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Acta Pharmaceutica Sinica B 2016年第2期6卷 163-169页

作者： mohamed Z.Dawoud mohamed nasr Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Helwan University

Colloidal lipid particles such as solid lipid nanoparticles and liquid crystalline nanoparticles have great opportunities as drug carriers especially for lipophilic drugs intended for intravenous administration. In order to evaluate drug release from these nanoparticles and determine their behavior after administration, emulsion droplets were used as a lipophilic compartment to which the transfer of a model drug was measured. The detection of the model drug transferred from monoolein cubic particles and trimyristin solid lipid nanoparticles into emulsion droplets was performed using a flow cytometric technique. A higher rate and amount of porphyrin transfer from the solid lipid nanoparticles compared to the monoolein cubic particles was observed. This difference might be attributed to the formation of a highly ordered particle which leads to the expulsion of drug to the surface of the crystalline ***, the sponge-like structure of the monoolein cubic particles decreases the rate and amount of drug transferred. In conclusion, the flow cytometric technique is a suitable technique to study drug transfer from these carriers to large lipophilic acceptors. Monoolein cubic particles with their unique structure can be used successfully as a drug carrier with slow drug release compared with trimyristin nanoparticles.

关键词： Cubic particles Drug release Drug transfer Flow cytometric technique Emulsion droplets Solid lipid nanoparticles Porphyrin

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

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Acta Pharmaceutica Sinica B 2015年第1期5卷 79-88页

作者： mohamed nasr mohamed K.Ghorab Ahmed Abdelazem Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Helwan University Department of Pharmaceutical Chemistry Faculty of Pharmacy Helwan University

The objective of this study was to prepare cubosomal nanoparticles containing a hydrophilic anticancer drug 5-fluorouracil(5-FU) for liver targeting. Cubosomal dispersions were prepared by disrupting a cubic gel phase of monoolein and water in the presence of Poloxamer 407 as a *** loaded with 5-FU were characterized in vitro and in vivo. In vitro, 5-FU-loaded cubosomes entrapped 31.21% drug and revealed nanometer-sized particles with a narrow particle size distribution. In vitro 5-FU release from cubosomes exhibited a phase of rapid release of about half of the entrapped drug during the first hour, followed by a relatively slower drug release as compared to 5-FU solution. In vivo biodistribution experiments indicated that the cubosomal formulation significantly(Po 0.05) increased5-FU liver concentration, a value approximately 5-fold greater than that observed with a 5-FU ***, serum serological results and histopathological findings revealed greater hepatocellular damage in rats treated with cubosomal formulation. These results demonstrate the successful development of cubosomal nanoparticles containing 5-FU for liver targeting. However, further studies are required to evaluate hepatotoxicity and in vivo antitumor activity of lower doses of 5-FU cubosomal formulation in treatment of liver cancer.

关键词： 5-Fluorouracil Hydrophilic drug Cubosomes Liver targeting Hepatotoxicity

Design and simulation of a 1-GWp solar photovoltaic power station in Sudan

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Clean Energy 2021年第1期5卷 57-78页

作者： Sohaib nasr mohamed Abdalla HakanÖzcan Department of Mechanical Engineering Ondokuz Mayis UniversitesiSamsun 55139Turkey

Developing nations have a critical need to increase electricity *** has much unrealized potential for generating solar energy,particularly in the northern *** research study focuses on designing a 1-GW solar power station in northern Sudan using the PVsyst7.0 software *** determine the appropriate location for the solar-energy station,14 criteria were *** process is generic and suitable for use in any other *** method for conducting cash-flow estimates and return on investment is illustrated in the economic *** city of Dongola,the capital of the northern state,was selected because of its high annual irradiance on a horizontal surface at~2333.2 kWh/*** simulation results show that the annual optimum tilt angle of inclination for photovoltaic(PV)modules is 30°,the energy production is 1979259 MWh/yr and the average annual performance rate is *** addition,the electric power consumption per capita in Sudan is 269 kWh/yr,so the proposed solar power plant with 1979259 MWh/yr can provide energy to 7.4 million people per year annually and reduce carbon emissions by~18 million tons of carbon dioxide per *** calculations show that the levelized cost of electricity(LCOE)is$0.06/kWh,the discounted payback period is~11 years and the net present value is$*** a result,the proposed grid-connected PV solar plant is considered economically,technically and environmentally feasible in Sudan.

