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Evaluation of Glomerular Filtration Rate and Urinary Abnormalities in Children with Cancer before Chemotherapy

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Open Journal of Pediatrics 2023年第4期13卷 594-603页

作者： Mamadou Moustapha Diop Aissata Barry Ouo Ouo Kolié Emanuel Camara mohamed lamine Diallo Kaba Bangoura Mamadou Aliou Doukouré Pé Neabel Beimy Dienab Diallo Moustapha Kouyate mohamed lamine Kaba Department of Pediatrics Faculty of Health Sciences and Technologies Gamal Abdel Nasser University Conakry Republic of Guinea Pediatric Emergency CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea Hemodialysis Department CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea

Introduction: Glomerular filtration is an important elimination pathway for many types of chemotherapy. Accurate estimation of glomerular filtration is essential in the management of children with cancer. Methodology: This was a prospective cross-sectional study of the descriptive type extending over a period of 6 months from July 01 to December 31, 2021 on all children with cancer followed in the pediatric hemato-oncology unit of the HND with a renal, blood and urinary assessment associated with the GFR calculated by the SCHWARTZ formula during the study period. Results: During the study period, we registered 41 new cases of cancer in the pediatric oncology unit. The age group of 0 - 5 years was the most represented, i.e. 65.85% and the average age was 5.6 ± 4 years. The most cited clinical signs were fever ie 56.10% followed by abdominal pain 34.15% and anemia 26.83%. The most represented diagnosis was Burkitt’s Lymphoma, i.e. 26.83% followed by Retinoblastoma 24.39%. Mean serum creatinine was 70.65 ± 68.93 μmol/L. In our series, patients whose normal glomerular filtration rate were more represented, i.e. 70.73% and 29.27% had an abnormal GFR with an average of 87.28 ± 70 mL/min/1.73m2. Proteinuria and leukocyturia were observed in 31.71% and 19.51% respectively. Glycosuria and hematuria with common frequencies of 2.44% of patients. Conclusion: The prevention of renal toxicity of anticancer drugs always involves the precise evaluation of renal function using the Schwartz formula in children. .

关键词： GFR Child Cancer Chemotherapy

Case Report for Two Hemodialysed Patients Diagnosed for COVID-19 at the Donka National Hemodialysis Center

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Open Journal of Nephrology 2020年第3期10卷 241-244页

作者： Mamadou Saliou Baldé Abdoulaye Touré Amadou Yalla Camara Joseph Donamou Aly Traoré Boubacar Atigou Drame M’mah lamine Camara Almamy Bangoura Mariam mohamed Camara mohamed lamine Kaba Department of Nephrology-Hemodialysis Hospital National Donka Conakry Guinea Department of Reanimation Hospital Ignace Deen Conakry Guinea Department of Reanimation Hospital National Donka Conakry Guinea

In December 2019, coronavirus disease (COVID-19) due to infection with the novel SARS-CoV-2 virus began to break out. Hemodialysis patients are at high risk because of the co-morbidities. We report the clinical and biological characteristics of two patients who developed COVID-19 infection in our dialysis center in Donka National Hospital. None of the patients had contact with an infected person. The age was 38 and 54 years. The symptoms common to both patients were: fatigue, diarrhea, fever. Lymphopenia was present in both patients. None of them had a chest X-ray or chest scan because they were positive for the test before admission.

关键词： Hemodialysis COVID-19 Coronavirus Donka

Prevalence and Associated Factors of Diabetic Kidney Disease in Senegalese Patients: A Cross-Sectional Study in Saint-Louis

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Open Journal of Nephrology 2020年第1期10卷 23-33页

作者： Sidy mohamed Seck Dominique Doupa Seraphin Ahou Serigne Gueye Macia Engerran lamine Gueye Internal Medicine-Nephrology Department Faculty of Health Sciences University Gaston Berger Saint-Louis Senegal UMI 3189 Environnement santé sociétés (CNRS/UCAD/Université de Bamako/CNRST Burkina-Faso) Faculté de Médecine de Pharmacie et d’Odontostomatologie Dakar Senegal Nephrology Department Faculty of Health Sciences University of Parakou Parakou Benin Nephrology and Hemodialysis Department CH Cahors Cahors France

