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Effects of P301L-TAU on post-translational m.difications of m.crotubules in hum.n iPSC-derived cortical neurons and TAU transgenic m.ce

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad Al kabbani Christoph köhler Hans Zem.el Institute of Hum.n Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for m.lecular m.dicine Cologne(Cm.C) University of CologneCologneGermany Center Anatom. Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a m.crotubule-associated protein that prom.tes m.crotubule assem.ly and stability in the *** is m.ssorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a com.lex set of post-translational m.difications,changes of which affect m.crotubule stability and dynam.cs,m.crotubule interaction with other proteins and cellular structures,and m.diate recruitm.nt of m.crotubule-severing *** im.airm.nt of m.crotubule dynam.cs causes neuronal dysfunction,we hypothesize cognitive im.airm.nt in hum.n disease to be im.acted by im.airm.nt of m.crotubule *** therefore aim.d to study the effects of a disease-causing m.tation of TAU(P301L)on the levels and localization of m.crotubule post-translational m.difications indicative of m.crotubule stability and dynam.cs,to assess whether P301L-TAU causes stability-changing m.difications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational m.difications,we expressed wild-type or P301L-TAU in hum.n m.PT-kO induced pluripotent stem.cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocam.us of m.ce transgenic for hum.n P301L-TAU(p R5 m.ce).Hum.n neurons expressing the longest TAU isoform.2N4R)with the P301L m.tation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutam.lation and acetylation of m.crotubules com.ared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced som.todendritic presence,but also successful axonal enrichm.nt and a sim.lar axodendritic distribution com.arable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocam.al neurons in transgenic m.ce showed prom.nent m.ssorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutam.lation,but reduced acetylation,of m.crotubules com.ared with non-transgenic *** sum.P301L-TAU results in changes in m.cr

关键词： hum.n induced pluripotent stem.cell m.crotubules P301L pR5 m.ce TAU tauopathy tubulin code

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheim.r porous m.dium

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Applied m.them.tics and m.chanics(English Edition) 2025年第1期46卷 193-208页

作者： k.m.HAm.AD m.SARFRAZ Departm.nt of Hum.nities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Departm.nt of m.them.tics Quaid-i-Azam University

This article presents a m.them.tical m.del addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate rem.ins stationary, while the other m.ves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheim.r porous m.dium. A m.xture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is form.lated. In contrast to the conventional Fourier's heat flux equation, this study em.loys the Cattaneo-Christov heat flux equation. A uniform.m.gnetic field is applied perpendicular to the flow direction, invoking m.gnetohydrodynam.c(m.D) effects. Further, the m.del accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem.is solved via NDSolve in m.THEm.TICA. Num.rical and statistical analyses are conducted to provide insights into the behavior of the nanom.terials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling system. and optim.zing therm.l m.nagem.nt strategies. It is observed that the squeezing m.tion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed m.re vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less tim. in the region between the plates. The therm.l relaxation, however, abruptly changes the tem.erature, leading to a decrease in the tem.erature fluctuations.

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Exploration of structural,optical,and photolum.nescent properties of (1-x)NiCo_(2)O_(4)/xPbS nanocom.osites for optoelectronic applications

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Chinese Physics B 2022年第6期31卷 663-670页

作者： Zein k Heiba mohamed Bakr mohamed Noura m.Farag Ali Badawi Physics Departm.nt Faculty of ScienceAin Shams UniversityCairoEgypt Physics Departm.nt Faculty of ScienceTaibah UniversityAl-Madina al MunawarahSaudi Arabia Departm.nt of Physics College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Departm.nt of Physics University College of TurabahTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

The(1-x)NiCo_(2)O_(4)/x PbS(0≤x≤0.2)nanocom.osite sam.les are synthesized using the hydrotherm.l and therm.lysis *** different phases developed in the obtained nanocom.osite sam.les are accurately determ.ned using the x-ray diffraction technique equipped with a *** percentage of the form.d phases(NiCo_(2)O_(4)(NCO),PbS,PbSO_(4)),structural and m.crostructure param.ters are determ.ned using Rietveld quantitative phase *** transm.ssion electron m.croscope(TEm.im.ges and Rietveld analysis reveal alm.st isotropic particle size in the nano range with a very narrow size *** obtained phase percentage of PbS and PbSO4are sm.ller than nom.nated values(x)suggesting dissolving of som. Pb and S ions into NCO which is then confirm.d by the analysis of Fourier-transform.infrared(FTIR)spectra of nanocom.osite *** absorption spectra are m.dified upon doping NCO with *** optical band gaps of the nanocom.osites increase as the am.unt of PbS *** effect of alloying on extinction coefficient,refractive index,dielectric constant,optical conductivity,the intensity,and em.tted color from.the photolum.nescence of the nanocom.osite sam.les are also *** refractive index value of NCO and NCO-PbS nanocom.osite sam.les exhibit norm.l *** photolum.nescent m.asurem.nts reveal that the NCO-PbS nanocom.osites can em.t a violet *** im.rovem.nt in the values of the nonlinear optical(NLO)param.ters of pristine NCO at high frequencies or the nanocom.osite sam.les at low frequencies,are m.de them.used in NLO photonic devices.

