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Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang Zhao Bo Zhi Chen Jia Li Gan Yun Hao Feng Ling Liang Lingyun Yu Zi Yi Wang Samin Abbaszadeh mohammad-ali Shahbazi Ruixing Yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

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Rhizobium Inoculation and Micronutrient Addition Influence the Growth,Yield,Quality and Nutrient Uptake of Garden Peas(Pisum sativum L.)

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 901-922页

作者： MdAbdul Quddus MdAtaur Rahman Razu Ahmed mohammad Eyakub ali Khokan Kumer Sarker MdAlamgir Siddiky Mohibur Rahman Lamya Ahmed Alkeridis Samy Sayed Ahmed Gaber Akbar Hossain Horticulture Research Centre Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Soil Science Division Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Irrigation and Water Management Division Bangladesh Agricultural Research InstituteGazipur1701Bangladesh Regional Agricultural Research Station Bangladesh Agricultural Research InstituteCumilla3500Bangladesh Department of Biology College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Science and Technology University College‑RanyahTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Economic Entomology and Pesticides Faculty of AgricultureCairo UniversityGiza12613Egypt Department of Genetics Faculty of AgricultureCairo UniversityGiza12613Egypt Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Division of Soil Science Bangladesh Wheat and Maize Research InstituteDinajpur5200Bangladesh

Garden pea productivity and qualities are hampered in zinc(Zn),boron(B),and molybdenum(Mo)deficient ***,the combination of micronutrients(i.e.,Zn,B,and Mo)and rhizobium is necessary to increase the productivity and quality of garden peas,since this management for garden peas is neglected in ***,the present study was made to assess the effectiveness of rhizobium inoculant singly or in combination with the micronutrients(i.e.,Zn,B,and Mo)on growth,yield,nutrient uptake,and quality of garden *** were:T_(1)=Control,T_(2)=Rhizobium inoculation at 50 g/kg seed,T_(3)=T_(2)+Zn_(3)Mo1,T_(4)=T_(2)+B_(2)Mo1,T_(5)=T_(2)+Zn_(3)B_(2),T_(6)=T_(2)+Zn_(3)B_(2)Mo1 and T_(7)=Zn_(3)B_(2)*** treatments were arranged in a randomized complete block design and repeated all treatments in three *** application of 3 kg Zn,2 kg B,and 1 kg Mo ha^(−1)with inoculation of Rhizobium at 50 g kg^(−1)seed(T_(6))facilitated to increase of 44.8%in the green pod and 29.7%seed yield over *** same treatment contributed to attaining the maximum nodulation(25.3 plant^(−1)),Vitamin C(43.5 mg 100 g^(−1)),protein content(22.2%),and nutrient uptake as well as accumulation in garden *** all treatment combinations,treatment T_(6)was found superior to others based on microbial activities,soil fertility,and *** results of the study found that the application of 3 kg Zn,2 kg B,and 1 kg Mo ha^(−1)in combination with Rhizobium inoculation(50 g kg^(−1)seed)can improve the yield and quality of garden *** results of the study have the potential for the areas,where there is no use of Rhizobium inoculant or Zn,B,and Mo fertilizer for cultivation of garden pea.

关键词： Nodulation nutrient content Pisum sativum L. profitability rhizobium Zn B Mo

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Clinically adaptable machine learning model to identify early appreciable features of diabetes

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Intelligent Medicine 2024年第1期4卷 22-32页

作者： Nurjahan Nipa Mahmudul Hasan Riyad Shahriare Satu Walliullah Koushik Chandra Howlader mohammad ali Moni Department of Information and Communication Technology Bangabandhu Sheikh Mujibur Rahman Digital UniversityBangladeshKaliakairGazipur1750 Bangladesh Department of Applied Mathematics Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Management Information Systems Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Computer Science and Telecommunication Engineering Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Computer Science North Dakota State UniversityFargo58105NDUnited States School of Health and Rehabilitation Sciences Faculty of Health and Behavioural SciencesThe University of QueenslandSt LuciaQLD 4072Australia