Introduction: Diabetes is a leading cause of chronic kidney disease in the world. During the next decade, its burden is expected to increase in Africa with potential complications such as chronic kidney disease. However, epidemiology and risk factors of diabetic kidney disease are poorly described at population level. This study aimed to determine prevalence of diabetic kidney disease (DKD) in adult diabetics living in Saint-Louis, northern Senegal. Methods: A cross-sectional study including diabetic patients followed-up aged ≥18 years during a five-year period (2013-2018) in Saint-Louis. Clinical and biological parameters were collected during annual community-based mass screening. Diabetes was defined as fasting blood glucose ≥ 1.26 g/L confirmed by a second lab dosage. DKD was defined as persistence of albuminuria ≥ 30 mg/24h and/or estimated glomerular filtration rate (eGFR) 2. Data were analyzed with Stata 12.0. Results: We included a total of 1310 diabetic patients among whom 3.7% (95% CI = 1.4% - 9.8%) presented DKD. Their mean age was 46.2 ± 11.8 years and sex-ratio was 0.7. Micro-albuminuria and macro-albuminuria were present respectively in 59.2% and 18.4% of patients with DKD and half of them had a normal eGFR. Before the survey 89.8% of patients with DKD were not aware of their renal disease and only four of them had seen a nephrologist. After multivariate analysis, age (OR = 1.5;95% CI = 1.1 - 3.4), duration of diabetes (OR = 1.2;95% CI = 1.6 - 4.4) and hypertension (OR = 2.5;95% CI = 1.4 - 4.6) were associated with the presence of DKD in diabetic patients while no significant association was not found with gender, blood glucose level, smoking and familial history. Conclusion: DKD is a frequent complication in diabetic adult population living in Saint-Louis. Early detection and management should be promoted in order to prevent progression to end-stage renal disease.

关键词： Diabetes Kidney Disease Epidemiology Saint-Louis

Emergency Drainage of Upper Urinary Tract with a Double Catheter in the Hospital General de Grand Yoff of Dakar (HOGGY)

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Open Journal of Urology 2016年第2期6卷 13-18页

作者： Madina Ndoye Mahamat Ali Mahamat Gille Natchagande mohamed Jalloh lamine Niang Serigne M. Gueye Cheikh Anta Diop University Grand Yoff General Hospital (HOGGY) of Dakar Dakar Senegal

Goals: The goals are to assess the use of Double Jendo-prostheses in urinary obstructions in the Hospital General de Grand Yoff of Dakar (HOGGY). Patients and methods: This is a 4-year retrospective study (1st January 2009-31st December 2012). The study included all patients with obstruction of the upper urinary tract, and with a reversing type Double Jendo-prostheses. Findings: A total of 82 patients were chosen for this study, including 41 males. Patient’s average age was 45 years. Kidney failure accounted for 11.5% of the causes of consultations. Lithiasic obstacles (34.2%) and tumours (21.5%) were the most recurrent. Catheter was successfully placed in 78% of cases, and highly contributed to improve renal function in 69% of cases. The frequently complications found in patients with Double J Catheters were back pain and urinary tract infections. Four cases of catheters calcifications were reported. Catheter was replaced in 62.2% of patients within an average period of 6.9 months. Conclusion: Double J Catheters remain important in the preservation of renal function in case of obstruction. Its use requires a mastery of these indications and a rigorous follow-up.

