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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik Shah Mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu Mona Abdulla taher Mustafa mohamed Hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

Outcome of Nurses with Occupational Dermatitis

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Open Journal of Nursing 2024年第6期14卷 239-251页

作者： Amira Omrane Chayma Harrathi Asma Kheder Maher Maoua Malek Ben Abdelkader Taoufik khalfallah Najib Mrizak mohamed Akrout mohamed Adnene Henchi Hichem Bel Hadj Ali Department of Occupational Medicine and Ergonomics Taher Sfar Teaching Hospital Mahdia Tunisia Department of Occupational Medicine Houcine Bouzaiene Teaching Hospital Gafsa Tunisia Department of Occupational Medicine Farhat Hached Teaching Hospital Sousse Tunisia Department of Occupational Medicine and Ergonomics Fattouma Bourguiba Teaching Hospital Monastir Tunisia Department of Dermatology Fattouma Bourguiba Teaching Hospital Monastir Tunisia

Background: Occupational dermatitis is considered as the second most common occupational disease. It accounts for 25% of all lost workdays. Several international studies reported a prevalence of occupational dermatitis in healthcare workers between 17% and 55%. This study aims to identify factors that affect the professional outcome of nurses suffering from occupational dermatitis. Methods: This was a multicenter cross-sectional study concerning nurses declared having occupational dermatitis in the central region of Tunisia. A synoptic sheet related to socio-professional and administrative data was completed. A self-administered Questionnaire going over medical and occupational characteristics was completed during a direct interview. Results: The study involved forty nurses working in four public hospitals in the center of Tunisia. Only 37 workers were included in the study. A professional reclassification was introduced among 19 workers (51% of study population). Work-station adaptation was requested in 14 cases (38%). Exposure to allergens in the workplace was eliminated in 20 cases. Two study participants were transferred to other departments (5.4%) and three people retired (8.1%). A statistically significant association was found between professional reclassification and a history of allergic manifestations (p = 0.003). Similarly, a significant association was found between professional reclassification and the allergic agent (p = 0.014). Workstation layout was significantly associated with a history of allergic manifestations (p = 0.039), the palm hand location (p = 0.04), professional eviction (p Conclusion: This study identified the main factors influencing the occupational outcome of nurses suffering from occupational dermatitis. This outcome depended on a history of atopy (especially allergic rhinitis) and sensitization to allergens (thiuram mix).

关键词： Nursing Occupational Dermatitis Hospital

Numerical Investigation of Rotating Stall in Centrifugal Compressor with Vaned and Vaneless Diffuser

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Journal of Thermal Science 2015年第4期24卷 323-333页

作者： taher Halawa mohamed Alqaradawi mohamed S.Gadala Ibrahim Shahin Osama Badr Mechanical Engineering Department UBC-University of British ColumbiaVancouverB.C.Canada Mechanical Engineering Department Cairo University Mechanical & Industrial Engineering Department Qatar University Mechanical Engineering Department Abu Dhabi University Mechanical and Industrial Engineering Department Qatar UniversityDohaQatar Mechanical Engineering Department Benha University Mechanical Engineering Department British University

This study presents a numerical simulation of the stall and surge in a centrifugal compressor and presents a description of the stall development in two different *** first case is for a compressor with vaneless diffuser and the second is for a compressor with vaned diffuser of the vane island *** main aim of this study is to compare the flow characteristics and behavior for the two compressors near the surge operating condition and provide further understanding of the diffuser role when back flow occurs at *** showed that for a location near the diffuser entrance,the amplitude of the static pressure fluctuations for the vaneless diffuser case is higher than that for the vaned diffuser case near surge *** pressure fluctuations in the case of the vaneless diffuser appear with a gradual decrease of the mean pressure value as a part of the surge *** for the case of the vaned diffuser,the pressure drop during surge occurs faster than the case of the vaneless ***,results indicated that during surge in the case of vaneless diffuser,there is a region with low velocity and back flow that appears as a layer connecting all impeller passages near shroud surface and this layer develops in size with *** the other hand,for the case of vaned diffuser during surge,the low velocity regions appear in random locations in some passages and these regions expand with time towards the shroud *** showed that during stall,the impeller passages are exposed to identical impact from stall cells in the case of vaneless diffuser while the stall effect varies from passage to another in the case of the vaned diffuser.