Objective Diabetes mellitus is a serious disease where the body of affected patients are failed to produce enough insulin that causes an abnormality of blood *** disease happens for a number of reasons including modern lifestyle,lethargic attitude,unhealthy food consumption,family history,age,overweight,*** aim of this study was to propose a machine learning based prediction model that detected diabetes at the *** In this work,we collected 520 patients records from the University of California,Irvine(UCI)machine learning repository of Sylhet Diabetes Hospital,***,a similar questionnaire of that hospital was followed and assembled 558 patients records from all over Bangladesh through this ***,we accumulated patient records of these two *** the next step,these datasets were cleaned and applied thirty five state-of-arts classifiers such as logistic regression(LR),K nearest neighbors(KNN),support vector classifier(SVC),Nave Byes(NB),decision tree(DT),random forest(RF),stochastic gradient descent(SGD),Perceptron,AdaBoost,XGBoost,passive aggressive classifier(PAC),ridge classifier(RC),Nu-support vector classifier(NuSVC),linear support vector classifier(LSVC),calibrated classifier CV(CCCV),nearest centroid(NC),Gaussian process classifier(GPC),multinomial NB(MNB),complement NB,Bernoulli NB(BNB),categorical NB,Bagging,extra tree(ET),gradiant boosting classifier(GBC),Hist gradiant boosting classifier(HGBC),one vs rest classifier(OVsRC),multi-layer perceptron(MLP),label propagation(LP),label spreading(LS),stacking,ridge classifier CV(RCCV),logistic regression CV(LRCV),linear discriminant analysis(LDA),quadratic discriminant analysis(QDA),and light gradient boosting machine(LGBM)to explore best stable predictive *** performance of the classifiers has been measured using five metrics such as accuracy,precision,recall,F1-score,and area under the receiver operating ***,these outcomes were interpret

关键词： Diabetes Early features Machine learning Classification

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Measuring Causal Effect with ARDL-BART: A Macroeconomic Application

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Applied Mathematics 2024年第4期15卷 292-312页

作者： Pegah Mahdavi mohammad ali Ehsani Daniel Felix Ahelegbey Mehrnaz mohammadpour Department of Economic and Administrative Sciences University of Mazandaran Babolsar Iran Department of Economics and Management Sciences University of Pavia Pavia Italy Department of Mathematical Sciences University of Mazandaran Babolsar Iran

Modeling dynamic systems with linear parametric models usually suffer limitation which affects forecasting performance and policy implications. This paper advances a non-parametric autoregressive distributed lag model that employs a Bayesian additive regression tree (BART). The performance of the BART model is compared with selection models like Lasso, Elastic Net, and Bayesian networks in simulation experiments with linear and non-linear data generating processes (DGP), and on US macroeconomic time series data. The results show that the BART model is quite competitive against the linear parametric methods when the DGP is linear, and outperforms the competing methods when the DGP is non-linear. The empirical results suggest that the BART estimators are generally more efficient than the traditional linear methods when modeling and forecasting macroeconomic time series.

关键词： BART Model Non Parametric Modeling Machine Learning Regression Trees Bayesian Network VAR

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Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

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Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat Goran Sedeeq Hama Faraj Fattma Abodi ali Abbas Salihi Aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy Wojciech Branicki mohammad Taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

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Effect of Light Emitting Diodes (LEDs) on Growth, Mineral Composition, and Nutritional Value of Wheat & Lentil Sprouts

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1117-1128页

作者： Abdul Momin Amana Khatoon Wajahat Khan Dilsat Bozdoğan Konuşkan Muhammad Mudasar Aslam Muhammad Jamil Shafiq Ur Rehman Baber ali Alevcan Kaplan Sana Wahab Muhammad Nauman Khan Sezai Ercisli mohammad Khalid Al-Sadoon Department of Botany Kohat University of Science&TechnologyKohat26000Pakistan Department of Food Engineering Faculty of AgricultureHatay Mustafa Kemal UniversityHatay31000Türkiye Department of Botany University of Science&TechnologyBannu28100Pakistan Department of Biotechnology and Genetic Engineering Kohat University of Science&TechnologyKohat26000Pakistan Department of Biology University of HaripurKhyber Pakhtunkhwa22620Pakistan School of Science Western Sydney UniversityPenrithNew South Wales2151Australia Department of Crop and Animal Production Sason Vocational SchoolBatman UniversityBatman72060Türkiye Department of Plant Sciences Quaid-i-Azam UniversityIslamabad45320Pakistan Department of Botany Islamia College PeshawarPeshawar25120Pakistan Department of Horticulture Agricultural FacultyAtaturk UniversityErzurum25240Türkiye HGF Agro Ata TeknokentErzurumTR-25240Türkiye Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Sprouts are ready-to-eat and are recognized worldwide as functional components of the human *** advances in innovative agricultural techniques could enable an increase in the production of healthy *** use of light-emitting diode(LED)in indoor agricultural production could alter the biological feedback loop,increasing the functional beneﬁts of plant foods such as wheat and lentil sprouts and promoting the bioavailability of *** effects of white(W),red(R),and blue(B)light were investigated on the growth parameters and nutritional value of wheat and lentil *** the laboratory,seeds were sown under three different LED treat-ments:white,red,and blue light,while normal incandescent light served as a *** seed germina-tion improved by 18.34%and 12.67%for wheat and 18.34%and 12.67%for lentil sprouts under LED treatments R and B,*** increase in total soluble protein and sugar by 33.4%and 9.23%in wheat and by 31.5%and 5.87%in lentils was observed under the R LED *** C concentrations in wheat and lentils were signiﬁcantly increased by R LED compared to all other *** parameters,including potassium and sodium concentrations,were signiﬁcantly increased under red and blue light compared to the control;white light,on the other hand,signiﬁcantly decreased all these *** to the experimental data,red and blue LED light could be beneﬁcial in the production of functional wheat and lentil sprouts with high nutrient concentrations.

