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Evaluation of urea breath test as a diagnostic tool for Helicobacter pylori infection in adult dyspeptic patients

World Journal of Gastroenterology 2024年第17期30卷 2302-2307页

作者： Zeinab nabil Ahmed Said Asmaa mohamed El-Nasser Department of Medical Microbiology&Immunology Faculty of Medicine for Girls Al-Azhar UniversityNasr City 11754CairoEgypt

In this editorial,we discuss the article in the World Journal of *** article conducts a meta-analysis of the diagnostic accuracy of the urea breath test(UBT),a non-invasive method for detecting Helicobacter pylori(***)infection in *** is based on radionuclide-labeled *** methods,both invasive and non-invasive,are available for diagnosing *** infection,inclu-ding endoscopy with biopsy,serology for immunoglobulin titers,stool antigen analysis,and *** guidelines recommend UBTs as the primary choice for diagnosing *** infection and for reexamining after eradication *** is used to be the first choice non-invasive test due to their high accuracy,specificity,rapid results,and ***,its performance remains unaffected by the distribution of *** in the stomach,allowing a high flow of patients to be *** its widespread use,the performance characteristics of UBT have been inconsistently described and remain incompletely *** are two UBTs available with Food and Drug Administration approval:The 13C and 14C *** tests are affordable and can provide real-time *** may prefer the 13C test because it is non-radioactive,compared to 14C which uses a radioactive isotope,especially in young children and pregnant *** there was heterogeneity among the studies regarding the diagnostic accuracy of both UBTs,13C-UBT consistently outperforms the *** makes the 13C-UBT the preferred diagnostic ***,the provided findings of the meta-analysis emphasize the significance of precise considerations when choosing urea dosage,assessment timing,and measurement techniques for both the 13C-UBT and 14C-UBT,to enhance diagnostic precision.

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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救援设备应包括便携式医疗成像系统

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Science Bulletin 2024年第12期69卷 1819-1822页

作者： mohamed L.Seghier nabil Maalej Department of Biomedical Engineering Khalifa University of Science and TechnologyAbu Dhabi 127788United Arab Emirates Healthcare Engineering Innovation Center(HEIC) Khalifa University of Science and TechnologyAbu Dhabi 127788United Arab Emirates Physics Department Khalifa University of Science and TechnologyAbu Dhabi 127788United Arab Emirates

In the last years,several countries have been devastated by natural disasters,resulting in thousands of casualties and *** missions were quick to respond to the needs of many devasted regions,providing critical interventions,life support equipment,and vital ***,rescue missions are still relying on traditional emergency equipment and tools that do not always have the capacity for critical diagnosis in disaster areas.

关键词：救援设备 injuries disaster

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The Upper Jurassic sediments,Marib-Shabwa Basin,Yemen:Lithofacies aspects and sequence stratigraphic analysis

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Energy Geoscience 2024年第1期5卷 342-357页

作者： Mohammed Albaroot mohamed M.Elhossainy nabil M.Al-Areeq Emad A.Abdullah Abdelhamid M.Salman Department of Applied Geology Faculty of Science and EducationUniversity of Saba RegionMaribYemen Department of Geology Faculty of ScienceKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Geology and Environment Faculty of Applied SciencesThamar UniversityYemen Department of Mineral Developing and Oil&Gas Engineering Academy of EngineeringPeoples’Friendship University of Russia(RUDN University)Moscow117198Russia Department of Geology Faculty of ScienceAssiut UniversityAssiut71516Egypt

The present study is devoted to understanding the evolution of the Upper Jurassic Sab'atayn Formation in the Marib-Shabwa Basin,Yemen,through a sequence stratigraphic analysis based on integrating datasets of sedimentology,seismic sections,and well *** Sab'atayn Formation(Tithonian age)is represented by a series of clastic and evaporites that were deposited under fluvio-deltaic to prodeltaic *** is divided into four members including Yah(at the base),upwards to Seen,Alif,and Safir at the *** third-order depositional sequences were determined for the Tithonian succession which were separated by three sequence *** sequences were classified into their systems tracts signifying several sedimentation patterns of progradational,aggradational,and retrogradational parasequence *** first depositional sequence corresponds to the early-middle Tithonian Yah and Seen units that can be classified into lowstand,transgressive,and highstand systems *** second sequence comprises the late Tithonian Alif unit that can be subdivided into transgressive and highstand systems *** sandy deposits of the Alif Member(highstand deposits)represent the most productive hydrocarbon reservoir in the *** Upper Jurassic sediments in the study area were resulted from a combination of eustatic and tectonic effects.

