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An Enhanced Lung Cancer Detection Approach Using Dual-Model Deep Learning Technique

Computer Modeling in Engineering & Sciences 2025年第1期142卷 835-867页

作者： Sumaia mohamed Elhassan saad mohamed Darwish Saleh Mesbah Elkaffas Department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt College of Computing and Information Technology Arab Academy for ScienceTechnology and Maritime TransportAlexandriaP.O.Box 1029Egypt

Lung cancer continues to be a leading cause of cancer-related deaths worldwide,emphasizing the critical need for improved diagnostic *** detection of lung tumors significantly increases the chances of successful treatment and ***,current diagnostic methods often fail to detect tumors at an early stage or to accurately pinpoint their location within the lung ***-model deep learning technologies for lung cancer detection,while beneficial,cannot capture the full range of features present in medical imaging data,leading to incomplete or inaccurate ***,it may not be robust enough to handle the wide variability in medical images due to different imaging conditions,patient anatomy,and tumor *** overcome these disadvantages,dual-model or multi-model approaches can be *** research focuses on enhancing the detection of lung cancer by utilizing a combination of two learning models:a Convolutional Neural Network(CNN)for categorization and the You Only Look Once(YOLOv8)architecture for real-time identification and pinpointing of *** automatically learn to extract hierarchical features from raw image data,capturing patterns such as edges,textures,and complex structures that are crucial for identifying lung ***8 incorporates multiscale feature extraction,enabling the detection of tumors of varying sizes and scales within a single *** is particularly beneficial for identifying small or irregularly shaped tumors that may be challenging to ***,through the utilization of cutting-edge data augmentation methods,such as Deep Convolutional Generative Adversarial Networks(DCGAN),the suggested approach can handle the issue of limited data and boost the models’ability to learn from diverse and comprehensive *** combined method not only improved accuracy and localization but also ensured efficient real-time processing,which is crucial for practical clinical applicati

关键词： Lung cancer detection dual-model deep learning technique data augmentation CNN YOLOv8

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Development of new potentiometric sensors for the determination of proguanil hydrochloride in serum and urine

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Chinese Chemical Letters 2016年第6期27卷 857-863页

作者： Fatehy M.Abdel-Haleem mohamed saad mohamed S.Rizk Chemistry Department Faculty of Science Cairo University

Potentiometric electrodes were developed for the rapid determination of proguanil hydrochloride in pure samples, pharmaceutical preparations and spiked serum and urine samples using PVC membrane,screen printed（SPE）, coated wired（CWE）, carbon paste（CPE） and modified carbon paste（MCPE）electrodes based on the ion-exchanger of proguanil with phosphotungestic acid（Pr-PT） as a chemical modifier. The prepared electrodes showed Nernestian slopes of 59.7, 58.1, 58.5, 58.5 and 57.0 for the PVC,SPE, CWE, CPE and MCPE for the proguanil ions in a wide concentration range of 1.0 ＊ 10^-5–1.0 ＊ 10^-2mol L^-1 at 25°C with detection limits of 7.94 ＊ 10^-6, 1.0 ＊ 10^-5, 1.0 ＊ 10^-6, 7.07 ＊ 10^-6 and 2.5 ＊ 10^-6 mol L^-1, respectively. The prepared electrodes exhibited high proguanil selectivity in relation to several inorganic ions and sugars and they could be successfully utilized for its determination in pure solutions, pharmaceutical preparations and serum and urine samples using the direct potentiometry and standard addition methods with very good recovery values.

关键词： Proguanil hydrochloride PVC membrane electrode Carbon paste electrode Screen printed electrode MWCNTs Coated wire electrode

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Insights into the adsorption performance and mechanism of Cr(Ⅵ)onto porous nanocomposite prepared from gossans and modified coal interface:Steric,energetic,and thermodynamic parameters interpretations

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Chinese Journal of Chemical Engineering 2023年第9期61卷 118-128页

作者： mohamed Mobarak Saleh Qaysi mohamed saad Ahmed Yasser F.Salama Ahmed mohamed Abbass mohamed Abd Elrahman Hamdy AAbdel-Gawwad Moaaz K.Seliem Physics Department Faculty of ScienceBeni-Suef UniversityEgypt Geology and Geophysics Department College of ScienceKing Saud University11451 RiyadhSaudi Arabia Geology Department Faculty of ScienceBeni-Suef UniversityEgypt Department of Building Materials and Construction ChemistryInstitute of Civil EngineeringTechnische Universitat BerlinBerlinGermany Structural Engineering Department Faculty of EngineeringMansoura UniversityMansouraEgypt Raw Building Materials and Processing Technology Research Institute Housing and Building National Research Center(HBRC)CairoEgypt Faculty of Earth Science Beni–Suef UniversityEgypt