关键词： Growth parameters LED nutritional value sprouts total soluble proteins

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Frequency of Uveitis among Juvenile Idiopathic Arthritis Patients in a Tertiary Care Hospital of Bangladesh: A Retrospective Study

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第3期14卷 144-156页

作者： Md. Asif ali Mujammel Haque Kamrul Laila mohammad Hafiz Al-Mamun Mohammed Mahbubul Islam mohammad Imnul Islam Manik Kumar Talukder Pediatric Rheumatology Division Department of Pediatrics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Background: Juvenile idiopathic arthritis (JIA) is the most frequently encountered pediatric rheumatologic disorder with an unknown etiology. At present there is no published data regarding the frequency of uveitis in patients with JIA in Bangladesh. This study aimed to observe the frequency of JIA-associated uveitis (JIAU) and distribution of uveitis among different sub-categories of JIA at the Pediatric Rheumatology division, both outdoor and indoor patients, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU) in Bangladesh. Methods: This was a retrospective study of 1784 JIA patients at the Pediatric Rheumatology division, BSMMU from July 2010 to March 2023. Results: Among the 1784 enrolled JIA patients, we observed that 0.73% of cases had uveitis. Here, 61.5% of JIAU cases were male. Most of the cases (92.3%) had bilateral uveitis and only 7.7% cases had unilateral uveitis. Among JIAU patients, the majority were Oligo JIA (53.8%), followed by ERA 30.8%, Poly JIA RF(−) 7.7% and Systemic JIA 7.7% cases respectively. This study also revealed that 15.4% of JIAU patients had ANA positivity and 23% had HLA B-27 positivity. Here we also found ocular complications associated with uveitis such as band keratopathy (23.1%), posterior synechiae (15.4%) and cataract (15.4%). Conclusions: In this study, we observed only 0.73% of patients of JIA had developed uveitis which is lower than the frequency observed in other European studies. This study also showed various ocular complications amongst JIA-associated uveitis patients which signifies the importance of adherence to periodic ophthalmological follow-up to prevent these ocular complications.

关键词： JIA Uveitis HLA-B27 ANA BSMMU

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Etiology of Pancytopenia in Tabriz Shahid Ghazi Hospital:A Cross-sectional Study in Iran

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Proceedings of Anticancer Research 2024年第4期8卷 104-115页

作者： Hossein Azari Bostanabad Safa Mousavi mohammad Hossein Hosseini Sadra Sarandili ali Esfahani Babak Nejati Department of Hematology and Oncology Faculty of MedicineTabriz University of Medical SciencesTabrizIran Liqvan Health Center Tabriz University of Medical SciencesTabrizIran Hematology and Oncology Research Center Tabriz University of Medical SciencesTabrizIran Department of Health Sciences Curtin Medical SchoolCurtin UniversityPerthWAAustralia