关键词： Sequence stratigraphy Sandstone reservoir Well logs Upper Jurassic Marib-Shabwa Basin Yemen

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The C161T Polymorphism in Peroxisome Proliferator-Activated Receptor ɣ2, but Not Pro12Ala, Is Associated with Diabetic Retinopathy in Type 2 Diabetes Mellitus in an Egyptian Population

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Journal of Diabetes Mellitus 2016年第1期6卷 1-9页

作者： Ragaa Abelkader Ramadan Moyassar Ahmad Zaki Rania mohamed El Sharkawy Lubna mohamed Desouky Marwa Ahmed Madkour Karim Mahmoud nabil mohamed Kamel Chemical Pathology Department Medical Research Institute Alexandria University Alexandria Egypt Department of Human Genetics Medical Research Institute Alexandria University Alexandria Egypt Clinical and Experimental Internal Medicine Department Medical Research Institute Alexandria University Alexandria Egypt Department of Ophthalmology Faculty of Medicine Alexandria University Alexandria Egypt

Objectives: Diabetic retinopathy (DR) is one of the most common microvascular complications of type 2 diabetes mellitus (T2DM). It is multifactorial with the contribution of multiple genetic factors. We questioned the association of polymorphisms in the peroxisome proliferator-activated receptor ?2 (PPAR?2) gene (Pro12Ala and C161T) with DR in an Egyptian population. Methods: This case control study included one hundred healthy individuals and 252 T2DM among them 122 with DR and 130 without DR. Genotyping was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The Pro12Ala Ala allele was associated with decreased risk of DR with an odds ratio (OR) of 0.484, 95% confidence interval (CI) (0.254 - 0.920), and a p value = 0.024. The C161T T allele was associated with increased risk of DR with OR = 2.593, 95% CI (1.672 - 4.020), p 1c) in multivariate regression analysis only C161T was associated with increased risk of DR with OR = 3.479, 95% CI (1.907 - 6.346), p 1c was higher in Pro/Pro genotype when compared to those with Ala/Ala and Pro/Ala genotypes. Conclusion: We report that T allele of C161T increased risk of DR in the studied population. Further studies are warranted to investigate functional implications of polymorphisms of the PPAR-? gene in DR development.

关键词： Type 2 Diabetes Mellitus Diabetic Retinopathy Polymorphism PPAR០ Pro12Ala C161T

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Transabdominal Pre-Peritoneal Mesh for Inguinal Hernia Repair with External Fixation versus Mesh Stapling

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Surgical Science 2013年第11期4卷 516-519页

作者： mohamed Abdelhamid Ahmed mohamed Sadat Ayman Refaat Abdelhaseeb Tamer mohamed nabil mohamed Salah Abdelbasset Amro mohamed Ali Bechet Hesham Ahmed Nafady Kalid Ahmed Shawky Faculty of Medicine Bani Swif University Bani Swif Egypt

Background: It is unknown whether stapling the mesh affects recurrence rate, incidence of neuralgia, and port-site hernia. We chose to fix it to the exterior reducing port size, cost and pain, at the same comparing this with traditional mesh stapling. Methods: We conducted a prospective trial for laparoscopic TAPP inguinal hernia repair on 120 patients in which we fixed the mesh to the anterior abdominal wall using either two prolene threads that passed to the exterior and tied in place or traditional mesh stapling. Results: The operative time is ranged from 35 to 70 minutes for external fixation, 30 to 60 minutes for mesh stapling, and 4 to 51 months for follow-up, and no recurrence occurred in both groups during the procedure. Two cases with post TAPP pain in mesh stapling patients are discussed with reduction of the cost and port size in external fixation patients. Conclusion: It is not necessary to secure the mesh during laparoscopic TAPP inguinal hernia repair from the interior and it is fixed only to the exterior allowing a reduction in size of the ports and considerable reduction in cost with elimination of TAPP associated post operative pain.