关键词： solar energy Sudan design simulation evaluation analytic hierarchy process photovoltaic

Reducing Condensation Inside the Photovoltaic(PV)Inverter according to the Effect of Diffusion as a Process of Vapor Transport

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Frontiers in Heat and Mass Transfer 2024年第4期22卷 1189-1207页

作者： Amal El Berry Marwa M.Ibrahim A.A.Elfeky mohamed F.nasr Mechanical Engineering Department Engineering and Renewable Energy Research InstituteNational Research Centre(NRC)Cairo12622Egypt

A photovoltaic(PV)inverter is a vital component of a photovoltaic(PV)solar ***(PV)inverter failure can mean a solar system that is no longer *** electronic devices such as photovoltaic(PV)inverter devices are subjected to vapor condensation,a risk could *** the amount of moisture in the air,saturation occurswhen the temperature drops to the dewpoint,and condensationmay formon *** simulation with“COMSOL Software”is important for obtaining knowledge relevant to preventing condensation by using two *** first,the assumption was that the device’s water vapor concentration was homogeneous to evaluate the amount of liquid water accumulated on the internal walls of the photovoltaic(PV)inverter ***,by considering the effect of external wind velocity onmoisture transport at the air interface to evaluate water vapor transport outdoors and reduce *** factorial designs are utilized for analyzing the nature of the relationship between the vapor condensation response and the *** vapor condensation inside the solar inverter by the effect of external wind speed on diffusion as a process of transporting moister air outside the inverter box is the main solution for this *** the movement and assessment of the flow of water vapor,the impact of vapor condensation is *** saturation period was determined by using a Boolean saturation *** saturation indicator was set to 1 when saturation was detected(relative humidity greater than or equal to 1)and 0 *** the flow and dispersion of moist air as a function of wind speed helped solve the problem.

关键词： Photovoltaic inverter failure vapor condensation wind velocity diffusion transport and general factorial

Synergetic effect of Egyptian propolis in immunization of BALB/c mice against bovine cysticercosis

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 324-330页

作者： Omnia mohamed Kandil Somia Ayesh Nassar Soad mohamed nasr Hatem Abdel Mawgoud Shalaby Seham Hendawy Faragalla mohamed El Moghazy Department of Parasitology and Animal Diseases National Research Centre Biology Department College of Science and Humanity Studies Salman Bin Abdul Aziz University

Objective: To evaluate the synergetic effect of an ethanolic extract of Egyptian propolis in immunization of BALB/c mice with Taenia saginata(T. saginata) crude antigen against bovine cysticercosis, with reference to its effects on liver and kidney ***: Sixty female mice BALB/c strain weighing 20 to 25 g and 6-8 weeks old were randomly allocated into six groups of ten mice each. Mice in groups 1 and 2(G1 and G2) were immunized intraperitoneally with 100 μg of T. saginata crude antigen in 100 μL phosphate buffer saline emulsified in Freund's adjuvant. Besides, the mice in G2 were administered with propolis extract simultaneously with immunization. Control mice were either administered with propolis extract(G3) or injected with the same volume of phosphate buffer saline emulsified in Freund's adjuvant(G4). The mice in G5 were non-immunized infected control while, those in G6 were non-immunized non-infected control. Two weeks after the last immunization, each mouse was challenged intraperitoneally with 5 000 oncospheres except those of G6. Ethanolic extract of propolis was prepared at a dose 50 mg/kg body ***: After 24 weeks of challenge, the mice in G2 showed the highest level of protection(100%), with no cyst being detected rather than mice in G1(33.3% protection). Additionally,the ELISA results, in this study, showed higher antibody titer in G2 with reduction the alteration in liver and kidney functions compared to ***: Egyptian propolis could increase the level of protection against experimental challenge infection with T. saginata eggs when administered simultaneously with immunization. Furthermore, it could enhance the production of antibodies to immunized antigen and decrease the alteration in liver and kidney functions.

关键词： Taenia saginata Vaccine BALB/c mice ELISA Serum biochemistry

Initial Experience of Face Augmentation Using Fat Graft-Platlet Rich Plasma Mix

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Surgical Science 2015年第11期6卷 489-498页

作者： Adel M. Tolba mohamed nasr Plastic Surgery Unit General Surgery Zagazig University Zagazig Egypt

Plastic surgeons accustomed to use autologous fat grafs for augmentation of soft tissues in the last two decades. The main drawback of fat grafting is unpredictable graft resorption. Several studies have searched for new ways of increasing the viability of the transplanted tissue to overcome this disadvantage. The most recent and promising approach is to mix the fat graft with Platelet-Rich Plasma (PRP) before transplantation. The purpose of this article is to present the initial experience using the autologous fat injection with platlet rich plasma as a method for fascial augmentation.