Herein,iron oxide/hydroxides deposits(gossans)were utilized,for the first time,in the fabrication of magnetite nanoparticles(MNPs)to load modified coal(MC).The as-synthesized MNPs@MC composite was characterized via different techniques and utilized for the Cr(Ⅵ)*** studies supported by theoretical treatment were applied to offer a new overview of the Cr(Ⅵ)adsorption geometry and mechanism at 25-45℃.Experimental results suggested that the Cr(Ⅵ)uptake was mainly governed by adsorption-reduction coupled *** Langmuir model fitted well the Cr(Ⅵ)adsorption data with maximum adsorption capacities extended from 115.24 to 129.63 mg·g^(-1).Theoretical calculations indicated that Cr(Ⅵ)ions were adsorbed on the MNPs@MC following the theory of the advanced monolayer statistical *** number of ions removed per site ranged from 1.88 to1.23 suggesting the involvement of vertical geometry and multi-ionic mechanism at all *** increment of the active sites density and the adsorption capacity at saturation with improving temperature reflected an endothermic ***,the Cr(Ⅵ)adsorption was controlled by physical forces as the adsorption energies were less than 40 kJ·mol^(-1).The calculated free enthalpy,*** internal energy explained the spontaneous nature and the viability of Cr(Ⅵ)adsorption on the MNPs@MC *** results offer a new approach in utilizing the iron-rich deposits as gossans in the preparation of magnetic and low-cost adsorbents for wastewater remediation.

关键词： Coal Magnetic nanoparticles Cr(Ⅵ)adsorption Statistical models Thermodynamic parameters

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Development of a Smart Technique for Mobile Web Services Discovery

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Computers, Materials & Continua 2021年第11期69卷 1483-1501页

作者： mohamed Eb-saad Yunyoung Nam Hazem M.El-bakry Samir Abdelrazek Department of Information Systems Faculty of Computers and InformationMansoura UniversityMansoura35516Egypt Department of Computer Science and Engineering Soonchunhyang UniversityAsan31538Korea

Web service(WS)presents a good solution to the interoperability of different types of systems that aims to reduce the overhead of high processing in a resource-limited *** the increasing demand for mobile WS(MWS),the WS discovery process has become a significant challenging point in the WS lifecycle that aims to identify the relevant MWSs that best match the service *** discovery process is a resource-consuming task that cannot be performed efficiently in a mobile computing environment due to the limitations of mobile ***,a cloud computing can provide rich computing resources for mobile environments given its unlimited and easily scalable *** paper proposes a semantic WS discovery and invocation framework in mobile environments based on cloud and a relationship-aware matchmaking *** discovery algorithm enriches MWS and user requests semantically with the functional and non-functional properties of Ontology Web Language for Services,such as Quality of Web Service,device context,and user *** WS repository is filtered based on logical reasoning and a parameter-based matching algorithm to minimize the matching space and improve runtime *** cosine similarity between the user request and services repository is then assessed to generate the most relevant *** relationships among concepts in the ontology are considered to improve the recall and precision *** the WS discovery process,users can invoke and test these services in a mobile environment through a dynamic user *** interface of the invocation process is changed according to the WS description *** application prototype is also developed to evaluate the framework based on a Cordova cross-mobile development framework.

关键词： Cloud web service web service discovery semantic matching mobile web service discovery

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Medical treatment of inflammatory punctual stenosis monitored by anterior segment optical coherence tomography

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1074-1078页

作者： Hanan Youssef Elalfy Mahmoud A Elsamkary Ahmed M Shafek Elridy Tarek M saad saad mohamed Rashad Samah M Fawzy Al Dorra Subspecialty Ophthalmology Centre Cairo 11751Egypt Department of Ophthalmology Ain Shams UniversityCairo 11471Egypt

AIM:To evaluate the role of medical treatment in the management of inflammatory punctum stenosis guided by spectral domain anterior segment optical coherence tomography(OCT).METHODS:This prospective study included 60 patients complaining of epiphora due to inflammatory punctual *** were divided into two groups:Group A(30 patients)treated with a combination of preservative free hydrocortisone sodium phosphate 3.35 mg/m L eye drops,and preservative free artificial tears based on sodium hyaluronate,polyethylene and propylene Glycol;Group B(30 patients)treated with the same preservative free artificial tears *** normal subjects were included for comparison of pre-treatment anatomical *** starting treatment,all patients underwent anterior segment assessment including slit lamp examination,measurement of intraocular pressure(IOP),fluorescein dye disappearance test,and measurement of the outer punctum diameter(OPD)by Spectral domain anterior segment *** assessments were repeated at each follow up done at 1 and 3 mo later,together with subjective evaluation of patient’s satisfaction of the treatment outcome by simple rating ***:Punctual diameter increased significantly with treatment in both groups(P<0.0001);although the widening was more in Group A as compared to group B(16.2%vs 8%of the original punctual size,mean difference of 28.933μm,P=0.0076).Subjective satisfaction with treatment outcome was also better in group A(70%vs 40%,Chi-square P=0.0397).CONCLUSION:A combination of preservative free steroid eye drops and artificial tears causes significant widening of inflammed stenotic punctae and improvement of the associated epiphora.

