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Journal of Renewable Materials 2018年第4期6卷 394-401页

作者： Ragab E.Abou-Zeid mohamed A.Diab salah A.A.mohamed Ahmed Salama Hind Abdullah Aljohani Kamel Rizq Shoueir Cellulose and Paper Department National Research Centre33 El-Bohouth St.DokkiP.O.12622GizaEgypt Packing and Packaging Materials Department National Research Centre33 El-Bohouth St.DokkiP.O.12622GizaEgypt Tabuk University Chemistry DepartmentCollege of Al WajhAl WajhSaudi Arabia Institute of Nanoscience&Nanotechnology Chemistry departmentKafr Elsheikh University33516 Kafr ElsheikhEgypt

The current article addresses a new strategy for the preparation of polylactic acid/cellulose nanocrystal(PLA/CNCs)nanobiocomposite films with improved structural morphology,mechanical and barrier properties for food packaging *** addition of hexadecyltrimethylammonium bromide(CTAB)and sodium lauryl sulfate(SLS)as cationic and anionic surfactants respectively,was found to play a crucial role in preventing re-aggregation of the CNCs during drying and improving the dispersion of CNCs in the *** coated paper was characterized using mechanical tests,water vapor permeability(WVP),X-ray diffraction(XRD),scanning electron microscopy(SEM)and air *** results showed that the paper coated with PLA containing 7.5%CNCs and 0.15%CTAB based on weight of PLA,gives the highest measured paper properties,where an increase in tensile strength(+133%),Young’s modulus(+309%),tear index(+183%),burst(+60.8)and a decrease in air permeability(−92%)was obtained.

关键词： Cellulose nanocrystal surfactant paper coating mechanical properties air permeability water vapor permeability

Antibacterial, Antioxidant Activities and GC-MS Analysis of Dichrostachys cinera (L.) Ethanolic Leaves Extract

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Pharmacology & Pharmacy 2022年第12期13卷 545-557页

作者： Sitelbanat Yassin mohamed Abubker Anwar mohamed Selma Omer salah Humeada Elhadi M. M. Ahmed Mirghani Abd Alrahman Department of Pharmaceutics (Pharmaceutical Microbiology) University of Gezira Wad Madani Sudan Department of Pharmaceutical Chemistry University of Gezira Wad Madani Sudan Central Laboratory University of Gezira Wad Madani Sudan Department of Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Madani Sudan Department of Chemistry Faculty of Education West Kordofan University Kordofan Sudan Department of Pharmacognosy University of Gezira Wad Madani Sudan Medicinal and Aromatic Plants Research Center University of Gezira Wad Madani Sudan Department of Clinical Pharmacy and Pharmacy Practice University of Gezira Wad Madani Sudan

Traditional medicinal plants are one of the potential sources of antimicrobial drugs and there is a great concern in the use and development of herbal medicine for the treatment of various infections. This study aimed to evaluate the antibacterial, and antioxidant activities of Dichrostachys cinera ethanolic leaves extract and to determine the components of the crude extract. D. cinera extract was evaluated against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. The antibacterial, antioxidant activities and active constituents were determined using standard methods. Antibacterial activity of the crude extract findings showed that all bacterial candidates were susceptible where S. aureus represent MIC at 12.5 mg/ml and MBC at 25 mg/ml, E. coli and P. aeruginosa both showed MIC 25 mg/ml and MBC 50 mg/ml. In the free radical scavenging assay of the extract and the standard quercetin at concentrations of 250 μg/ml, 125 μg/ml, 50 μg/ml, 10 μg/ml, and 5 μg/ml. The radical scavenging activity for the extract was about 92%, 89.6%, 86.8%, 82.8% and 37.8% respectively, compared to quercetin which gave 89.7%, 85.8%, 62.1%, 55.5%, and 45% radical scavenging activity. The GC-Ms analysis of the total constituents demonstrated that 1,6-Anhydro-2,4-dideoxy-.beta.-D-ribo-hexo (21.26%) with different peaks, followed by Glycerin (11.56%), 1,2,3-Cyclopentanetriol (10.18%), 8,11,14-Eicosatrienoic acid, (Z,Z,Z)-(6.18%), 1H-Pyrrole, 1-methyl-(6.08%), Phytol (5.91%) and 7-Bromo-6-(2-diethylaminoethoxy)-2,3-dihyd (5.44%) as major components in the extract. Finally, this study provided useful information on the therapeutic potential of D. cinera as an antibacterial agent and recommended to be evaluated against a wide range of Bacterial and fungal strains using different solvents and different parts from the plant.