关键词： Laparoscopic Transabdominal Preperitoneal Inguinal Hernia Repair Mesh Prosthesis Fixation Cost-Stapling

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The Impact of Human Parvovirus B19 Co-Infection on Liver Function of HCV Infected Patients

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Open Journal of Applied Sciences 2019年第1期9卷 17-25页

作者： mohamed nabil Mohammed H. Saiem Al-Dahr Waleed Abu Al-Soud Omar Alfaruok Department of Clinical Laboratories College of Applied Medical Sciences Jouf University Al-Qurayyat KSA Department of Microbiology Faculty of Science Ain Shams University Cairo Egypt

Background: Human Parvovirus B19 is most known for causing disease in the pediatric population but can also affect adults. Human co-infection with Parvovirus B19 could deteriorate the prognosis of patient with chronic ill-ness. Objectives: This paper attempts to determine the prevalence of Parvovirus B19 in HCV infected patients and to evaluate the impact of Parvovirus B19 on liver enzymes activity of Hepatitis C patients. Study Design: The study population includes 74 chronic HCV (patient group) and 49 cases without viral hepatitis (control group). Nucleic acid of Parvovirus B19 was detected in Serum samples by nested polymerase chain reaction (nested-PCR) method. Results: Parvovirus B19-DNA infection was detected in 28.0% of chronic HCV patients. Parvovirus B19-HCV co-infection caused increasing in Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) activity than in B19-negative HCV patients. Conclusion: We conclude that Parvovirus B19 acted synergistically with HCV by increasing the levels alanine ami-notransferase (ALT) and Aspartate aminotransferase (AST).

关键词： Parvovirus B19 HCV Co-Infection ALT and AST

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Concordance of HER-2/Neu over Expression with Steroid Receptor Status in Female Breast Cancers

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Surgical Science 2014年第8期5卷 354-362页

作者： mohamed Salah Abdelhamid Solafa Amin Abdelaziz Sahar Ali Daoud Ahmed mohamed Sadat Ayman Refaat Abdelhaseeb Tamer mohamed nabil mohamed Salah Abdelbasset Hesham Ahmed Nafady Khaled Ahmed Shawky mohamed Hasssen Abdelmoola Benisuef Faulty of Medicine Benisuef Egypt Kasr Al Aini Faculty of Medicine Cairo Egypt

HER-2/neu over expression is associated with increased tumor aggressiveness, increased rates of recurrence, and increased mortality in node positive patients. It is amplified and/or over expressed in approximately 30% of female breast cancers. This study was to detect the relation between HER-2/neu over expression and steroid hormone receptor status. It was conducted at Cairo and Bani Suif university hospitals between February 2012 to February 2014. HER-2/neu over expression was found to be positive in thirteen patients (41%) out of the thirty two patients included in the study, more positive (52%) HER-2/neu was found among estrogen receptor (ER) positive patients, on the other hand, only 18% positive HER-2/neu was detected among ER negative patients. This difference was statistically significant (P < 0.03). The same outcome was with progesterone receptors (PR) and HER-2/neu with statistically significant difference also (P = 0.02). Conclusion: HER-2/neu over expression is strongly related to ER and PR, this was more evident in negative steroid receptors status. The failure of treatment in positive steroid receptors could be explained by HER-2/neu positivity.

关键词： HER-2/Neu ER PR

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Cervical Spine Tuberculosis： A Case Report

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Journal of Pharmacy and Pharmacology 2016年第8期4卷 375-377页

作者： Rafik Elafram Rim Boussetta Ismail Jerbi Sami Bouchoucha Walid Saied mohamed nabil Nessib Department of Pediatric Orthopedic Children Hospital Tunis 1006 Tunisia

Bone localization of tuberculosis mainly affects the thoraco-lumbar spine. The cervical spine is rare. Its diagnosis is often late which exposes to great instability and potentially serious complications. We reported the case of a 10-year old boy with no medical history, showed torticollis and high temperature without neurological complication. In the physical examination, he had torticollis and pain in the third, fourth and fifth cervical vertebra. When biopsy was performed, we fred an inter apophysis （between C3 and C4） collection. The histological examination confirmed the diagnosis of apophysis tuberculosis. The management based on tuberculosis chemotherapy and immobilization started as soon as possible.