关键词： Renal Failure Drainage Double J Stent

Transient Diabetes Induced by L-Asparaginase

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Open Journal of Pediatrics 2023年第6期13卷 862-865页

作者： Mamadou Moustapha Diop M’mah Aminata Bangoura Aissata Barry Emmanuel Camara Kolié Ouo Ouo Pé Neabei Beimy mohamed lamine Diallo Kaba Bangoura Moustapha Kouyate mohamed lamine Kaba Aka Nbga Department of Paediatrics Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Republic of Guinea Urgence Pédiatrique CHU Donka Ministère de l’enseignement de la recherche scientifique et de l’innovation Conakry Republic of Guinea Haemodialysis Department CHU Donka Ministry of Education Scientific Research and Innovation Conakry Republic of Guinea

Background: Although hyperglycaemia is one of the known side effects of L-asparaginase, its contribution to the development of diabetic ketoacidosis (DKA) is less well known in the literature. Asparaginase is an essential component of treatment protocols for acute lymphoblastic leukaemia (ALL) in combination with other chemotherapeutic drugs. On further evaluation, she was found to have high anion gap metabolic acidosis, hyperglycaemia and ketonuria. In recent decades, the use of these chemotherapeutic agents has led to a decrease in mortality and disease-free survival in ALL. L-asparaginase is one of the chemotherapy protocols used in the treatment of acute lymphoblastic leukaemia (ALL) and can induce hyperglycaemia which is aggravated by the concomitant use of corticosteroids. We report the observation of a 14-year-old girl treated with chemotherapy (GFA LAL protocol) who developed transient diabetes following the use of L-asparaginase. She was treated at the Donka paediatric haemato-oncology unit by a multidisciplinary team including a paediatric oncologist, a psychologist and a diabetologist. The aim of this study was to highlight blood glucose monitoring before and after the use of asparaginase in acute lymphoblastic leukaemia. Conclusion: We conclude that the occurrence of ketoacidosis following the use of asparaginase is a rare event. We recommend close monitoring of blood glucose levels for hyperglycaemia in patients with ALL receiving L-asparaginase.

关键词： Asparaginase Diabetes ALL Donka

PI and RST Control Design and Comparison for Matrix Converters Using Venturini Modulation Strategy

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Journal of Power and Energy Engineering 2015年第8期3卷 36-54页

作者： Bekhada Hamane Mamadou lamine Doumbia Hicham Chaoui mohamed Bouhamida Ahmed Chériti Mustapha Benghanem Department of Electrical and Computer Engineering UQTR Trois-Rivières Canada Center for Energy Systems Research Department of Electrical and Computer Engineering Tennessee Technological University Cookeville USA Department of Electrical Engineering University Mohamed Boudiaf Oran Algeria

This paper presents a thorough design and comparative study of two popular control techniques, i.e., classical Proportional Integral (PI) and RST, for Matrix Converters (MCs) in terms of tracking the reference and robustness. The output signal of MCs is directly affected by unbalanced grid voltage. Some research works have attempted to overcome this problem with PI control. However, this technique is known to offer lower performance when it is used in complex and nonlinear systems. On the other hand, RST control offers better performance, even in case of highly nonlinear systems. Therefore, the RST can achieve better performance to overcome the limitation of PI control of nonlinear systems. In this paper, a RST control method is proposed as output current controller to improve the performance of the MC powered by unbalanced grid voltage. The overall operating principle, Venturini modulation strategy of MC, PI control and characteristics of RST are presented.

关键词： Matrix Converter Unbalanced Grid Venturini Modulation Strategy PI Control RST Control

Production and Characterization of Pozzolan with Raw Clay from Burkina Faso

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Journal of Minerals and Materials Characterization and Engineering 2016年第3期4卷 195-209页

作者： mohamed Seynou Younoussa Millogo lamine Zerbo Issiaka Sanou François Ganon Raguilnaba Ouedraogo Kalsibiri Kaboré Laboratoire de Chimie Moléculaire et des Matériaux UFR/Sciences Exactes et Appliquées Université Ouaga I Ouagadougou Burkina Faso Université Polytechnique de Bobo-Dioulasso UFR/Sciences et Techniques Bobo-Dioulasso Burkina Faso Laboratoire National de Batiment et de Travaux Publics Ouagadougou Burkina Faso