关键词： centrifugal compressors rotating stall surge vaneless diffuser vaned diffuser

Performance Analysis of a Vertical Axis Tidal Turbine With Flexible Blades

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Journal of Marine Science and Application 2017年第1期16卷 73-80页

作者： mohamed taher Bouzaher Belhi Guerira mohamed Hadid Laboratoire de Génie Mécanique Université de Biskra Biskra 07000 Algeria Unit of Applied Research in Renewable Energy BP 88 Garat Ettaam Ghardaia Algeria

In this study, a vertical axis tidal turbine with flexible blades is investigated. The focus is on analyzing the effect of flexible airfoils types and blade flexibility on turbine net output power. To this end, five different flexible airfoils （Symmetric and Non-symmetric） are employed. The results show that the use of a thick flexible symmetric airfoil can effectively increase output power compared to that achievable with a conventional rigid blade. Moreover, the use of highly flexible blades, as opposed to less flexible or rigid blades, is not recommended.

关键词： flexible blades vertical axis tidal turbine energy harnessing efficiency flow control rigid blade performance analysis

Automated diagnosis and staging of Fuchs’endothelial cell corneal dystrophy using deep learning

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Eye and Vision 2020年第1期7卷 423-433页

作者： taher Eleiwa Amr Elsawy EyüpÖzcan mohamed Abou Shousha Bascom Palmer Eye Institute Miller School of MedicineUniversity of MiamiMiamiFlorida 33136USA Department of Ophthalmology Faculty of MedicineBenha UniversityBenhaEgypt Electrical and Computer Engineering University of MiamiCoral GablesFloridaUSA Net Eye Medical Center GaziantepTurkey Biomedical Engineering University of MiamiCoral GablesFloridaUSA

Background:To describe the diagnostic performance of a deep learning algorithm in discriminating early-stage Fuchs’endothelial corneal dystrophy(FECD)without clinically evident corneal edema from healthy and late-stage FECD eyes using high-definition optical coherence tomography(HD-OCT).Methods:In this observational case-control study,104 eyes(53 FECD eyes and 51 healthy controls)received HDOCT imaging(Envisu R2210,Bioptigen,Buffalo Grove,IL,USA)using a 6 mm radial scan pattern centered on the corneal *** was clinically categorized into early(without corneal edema)and late-stage(with corneal edema).A total of 18,720 anterior segment optical coherence tomography(AS-OCT)images(9180 healthy;5400 early-stage FECD;4140 late-stage FECD)of 104 eyes(81 patients)were used to develop and validate a deep learning classification network to differentiate early-stage FECD eyes from healthy eyes and those with clinical *** 5-fold cross-validation on the dataset containing 11,340 OCT images(63 eyes),the network was trained with 80%of these images(3420 healthy;3060 early-stage FECD;2700 late-stage FECD),then tested with 20%(720 healthy;720 early-stage FECD;720 late-stage FECD).Thereafter,a final model was trained with the entire dataset consisting the 11,340 images and validated with a remaining 7380 images of unseen AS-OCT scans of 41 eyes(5040 healthy;1620 early-stage FECD 720 late-stage FECD).Visualization of learned features was done,and area under curve(AUC),specificity,and sensitivity of the prediction outputs for healthy,early and late-stage FECD were ***:The final model achieved an AUC of 0.997±0.005 with 91%sensitivity and 97%specificity in detecting early-FECD;an AUC of 0.974±0.005 with a specificity of 92%and a sensitivity up to 100%in detecting late-stage FECD;and an AUC of 0.998±0.001 with a specificity 98%and a sensitivity of 99%in discriminating healthy corneas from all ***:Deep learning algorithm is an accurate autonomous nove

关键词： Optical coherence tomography Descemet’s membrane Corneal endothelium Fuchs endothelial dystrophy

Cardiac Arrhythmia Disease Classifier Model Based on a Fuzzy Fusion Approach

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Computers, Materials & Continua 2023年第5期75卷 4485-4499页

作者： Fatma taher Hamoud Alshammari Lobna Osman mohamed Elhoseny Abdulaziz Shehab Eman Elayat College of Technological Innovation Zayed UniversityDubaiUAE Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaSaudi Arabia Department of Electronics and Communications Engineering Delta Higher Institute for Engineering&TechnologyMansouraEgypt College of Computing and Informatics University of SharjahSharjahUnited Arab Emirates Department of Information Systems Mansoura UniversityMansoura35516Egypt Department of Teacher Preparation Faculty of Specific EducationMansoura UniversityMansouraEgypt

Cardiac diseases are one of the greatest global health *** to the high annual mortality rates,cardiac diseases have attracted the attention of numerous researchers in recent *** article proposes a hybrid fuzzy fusion classification model for cardiac arrhythmia *** fusion model is utilized to optimally select the highest-ranked features generated by a variety of well-known feature-selection *** ensemble of classifiers is then applied to the fusion’s *** proposed model classifies the arrhythmia dataset from the University of California,Irvine into normal/abnormal classes as well as 16 classes of ***,at the preprocessing steps,for the miss-valued attributes,we used the average value in the linear attributes group by the same class and the most frequent value for nominal ***,in order to ensure the model optimality,we eliminated all attributes which have zero or constant values that might bias the results of utilized *** preprocessing step led to 161 out of 279 attributes(features).Thereafter,a fuzzy-based feature-selection fusion method is applied to fuse high-ranked features obtained from different heuristic feature-selection *** short,our study comprises three main blocks:(1)sensing data and preprocessing;(2)feature queuing,selection,and extraction;and(3)the predictive *** proposed method improves classification performance in terms of accuracy,F1measure,recall,and precision when compared to state-of-the-art *** achieves 98.5%accuracy for binary class mode and 98.9%accuracy for categorized class mode.

