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World Journal of Cardiovascular Diseases 2019年第11期9卷 781-795页

作者： Wassam Eldin Elshafey Walaa Farid Abdel Aziz Ahmed Magdy Kamal Eldin mohamed mahmoud khattab Menoufia University Shibin El Kom Al Minufya Egypt

Background: Chronic kidney disease patients are at a greater risk for nephropathy requiring dialysis after percutaneous coronary intervention. Such patients are usually deferred due to fear of “Renalism”.?Objectives This study assesses the outcome of Low dose contrast protocol during PCI in CKD patients whose e-GFR 60 ml/min/1.72 m and investigates a safety margin for contrast use in these high-risk categories.?Methods: Patients were into three groups according to CV/e-GFR ratio: Group (A) low-dose: CV/e-GFR ratio 2.0 Group (B) medium-dose: CV/e-GFR ratio > 2.0 and × bodyweight\***). Group (C) high-dose: CV/e-GFR ratio > MACD. Results: A total of 73 patients were enrolled. Average age was 54 ± 8 years,81.4% were male and 18.6% were females and 52% were diabetic. Mean baseline e-GFR was 40 ± 8.0 ml/min/1.73m2. Contrast Volume used in group A was (58.26 ± 15.05) (n = 24), in group B (109.42 ± 17.11) (n = 26) and in group C (304.5 ± 60.30) (n = 23), respectively. The incidences of CI-AKI in the 3 groups were 0%, 11.5% and 35%, respectively (p = 0.02). All-cause death 0%, 17% and introduction of maintenance hemo dialysis was 0%, 11.5% and 26%, respectively (p Conclusion: Low dose contrast protocol is safe, effective and easily applicable technique without CI-AKI or death.

关键词： Chronic Kidney Disease (CKD) Maximum Allowed Contrast Dose (MACD) Contrast Induced Acute Kidney Injury (CI-AKI) Low Dose Protocol Contrast Volume to e-GFR Ratio

Trauma to the solid abdominal organs:The missed dark box of colonoscopy

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World Journal of Gastroenterology 2024年第7期30卷 624-630页

作者： mohamed H Emara Usama Mazid Yasmine A Elshaer mahmoud A Elkerdawy Dilaver Farooq Malik Aya M Mahros Department of Hepatology Gastroenterologyand Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 31952Saudi Arabia

Colonoscopy is an integral part of the lower bowel care and is generally considered a potentially safe diagnostic and therapeutic procedure performed as a daycare outpatient *** is associated with different complications that are not limited to adverse events related to the bowel preparation solutions used,the sedatives used,but to the procedure related as well including bleeding and *** to the extra-luminal abdominal organs during colonoscopy are uncommon,however,serious complications related to the procedure have been reported infrequently in the *** threatening injuries to the spleen,liver,pancreas,mesentery,and urinary bladder have been reported as early as in *** injuries should not be overlooked by clinicians and *** increasing abdominal pain,abdominal distension,and hemodynamic instability in absence of rectal bleeding should raise the possibility of severe organ *** and hepatic injury following colonoscopy are usually serious and may be life *** conservative management may help,yet they usually need interventional radiology or surgical *** pancreatitis following colonoscopy is usually mild and is mostly managed *** mechanism of abdominal organ injuries during colonoscopy is not fully understood,however many risk factors have been identified,which can be classified as-organ related,procedure related,and local abdominal *** colonoscopy and prior intra-abdominal adhesions are probably the most relevant risk factors for these *** lateral position,avoidance of looping and excessive force during the procedure would probably reduce the risk of such injuries.

关键词： Colonoscopy Pancreatitis Trauma Complications Adhesions

Insulin therapy in type 2 diabetes: Insights into clinical efficacy, patient-reported outcomes, and adherence challenges

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World Journal of Diabetes 2024年第5期15卷 828-852页

作者： mahmoud Emad-Eldin Gehan F Balata Eman A Elshorbagy Mona S Hamed mohamed S Attia Department of Pharmacy Practice Faculty of PharmacyZagazig UniversityZagazig HFQM+872Al-Sharqia GovernorateEgypt Department of Pharmacy Practice Faculty of PharmacyHeliopolis UniversityCairo 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt Department of Internal Medicine Faculty of MedicineZagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt Department of Community at Faculty of Medicine Zagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt

