML and DL in enhancing their ***,every year,a large amount of data related to epidemic outbreaks,particularly Twitter data is generated by *** paper outlines the theme of SM analysis for tracking health-related issues and detecting epidemic outbreaks in SM,along with the ML and DL techniques that have been configured for the detection of epidemic *** has emerged as a promising ML technique that adaptsmultiple layers of representations or features of the data and yields state-of-the-art extrapolation *** recent years,along with the success of ML and DL in many other application domains,both ML and DL are also popularly used in SM *** paper aims to provide an overview of epidemic outbreaks in SM and then outlines a comprehensive analysis of ML and DL approaches and their existing applications in SM ***,this review serves the purpose of offering suggestions,ideas,and proposals,along with highlighting the ongoing challenges in the field of early outbreak detection that still need to be addressed.

关键词： Social media epidemic machine learning deep learning health informatics pandemic

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Clinically adaptable machine learning model to identify early appreciable features of diabetes

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Intelligent Medicine 2024年第1期4卷 22-32页

作者： Nurjahan Nipa Mahmudul Hasan Riyad Shahriare Satu Walliullah Koushik Chandra Howlader mohammad ali Moni Department of Information and Communication Technology Bangabandhu Sheikh Mujibur Rahman Digital UniversityBangladeshKaliakairGazipur1750 Bangladesh Department of Applied Mathematics Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Management Information Systems Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Computer Science and Telecommunication Engineering Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Computer Science North Dakota State UniversityFargo58105NDUnited States School of Health and Rehabilitation Sciences Faculty of Health and Behavioural SciencesThe University of QueenslandSt LuciaQLD 4072Australia

Objective Diabetes mellitus is a serious disease where the body of affected patients are failed to produce enough insulin that causes an abnormality of blood *** disease happens for a number of reasons including modern lifestyle,lethargic attitude,unhealthy food consumption,family history,age,overweight,*** aim of this study was to propose a machine learning based prediction model that detected diabetes at the *** In this work,we collected 520 patients records from the University of California,Irvine(UCI)machine learning repository of Sylhet Diabetes Hospital,***,a similar questionnaire of that hospital was followed and assembled 558 patients records from all over Bangladesh through this ***,we accumulated patient records of these two *** the next step,these datasets were cleaned and applied thirty five state-of-arts classifiers such as logistic regression(LR),K nearest neighbors(KNN),support vector classifier(SVC),Nave Byes(NB),decision tree(DT),random forest(RF),stochastic gradient descent(SGD),Perceptron,AdaBoost,XGBoost,passive aggressive classifier(PAC),ridge classifier(RC),Nu-support vector classifier(NuSVC),linear support vector classifier(LSVC),calibrated classifier CV(CCCV),nearest centroid(NC),Gaussian process classifier(GPC),multinomial NB(MNB),complement NB,Bernoulli NB(BNB),categorical NB,Bagging,extra tree(ET),gradiant boosting classifier(GBC),Hist gradiant boosting classifier(HGBC),one vs rest classifier(OVsRC),multi-layer perceptron(MLP),label propagation(LP),label spreading(LS),stacking,ridge classifier CV(RCCV),logistic regression CV(LRCV),linear discriminant analysis(LDA),quadratic discriminant analysis(QDA),and light gradient boosting machine(LGBM)to explore best stable predictive *** performance of the classifiers has been measured using five metrics such as accuracy,precision,recall,F1-score,and area under the receiver operating ***,these outcomes were interpret

关键词： Diabetes Early features Machine learning Classification

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Exploring the meaning of care among lived experiences of patients with blindness:an interpretive phenomenological study

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Frontiers of Nursing 2024年第3期11卷 319-326页

作者： mohammad ali mohammadi Mehdi Heidarzadeh Saeed Mehri Mahmood Shamshiri Department of Medical-Surgical Nursing School of Nursing and MidwiferyArdabil University of Medical SciencesArdabil ***Iran Department of Emergency Nursing School of Nursing and MidwiferyArdabil University of Medical SciencesArdabil ***Iran Department of Critical Care Nursing School of Nursing and MidwiferyArdabil University of Medical SciencesArdabil ***Iran

Objective:To explore the meaning of care experienced by people with blindness in ***:Interpretive phenomenology along with the 6-step method of van Manen was used to conduct the *** purposeful sampling,15 people with legal blindness were *** analysis was used to isolate the meaning of ***:Five themes emerged:(a)nurses in the eyes of patients with blindness;(b)negligence in the caring moments;(c)being cared for in ambiguity;(d)Uncoordinated care;and(e)Psychological discomfor *** sub-themes were condensed into an overarching theme titled as“marginalized patients inside the stereotypical healthcare system.”Conclusions:Lived experiences of patients with blindness revealed that hospitals provide stereotypic or inappropriate care for this minority group in *** professionals par ticularly nurses should be skilled to provide person-centered and coordinated care for patients with blindness.