Four raw deposits clayey materials in Burkina Faso have been characterized using X-ray diffraction, infrared spectroscopy and ICP-AES to evaluate their suitability to be used as pozzolan in cement. The samples have been activated by thermal treatment at 730°C during 5 hours. The obtained metakaolin was investigated by means of complementary techniques for their use as pozzolan in building materials. Fineness, surface area and amorphousness of metakaolins were the dominant factors which influenced their pozzolan reactivity. The compressive strengths of blended specimens were slightly increased with metakaolins named MK1 and MK2 than the reference for the substitution of 20 - 25 wt%. This was due to the metakaolins’ pozzolan reactivity and their filler effects which promoted CSH formation and reduced pores in the specimens. MK1 and MK2 were suitable for replacement of Portland cement in the field of building materials.

关键词： Raw Clayey Materials Characterization Metakaolin Pozzolan Reactivity Building Materials

An unusual cause of gastric outlet obstruction in a young girl: Trichobezoar

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Open Journal of Gastroenterology 2012年第4期2卷 206-208页

作者： Mahdi Bouassida Hédi Charrada mohamed Fadhel Chtourou lamine Hamzaoui mohamed Monji Mighri mohamed Msaddak Azzouz Hassen Touinsi Sadok Sassi Department of Gastrology Mohamed Tahar Maamouri Hospital Nabeul Tunisia Department of Reanimation Mohamed Tahar Maamouri Hospital Nabeul Tunisia Department of Surgery Mohamed Tahar Maamouri Hospital Nabeul Tunisia

Trichobezoars are an infrequent form of bezoars formed from ingested hair. They are more common in adolescent females with history of trichotillomania. Exceptionally, it can occur in young children making the diagnosis difficult. We report the case of a 6-year-old girl with a history of abdominal pain, distension, weight loss, and attacks of vomiting. Upper gastrointestinal endoscopy revealed a trichobezoar occupying almost the whole gastric cavity. The gastric bezoar was removed by surgery. Gastric trichobezoar is exceptional in young children and can lead to stunting and gastric outlet obstruction. After definitive surgical or endoscopic treatment, pediatric psychiatric consultation should be opted for any mental disorder and for prevention of further recurrence.

关键词： Trichobezoar Young Children Gastric Outlet Obstruction Trichotillomania

Solitary Endobronchial Papilloma Mimicking a Neoplastic Lesion

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Open Journal of Respiratory Diseases 2018年第3期8卷 38-42页

作者： Smadhi Hanen Khalfallah Ikbel Diouani mohamed Fethi Abdennadher Mahdi Attia Monia Ayadi-Kaddour Aida Megdiche mohamed lamine Department of Pneumology Ibn Nafis Abderrahman Mami University Hospital Ariana Tunisia Faculté de Médecine de Tunis Université Tunis El Manar Tunis Tunisia Faculté des Sciences de Bizerte Université de Carthage Carthage Tunisia Laboratoire d’Epidémiologie et de Microbiologie Vétérinaire Institut Pasteur de Tunis Tunis Tunisia Department of Thoracic Surgery Abderrahman Mami University Hospital Ariana Tunisia Department of Radiology Abderrahman Mami University Hospital Ariana Tunisia Department of Pathology Abderrahman Mami University Hospital Ariana Tunisia

Papilloma is a rare benign tumor. Laryngeal location is the most frequent. The bronchial involvement remains unusual. It represents 0.38% of pulmonary tumors. We report the case of a 39-year-old, smoker man, who consulted for a cough following during six months with persistent radiological opacity despite antibiotic treatment. The physical examination was without particularities. Flexible bronchoscopy revealed a swollen endobronchial lesion completely obstructing the orifice of the intermediate trunk. Bronchial biopsies at this level showed inflammatory mucosa. The chest CT scan objectified an endobronchial tissular mass in the intermediate trunk. Pulmonary neoplasia was suspected. Diagnostic and therapeutic surgery was performed. Histopathological examination concluded to an endobronchial squamous papilloma.

关键词： Papilloma Smoking Lung Cancer Surgery