Insulin therapy plays a crucial role in the management of type 2 diabetes as the disease *** the past century,insulin formulations have undergone significant modifications and bioengineering,resulting in a diverse range of available insulin *** products show distinct pharmacokinetic and pharmacodynamic ***,various insulin regimens have em-erged for the management of type 2 diabetes,including premixed formulations and combinations of basal and bolus *** utilization of different insulin regimens yields disparate clinical outcomes,adverse events,and,notably,patient-reported outcomes(PROs).PROs provide valuable insights from the patient’s perspective,serving as a valuable mine of information for enhancing healthcare and informing clinical *** to insulin therapy,a critical patient-reported outcome,significantly affects clinical outcomes and is influenced by multiple *** review provides insights into the clinical effectiveness of various insulin preparations,PROs,and factors impacting insulin therapy adherence,with the aim of enhancing healthcare practices and informing clinical decisions for individuals with type 2 diabetes.

关键词： Adherence Diabetes Insulin Patient-reported outcomes Pharmacokinetic Pharmacodynamic

Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam mahmoud S.Alkhoudary Ikuo Igarashi mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

Childhood asthma biomarkers including zinc: An exploratory crosssectional study

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World Journal of Clinical Pediatrics 2024年第1期13卷 31-40页

作者： Hoda Atef Abdelsattar Ibrahim Mona Mohsen Boles Salep Aziz Hanna Dina mahmoud Khaled mohamed Abdelhamid El-Khashab Pediatric Clinical Nutrition Unit Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Pediatrics Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Clinical Pathology Faculty of MedicineCairo UniversityCairo 12613Egypt

BACKGROUND Childhood bronchial asthma(BA)is a chronic inflammatory respiratory *** conditions,including zinc deficiency,can affect such allergic *** To outline the difference in serum zinc levels between asthmatic children and healthy *** A cross-sectional study was carried out at Children’s Hospital,Cairo University,investigating serum zinc levels in children with BA(n=40)and healthy children(n=21).Other markers included serum ferritin,iron,hemoglobin(Hb),and immunoglobulin E(IgE)*** t-tests and Mann-Whinny tests were used for *** Kruskal-Wallis test was applied to compare serum ferritin and IgE levels with regard to asthma ***'s rank correlation was performed to explore the relationship between serum ferritin levels and both iron and Hb levels in asthmatic *** Children with BA had higher levels of zinc,yet the difference was not significant(P=0.115).Serum ferritin and IgE levels were significantly higher in asthmatic children(P=0.006 and 0.001,respectively),yet their levels did not differ significantly by severity(P=0.623 and 0.126,respectively).There was a nonsignificant weak correlation between serum ferritin levels and both serum iron and Hb *** Serum zinc levels do not seem to differ between asthmatic children and healthy *** ferritin levels may be a marker of asthma *** IgE levels are not markers of asthma severity.

关键词： Children Asthma Zinc Ferritin

Multi-timescale Modeling and Dynamic Stability Analysis for Sustainable Microgrids:State-of-the-art and Perspectives

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Protection and Control of Modern Power Systems 2024年第3期9卷 1-35页

作者： Mingyue Zhang Yang Han Yuxiang Liu Amr S.Zalhaf Ensheng Zhao Karar mahmoud mohamed M.F.Darwish Frede Blaabjerg the School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE 不详 the University of Electronic Science and Technology of China(UESTC) ChengduChina Aswan University the School of Electrical Engineering Aalto UniversityFinland the Department of Electrical Engineering Faculty of Engineering at ShoubraBenha University the Department of EEA School of Electrical EngineeringAalto University

The increasing trend for integrating renewable energy sources into the grid to achieve a cleaner energy system is one of the main reasons for the development of sustainable microgrid(MG)*** typical power-electronized power systems,MGs make extensive use of power electronics converters,which are highly controllable and flexible but lead to a profound impact on the dynamic performance of the whole *** with traditional large-capacity power systems,MGs are less resistant to perturbations,and various dynamic variables are coupled with each other on multiple timescales,resulting in a more complex system instability *** meet the technical and economic challenges,such as active and reactive power-sharing,voltage,and frequency deviations,and imbalances between power supply and demand,the concept of hierarchical control has been introduced into MGs,allowing systems to control and manage the high capacity of renewable energy sources and ***,as the capacity and scale of the MG system increase,along with a multi-timescale control loop design,the multi-timescale interactions in the system may become more significant,posing a serious threat to its safe and stable *** investigate the multi-timescale behaviors and instability mechanisms under dynamic inter-actions for AC MGs,existing coordinated control strategies are discussed,and the dynamic stability of the system is defined and classified in this ***,the modeling and assessment methods for the stability analysis of multi-timescale systems are also ***,an outlook and discussion of future research directions for AC MGs are also presented.

