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Anti-inflammatory and analgesic properties of Moroccan medicinal plants:Phytochemistry,in vitro and in vivo investigations,mechanism insights,clinical evidences and perspectives

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Journal of Pharmaceutical Analysis 2022年第1期12卷 35-57页

作者： Abdelhakim Bouyahya Fatima-Ezzahrae Guaouguaou Nasreddine el Omari Naoual el Menyiy Abdelaali Balahbib mohamed el-shazly Youssef Bakri Laboratory of Human Pathologies Biology Department of BiologyFaculty of Sciencesand Genomic Center of Human PathologiesFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat4014Morocco Mohammed Ⅴ University in Rabat LPCMIOMaterials Science Center(MSC)Ecole Normale SuperieureRabat1014Morocco Laboratory of Histology Embryology and CytogeneticFaculty of Medicine and PharmacyMohammed Ⅴ University in Rabat10100Morocco Department of Biology Faculty of Sciences Dhar El MahrazUniversity Sidi Mohamed Ben AbdellahFez30003Morocco Laboratory of Zoology and General Biology Faculty of SciencesMohammed Ⅴ University in RabatRabat1014Morocco Department of Pharmacognosy Faculty of PharmacyAin-Shams UniversityCairo11566Egypt Department of Pharmaceutical Biology Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Moroccan medicinal plants exhibit several pharmacological properties such as antimicrobial,anticancer,antidiabetic,analgesic,and anti-inflammatory effects,which are related to the presence of numerous bioactive compounds,including phenolic acids,flavonoids,and *** the present review,we systematically evaluate previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal *** in vitro investigations revealed that Moroccan medicinal plants inhibit several enzymes related to inflammatory processes,whereas in vivo studies noted significant anti-inflammatory and analgesic effects as demonstrated using different experimental *** bioactive compounds exhibiting in vitro and in vivo anti-inflammatory and analgesic effects,with diverse mechanisms of action,have been *** plants and their bioactive compounds reveal specific secondary metabolites that possess important anti-inflammatory effects in clinical *** review proposes the potential applications of Moroccan medicinal plants as sources of anti-inflammatory and analgesic agents.

关键词： Inflammation Medicinal plants Bioactive compounds Anti-inflammatory Analgesic

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Radiographic and magnetic resonances contrast agents:Essentials and tips for safe practices

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World Journal of Radiology 2017年第9期9卷 339-349页

作者： mohamed R Nouh mohamed A el-shazly Department of Radiology and Clinical Imaging Faculty of MedicineAlexandria UniversityAlexandria 21563Egypt

With extended and continued expansion of medical imaging utilization in modern medical practice over last decade, radiologists as well as other faculty staff dealing with radiographic and magnetic resonances contrast media(CM) have to be well oriented with their potential hypersensitivity reactions and recognize high-risk groups liable to develop it so as to enable early recognition. Radiologists and other medical staff involved in administration and dealing with CM have to be ready to implement prompt, practical and effective management plan to deal with these scenarios should they emerge. Strategies to prevent potential contrastinduced acute and delayed renal injuries have to be routinely exercised. Paying attention to the pregnant and nursing women, pediatrics, diabetics, as well as other fragile populations is of utmost importance for patient safety during contrast administrations. Radiologists should play a pivotal role in orienting patients about necessity to use CM for their imaging studies, in case it is needed, and assure them about its safety. Moreover, they have to be oriented with the medico-legal issues related to use of CM. These will pay as improved patient safety as well as safe daily working environmentat different levels of radiology practices.

关键词： Radiographic Magnetic resonances Contrast Safe practice Medico-legal

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Uncoupling tumor necrosis factor-αand interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

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BIOCelL 2022年第3期46卷 769-783页