关键词： Dichrostachys cinera Antibacterial Activity Antioxidant GC MS Analysis

Circulating microRNA 9-3p and serum endocan as potential biomarkers for hepatitis C virus-related hepatocellular carcinoma

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World Journal of Hepatology 2021年第11期13卷 1753-1765页

作者： Amany mohamed salah Eldin Wahb mohamed El Kassas Ahmed Kamal Khamis Mostafa Elhelbawy Nesreen Elhelbawy Mona salah Eldin Habieb Department of Medical Biochemistry and Molecular Biology Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin Elkom 32512MenoufiaEgypt Department of Medical Biochemistry and Molecular Biology Faculty of MedicineMenoufia UniversityShebin Elkoum 3511Egypt

BACKGROUND The high mortality rate of hepatocellular carcinoma(HCC)in Egypt is due mainly to the increasing prevalence of hepatitis C virus infection(HCV)and late diagnosis of the ***(miRNA),which regulate tumor proliferation and metastasis in HCC,may serve as a useful diagnostic approach for the early detection of HCC,thus decreasing its ***,endocan is a protein with angiogenic and inflammatory properties that are associated with tumor progression and poor *** To analyze the levels of miRNA 9-3p and endocan in HCV-infected HCC patients and correlate them with clinicopathological *** We compared levels of endocan and circulating miRNA 9-3p from 35 HCVrelated HCC patients to 33 patients with HCV-induced chronic liver disease and 32 age and gender matched healthy controls recruited from inpatient and outpatient clinics of the National Liver Institute,Menoufia University,Egypt in the period from January to March 2021 in a case-control *** samples from all groups were analyzed for *** was measured by enzymelinked immunosorbent assays,and the expression levels of circulating miRNA 9-3p were measured by real-time quantitative reverse transcriptase *** The levels of circulating miRNA 9-3p were significantly lower in the HCC group compared to the chronic liver disease(P<0.001)and control(P<0.001)groups,while levels in the chronic liver disease were significantly lower than those in the control group(P<0.001).The levels of serum endocan were significantly higher in the HCC group compared to the chronic liver disease(P<0.001)and control(P<0.001)*** miRNA 9-3p and endocan performed better thanα-fetoprotein in discriminating HCC patients from cirrhosis and healthy *** levels of miRNA 9-3p were significantly inversely correlated to vascular invasion(P=0.002),stage of advancement of Barcelona Clinical Liver Cancer(P<0.001)and the metastatic site(P<0.001)of the HCC ***

关键词： MicroRNA 9-3p Hepatocellular carcinoma Endocan Diagnostic Biomarker Egypt

Essential oils from Elaeoselinum asclepium: Chemical composition, antimicrobial and antioxidant properties

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 851-857页

作者： Moufida Bouchekrit Hocine Laouer mohamed Hajji Moncef Nasri Serkos Artin Haroutounian salah Akkal Laboratory of Natural Biological Resources Valorization Faculty of Sciences University of Setif Laboratory of Enzyme Engineering and Microbiology National School of Engineers of Sfax Chemistry Laboratory Agricultural University of Athens Valorization of Natural Resources Bioactive Molecules and Biological Analysis Unit Department of Chemistry University of Mentouri Constantine1