关键词： Fat Grafting Platelet-Rich Plasma (PRP) Experience

Surgical Treatment of Gynaecomastia: A Prospective Study in 75 Patients

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Surgical Science 2015年第11期6卷 506-517页

作者： Adel M. Tolba mohamed nasr Plastic Surgery Unit General Surgery Zagazig University Zagazig Egypt

Introduction: Gynaecomastia is a benign enlargement of male breast;many techniques have been described for management but none have gained universal acceptance. We discuss the outcomes of the surgical management of gynaecomastia and assess the morbidity and complication rates associated with the procedure to determine whether certain surgical techniques produce better outcomes. Materials and Methods: 75 patients with gynaecomastia were operated in our hospital during the period from Jan. 2009 to Jan. 2015. Results: A total of 140 breasts were operated on during the study period. Patients underwent either liposuction alone (20 breasts), excision alone (70 breasts), both excision and liposuction (36 breast) or skin reduction procedure (14 breasts). 19 operated breasts (13.4%) experienced some form of complications. Minor complications included seroma (4 patients), superficial wound dehiscence (3 patients) and two patients developed haematomas requiring evacuation in theatre. Unsatisfactory cosmotic result was present in 10 breasts and surgical revision was done in 5 breasts. Simon grade 111 breasts experienced the highest complication rate. Conclusion: The study has found that moderate sized gynaecomastia whether true or pseudo gynaecomastia with mild to moderate breast redundancy can be managed easily and effectively by liposuction alone or combined with glandular resection while the conventional infraareolar subcutaneous mastectomy still gives satisfactory results and with no need to remove extra skin. On the other hand, large gynaecomastia with severe breast redundancy can be treated effectively by the inferior pedicle technique without vertical scar.

关键词： Gynaecomastia Male Breast Surgical Management

Efficient Fast Multiplication Free Integer Transformation for the 1-D DCT of the H.265 Standard

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Journal of Software Engineering and Applications 2010年第8期3卷 784-795页

作者： mohamed nasr Haggag mohamed El-Sharkawy Gamal Fahmy Maher Rizkalla German University at Cairo New Cairo City Cairo Egypt Egypt Japan University of Science and Technology Borg Al Arab Alexandria Egypt Electrical Engineering Dept. Assiut University Egypt

In this paper, efficient one-dimensional (1-D) fast integer transform algorithms of the DCT matrix for the H.265 stan-dard is proposed. Based on the symmetric property of the integer transform matrix and the matrix operations, which denote the row/column permutations and the matrix decompositions, along with using the dyadic symmetry modification on the standard matrix, the efficient fast 1-D integer transform algorithms are developed. Therefore, the computational complexities of the proposed fast integer transform are smaller than those of the direct method. In addition to computational complexity reduction one of the proposed algorithms provides transformation quality improvement, while the other provides more computational complexity reduction while maintaining almost the same transformation quality. With lower complexity and better transformation quality, the first proposed fast algorithm is suitable to accelerate the quality-demanding video coding computations. On the other hand, with the significant lower complexity, the second proposed fast algorithm is suitable to accelerate the video coding computations.

关键词： Fast Algorithm HDTV H.265 ICT Order-16 Transform Video Coding

Harmonic Distortion Rate Analysis of H-Bridges Multilevel Inverter

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材料科学与工程（中英文B版） 2011年第3期1卷 308-315页

作者： mohamed Nejib Ben nasr Khammassi Anis Kebir Faouzi Ben Ammar Unite de recherche SICISI ESSTT 5av. Taha Hussein BP 56 Bab Mnara-1008 Universite de Tunis Tunisia Unite de recherche. LSE INSAT Centre Urbain Nord BP 676 1080 Tunisia

Cascaded H-Bridges Asymmetrical 11-Levels Optimization

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材料科学与工程（中英文B版） 2011年第4期1卷 496-503页

作者： mohamed Nejib Ben nasr Khammassi Anis Kebir Faouzi Ben Ammar Unite de Recherche SICISI ESSTT 5av. Taha Hussein BP 56 Bab Mnara-lO08 Universite de Tunis Tunisia Unitd de Recherche.＂ LSE INSA T Centre Urbain Nord BP 676 1080 Tunis