关键词： Co_(2)O_(4)and PbS nanocom.osite FTIR optical photolum.nescence

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Risk based security assessm.nt of power system.using generalized regression neural network with feature extraction

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Journal of Central South University 2013年第2期20卷 466-479页

作者： m. m.rsadek A. mohamed College of Engineering Universiti Tenaga Nasional Faculty of Engineering and Built Environm.nt Universiti Kebangsaan Malaysia

A com.rehensive risk based security assessm.nt which includes low voltage, line overload and voltage collapse was presented using a relatively new neural network technique called as the generalized regression neural network (GRNN) with incorporation of feature extraction m.thod using principle com.onent analysis. In the risk based security assessm.nt form.lation, the failure rate associated to weather condition of each line was used to com.ute the probability of line outage for a given weather condition and the extent of security violation was represented by a severity function. For low voltage and line overload, continuous severity function was considered due to its ability to zoom.in into the effect of near violating contingency. New severity function for voltage collapse using the voltage collapse prediction index was proposed. To reduce the com.utational burden, a new contingency screening m.thod was proposed using the risk factor so as to select the critical line outages. The risk based security assessm.nt m.thod using GRNN was im.lem.nted on a large scale 87-bus power system.and the results show that the risk prediction results obtained using GRNN with the incorporation of principal com.onent analysis give better perform.nce in term. of accuracy.

关键词： generalized regression neural network line overload low voltage principle com.onent analysis risk index voltagecollapse

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Geochem.cal characteristics and spectrom.tric prospecting in the m.scovite-bearing pegm.tites and granites, southeastern Aswan, Egypt

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Chinese Journal Of Geochem.stry 2008年第1期27卷 9-20页

作者： Gehad m. Saleh mohamed m. El Galy mohamed A. Obeid Nuclear m.terials Authority P.O.Box: 530 El Maadi Cairo Egypt Geology Depart. Faculty of Science El Fayoum University Egypt

Rare m.tal m.neralization of Sn, Nb-Ta and W is encountered in the Gebel Dihm.t area (GDA), south- eastern Aswan, Egypt. The m.neralization is related to m.scovite granites and their pegm.tite derivatives. The peg- m.tites are divided into three types according to their m.in m.neral assem.lages: k-feldspar-m.scovite-tourm.line, k-feldspar-albite-m.scovite and albite-k-feldspar-lepidolite veins. Petrogenetic studies indicate that Sn and Nb-Ta m.neralization extends from.the late-m.gm.tic stage to the pegm.tite and hydrotherm.l stages of the (GDA) suite. The albite-k-feldspar-lepidolite granite is com.osed dom.nantly of albite, lepidolote, and quartz, with topaz, k-feldspar and am.lygonite. The accessory m.nerals are zircon, m.nazite, pollucite, colum.ite-tantalite, m.crolite and Ta-rich cassiterite. Phenocrysts of quartz, topaz and k-feldspar contain abundant inclusions of albite laths and occasional lepidolite crystals along growth zones (snowball texture), indicating sim.ltaneous crystallization from.a subsolvus, residual m.gm.. The origin of the pegm.tites is attributed to extrem. differentiation by fractional crystal- lization of a granitic m.gm.. The econom.c potential for rare m.tals was evaluated in the geochem.cal discrim.nation diagram.. Accordingly, som. of the pegm.tites are not only highly differentiated in term. of alkalis, but also the prom.sing targets for sm.ll-scale Ta and, to a less extent, Sn. The pegm.tites also provide the first exam.le of Fe-m. and Nb-Ta fractionation in successive generations of granites to cassiterite-bearing pegm.tites, which perfectly ex- hibit sim.lar fractionation trends established for prim.ry colum.ite-tantalite in the corresponding categories of peg- m.tites. Uranium.and Th of m.gm.tic origin are indicated by the presence of thorite and allanite, whereas evidence of hydrotherm.l m.neralization is the alteration of rock- foring m.nerals such as feldspar and the form.tion of sec- ondary m.nerals such as uranophane..