关键词： Sustainable microgrid hierarchical control modeling model simplification multi-timescale dynamic stability analysis timescale decomposition.

Childhood Papillary Thyroid Carcinoma: A Case Report

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Case Reports in Clinical Medicine 2024年第4期13卷 108-114页

作者： Alma Al Mansour Hayder Makki Hamadi mahmoud Elshafey mohamed Maryam Alkhatry Alqassemi Hospital Emirates Health Services Sharjah UAE Ibrahim Bin Hamad Obaidulla Hospital Ras Al Khaimah UAE

Background: Thyroid cancer is a rare disease yet the most common endocrine malignancy in pediatrics. Unlike adult patients, children with thyroid nodules typically don’t complain of pain, soreness, or difficulty swallowing. Additionally, using the recommended therapy for adults to treat paediatrics is not appropriate. There is an unmet need for updated unique guidelines for the management of papillary thyroid carcinoma (PTC) in paediatrics and adolescents. Case Report: A 12-year-old girl had an atypical presentation of metastatic PTC in lymph nodes. She was treated initially with hemi-thyroidectomy, followed by total thyroidectomy. A multidisciplinary team followed her up till successful results were found. Conclusion: Due to the difference in pathophysiology between thyroid tumors in children and adults, a unique approach to PTC management is to be implemented. Further trials are required for a better understanding of risk factors, the likelihood of recurrence, and the long-term side effects of the chosen management plan.

关键词： Papillary Thyroid Carcinoma Childhood Thyroidectomy Case Report

Treatment of Prostatorectal Fistula by Transanorectal Route: About an Observation

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Open Journal of Urology 2024年第4期14卷 262-266页

作者： mohamed mahmoud Beya Ahmed Salem Terouzi Y. Tfeil Diagana Mouhamadou Urology Department Cheikh Zayed Hospital Nouakchott Mauritania

This is a 54-year-old patient admitted for the management of urinary leakage through the anus that had been occurring for a month, in whom the diagnosis of a prostatorectal fistula was made. The fistula was successful... 详细信息

关键词： Fistula Prostate Rectum York Masson

Optimizing Grey Wolf Optimization: A Novel Agents’ Positions Updating Technique for Enhanced Efficiency and Performance

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Open Journal of Optimization 2024年第1期13卷 21-30页

作者： mahmoud Khatab mohamed El-Gamel Ahmed I. Saleh Asmaa H. Rabie Atallah El-Shenawy Department of Mathematics and Engineering Physics Faculty of Engineering Mansoura University Mansoura Egypt Department of Computers and Control Faculty of Engineering Mansoura University Mansoura Egypt Department of Mathematics Faculty of Science New Mansoura University Mansoura Egypt

Grey Wolf Optimization (GWO) is a nature-inspired metaheuristic algorithm that has gained popularity for solving optimization problems. In GWO, the success of the algorithm heavily relies on the efficient updating of the agents’ positions relative to the leader wolves. In this paper, we provide a brief overview of the Grey Wolf Optimization technique and its significance in solving complex optimization problems. Building upon the foundation of GWO, we introduce a novel technique for updating agents’ positions, which aims to enhance the algorithm’s effectiveness and efficiency. To evaluate the performance of our proposed approach, we conduct comprehensive experiments and compare the results with the original Grey Wolf Optimization technique. Our comparative analysis demonstrates that the proposed technique achieves superior optimization outcomes. These findings underscore the potential of our approach in addressing optimization challenges effectively and efficiently, making it a valuable contribution to the field of optimization algorithms.

关键词： Grey Wolf Optimization (GWO) Metaheuristic Algorithm Optimization Problems Agents’ Positions Leader Wolves Optimal Fitness Values Optimization Challenges

Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： Manal Abd El-Salam Marwa mohamed Anwar Rasha mahmoud Gouda Naglaa Abou El Fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status