关键词： Tuberculosis cervical spine apophysis.

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Monitoring the Treatment of Hepatitis C Viral Infection by Molecular Techniques

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Journal of Biosciences and Medicines 2019年第11期7卷 91-100页

作者： mohamed nabil Mohammed H. Saiem Al-Dahr Ahmed Haridi Waleed S. mohamed Ezeldine K. Abdalhabib Bi Bi Zainab Mazahari Department of Clinical Laboratories College of Applied Medical Sciences Jouf University Al-Jouf Saudi Arabia Department of Microbiology Faculty of Science Ain Shams University Cairo Egypt

The prevalence of Hepatitis C viral infection in Egypt is the highest rate in the world. It is a major public health problem in Egypt. The objective of this study was to detect the clearance of HCV-RNA in Egyptian patients who were recommended for combination therapy of pyglated interferon α 2a and ribavirin (PEG-interferon/Ribavirin). Ninety-five positive HCV-IgG cases were tested for HCV-RNA at baseline and at weeks 4, 12, 24, 48 and 72 of treatment with PEG-interferon α 2a/Ribavirin. The correlations between the viral parameters during and after treatment were evaluated. Patients recommended receiving PEG-interferon 2a/ribavirin combination therapy showed high response rate determined as 71.9% achieved Sustained Virological Response (SVR) from total patients, and 71.4% from patients who received 48 weeks therapy. In general, the employment of TMA provided us the accuracy of results with confidence in our work. There was a significant relation (p < 0.001) between results of Transcription mediated amplification (TMA) and response to therapy that indicate to positive correlation. The development of sensitive accurate assays for HCV-RNA detection and quantification is necessary to improve not only the assessment of the response to antiviral therapy but also our understanding of the mechanism underlying antiviral resistance.

关键词： Monitoring Hepatitis C Infection RNA Treatment Molecular Techniques

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Effect of Atrial Fibrillation on Acute Ischemic Stroke Severity

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Open Journal of Medical Imaging 2014年第2期4卷 95-101页

作者： Taha Kamel Alloush Mahmoud Haroun Ibrahim Nahed Salah El Dein Ahmed Ibrahim Ghada Samir El-Shahed Lobna mohamed nabil El-Sayed mohamed Hamdy Ibrahim Hosam Ahmed Azmy Faculty of Medicine Ain Shams University Cairo Egypt Ministry of Health Cairo Egypt

Objectives: To assess the impact of atrial fibrillation on stroke severity and short-term (1 month) mortality. Materials and Methods: Totally 200 patients admitted to Ain Shams University Specialized Hospital were recruited and diagnosed clinically to have acute ischemic stroke within 3 days. Patients with hemorrhagic infarctions were excluded. History taking about previous heart disease was taken, full general and neurological examinations were done. Full metabolic profile, full cardiac investigations, carotid duplex, MRI brain stroke protocol with initial clinical evaluation and after 1 month re-evaluation using (NIHSS ) scale. Results: All patients underwent transthoracic echocardiography which revealed absence of “A” wave corresponding to atrial fibrillation in 33 patients (16.5%). Those Patients with atrial fibrillation had a median NIHSS score of 11.00 with IQR of 6.00 - 18.50 at admission and 6.00 with IQR of 2.00 - 14.50 after one month. Patients with atrial fibrillation showed significantly higher NIHSS at admission than patients in sinus rhythm, P < 0.05. Magnetic resonance imaging findings showed that MRA showed significant intracranial vessel stenosis in 117 (79.1%) patients. 51 (34.4%) patients had lacunar infarction, 65 (43.9%) patients had partial anterior circulation infarction, 25 (16.2%) patients had posterior circulation infarction and 7 (4.7%) patients had total anterior circulation infarction. 111 (75%) patients showed leucoaraiosis. Conclusion: Atrial fibrillation was found not to have significantly statistical effect on stroke severity and short term mortality.

关键词： Atrial Fibrillation (AF)

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