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Antioxidant, hepatoprotective and nephroprotective activities of Gazania rigens against carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats

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Traditional Medicine Research 2022年第5期7卷 29-39页

作者： Alshymaa Abdel-Rhman Gomaa Mamdouh Nabil Samy Eman Zekry Attia Mina Ezzat Attya Michael Atef Fawzy Samar Yehia Desoukey mohamed salah kamel Department of Pharmacognosy Faculty of PharmacyMinia UniversityMinia 61519Egypt Department of Pathology Faculty of MedicineMinia UniversityMinia 61519Egypt Department of Biochemistry Faculty of PharmacyMinia UniversityMinia 61519Egypt

Objective:The current study investigated the efficacy of total ethanolic extract and various fractions of Gazania rigens to protect against carbon tetrachloride-induced liver and kidney damage in rats and evaluated their antioxidant ***:The antioxidant activity of the total extract and fractions(petroleum ether,ethyl acetate,and aqueous)of Gazania rigens was examined using 2,2’-diphenyl-1-picrylhydrazyl radical scavenging and phosphomolybdate assays,and their total phenolic and flavonoid contents were *** hepatoprotective and nephroprotective potentials were studied at a dose of 300 mg/kg for six consecutive days followed by induction of hepatorenal injury using carbon tetrachloride single dose(1.5 mL/kg,1:1 v/v in olive oil,intraperitoneal)the next ***:The results revealed the potent hepato and nephroprotective effects of ethyl acetate and aqueous fractions by significantly(P<0.01 or P<0.001)reducing the serum levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,creatinine,urea,triglycerides,cholesterol,and lactate dehydrogenase,along with elevated serum albumin *** improvement of hepatic and renal antioxidant capacities and catalase activities,together with the prominent reduction of hepatic and renal malondialdehyde contents,were confirmed by histopathological ***:The potent hepatoprotective and nephroprotective effects of the total extract and different fractions of Gazania rigens may be attributed to the presence of highly phenolic and flavonoid compounds along with their complementary antioxidant scavenging properties.

关键词： Asteraceae Gazania rigens antioxidant hepatoprotective nephroprotective

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Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 663-675页

作者： mohamed Naguib Abouelsaad Mohammed Shaaban salah El Bagalaty mohamed E.El Madawy Structural Engineering Department Faculty of EngineeringMansura UniversityMansoura 35511Egypt Faculty of Engineering Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise *** addition,the difference between the seismic performance of using twisting towers over regular ones is *** twisting tower is a simulation of the Evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft *** soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,Egypt).The only difference between both towers is their shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in *** analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some *** on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases.

关键词： soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX

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Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review

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World Journal of Clinical Pediatrics 2024年第1期13卷 125-140页

作者： Mohammed Al-Beltagi Nermin Kamal Saeed Adel salah Bediwy Reem Elbeltagi mohamed Basiony Hamza Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlgahrbiaEgypt

BACKGROUND Infants'nutrition significantly influences their growth,development,and overall *** the increasing demand for organic infant formula driven by the perception of health benefits and growing awareness of natural feeding options,it is crucial to conduct a comparative analysis of the gastrointestinal tolerability between organic and traditional infant *** To provide a concise and precise analysis of the gastrointestinal tolerability of organic infant formula compared to traditional infant *** to limited direct comparisons,the review synthesizes available literature on each formula type,presenting insights into their potential effects on infants'digestive *** An extensive literature search was conducted,compiling studies on organic and traditional infant formulas,their compositions,and reported effects on gastrointestinal *** searched academic databases such as PubMed and Google Scholar and specialized nutrition,paediatrics,and infant health journals using relevant keywords till October 1,*** Although specific comparative studies are scarce and formula heterogeneity is a significant limitation,this systematic review provides an in-depth understanding of organic infant formulas'composition and potential *** scientific evidence directly comparing gastrointestinal tolerability is limited,organic formulas strive to use carefully selected organic ingredients to imitate breast milk *** benefits include improved lipid profiles,higher methionine content,and decreased antibiotic-resistant bacteria *** the gastrointestinal tolerability of organic and traditional infant formulas is crucial for parents and healthcare providers to make informed *** Despite limitations in direct comparisons,this systematic review provides insights into the composition and potential benefits of organic infant *** emphasizes the need for further research to eluci

关键词： Organic infant formula Traditional infant formula Gastrointestinal tolerability Formula ingredients Digestive health Infant nutrition Organic farming

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Ultralong hydroxyapatite-based forward osmosis membrane for freshwater generation

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 37-49页

作者： mohamed Gamal Gomaa Hamdy Maamoun Abdel-Ghafar Francesco Galiano Francesca Russo Alberto Figoli El-Sayed Ali Abdel-Aal Abdel-Hakim Taha Kandil Bahaa Ahmed salah Central Metallurgical Research and Development Institute(CMRDI) 11421 CairoEgypt Chemistry Department Faculty of ScienceHelwan University11795 CairoEgypt Institute on Membrane Technology(CNR-ITM) 87036 RendeItaly