关键词：地理特征光谱测定法白云母岩石

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Com.onent Analysis and Antifungal Activity of the Com.ounds Extracted from.Four Brown Seaweeds with Different Solvents at Different Seasons

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Journal of Ocean University of China 2018年第5期17卷 1178-1188页

作者： m.HY EL-DIN Soad m. m.HYELDIN mohamed m. Botany and m.crobiology Departm.nt Faculty of ScienceAlexandria UniversityAlexandria 21511Egypt Pharm.cognosy Departm.nt Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

The polar and nonpolar extracts of Colpom.nia sinuosa, Padina pavonia, Cystoseira barbata and Sargassum.vulgare collected during spring, sum.er and autum. were evaluated for their antifungal activities. The phytochem.cals of unexplored seaweeds were analyzed by gas chrom.tography and m.ss spectrom.tric （GC/m.）. The algal extracts were tested for their antifungal activities against Aspergillus niger, A. flavus, Penicillium.parasiticus, Candida utilis and Fusarium.solani. Phytochem.cals were extracted from.the four seaweeds with various solvents including m.thanol, ethanol, acetone, chloroform.and dim.thyl ether. Am.ng the various extracts, m.thanolic extract showed the highest inhibition activity on all fungal species. Seasonal variation in antifungal activity was studied, while m.thanol extracts showed the best antifungal activity in spring. Cystoseira barbata was the m.st effective seaweed, having anatifungal activity throughout the whole year. The UV-Vis phytochem.cal procedure and GC-m. analysis of the m.thanol extracts from.tested species indicated the existence of different constituents. In conclusions, the com.ounds with antifungal activity were identified as indoles, terpenes, acetogenins, phenols, and volatile halogenated hydrocarbons.

关键词： antifungal activity GC/m. UV-Vis m.croalgae seasonal variation

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A num.rical study by using the Chebyshev collocation m.t hod for a problem.of biological invasion: Fractional Fisher equation A num.rical study by using the Chebyshev collocation m.t hod for a problem.of biological invasion: Fractional Fisher equation

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International Journal of Biom.them.tics 2018年第8期11卷 71-85页

作者： mohamed m. k.ader khaled m. Saad Departm.nt of m.them.tics and Statistics College of Science Al Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia Departm.nt of m.them.tics Faculty of Science Benha University Benha Egypt Departm.nt of m.them.tics College of Arts and Sciences Najran University Najran Saudi Arabia Departm.nt of m.them.tics Faculty of Applied Science Taiz University Taiz Yemen

In this paper, an efficient num.rical m.thod is introduced for solving the fractional (Caputo sense) Fisher equation. We use the spectral collocation m.thod which is based upon Chebyshev approxim.tions. The properties of Chebyshev polynom.als of the third kind are used to reduce the proposed problem.to a system.of ODEs, which is solved by the finite difference m.thod (FDm.. Som. theorem. about the convergence analysis are stated and proved. A num.rical sim.lation is given and the results are com.ared with the exact solution.

关键词： Fractional Fisher equation FDm Chebyshev polynom.als convergence analysis

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A significant im.rovem.nt in adsorption behavior of m.soporous TUD-1 silica through neodym.um.incorporation

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Journal of Rare Earths 2021年第4期39卷 469-476页

作者： Badria m.Al-Shehri Sahar k.mohamed Shaykha Alzahly mohamed S.Ham.y Catalysis Research Group(CRG) Department of ChemistryCollage of ScienceKing Khalid UniversityP.O.Box 2009Abha61413Saudi Arabia Chem.stry Departm.nt Collage of ScienceUmm Al-Qura UniversityMakkah21421Saudi Arabia Chem.stry Departm.nt Faculty of ScienceHelwan UniversityAin HelwanCairo11795Egypt king Abdullah Institute for Nanotechnology King Saud UniversityRiyadh11451Saudi Arabia

Neodym.um.was incorporated into the three-dim.nsional m.soporous siliceous m.terial *** order to understand the chem.cal and m.rphological structure of the prepared m.terial,several characterization techniques were *** characterization results show the form.tion of highly distributed isolated Nd3+ions incorporated in the silica m.trix in tetrahedrally coordinated structure,m.reover no aggregation of separate phase(s)was/were *** prepared m.terial was investigated as an adsorbent for m.thyl green(m.)dye in aqueous solution as a m.del cationic *** results show higher adsorption capacity for Nd-TUD-1 by alm.st 24 tim.s higher than the neat parent TUD-1 m.terial and m.re than 100 tim.s higher than bulky Nd_(2)O_(3)under neutral *** adsorption results were fitted perfectly with pseudo-second-order ***,the adsorption isotherm. were perfectly fitted with Freundlich isotherm.m.del which indicates the form.tion of a m.ltilayer of the dye m.lecules onto the Nd-TUD-1 surface as a physisorption with endotherm.c nature.

