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Efficacy of Intravenous versus Intrathecal Meperidine on Post-Spinal Shivering after Knee Arthroscopy: A Randomized Controlled Study

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Open Journal of Anesthesiology 2022年第6期12卷 197-209页

作者： mohamed said mostafa elmeligy mohamed Fouad mohamed Elmeliegy Anaesthesia Department Benha University Benha Egypt

Background and Aims: Hypothermia is considered a common problem with anesthesia. Spinal anesthesia, affects the process of temperature regulation. The aim of this study was to compare the prophylactic effect of intravenous (IV) meperidine with intrathecal (IT) meperidine on the prevention of shivering during spinal anesthesia in patients underwent knee arthroscopy. Aim of the Study: The aim of this work is to study the effect of meperidine either intravenous (IV) vs intrathecal (IT) on controlling postoperative shriving after knee arthroscopy. Materials and Methods: This study will be conducted in accordance with the principles of the ethics committee Benha University hospitals. Full written informed consent will be obtained from all patients before inclusion in the study, and a prospective randomized double-blinded study was conducted in adult patients undergoing knee arthroscopy under spinal anesthesia. Cases are divided into three equal groups (20 patients in each). Group IT: will receive spinal anesthesia (12.5 mg heavy bupivacaine) with intrathecal meperidine (25 mg). Group IV: will receive spinal anesthesia (12.5 mg heavy bupivacaine) with intravenous meperidine (25 mg). Group C: will receive spinal anesthesia (12.5 mg heavy bupivacaine) only postoperatively. Incidence and degree of shivering (SS), sedation score (RSS), pain score (VAS), hemodynamics, and PONV will be measured at the following intervals: 0 min (once arrived at PACU), 20 min later, 40 min later, 80 min later. Results: Shivering was observed in 0%, 0%, and 10.5% of patients in Groups IT, IV, and C, respectively. There was a significant difference between Group IT and IV compared to Group C (P Conclusion: We concluded that IT meperidine and IV meperidine comparably can decrease intensity and incidence of shivering compared to control group as well as decrease the requirement for additional doses of meperidine for shivering control without any hemodynamic side effect. And intrathecal meperidine sh

关键词： Shivering Mepridine Spinal Anesthesia Knee Arthroscopy

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Effect of Height Adjusted Dose of Intrathecal Hyperbaric Bupivacine for Elective Cesarean Section: A Study of 2 Different Concentrations

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Open Journal of Anesthesiology 2023年第12期13卷 241-253页

作者： mohamed Fouad mohamed Elmeliegy mohamed said mostafa elmeligy Anaesthesia Department Benha University Benha Egypt

Introduction: Study compare spinal anesthesia using hyperbaric bupivacine (0.5% - 0.75%) between fixed dose and height adjusted dose during elective cesarean section. Methods: Hundred parturients who had given their consent and were scheduled for elective cesarean section under spinal anesthesia, were divided into four groups—first group received 0.5% hyperbaric bupivacine fixed dose, the second group received 0.5% hyperbaric bupivacine in a dose adjusted to the height, the third received 0.75% hyperbaric bupivacine fixed dose, the fourth group received 0.75% hyperbaric bupivacine in a dose adjusted to height. The anesthesia onset time, haemodynamic changes, side effects and fetal outcome observed. Results: Spinal block provide excellent surgical anesthesia in all patients. Anesthesia onset time is longer in adjusted than fixed groups, in 0.5% (5 ± 0.816 vs. 3.84 ± 0.746) (P Conclusion: Adjusting dose of hyperbaric bupivacine (0.5% - 0.75%) to patient’s height, decreases the dose of bupivacine in use, it also provide adequate anesthesia for elective cesarean section with decrease the use of vasopressors, the incidence and severity of maternal hypotention also markedly reduced.