Objective: To evaluate the chemical composition of the essential oil isolated from Elaeoselinum asclepium(L.) Bertol.(E. asclepium), and test the efficiency of the essential oil as an antimicrobial and antioxidant ***: Essential oil was obtained from the aerial parts of E. asclepium by hydro distillation and analyzed by gas chromatography and gas chromatography coupled with mass spectrometry. We study for the first time the chemical composition of the essential oil of E. asclepium, followed by the in vitro antimicrobial activities, which were evaluated by agar diffusion method against six Gram-positive bacteria, five Gram-negative bacteria, and two fungi. In addition, The antioxidant activities were also investigated using assays of 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferricreducing ***: The analyzed essential oil of the aerial parts of E. asclepium was rich in apinene(43.9%), other compounds detected in appreciable amounts were sabinene(27.9%) and b-pinene(16.0%). The essential oil yields 1.2%, the IC50 values of essential oil in 1,1-diphenyl-2-picrylhydrazyl assay in the reducing power assay were 48.26 mg/m L and at 1 mg/m L, respectively. The absorbance value of essential oil at 700 nm was0.956. The antimicrobial effect was higher on Candida albicans ATCC 1024 strain with the inhibition zone 14.5 mm than bacteria and ***: The essential oil of E. asclepium has antimicrobial and antioxidant activities. These species may be used as an important source of natural antimicrobial and antioxidant agents.

关键词： Elaeoselinum asclepium Apiaceae Essential oil Antimicrobial activity Antioxidant activity Reducing power

Medical treatment for sphincter of oddi dysfunction:Can it replace endoscopic sphincterotomy?

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World Journal of Gastroenterology 2012年第14期18卷 1610-1615页

作者： Véronique Vitton salah Ezzedine Jean-Michel Gonzalez mohamed Gasmi Jean-Charles Grimaud Marc Barthet Department of Gastroenterology Hôpital NordChemin des Bourrely13915 Marseille cedex 20France

AIM:To report the results of a medical management of sphincter of oddi dysfunction(SOD) after an intermediate follow-up ***:A total of 59 patients with SOD(2 men and 57 women,mean age 51 years old) were included in this prospective *** medical treatment for one year,the patients were clinically re-evaluated after an average period of 30 ***:The distribution of the patients according to the Milwaukee's classification was the following:11 patients were type 1,34 were type 2 and 14 were type *** patients underwent an endoscopic sphincterotomy(ES) after one year of medical *** median intermediate follow-up period was 29.8 ± 3 mo(3-72 mo).The initial effectiveness of the medical treatment was complete,partial and poor among 50.8%,13.5% and 35%,respectively,of the *** the end of the follow-up period,37 patients(62.7%) showed more than 50% *** rate of improvement in patients who required ES was not significantly different compared with the patients treated conservatively(64.2% vs 62.2%,respectively).CONCLUSION:Our study confirms that conservative medical treatment could be an alternative to endoscopic sphincterotomy because,after an intermediate follow-up period,the two treatments show the same success rates.

关键词：药物治疗功能障碍括约肌内镜超氧化物歧化酶保守治疗平均年龄平均周期

Dolomite apatite separation by amphoteric collector in presence of bacteria

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Journal of Central South University 2013年第6期20卷 1645-1652页

作者： Elmahdy Ahmed El-Mofty salah Abdel-Khalek mohamed Abdel-Khalek Nagui El-MidanyAyman Central Metallurgical Research and Development Institute Mining Petroleum and Metallurgical Engineering DepartmentCairo University

Bioflotation represents one of the growing trends to enhance the selectivity of conventional flotation *** utilizes the micro-organisms to replace or to interact with the chemical reagents to increase the gap between surface properties of similar minerals and to enhance the separation *** this work,dolomite-phosphate separation was investigated using amphoteric collector (dodecyl-N-carboxyethyl-N-hyroxyethyl-imidazoline) in presence of *** types of bacteria,Corynebacteriumdiphtheriae-intermedius (CDI),and Pseudomonas aeruginosa (PA),were *** collector bacteria interaction was characterized by Fourier transform infra-red (FTIR),frothing height and Zeta *** results show that the collector bacteria interaction improves the flotation ***,the PA positively affects the separation results,the CDI cannot lower the MgO to less than 1%.A phosphate content of 0.7% MgO and 31.77% P2O5 with a recovery of 68% at pH 11,3.0 kg/t amphoteric collector,4×107 cells of PA is obtained.