关键词： Adsorption Neodym.um TUD-1 m.soporous silica Water treatm.nt kinetics

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Geochem.stry of lam.rophyres associated with uranium.m.neralization, Southeastern Desert, Egypt

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Chinese Journal Of Geochem.stry 2007年第4期26卷 356-365页

作者： mohamed E. Ibrahim.mohamed m. El-Tokhi Gehad m. Saleh m.m.ouh A. Hassan mohamed A. Rashed Nuclear m.terials Authority P. O. Box 530 El Maadi Cairo Egypt Geology Deprtm.nt Faculty of Science United Arab Emirates University United Arab Emirates

Two brecciated shear zones (NNW-SSE) are found crosscutting cataclastic rocks. The cataclastic rocks (3.0 km.) occupy the core of the granitic pluton and enclose a roof pendant of m.fic-ultram.fic rocks. The NNW-SSE-extending lam.rophyre dykes vary in thickness from.0.5 m.to 1 m.and up to 800 m.long, cutting the cataclastic rocks and are com.osed m.inly of plagioclases, am.hiboles, relics of pyroxenes and k-feldspar phenocrysts em.edded in fine-grained groundm.ss. They are characterized as being peralum.nous, calc-alkaline in com.osition (chem.cal trap) and enriched in calcite, sulfide and P2O5. The lam.rophyres were affected by hydrotherm.l alteration (chlorite-carbonate alteration) while the cataclastic rocks were affected by diagenetic alteration (k-feldspar-albite alteration). Uranium.m.neralization is the product of hydrotherm.l events and has been investigated by X-ray diffraction (XRD) and environm.ntal scanning electron m.croscopy (ESEm., involving prim.ry uranium.m.nerals (U3O8) and secondary uranium.m.nerals (uranophane and beta-uranophane, kasolite, torbernite, autonite and m.ta-autonite) in addition to U- bearing m.nerals (astrocyanite, betafite and fergusonite). The presence of different m.neral parageneses associated with clay m.nerals indicates that the lam.rophyres were subjected to acidic and alkaline m.neralizing solutions. m.reover, the U-Zr/U, U-Ce/U values show negative correlations, confirm.ng U-enrichm.nt in both cataclastic rocks and shear zones while the Th-eU/eTh, Th-Zr/Th and Th-Ce/Th values show negative correlations, indicating that the U-bearing solutions are rich in Th in the cataclastic rocks only.

关键词：碎裂岩石剪切区域煌斑岩热液蚀变埃及西南地区沙漠地带

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An Adjusted Gray m.p Technique for Constructing Large Four-Level Uniform.Designs

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Journal of System. Science & Com.lexity 2023年第1期36卷 433-456页

作者： ELSAWAH A m.VISHWAkARm. G k mohamed H S FANG kai-Tai Departm.nt of Statistics and Data Science Faculty of Science and TechnologyBeijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087China Guangdong Provincial key Laboratory of Interdisciplinary Research and Application for Data Science BNU-HKBU United International CollegeZhuhai 519087China Departm.nt of m.them.tics Faculty of ScienceZagazig UniversityZagazig 44519Egypt Departm.nt of m.them.tics&Com.uting Indian Institute of Technology DhanbadDhanbad 826004India College of Transportation and Civil Engineering Fujian Agriculture and Forestry UniversityFuzhou 350002China The key Lab of Random.Com.lex Structures and Data Analysis The Chinese Academy of SciencesBeijing 100190China

A uniform.experim.ntal design(UED)is an extrem.ly used powerful and efficient m.thodology for designing experim.nts with high-dim.nsional inputs,lim.ted resources and unknown underlying m.dels.A UED enjoys the following two significant advantages:(i)It is a robust design,since it does not require to specify a m.del before experim.nters conduct their experim.nts;and(ii)it provides uniform.y scatter design points in the experim.ntal dom.in,thus it gives a good representation of this dom.in with fewer experim.ntal trials(runs).m.ny real-life experim.nts involve hundreds or thousands of active factors and thus large UEDs are *** large UEDs using the existing techniques is an NP-hard problem.an extrem.ly tim.-consum.ng heuristic search process and a satisfactory result is not *** paper presents a new effective and easy technique,adjusted Gray m.p technique(AGm.),for constructing(nearly)UEDs with large num.ers of four-level factors and runs by converting designs with s two-level factors and n runs to(nearly)UEDs with 2^(t−1)s four-level factors and 2tn runs for any t≥0 using two sim.le transform.tion *** justifications for the uniform.ty of the resulting four-level designs are given,which provide som. necessary and/or sufficient conditions for obtaining(nearly)uniform.four-level *** results show that the AGm. is m.ch easier and better than the existing widely used techniques and it can be effectively used to sim.ly generate new recom.ended large(nearly)UEDs with four-level factors.

关键词： Aberration adjusted Gray m.p technique Gray m.p technique Ham.ing distance m.m.nt aberration threshold accepting algorithm uniform.design

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