关键词： Cesarean Section Height Spinal Anesthesia Local Anesthesia

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Effect of Magnesium Sulfate Nebulization on Stress Response Induced Tracheal Intubation;Prospective, Randomized Study

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Open Journal of Anesthesiology 2021年第4期11卷 128-135页

作者： mohamed said mostafa elmeligy mohamed Fouad mohamed Elmeliegy Anaesthesia Department Benha University Benha Egypt

Background and Aims: Multiple, nonpharmacological and pharmacological measures have been used for attenuating stress response of intubation with variable results. N-methyl-D-aspartate (NMDA) receptors have a role in nociception and inflammation. NMDA receptors are located in peripheral and the central nervous system. Magnesium is also a NMDA receptor blocker. Aim of the Study: To evaluate the effect of nebulized magnesium sulfate on reduce the stress response induced tracheal intubation Material and Methods: Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologists (ASA) status 1 or 2 undergoing elective surgery requiring tracheal intubation. Patients will be recruited in the study divided into two equal groups;Patients in Group A: will receive nebulized magnesium sulfate in 3 ml (240 mg) over 15 min. While group B: will receive nebulized normal saline in 3 ml over 15 min, ending 5 min before the induction of anesthesia. SBP, DBP, HR, and blood glucose level will be measured at the following intervals;Baseline (before induction), after premedication (sedation), after induction, after ETT intubation, 3 min later, 6 min later. Results: Preoperative magnesium sulfate nebulization has a significant effect (p value Conclusion: Magnesium sulfate significantly reduces the stress response of intubation.

关键词： Magnesium Intubation

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Intermittent fasting and the liver: Focus on the Ramadan model

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World Journal of Hepatology 2024年第8期16卷 1070-1083页

作者： mohamed H Emara Hanan Soliman Ebada M said Hassan Elbatae mostafa Elazab Shady Elhefnawy Tarik I Zaher Ahmed Abdel-Razik mohamed Elnadry Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 34622Saudi Arabia Department of Tropical Medicine and Infectious Diseases Tanta UniversityTanta 31512Egypt Department of Hepatology Gastroenterology and Infectious DiseasesBenha UniversityBenha 13511Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Mansoura UniversityMansoura 35516Egypt Department of Hepato-Gastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt

Intermittent fasting(IF)is an intervention that involves not only dietary modific-ations but also behavioral changes with the main core being a period of fasting alternating with a period of controlled *** duration of fasting differs from one regimen to *** fasting(RF)is a religious fasting for Muslims,it lasts for only one month every one lunar *** this model of fasting,observers abstain from food and water for a period that extends from dawn to *** period of daily fasting is variable(12-18 hours)as Ramadan rotates in all seasons of the ***,longer duration of daily fasting is observed during the *** fact,RF is a peculiar type of *** is a dry IF as no water is allowed during the fasting hours,also there are no calorie restrictions during feeding hours,and the mealtime is exclusively *** three variables of the RF model are believed to have a variable impact on different liver *** was evaluated by different observational and interventional studies among patients with non-alcoholic fatty liver disease and it was associated with improve-ments in anthropometric measures,metabolic profile,and liver biochemistry regardless of the calorie restriction among lean and obese *** situation is rather different for patients with liver *** was associated with adverse events among patients with liver cirrhosis irrespective of the underlying etiology of *** patients developed new ascites,ascites were increased,had higher serum bilirubin levels after Ramadan,and frequently developed hepatic encephalopathy and acute upper gastrointestinal *** complications were higher among patients with Child class B and C cirrhosis,and some fatalities occurred due to *** transplant recipients as a special group of patients,are vulnerable to dehydration,fluctuation in blood immunosuppressive levels,likelihood of deterioration and hence observing RF without special precautions

关键词： Intermittent fasting Ramadan fasting Non-alcoholic fatty liver disease Liver cirrhosis Peptic ulcer Liver transplantation Gilbert syndrome

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A Multi-Factor Authentication-Based Framework for Identity Management in Cloud Applications

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Computers, Materials & Continua 2022年第5期71卷 3193-3209页

作者： Wael said Elsayed mostafa M.M.Hassan Ayman mohamed mostafa Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt College of Computer and Information Sciences Jouf UniversitySakaka72314Saudi Arabia

User’s data is considered as a vital asset of several *** data to the cloud computing is not an easy decision for any organization due to the privacy and security *** providers must ensure that both data and applications that will be stored on the cloud should be protected in a secure *** data stored on the public cloud will be vulnerable to outside and inside *** paper provides interactive multi-layer authentication frameworks for securing user identities on the *** access control policies are applied for verifying users on the cloud.A security mechanism is applied to the cloud application that includes user registration,granting user privileges,and generating user authentication *** intrusion detection system is embedded to the security mechanism to detect malicious *** multi factor authentication,intrusion detection,and access control techniques can be used for ensuring the identity of the ***,encryption techniques are used for protecting the data from being *** results are carried out to verify the accuracy and efficiency of the proposed frameworks and *** results recorded high detection rate with low false positive alarms.