作者： RAGHDA A.SOLIMAN RANA A.YOUNESS TAMER M.MANIE EMAD KHALLAF mohamed el-shazly MONA ABDelMOHSEN HEBA HANDOUSSA mohamed Z.GAD Pharmaceutical Biology Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt School of Life and Medical Sciences University of Hertfordshire Hosted by Global Academic FoundationNew Administrative Capital11578Egypt Breast Surgery Department National Cancer InstituteCairo UniversityCairoEgypt General Surgery Department Faculty of MedicineCairo UniversityCairoEgypt Department of Phytochemistry National Research CentreGiza12622Egypt Biochemistry Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Triple Negative Breast Cancer(TNBC)immunotherapy has recently shown promising ***,some TNBC patients presented with *** of the reasons was attributed to the excessive release of cytokines at the tumor microenvironment(TME)such as Tumor necrosis factor alpha(TNF-α)and Interleukin-10(IL-10).Fine regulation of these cytokines’levels via non-coding RNAs(ncRNAs)might alleviate the immune quiescent nature of TME at TNBC ***,the extrapolation of ncRNAs as therapeutic tools is highly ***,disentanglement the nature for the isolation of natural compounds that could modulate the ncRNAs and their respective targets is an applicable translational therapeutic ***,this study aimed to targeting the chief immune suppressive cytokines at the TME(TNF-αand IL-10)via ncRNAs and to examine the effects of Rosemary aerial parts extract on the expression levels of these ncRNAs in *** revealed miR-17-5p as a dual regulator of TNF-αand ***,an intricate interaction has been shown between miR-17-5p and the oncogenic lncRNAs:MALAT1 and *** down of MALAT1 and/or H19 caused an induction in miR-17-5p and reduction in TNF-αand IL-10 expression ***-17-5p was found to be down-regulated,while TNF-α,IL-10,MALAT1 and H19 were up-regulated in BC *** expression of miR-17-5p in MDA-MB-231 cells reduced TNF-α,IL-10,MALAT1 and H19 expression levels,as well as several BC *** a translational approach,ursolic acid(UA)isolated from rosemary induced the expression of miR-17-5p,MALAT1 and decreased H19 expression *** conclusion,this study suggests miR-17-5p as a tumor suppressor and an immune-activator miRNA in BC through tuning up the immunological targets TNF-α,IL-10 at the TME and the oncological mediators MALAT1 and H19 lncRNAs.

关键词： Breast cancer Tumor microenvironment Cytokines TNF-α IL-10 miR-17-5p MALAT1 H19 lncRNAs miRNA Ursolic acid

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Laryngopharengeal Reflux in Gastroesophageal Reflux Disease: Does “Silent Laryngopharengeal Reflux” Really Exist?

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Open Journal of Gastroenterology 2014年第3期4卷 130-140页

作者： Iman Ramzy mohamed el shazly Raghda Marzaban Tamer elbaz Mina Safwat Botros Latif Endemic Medicine and Hepatogastroenterology Faculty of Medcinie Cairo University Cairo Egypt Hepatogastroenterology Police Recruits Hospital Cairo Egypt Otorhinolaryngeology Faculty of Medicine Cairo University Cairo Egypt

Background: Gastroesophageal reflux disease (GERD) is a disorder resulting from the reversed flow of gastroduodenal contents into the esophagus, and producing different symptoms, while laryngopharyngeal reflux (LPR) is a disorder resulting from the reversed flow of gastric contents into the hypopharynx. The aim of this work is to evaluate LPR in cases of GERD. Methods: The present study was performed on fifty GERD patients diagnosed by gastroscope. LPR was assessed by reflux symptoms score (RSI) and reflux finding score (RFS). Accordingly, patients are classified into: Group I = 25 patients with manifest LPR, and Group II = 25 control patients without LPR symptoms. Results: GERD accounts for 17.4% of attendants of gastroscope unit, where manifest LPR accounts for 29.1% of GERD cases recording mean RSI and RFS 16.48 and 8.44 respectively. Silent LPR accounts for 8% recording mean RFS 7. Conclusion: There is a significant direct proportional relationship between severity of GERD and the RSI and RFS (p = 0.015 and 0.005 respectively).

关键词： Gastroesophageal Reflux Disease (GERD) Laryngopharyngeal Reflux (LPR) Reflux Symptoms Index (RSI) Reflux Finding Score (RFS)

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Research and development of Cordyceps in Taiwan

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Food Science and Human Wellness 2016年第4期5卷 177-185页

作者： Ching-Peng Chiu Tsong-Long Hwang You Chan mohamed el-shazly Tung-Ying Wu I-Wen Lo Yu-Ming Hsu Kuei-Hung Lai Ming-Feng Hou Shyng-Shiou Yuan Fang-Rong Chang Yang-Chang Wu Graduate Institute of Natural Products College of PharmacyKaohsiung Medical UniversityKaohsiung 80708TaiwanChina Graduate Institute of Natural Products College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology Chang Gung University of Science and TechnologyTaoyuan 33302TaiwanChina Department of Anesthesiology Chang Gung Memorial HospitalTaoyuan 33302TaiwanChina Department of Microbiology and Immunology and Institute of Microbiology and ImmunologySchool of MedicineChung Shan Medical UniversityTaichung 40201TaiwanChina Department of Pharmacognosy and Natural Products Chemistry Faculty of PharmacyAin-Shams UniversityCairoEgypt Chinese Medicine Research and Development Center China Medical University HospitalTaichung 40402TaiwanChina Cancer Center Kaohsiung Medical University HospitalKaohsiung 80708TaiwanChina Lipid Science and Aging Research Center Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina Department of Marine Biotechnology and Resources National Sun Yat-sen UniversityKaohsiung 80424TaiwanChina Research Center for Environmental Medicine Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina Center for Infectious Disease and Cancer Research Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Pharmacy College of PharmacyChina Medical UniversityTaichung 40402TaiwanChina Center of Molecular Medicine China Medical University HospitalTaichung 40402TaiwanChina