关键词： Cardiac arrhythmia preprocessing missing values classification model fusion

Automated diagnosis and staging of Fuchs' endothelial corneal dystrophy using deep learning

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Eye and Vision 2023年第2期9卷 1-11页

作者： taher Eleiwa Amr Elsawy Eyup Ozcan mohamed Abou Shousha Bascom Palmer Eye Institute Miller School of MedicineUniversity of MiamiMiamiFlorida 33136USA Department of Ophthalmology Faculty of MedicineBenha UniversityBenhaEgypt Electrical and Computer Engineering University of MiamiCoral GablesFloridaUSA Net Eye Medical Center GaziantepTurkey Biomedical Engineering University of MiamiCoral GablesFloridaUSA.

Background:To describe the diagnostic performance of a deep learning algorithm in discriminating early-stage Fuchs'endothelial corneal dystrophy(FECD)without clinically evident corneal edema from healthy and late-stage FECD eyes using high-definition optical coherence tomography(HD-OCT).Methods:In this observational case-control study,104 eyes(53 FECD eyes and 51 healthy controls)received HDOCT imaging(Envisu R2210,Bioptigen,Buffalo Grove,IL,USA)using a 6 mm radial scan pattern centered on the corneal *** was clinically categorized into early(without corneal edema)and late stage(with corneal edema).A total of 18,720 anterior segment optical coherence tomography(AS-OCT)images(9180 healthy;5400 early-stage FECD;4140 late-stage FECD)of 104 eyes(81 patients)were used to develop and validate a deep learning classification network to differentiate early-stage FECD eyes from healthy eyes and those with clinical *** 5-fold cross-validation on the dataset containing 11,340 OCT images(63 eyes),the network was trained with 80%of these images(3420 healthy;3060 early-stage FECD;2700 late-stage FECD),then tested with 20%(720 healthy;720 early-stage FECD;720 late-stage FECD).Thereafter,a final model was trained with the entire dataset consisting the 11,340 images and validated with a remaining 7380 images of unseen AS-0CT scans of 41 eyes(5040 healthy;1620 early-stage FECD 720 late-stage FECD).Visualization of learned features was done,and area under curve(AUC),specificity,and sensitivity of the prediction outputs for healthy,early and late-stage FECD were ***:The final model achieved an AUC of 0.997±0.005 with 91%sensitivity and 97%specificity in detecting early-stage FECD;an AUC of 0.974±0.005 with a specificity of 92%and a sensitivity up to 100%in detecting late-stage FECD;and an AUC of 0.998±0.001 with a specificity 98%and a sensitivity of 99%in discriminating healthycorneas fromall ***:Deep learning algorithm is an accurate autonomous

关键词： Optical coherence tomography Descemet's membrane Comeal endothelium Fuchs endothelial dystrophy

Atlanto-axial langerhans cell histiocytosis in a child presented as torticollis

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World Journal of Clinical Cases 2017年第8期5卷 344-348页

作者： Miniar Tfifha Mehdi Gaha Nadia Mama mohamed taher Yacoubi Saoussen Abroug Hela Jemni Pediatrics Department Sahloul University Hospital Radiology Department Sahloul University Hospital Pathology Department Farhat Hached University Hospital

Langerhans cell histiocytosis(LCH) is a rare condition mostly seen in children and adolescents. Eosinophilic granuloma(EG) is one of its three clinical entities and is considered as a benign osteolytic lesion. Many reports of patients with spine histiocytosis are well documented in the literature but it is not the case of atlantoaxial localization. We report here a new observation of atlantoaxial LCH in a 4-year-old boy revealed by persistent torticollis. He was successfully treated with systemic chemotherapy and surgery. Inter-body fusion packed by autologous iliac bone was performed with resolution of his symptoms. It is known that conservative treatment is usually sufficient and surgery should be reserved for major neurologic defects in spine EG. In atlantoaxial lesion, surgical treatment should be frequently considered.

关键词： Langerhans cell histiocytosis Eosinophilic granuloma Torticollis Cervical spine

Physical Defense and Aversion Factor of Some Range plants in the United Arab Emirates

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Physical Defense and Aversion Factor of Some Range plants in...