关键词： Cloud computing service providers multi-layer authentication frameworks and access control

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An E-Business Event Stream Mechanism for Improving User Tracing Processes

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Computers, Materials & Continua 2021年第10期69卷 767-784页

作者： Ayman mohamed mostafa Saleh N.Almuayqil Wael said College of Computers and Information Sciences Jouf UniversitySakaka72314Saudi Arabia Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt College of Computer Science and Engineering Taibah UniversityMedina42353Saudi Arabia

With the rapid development in business transactions,especially in recent years,it has become necessary to develop different mechanisms to trace business user records in web server log in an efficient *** business transactions have increased,especially when the user or customer cannot obtain the required *** example,with the spread of the epidemic Coronavirus(COVID-19)throughout the world,there is a dire need to rely more on online business *** order to improve the efficiency and performance of E-business structure,a web server log must be well utilized to have the ability to trace and record infinite user *** paper proposes an event stream mechanism based on formula patterns to enhance business processes and record all user activities in a structured log *** user activity is recorded with a set of tracing parameters that can predict the behavior of the user in business *** experimental results are conducted by applying clustering-based classification algorithms on two different datasets;namely,Online Shoppers Purchasing Intention and Instacart Market Basket *** clustering process is used to group related objects into the same cluster,then the classification process measures the predicted classes of clustered *** experimental results record provable accuracy in predicting user preferences on both datasets.

关键词： Business transactions event stream log file tracing parameters clustering-based classification

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Multiphysics simulation of VVER-1200 fuel performance during normal operating conditions

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Nuclear Science and Techniques 2023年第2期34卷 139-152页

作者： Khaled M.Yassin mohamed H.Hassan Mohammad M.Ghoneim mostafa S.Elkolil Adel Alyan said A.Agamy Nuclear Research Center Egyptian Atomic Energy AuthorityAbo Zaabal 13759CairoEgypt Department of Nuclear and Radiological Engineering Faculty of EngineeringAlexandria UniversityAlexandria 21544Egypt Faculty of Engineering Egyptian Russian UniversityBadr 11829Egypt

Nuclear fuel performance modeling and simulation are critical tasks for nuclear fuel design optimization and safety analysis under normal and transient *** performance is a complicated phenomenon that involves thermal,mechanical,and irradiation mechanisms and requires special multiphysics *** this study,a fuel performance model was developed using the COMSOL Multiphysics *** modeling was performed for a 2D axis-symmetric geometry of a UO2fuel pellet in the E110 clad for VVER-1200 *** modeling considers all relevant phenomena,including heat generation and conduction,gap heat transfer,elastic strain,mechanical contact,thermal expansion,grain growth,densification,fission gas generation and release,fission product swelling,gap/plenum pressure,and cladding thermal and irradiation *** model was validated using a code-to-code evaluation of the fuel pellet centerline and surface temperatures in the case of constant power,in addition to validation of fission gas release(FGR)*** prediction proved that the model could perform according to previously published VVER nuclear fuel performance parameters.A sensitivity study was also conducted to assess the effects of uncertainty on some of the model *** model was then used to predict the VVER-1200 fuel performance parameters as a function of burnup,including the temperature profiles,gap width,fission gas release,and plenum pressure.A compilation of related material and thermomechanical models was conducted and included in the modeling to allow the user to investigate different material/performance *** the model was developed for normal operating conditions,it can be modified to include off-normal operating conditions.

关键词： VVER-1200 Fuel performance COMSOL code Zr-1%Nb cladding UO2 fuel rod

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On the Computing of the Minimum Distance of Linear Block Codes by Heuristic Methods

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International Journal of Communications, Network and System Sciences 2012年第11期5卷 774-784页

作者： mohamed Askali Ahmed Azouaoui said Nouh mostafa Belkasmi SIME Lab National School of Computer Science and Systems Analysis(ENSIAS)Mohammed V-Souisi UniversityRabatMorocco

The evaluation of the minimum distance of linear block codes remains an open problem in coding theory, and it is not easy to determine its true value by classical methods, for this reason the problem has been solved in the literature with heuristic techniques such as genetic algorithms and local search algorithms. In this paper we propose two approaches to attack the hardness of this problem. The first approach is based on genetic algorithms and it yield to good results comparing to another work based also on genetic algorithms. The second approach is based on a new randomized algorithm which we call 'Multiple Impulse Method (MIM)', where the principle is to search codewords locally around the all-zero codeword perturbed by a minimum level of noise, anticipating that the resultant nearest nonzero codewords will most likely contain the minimum Hamming-weight codeword whose Hamming weight is equal to the minimum distance of the linear code.