Cordyceps is treasured entomopathogenic fungi that have been used as antitumor,immunomodulating,antioxidant,and pro-sexual ***,also called DongChongXiaCao in Chinese,Yartsa Gunbu(Tibetan),means winter worm-summer *** Cordyceps sinensis with parasitic hosts is difficult to be collected and the recent findings on its potential pharmacological functions,resulted in skyrocketing ***,finding a mass-production method or an alternative for *** products is a top-priority *** this review,we describe current status of Cordyceps research and its recent developments in *** content and pharmacological activities of four major industrial species of Cordyceps(***,Cordyceps militaris,Cordyceps cicadae and Cordyceps sobolifera)used in Taiwan,were ***,we highlighted the effect of using different methods of fermentation and production on the morphology and chemical content of Cordyceps ***,we summarized the bottle-necks and challenges facing Cordyceps research as well as we proposed future road map for Cordyceps industry in Taiwan.

关键词： Entomopathogenic fungi Biofunction Cordyceps sp. C.sinensis C.militaris C.cicadae C.sobolifera

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Influence of host age and host deprivation on longevity, egg load dynamics and oviposition rate in Microplitis rufiventris

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Insect Science 2007年第6期14卷 485-495页

作者： ESMAT mohamed HEGAZI GEHAN mohamed ABD el-AZIZ AHMED YOUSEF el-shazly WEDAD EMAM KHAFAG Department of Entomology Faculty of Agriculture University of Alexandria Plant Protection Research Institute Sabahia Alexandria Egypt

Adult size, longevity, egg load dynamics and oviposition ofMicroplitis rufiventris Kok. which began their development in the first, second, third （preferred hosts） or fourth （non-preferred hosts） instar larvae of Spodoptera littoralis （Boisd.） were studied. The parasitoid size was largely determined by the initial host size at parasitism. Non-ovipositing females derived from older hosts lived for longer periods than those derived from younger ones. However, the ovipositing females, irrespective of their size, lived for almost the same periods. At emergence, the oviducts of adult females contain a significant amount of mature eggs available for oviposition for a few hours on eclosion day. Egg load increases during the early phase of adult life. The amount of additional mature eggs and rate of egg maturation per hour was greater for wasps derived from preferred hosts compared with those in females derived from non-preferred hosts. The pattern of egg production in M. rufiventris females depended on the availability of hosts for parasitization. Host-deprived females depleted the egg complement with aging; the longer the host deprivation, the lower the oviduct egg load. Marked reduction in both realized or potential fecundity of host-deprived females was observed following host availability. Host privation for more than 3 days induced a marked deficit fecundity pattern through the female＇ s life. The realized fecundity was determined by the interaction among host availability, the number of eggs that are matured over the female＇ s life span, oviposition rate and host size from which the female was derived. These results suggest that：（i） M. rufiventris wasp is a weak synovigenic species; （ii） the maturation of additional eggs is inhibited once the maximum oviduct egg load is reached; （iii） the egg load of the newly emerged female is significantly less than the realized fecundity; and （iv） because M. rufiventris females oviposit fewer eggs when they begin depleting their

关键词： aging egg production host privation longevity Microplitis rufiventris,oviposition Spodoptera littoralis wasp size

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Laterites-bearing REEs,Wadi Natash,Southeastern Desert,Egypt

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Journal of Rare Earths 2010年第3期28卷 471-476页

作者： mohamed el-Ahmady Ibrahim Nuclear Materials Authority P.O.Box530EL MaadiCairoEgypt

The present paper recorded the occurrence of laterites-bearing REEs in Natash *** laterite deposits occur as horizons(5-15 m in thickness) at the boundary between the Cretaceous sandstones,and Natash *** was recorded in more than twenty six occurrence distributed over an area of about 500 km2 along and around Wadi *** ranges in color from light-grey,dark-grey to *** distribution of laterite deposits is structural *** results of laterites proved the...