关键词： hospitalization lived experience meaning of care people with blindness phenomenology

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Classification and Comprehension of Software Requirements Using Ensemble Learning

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Computers, Materials & Continua 2024年第8期80卷 2839-2855页

作者： Jalil Abbas Arshad Ahmad Syed Muqsit Shaheed Rubia Fatima Sajid Shah mohammad Elaffendi Gauhar ali School of Computer Science and Technology Anhui UniversityHefei230039China School of Computing Sciences Pak Austria FachhochschuleInstitute of Applied Sciences and TechnologyHaripur22620Pakistan Department of Computer Science and IT University of LahoreLahore55150Pakistan Department of Computer Science Emerson UniversityPunjabMultan60000Pakistan EIAS(Emerging Intelligent Autonomous Systems)Data Science Lab Prince Sultan UniversityRiyad12435Saudi Arabia

The software development process mostly depends on accurately identifying both essential and optional ***,user needs are typically expressed in free-form language,requiring significant time and human resources to translate these into clear functional and non-functional *** address this challenge,various machine learning(ML)methods have been explored to automate the understanding of these requirements,aiming to reduce time and human ***,existing techniques often struggle with complex instructions and large-scale *** our study,we introduce an innovative approach known as the Functional and Non-functional Requirements Classifier(FNRC).By combining the traditional random forest algorithm with the Accuracy Sliding Window(ASW)technique,we develop optimal sub-ensembles that surpass the initial classifier’s accuracy while using fewer *** results demonstrate that our FNRC methodology performs robustly across different datasets,achieving a balanced Precision of 75%on the PROMISE dataset and an impressive Recall of 85%on the CCHIT *** datasets consistently maintain an F-measure around 64%,highlighting FNRC’s ability to effectively balance precision and recall in diverse *** findings contribute to more accurate and efficient software development processes,increasing the probability of achieving successful project outcomes.

关键词： Ensemble learning machine learning non-functional requirements requirement engineering accuracy sliding window

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Surface Morphology and Thermo-Electrical Energy Analysis of Polyaniline (PANI) Incorporated Cotton Fabric

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Energy Engineering 2024年第1期121卷 1-12页

作者： Md.Shohan Parvez Md.Mustafizur Rahman Mahendran Samykano mohammad Yeakub ali Automotive Engineering Research Group Faculty of Mechanical and Automotive Engineering TechnologyUniversiti Malaysia Pahang Al-Sultan AbdullahPekanMalaysia Department of Textile Engineering Khulna University of Engineering&Technology(KUET)KhulnaBangladesh Centre for Research in Advanced Fluid and Processes(CARIFF) Universiti Malaysia Pahang Al-Sultan AbdullahLebuhraya Tun RazakGambangMalaysia Mechanical Engineering Programme Area Faculty of EngineeringUniversiti Teknologi BruneiBruneiDarussalam

With the exponential development in wearable electronics,a significant paradigm shift is observed from rigid electronics to flexible wearable ***(PANI)is considered as a dominant material in this sector,as it is endowed with the optical properties of both metal and ***,its widespread application got delineated because of its irregular rigid form,level of conductivity,and precise choice of *** PANI in textile materials can generate promising functionality for wearable *** research work employed a straightforward in-situ chemical oxidative polymerization to synthesize PANI on Cotton fabric surfaces with varying dopant(HCl)***-treatment using NaOH is implemented to improve the conductivity of the fabric surface by increasing the monomer *** research explores the morphological and structural analysis employing SEM,FTIR and *** surface resistivity was measured using a digital multimeter,and thermal stability is measured using *** successful polymerization,a homogenous coating layer is *** is revealed that the simple pre-treatment technique significantly reduces the surface resistivity of Cotton fabric to 1.27 kΩ/cm with increasing acid concentration and thermal *** electro-thermal energy can also reach up to 38.2°C within 50 s with a deployed voltage of 15 *** modified fabric is anticipated to be used in thermal regulation,supercapacitor,sensor,UV shielding,antimicrobial and other prospective functional applications.

关键词： Polyaniline cotton in-situ polymerization SEM TGA heating fabric

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