关键词：分离选择性集电极白云石细菌磷灰石磷酸盐含量铜绿假单胞菌 Zeta电位

Effect of treating chronic hepatitis C with direct-acting antivirals on extrahepatic cutaneous manifestations

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World Journal of Hepatology 2020年第10期12卷 841-849页

作者： mohamed El Kassas Osama MO Hegazy Eman M salah Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineHelwan UniversityCairo 11795Egypt

BACKGROUND Hepatitis C virus(HCV)is a disease with a significant global impact,affecting approximately 2%-2.5%of the world’s *** direct-acting antivirals(DAAs)have been introduced over the past few years with great success in viral *** association of chronic HCV infection with a wide spectrum of cutaneous manifestations has been widely reported in the *** To assess the effect of treating HCV with DAAs on the extrahepatic cutaneous manifestations of *** This prospective observational study included 1039 HCV positive Egyptian patients who were eligible to receive DAAs.A total of 30 patients were diagnosed with extrahepatic cutaneous manifestations and fulfilled the inclusion criteria of the *** these patients,6 had classic lichen planus,8 were diagnosed with psoriasis vulgaris and 16 had *** patients received DAAs from October 2018 to July 2019 in the form of a three-month course of sofosbuvir/daclatasvir *** with lichen planus or psoriasis were dermoscopically evaluated before treatment and 6 mo after treatment,while patients with hepatic pruritus were assessed using the 12-Item Pruritus Severity Scale over the same *** All patients with psoriasis showed significant improvement in all psoriatic plaques,and all patients with hepatic pruritus scored 0 on the 12-Item Pruritus Severity Scale indicating total improvement of *** addition,four of six patients with lichen planus showed complete *** Treatment of HCV with DAAs was significantly effective in improving virusrelated extrahepatic cutaneous manifestations.

关键词： Directly acting antivirals Extrahepatic manifestations Hepatitis C virus Lichen planus Pruritus Cutaneous manifestations

Chronic neuroprotective effects of low concentration lithium on SH-SY5Y cells:possible involvement of stress proteins and gene expression

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Neural Regeneration Research 2014年第7期9卷 735-740页

作者： Riadh Nciri Ezzeddine Bourogaa Samira Jbahi mohamed salah Allagui Abdelfattah Elfeki Christian Vincent Franoise Croute Cellular Biology Laboratory Purpan Medicine Faculty Paul Sabatier University Ecophysiology Laboratory Sciences Faculty of Sfax

To investigate the molecular mechanism underlying the neuroprotective effect of lithium on cells, in this study, we exposed SH-SY5Y cells to 0.5 mmol/L lithium carbonate （Li2CO2） for 25-50 weeks and then detected the expression levels of some neurobiology related genes and post-translational modifications of stress proteins in SH-SYSY cells, cDNA arrays showed that pyruvate kinase 2 （PKM2） and calmodulin 3 （CaM 3） expression levels were significantly down-regulated, phosphatase protein PP2A expression was lightly down-regulated, and casein kinase II （CK2）, threonine/tyrosine phosphatase 7 （PYST2）, and dopamine beta-hydroxylase （DBH） expression levels were significantly up-regulated. Besides, western blot analysis of stress proteins （HSP27, HSP70, GRP78 and GRP94） showed an over-expression of two proteins： a 105 kDa protein which is a hyper-phosphorylated isoform of GRP94, and a 108 kDa protein which is a phosphorylated tetramer of HSP27. These results suggest that the neuroprotective effects of lithium are likely related to gene expressions and post-translational modifications of proteins cited above.