关键词： Natash flows laterites clay minerals REEs

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Wear properties of copper and copper composites powders consolidated by high-pressure torsion

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Friction 2020年第2期8卷 433-450页

作者： mohamed Ibrahim Abd el AAL Mechanical Engineering Department College of EngineeringPrince Sattam Bin Abdulaziz UniversityWadi Addawaser 11991Saudi Arabia Mechanical Design&Production Department Faculty of EngineeringZagazig UniversityZagazig 44519Egypt

The wear characteristics of Cu and Cu-SiC composite microsize powders consolidated by cold compaction combined with sintering or high-pressure torsion(HPT)were *** HPT processed(HPTed)samples with bimodal and trimodal microstructures and fine Cu grains and SiC particle sizes have superior hardness,reasonable ductility level,and high wear *** wear mass loss and coefficient of friction of HPTed samples were remarkably lower than that of cold-compacted and sintered samples as well as that of micro and nano Cu and Cu-SiC composites from previous *** sample fabrication method has an apparent influence on the wear *** wear mechanism was converted from adhesive,delamination,three-body mechanism,grooves(take off the SiC particles),and cracks into abrasive wear after *** can be considered a dominant wear mechanism in all *** worn surface morphology and analysis support the relationship between wear mechanism and characteristics.

关键词： Cu-SiC composite powders high-pressure torsion(HPT) fine and coarse grains wear characteristics worn surface morphology

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On the Gosper’s q-constant Ⅱ_q

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Acta Mathematica Sinica,English Series 2018年第11期34卷 1755-1764页

作者： mohamed el BACHRAOUI Department Mathematical Sciences UAE University

Gosper introduced the functions sinq z and cosq z as q-analogues for the trigonometric functions sin z and cos z respectively. He stated a variety of identities involving these two q-trigonometric functions along with certain constants denoted by Πqn （n ∈ N）. Gosper noticed that all his formulas on these constants have more than two of the Πqn. So, it is natural to raise the question of establishing identities involving only two of the Πqn. In this paper, our main goal is to give examples of such formulas in only two Πqn.

关键词： q-trigonometric functions elliptic functions theta function identities

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Ore Controls and Metallogenesis of Au-Ag Deposits at Atalla Mine,Central Eastern Desert of Egypt

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Acta Geologica Sinica(English Edition) 2020年第5期94卷 1451-1470页

作者： mohamed ABD el MONSEF Geology Department Faculty of ScienceTanta UniversityTanta 31527Egypt Institute of Geological Sciences Faculty of ScienceMasaryk UniversityBrnoCzech Republic

Gold-silver deposits in the Atalla area occur as hydrothermal quartz veins in NE–SW pre-existing fractures within the Atalla granitic *** orientation of such quartz veins has been attributed to extensional behavior related to the Atalla Shear Zone(ASZ).The Atalla area is covered by a variety of lithologies that are(from oldest to youngest):metasedimentary rocks,metavolcanic rocks,ophiolite assemblage(serpentinites/talc-carbonates),Atalla granite and Dokhan volcanic ***,Atalla granite ranges in composition from granodiorite to *** geochemistry constrains the calc-alkaine affinity of the Atalla granite that was intruded within an orogenic(syncollision)tectonic *** ore minerals are represented by gold/silver(electrum),pyrite(Py1&Py2),arsenopyrite,pyrrhotite,sphalerite,chalcopyrite,galena,covellite and *** temperature of ore formation ranges from 240 to 285℃and the estimated fluid pressure is in the range of 20–100 *** on the geological setting,ore textures and fluid characteristics;the Atalla Au-Ag deposits are considered to be orogenic in nature,formed from a continental collision(~653-590 Ma),synchronous with the emplacement of calc-alkaline magmatism during the evolutionary history of the Arabian Nubian Shield(ANS).The initial ore-forming fluid was primarily derived from a metamorphic source related to ophiolitic-serpentinite rocks under deep regional conditions of greenschist-amphibolite facies,where the Atalla granitic eruption provided the required temperature conditions for the metamorphic process to take *** such conditions,the transportation of ore metals as bisulfide complexes is *** deposition of ore minerals was triggered by fluidwallrock interaction through fracture pathways in conjunction with a temperature-pressure drop that is likely to have been related to uplift into the crustal levels.

关键词： Gold-silver arsenopyrite geothermometry fluid inclusions orogenic deposits Atalla Shear Zone(ASZ)

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