关键词： Minimum Distance Error Impulse Method Heuristic Methods Genetic Algorithms NP-Hardness Linear Error Correcting Codes BCH Codes QR Codes Double Circulant Codes

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Utility of 2-Methyl-quinazolin-4(3H)-one in the Synthesis of Heterocyclic Compounds with Anticancer Activity

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Open Journal of Medicinal Chemistry 2014年第1期4卷 12-37页

作者： Aisha Youssif Hassan Helali Marwa Taha mostafa Sarg Makarem mohamed said Koraa Mona said Fathy El-Zoghbi Department of Chemistry Faculty of Science (Girls) Al-Azhar University Cairo Egypt Department of Organic Chemistry Faculty of Pharmacy (Girls) Al-Azhar University Cairo Egypt Department of Organic Chemistry Faculty of Pharmacy Cairo University Giza Egypt

Quinolino[2,1-b]quinazolines 3 and 4, pyrrolo[2,1-b]quinazoline 5 and various substituted 2-(4-chlorostyryl)quinazoline derivatives including: 4-amino derivative 8, 4-hydrazino derivative 9, thiourea derivative 10, thiosemicarbazide derivative 19, 4-benzylidene hydrazinyl derivative 21, 4-amino thiazolidene derivatives 11, 12, 13, 22, imidazoquinazolines 15, 16, quinazolinium chloride 14, triazino[4,3-c]quinazolines 17, 18, tetrazino[1,6-c]quinazoline 20, 4-amino azetidinyl derivative 23, triazolo[4,3-c]quinazoline 24, 4-amino substituted quinazolines 25, 26, 27, 29 and quinazolino quinazoline 28 were synthesized through different chemical reactions. The obtained compounds were evaluated for their in vitro antitumor activity against HEPG2 and MCF-7 cell lines compared to the reference drug (doxorubicin). Compounds 18, 19, 20, 23 and 24 were found to be the most active against both cell lines exhibiting IC50 values ranging from 10.82 - 29.46 μM/L and 7.09 - 31.85 μM/L against Hep-G2 and MCF-7 cell lines, respectively, in addition to docking study of these five compounds against thymidylate synthase and dihydrofolate reductase enzymes active sites.

关键词： Quinazoline Anticancer DHFR TS

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Immunological,hematological and biochemical changes induced by short term exposure to cadmium in catfish(Clarias gariepinus)

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Journal of Coastal Life Medicine 2014年第3期 175-180页

作者： mohamed El-said El-Boshy Hossam Ali Gadalla Fatma mostafa Abd El-Hamied Department of Clinical Pathology Faculty of Veterinary MedicineMansoura University 35516Egypt Laboratory Medicine Department Faculty of Applied Medical ScienceUmm Al-Qura UniversityMakkah 21955Saudi Arabia

Objective:To investigate the hematological,biochemical and immunological changes in catfish(Clarias gariepinus)(***)experimental exposed to ***:*** were exposed to different concentrations of cadmium(Cd)(0,2,5,and 10 mg/L)for 3 *** samples were collected for assessing some hematological,biochemical and immunological studies at the end of ***:neutrophilia and lymphopenia in 5,10 mg/L in cadmium exposed *** the blood level activities of ALT and AST significantly increased,as well as glucose,creatinine,urea,potassium and uric *** total protein,albumin and sodium were significantly decreased at 5,10 mg/L of cadmium exposed *** immunological parameters in cadmium exposed experimental dose groups decreased serum bactericidal activity,lysozyme,neutrophils adhesion test as well as decreased resistance to Aeromonas hydrophilla with increasing exposure dose seemed to correspond with suppressive of non-specific immune ***:The treatment of *** with cadmium under the same conditions had immunosuppressive and decrease diseases resistance in a dose-dependent effect.

关键词： Cadmium Immune response Hematological parameters Biochemical parameters Catfish(Clariasgariepinus)

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