Increasing global water shortages are accelerating the pace of membrane manufacturing,which generates many environmentally harmful *** challenges need a radical rethink of developing innovative membranes that can address freshwater production without generating environmentally harmful *** work utilized the synthesized ultra-long hydroxyapatite(UHA)by the solvothermal method using the green solvent oleic acid in preparing UHA-based forward osmosis *** membranes were developed using different loading ratios of graphene oxide(GO)by vacuum-assisted filtration *** prepared GO/UHA membranes were identified using X-ray diffraction,scanning electron microscope,Fourier-transform infrared spectroscopy,and X-ray photoelectron *** contact angle and pore size distribution were determined for the obtained GO/UHA *** obtained hierarchical porous structure in the prepared membranes with interconnected channels results in a stable water flux with reverse salt *** best water flux rate of 42±2 L·m^(–2)·h^(–1)was achieved using the 50 mg GO/UHA membrane,which is 3.3 times higher than the pristine membrane,and a reverse salt flux of 67 g·m^(-2)·h^(–1).The obtained results showed a promising capability of a new generation of sustainable inorganic-based membranes that can be utilized in freshwater generation by energy-efficient techniques such as forward osmosis.

关键词： forward osmosis ultra-long hydroxyapatite graphene oxide inorganic-based membrane

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Standardization of meibomian gland dysfunction in an Egyptian population sample using a non-contact meibography technique

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 61-65页

作者： Ahmed mohamed Karara Zeinab El-Sanabary Mostafa Ali El-Helw Tamer Ahmed Macky Mohamad Amr salah Eddin Abdelhakim Department of Ophthalmology Kasr Al-Ainy HospitalCairo UniversityCairo 11431Egypt

AIM:To develop normative data for meibomian gland dysfunction(MGD)parameters,using non-contact meibography technique of Sirius Costruzione Strumenti Oftalmici(CSO)machine,in an Egyptian population ***:Observational,cross-sectional,analytic study,in which 104 Egyptian volunteers were *** upper lids were examined,using“Sirius CSO”*** eyelid was given a degree of meibomian gland loss(MGL),which was calculated by the software of the ***:Mean percentage MGL in right upper lid was of 30.9%±12.6%,and that of left upper lid was 32.6%±11.8%.Thirty-four volunteers(32.7%)had first-degree MGL in their right upper lid,and 67.3%had second-degree *** volunteer(1%)had zero-degree MGL in left upper lid,28(26.9%)had first-degree loss,and 75(72.1%)had second-degree *** of MGL in right upper eyelid was not related to age,but degree of MGL in left upper eyelid increased with *** was statistically significant difference between both genders for degree of MGL in right eye(P=0.036)and in left eye(P=0.027).CONCLUSION:Noncontact meibography is a useful non-invasive tool for diagnosing *** is diagnosed in 100%of apparently normal individuals;26.9%-32.7%of which have first-degree MGL,and 67.3%-72.1%have second-degree MGL.

关键词： Egyptian population meibomian gland dysfunction non-contact meibography standardization upper lid

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-Hashem salah O.Bashir Amal F.Dawood Moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni mohamed D.Morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic Medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the Morris Water Maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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Innovative surfactant of Gemini-type for dissolution mitigation of steel in pickling HCl medium

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Chinese Journal of Chemical Engineering 2021年第6期34卷 125-133页

作者： Medhat kamel mohamed Hegazy salah Rashwan mohamed El Kotb Department of Chemistry Faculty of ScienceSuez Canal UniversityIsmailia 41522Egypt Egyptian Petroleum Research Institute(EPRI) Nasr CityCairo 11727Egypt

A new surfactant of Gemini-type,N,N'-((phthylbis(oxy))bis(ethane-2,1-diyl))bis(N,N-dimethyldodecan-1-aminium bromide)is prepped&*** dissolution suppression impact of the new compound on steel is performed in 1 mol·L^(-1)HCl environment by means of chemical and electrochemical *** prepared surfactant is an agreeable dissolution inhibitor for *** mitigation efficacy rises with the quantity of the *** surfactant belongs to inhibitors of *** adsorption of the synthesized compound followed the Langmuir's *** negative magnitudes of bothΔG_(ads)^(θ) andΔH^(adsθ)indicate that the adsorption process proceeds from its own accord and *** mechanism of adsorption is elucidated by scanning *** is established that the transfer resistance(R_(ct))value rose,where the value of the phase element(CPE)reduced with the amount of synthesized *** to the experimental data arrived by surface tension measurements,the prepared compound is a powerful active agent at the air/water boundary.