Objective:Pancytopenia is characterized by a reduction in all three types of blood cells:erythrocytes,leukocytes,and *** is caused by a wide range of diseases,leading to diagnostic *** causes can range from drug reactions to life-threatening diseases such as aplastic anemia and *** study aims to investigate the causes of pancytopenia,specifically focusing on age and gender differences among ***:This cross-sectional study includes patients of all ages diagnosed with pancytopenia,as indicated by a CBC/H1 showing a WBC count less than 4,000/μL,platelet count less than 150,000/μL,and hemoglobin levels below 12 g/dL in women and less than 13 g/dL in *** study only included patients with pancytopenia who underwent bone marrow examination and were not subjected to chemotherapy or radiation ***:A total of 133 patients with pancytopenia were included in the *** average age was 47.35±17.62 years old,with 66%of the participants being male and 34%being *** leukemia,specifically acute myeloid leukemia(AML)and acute lymphoid leukemia(ALL),was identified as the primary cause of pancytopenia,accounting for 31.5%of *** anemia was the second most common cause,accounting for 30%of cases,followed by aplastic anemia at 7.5%.Conclusion:Pancytopenia,a condition marked by the decrease in both erythrocytes and leukocytes as well as thrombocytes,can arise from a myriad of *** main findings of this study revealed that megaloblastic anemia,acute myeloid leukemia(AML),and acute lymphoid leukemia(ALL)were the most common ***,a considerable proportion of cases of pancytopenia can be attributed to acute ***,expeditious and accurate diagnosis is imperative and has the potential to save lives in such cases.

关键词： Pancytopenia Leukemia Anemia Bone marrow Blood cells

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New-fashioned solitons of coupled nonlinear Maccari systems describing the motion of solitary waves in fluid flow

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Journal of Ocean Engineering and Science 2024年第4期9卷 353-363页

作者： Tarikul Islam ali Akbar Hadi Rezazadeh Ahmet Bekir Department of Mathematics Hajee Mohammad Danesh Science and Technology UniversityDinajpurBangladesh Department of Applied Mathematics University of RajshahiBangladesh Faculty of Modern Technologies Engineering Amol University of Special Modern TechnologiesAmolIran Neighbourhood of Akcaglan Imarli StreetNo.28/4Eskisehir 26030Turkey

The Schrodinger equation type nonlinear coupled Maccari system is a significant equation that flourished with the wide-ranging arena concerning fluid flow and the theory of deep-water waves,physics of plasma,nonlinear optics,*** exploit the enhanced tanh approach and the rational(G/G)-expansion process to retrieve the soliton and dissimilar soliton solutions to the Maccari system in this *** suggested systems of nonlinear equations turn into a differential equation of single variable through executing some operations of wave variable ***,with the successful implementation of the advised techniques,a lot of exact soliton solutions are *** obtained solutions are depicted in 2D,3D,and contour traces by assigning appropriate values of the allied unknown *** diverse graphical appearances assist the researchers to understand the underlying processes of intricate phenomena of the leading *** individual performances of the employed methods are praise-worthy which justify further application to unravel many other nonlinear evolution equations ascending in various branches of science and engineering.

关键词： Rational(G'/G)-expansion method Coupled nonlinear schrodinger equations Soliton Improved tanh method Exact solutions

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An Electrical Impedance Imaging System Towards Edge Intelligence for Non-Destructive Testing of Concrete

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Tsinghua Science and Technology 2024年第3期29卷 883-896页

作者： Abolfazl Roshanpanah Mahdi Abbasi Hani Attar Ayman Amer mohammad R.Khosravi Ahmed A.Solyman Department of Electrical Engineering Islamic Azad UniversityScience and Research BranceTehran ***Iran Department of Computer Engineering Bu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Department of Computer Engineering Persian Gulf UniversityBushehr ***Iran Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNişantaşıUniversityIstanbul 34398Turkey

In the construction industry,to prevent accidents,non-destructive tests are necessary and *** impedance tomography is a new technology in non-invasive imaging in which the image of the inner part of conductive bodies is reconstructed by the arrays of external electrodes that are connected on the periphery of the *** equipment is cheap,fast,and edge *** this imaging method,the image of electrical conductivity distribution(or its opposite;electrical impedance)of the internal parts of the target object is *** image reconstruction process is performed by injecting a precise electric current to the peripheral boundaries of the object,measuring the peripheral voltages induced from it and processing the collected *** an electrical impedance tomography system,the voltages measured in the peripheral boundaries have a non-linear equation with the electrical conductivity *** paper presents a cheap Electrical Impedance Tomography(EIT)instrument for detecting impurities in the concrete.A voltage-controlled current source,a micro-controller,a set of multiplexers,a set of electrodes,and a personal computer constitute the structure of the *** conducted tests on concrete with impurities show that the designed EIT system can reveal impurities with a good accuracy in a reasonable time.

关键词： non-destructive testing system concrete electrical impedance tomography

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