关键词： lithium neuroprotection kinase phosphatase stress proteins SH-SY5Y cells geneexpression mechanism of action

Compressive Sensing Approach in Multicarrier Sparsely Indexing Modulation Systems

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China Communications 2017年第11期14卷 151-166页

作者： Mostafa salah Osama A.Omer Usama S.mohamed Dept. of Electrical Engineering Sohag University Sohag Egypt Dept. of Electrical Engineering Aswan University Aswan 81542 Egypt Dept. of Electrical Engineering Assiut University Assiut Egypt Dept. of Electronics & Comm. Engineering Arab Academy for Science Technology and Maritime Transport Aswan

recently the indexed modulation(IM) technique in conjunction with the multi-carrier modulation gains an increasing attention. It conveys additional information on the subcarrier indices by activating specific subcarriers in the frequency domain besides the conventional amplitude-phase modulation of the activated subcarriers. Orthogonal frequency division multiplexing(OFDM) with IM(OFDM-IM) is deeply compared with the classical OFDM. It leads to an attractive trade-off between the spectral efficiency(SE) and the energy efficiency(EE). In this paper, the concept of the combinatorial modulation is introduced from a new point of view. The sparsity mapping is suggested intentionally to enable the compressive sensing(CS) concept in the data recovery process to provide further performance and EE enhancement without SE loss. Generating artificial data sparsity in the frequency domain along with naturally embedded channel sparsity in the time domain allows joint data recovery and channel estimation in a double sparsity framework. Based on simulation results, the performance of the proposed approach agrees with the predicted CS superiority even under low signal-to-noise ratio without channel coding. Moreover, the proposed sparsely indexed modulation system outperforms the conventional OFDM system and the OFDM-IM system in terms of error performance, peak-to-average power ratio(PAPR) and energy efficiency under the same spectral efficiency.

关键词： indexed modulation combinatorial modulation double sparsity critical sparsity sparsely indexed modulation OFDM-IM

Study of Aerosol Direct and Indirect Effects and Auto-conversion Processes over the West African Monsoon Region Using a Regional Climate Model

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Advances in Atmospheric Sciences 2018年第2期35卷 182-194页

作者： Zeinab salah Ahmed SHALABY Allison L. STEINER Ashraf S. ZAKEY Ritesh GAUTAM mohamed M. ABDEL WAHAB The Egyptian Meteorological Authority Cairo 11784 Egypt University of Michigan Department of Climate and Space Sciences and Engineering Ann Arbor M148109-2143 USA Centre of Studies in Resources Engineering and Interdisciplinary Program in Climate Studies Indian Institute of Technology Bombay Bombay 400076 India Cairo University Department of Astronomy Space Science and Meteorology Giza 12613 Egypt Environmental Defense Fund Washington DC 20009 USA

This study assesses the direct and indirect effects of natural and anthropogenic aerosols （e.g., black carbon and sulfate） over West and Central Africa during the West African monsoon （WAM） period （June-July-August）. We investigate the impacts of aerosols on the amount of cloudiness, the influences on the precipitation efficiency of clouds, and the associated radiative forcing （direct and indirect）. Our study includes the implementation of three new formulations of auto-conversion parameterization [namely, the Beheng （BH）, Tripoli and Cotton （TC） and Liu and Daum （R6） schemes] in RegCM4.4.1, besides the default model＇s auto-conversion scheme （Kessler）. Among the new schemes, BH reduces the precipitation wet bias by more than 50% over West Africa and achieves a bias reduction of around 25% over Central Africa. Results from detailed sensitivity experiments suggest a significant path forward in terms of addressing the long-standing issue of the characteristic wet bias in RegCM. In terms of aerosol-induced radiative forcing, the impact of the various schemes is found to vary considerably （ranging from -5 to -25 W m-2）.

关键词： aerosol, cloud West African monsoon auto-conversion RegCM