关键词： Innovative Gemini surfactant Synthesis Dissolution mitigation Steel Pickling HCl media

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Photovoltaic Models Parameters Estimation Based on Weighted Mean of Vectors

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Computers, Materials & Continua 2023年第3期74卷 5229-5250页

作者： mohamed Elnagi salah kamel Abdelhady Ramadan mohamed F.Elnaggar Department of Electrical Engineering Faculty of EngineeringAl-Azhar UniversityQena83518Egypt Department of Electrical Engineering Faculty of EngineeringAswan UniversityAswan81542Egypt Department of Electrical Engineering College of EngineeringPrince Sattam Bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia Department of Electrical Power and Machines Engineering Faculty of EngineeringHelwan UniversityHelwan11795Egypt

Renewable energy sources are gaining popularity,particularly photovoltaic energy as a clean energy *** is evident in the advancement of scientific research aimed at improving solar cell *** to the non-linear nature of the photovoltaic cell,modeling solar cells and extracting their parameters is one of the most important challenges in this *** a result,the use of optimization algorithms to solve this problem is expanding and evolving at a rapid *** this paper,a weIghted meaN oF vectOrs algorithm(INFO)that calculates the weighted mean for a set of vectors in the search space has been applied to estimate the parameters of solar cells in an efficient and precise *** each generation,the INFO utilizes three operations to update the vectors’locations:updating rules,vector merging,and local *** INFO is applied to estimate the parameters of static models such as single and double diodes,as well as dynamic models such as integral and fractional *** outcomes of all applications are examined and compared to several recent *** well as the results are evaluated through statistical *** results analyzed supported the proposed algorithm’s efficiency,accuracy,and durability when compared to recent optimization algorithms.

关键词： Photovoltaic(PV)modules weIghted meaN oF vectOrs algorithm(INFO) renewable energy static PV models dynamic PV models solar energy

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Surfactant-Assisted Poly(lactic acid)/Cellulose Nanocrystal Bionanocomposite for Potential Application in Paper Coating

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Journal of Renewable Materials 2018年第4期6卷 394-401页

作者： Ragab E.Abou-Zeid mohamed A.Diab salah A.A.mohamed Ahmed Salama Hind Abdullah Aljohani kamel Rizq Shoueir Cellulose and Paper Department National Research Centre33 El-Bohouth St.DokkiP.O.12622GizaEgypt Packing and Packaging Materials Department National Research Centre33 El-Bohouth St.DokkiP.O.12622GizaEgypt Tabuk University Chemistry DepartmentCollege of Al WajhAl WajhSaudi Arabia Institute of Nanoscience&Nanotechnology Chemistry departmentKafr Elsheikh University33516 Kafr ElsheikhEgypt

The current article addresses a new strategy for the preparation of polylactic acid/cellulose nanocrystal(PLA/CNCs)nanobiocomposite films with improved structural morphology,mechanical and barrier properties for food packaging *** addition of hexadecyltrimethylammonium bromide(CTAB)and sodium lauryl sulfate(SLS)as cationic and anionic surfactants respectively,was found to play a crucial role in preventing re-aggregation of the CNCs during drying and improving the dispersion of CNCs in the *** coated paper was characterized using mechanical tests,water vapor permeability(WVP),X-ray diffraction(XRD),scanning electron microscopy(SEM)and air *** results showed that the paper coated with PLA containing 7.5%CNCs and 0.15%CTAB based on weight of PLA,gives the highest measured paper properties,where an increase in tensile strength(+133%),Young’s modulus(+309%),tear index(+183%),burst(+60.8)and a decrease in air permeability(−92%)was obtained.

关键词： Cellulose nanocrystal surfactant paper coating mechanical properties air permeability water vapor permeability

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Design of adaptive intuitionistic fuzzy controller for synchronisation of uncertain chaotic systems

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 237-246页

作者： mohamed Hamdy salah Helmy mohamed Magdy Department of Industrial Electronics and Control Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf-32952Egypt Department of Mechatronics Engineering Higher Institute of Engineering and TechnologyEl-Mahalla El-Kobra-31951Egypt

This study presents the synchronisation between two non-linear Lorenz chaotic systems using an adaptive intuitionistic fuzzy controller(AIFC).This problem is solved in the presence of external disturbances and *** classes of Lorenz systems have been formulated one as the master and the other as the *** master and slave systems have different initial *** different initial conditions,both systems *** is called the butterfly effect that rules the behaviour of chaotic *** is chosen as a different method that has not been used before to synchronise the chaotic *** scaling factors of the inputs and the output of the intuitionistic fuzzy controller(IFC)are tuned using the artificial bee colony(ABC)algorithm depending on a specified objective *** IFC stability is studied when it is applied to synchronise the Lorenz *** simulation results achieved to assess the adequacy of the proposed control and to exhibit its dependability to synchronise the Lorenz system.

关键词： function. chaotic specified

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