关键词： artificial tears hydrocortisone inflammatory punctual stenosis optical coherence tomography preservatives

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Ophthalmological instruments of Al-Halabi fill in a gap in the biomedical engineering history

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World Journal of Methodology 2022年第1期12卷 1-19页

作者： mohamed N saad Biomedical Engineering Department Faculty of EngineeringMinia UniversityMinia 61111Egypt

Al-Halabi is an intriguing ophthalmologist who invented numerous surgicalinstruments for treating various eye diseases. The illustrations of such instrumentsin his invaluable book “Kitab Al-Kafi fi Al-Kuhl” reflect his willingness toteach. Moreover, he included in his book a magnificent illustration of theanatomical structure of the eye. The book reflects Al-Halabi’s medical practice andteaching and shows several advanced medical techniques and tools. Hisinvaluable comments reflect his deep experimental observations in the field ofophthalmology. The current article provides proof that Al-Halabi is one of ourearly biomedical engineers from more than 800 years ago. Al-Halabi represents aring in the chain of biomedical engineering history. His surgical instrumentsrepresent the biomechanics field. Al-Halabi should be acknowledged among thebiomedical engineering students for his various contributions in the field ofsurgical instruments.

关键词： Al-Halabi Biomedical engineering education Biomedical engineering history Ophthalmological instruments

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Treatment of COVID-19 by Controlling the Activity of the Nuclear Factor-Kappa B

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CellBio 2020年第2期9卷 109-121页

作者： Mahmoud saad mohamed Elkhodary General Organization for Exporting and Importing Control Suez Egypt

Heavy infection of the virus leads to overproduction of cytokines. The overproduction of cytokine (cytokines storms) is responsible for the critical cases and deaths of COVID-19. The nuclear factor kappa-B stimulates the expression of the genes, which is responsible for cytokines storm and RNA transcription. The COVID-19 virus can be controlled by inhibition of nuclear factor kappa-B. Nuclear factor kappa-B is controlled by inhibition of hydrogen peroxide and inhibitor kappa-B kinase enzyme.

关键词： Cytokine Storm COVID-19 Nuclear Factor Kappa-B

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Dynamic Optimization of Caregiver Schedules Based on Vital Sign Streams

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E-Health Telecommunication Systems and Networks 2013年第2期2卷 36-47页

作者： mohamed saad Bilal Khan Department of Math and Computer Science John Jay College (CUNY) New York USA NYC Social Network Research Group John Jay College (CUNY) New York USA

Hospital facilities use a collection of heterogeneous devices, produced by many different vendors, to monitor the state of patient vital signs. The limited interoperability of current devices makes it difficult to synthesize multivariate monitoring data into a unified array of real-time information regarding the patients state. Without an infrastructure for the integrated evaluation, display, and storage of vital sign data, one cannot adequately ensure that the assignment of caregivers to patients reflects the relative urgency of patient needs. This is an especially serious issue in critical care units (CCUs). We present a formal mathematical model of an operational critical care unit, together with metrics for evaluating the systematic impact of caregiver scheduling decisions on patient care. The model is rich enough to capture the essential features of device and patient diversity, and so enables us to test the hypothesis that integration of vital sign data could realistically yield a significant positive impact on the efficacy of critical care delivery outcome. To test the hypothesis, we employ the model within a computer simulation. The simulation enables us to compare the current scheduling processes in widespread use within CCUs, against a new scheduling algorithm that makes use of an integrated array of patient information collected by an (anticipated) vital sign data integration infrastructure. The simulation study provides clear evidence that such an infrastructure reduces risk to patients and lowers operational costs, and in so doing reveals the inherent costs of medical device non-interoperability.

关键词： Critical Care Nurse Scheduling Optimization

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Cell Fleeing from Death Phenomenon

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CellBio 2020年第1期9卷 1-13页

作者： Mahmoud saad mohamed El-Khodary General Organization for Export and Import Control Suez Egypt

Cell fleeing from death phenomenon occurs as either complete or incomplete;the phenomenon is incomplete fleeing from death when cell blocks intrinsic death program only. But, it becomes complete fleeing from death if the cell successfully blocks the pathway of intrinsic and extrinsic programs of cell death. This phenomenon is induced by the formation of hydrogen peroxide which activates nuclear factor kappa B. The nuclear factor-kappa B stimulates the expression of several genes, to produces 6 factors (BcL-2, Muc-1, MMPs, DcR3, Muc-4, muc-16, and TNF-α). Such factors act as blockers of the pathway of intrinsic and extrinsic programs of cell death. These blockers convert normal cell to a cancer cell. If these blockers are removed, the death programs of cancer cells will run again and cancer will disappear.

关键词： Phenomenon Apoptosis Cancer

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Quranic Verse No. 8 of Surat Al-Jumu’ah Describes Cancer as a Complete and Accurate Description and Leads Us to Determine the True Cause of Cancer. “Part-1”

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CellBio 2018年第1期7卷 1-11页

作者： Mahmoud saad mohamed El-Khodary Department of Veterinary Medicine Zagazig University Zagazig Egypt Department of Fish Diseases Suez Canal University Ismailia Egypt General Organization for Export and Import Control Suez Egypt

Cancer is the cell fleeing from death by blocking the pathways of the intrinsic and the extrinsic program of cell death (Apoptosis). The success depends on making the programs of cell death run again.

关键词： Cancer Description Intrinsic Apoptosis Extrinsic Apoptosis

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