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Identification of Secondary Metabolites in Tunisian Tilia platyphyllos *** MALDI-TOF and GC-MS

Journal of Renewable Materials 2024年第4期12卷 827-842页

作者： Ayda Khadhri mohamed Mendili Marwa Bannour-Scharinger Eric Masson Antonio Pizzi University of El-Manar II Faculty of SciencesPlantSoilEnvironment Interactions LaboratoryCampus AcademiaTunis2092Tunisia LERMAB University of Lorraine27 Rue Philippe SeguinEpinal88000France

This study is the first to evaluate the phytochemical content and biological properties of Tunisian *** Scop.A total of 23 compounds of essential oils were identified by gas chromatography-mass spectrometry(GC-MS)analysis of bracts and fruit *** results show that oxygenated monoterpenes were the dominant class of essential *** phenolic composition was investigated by matrix-assisted laser desorption/ionizationtime of flight(MALDI-TOF).The analysis showed that the chemical profiles of the ethanolic extracts of bracts and fruits are substantially *** highest polyphenol content was found in the ethanolic extracts of the fruits(7.65 mg gallic acid equivalents(GAE).g−1 on dry weight(DW).As for the antioxidant capacity,it was recorded in the essential oils of the fruits(IC_(50)=0.91 ***^(−1)).The results obtained showed that the antioxidant activity of the fruit essential oil was higher than that of the ethanol *** fruit essential oil was also found to have the highest reducing power(IC_(50)=0.67 ***^(−1)).In terms of iron-chelating power,fruit essential oil has the highest chelating power(IC_(50)=2.03 ***^(−1)).Compared to the ethanolic extract,the essential oil had the maximum antioxidant *** enzymatic activity of acetylcholinesterase(AChE)inhibition of the essential oil from *** bracts had the most potent inhibitory effect(IC_(50)=0.77 ***^(−1)),followed by the essential oil from the fruits(IC_(50)=0.95 ***^(−1)).The results suggest that *** can be used as a potential source of naturally occurring bioactive compounds and antioxidants.

关键词： T.platyphyllos antioxidant activity acetylcholinesterase inhibition essential oil MALDI-TOF GC-MS

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Mitigating diabetes-related complications:Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats

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World Journal of Diabetes 2024年第8期15卷 1778-1792页

作者： Mai S Attia Fadwa Ayman mohamed S Attia Galal Yahya Mansour H Zahra Magdi mohamed Ibrahim Khalil Abdel Aziz A Diab Department of Zoology Faculty of ScienceZagazig 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig 44519Egypt Department of Microbiology and Immunology Faculty of PharmacyZagazig UniversityZagazig 44519Egypt Department of Biochemistry Faculty of MedicineZagazig 44519Egypt

BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of *** treatment options like metformin(MET)effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy,neuropathy,nephropathy,hepatopathy,and cardiovascular *** To propose the supplementation of cholecalciferol(CHO)and taurine(TAU)to enhance MET efficacy in controlling diabetes while minimizing the risk of associated *** The study involved sixty rats,including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by *** experimental rats were further subdivided into positive control and treatment *** four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO,TAU,or *** Diabetic rats exhibited elevated levels of glucose,insulin,Homeostasis Model Assessment of Insulin Resistance(HOMA-IR),glycated hemoglobin percentage,lipid markers,aspartate aminotransferase,and malondialdehyde,along with reduced levels of antioxidant enzymes(catalase and superoxide dismutase).The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet *** antioxidative,anti-inflammatory,and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned *** The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative,anti-inflammatory,and antiapoptotic effects.

关键词： Diabetes complications Metformin Cholecalciferol Taurine Glycated hemoglobin% Antioxidant

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Salivary C-reactive protein and mean platelet volume as possible diagnostic markers for late-onset neonatal pneumonia

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World Journal of Clinical Pediatrics 2024年第1期13卷 41-51页

作者： Wafaa Ahmed Metwali Abdelrahman mohamed Elmashad Sahar Mohey Eldin Hazzaa Mohammed Al-Beltagi mohamed Basiony Hamza Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlgahrbiaEgypt Department of Clinical Pathology Faculty of MedicineTanta UniversityTanta 31511AlgahrbiaEgypt Department of Pediatric University Medical CenterDr.Suliaman Al Habib Medical GroupManama 26671ManamaBahrain Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain

BACKGROUND Neonatal sepsis,a formidable threat to newborns,is a leading cause of neonatal mortality,with late-onset sepsis manifesting after 72 hours post-birth being particularly ***,a prevalent sepsis presentation,poses a significant risk,especially during the neonatal phase when lung defenses are *** diagnosis of pneumonia is imperative for timely and effective ***,a minimally invasive diagnostic medium,holds great promise for evaluating infections,especially in *** To investigate the potential of serum C-reactive protein(CRP),salivary CRP(sCRP),and mean platelet volume(MPV)as diagnostic markers for late-onset neonatal pneumonia(LONP).METHODS Eighty full-term neonates were systematically examined,considering anthropometric measurements,clinical manifestations,radiology findings,and essential biomarkers,including serum CRP,sCRP,and *** The study reveals noteworthy distinctions in serum CRP levels,MPV,and the serum CRP/MPV ratio between neonates with LONP and healthy *** exhibited a robust discriminatory ability[area under the curve(AUC)=0.87]with high sensitivity and specificity at a cutoff value of>*** between serum CRP,sCRP,and MPV were also ***,sCRP demonstrated excellent predictive value for serum CRP levels(AUC=0.89),underscoring its potential as a diagnostic *** This study underscores the diagnostic promise of salivary and serum biomarkers,specifically MPV and CRP,in identifying and predicting LONP among *** findings advocate for further research to validate their clinical utility in larger neonatal cohorts.

关键词： Neonatal sepsis Late-onset pneumonia Salivary C-reactive protein Mean platelet volume Diagnostic markers Newborn infections

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Designing single atom catalysts for exceptional electrochemical CO_(2) reduction

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Chinese Journal of Structural Chemistry 2024年第1期43卷 3-5页

作者： Muhammad Humayun mohamed Bououdina Abbas Khan Sajjad Ali Chundong Wang Energy Water and Environment LabCollege of Humanities and SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan430074PR China Department of Chemistry Abdul Wali Khan University MardanMardan23200Pakistan

The release of anthropogenic CO_(2)emissions into the atmosphere has significantly accelerated global warming within the past few *** to the latest data,it is predicted that the concentration of CO_(2)will rise to 800 ppm over this century,and could reach 2000 ppm by *** high level of CO_(2)is expected to result in significant increase in global temperature as well as ocean acidification[1].

关键词： exceptional global release

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Phytoconstituents Profiling of Indigenous Herbal Drugs and Its in vitro Microbial,in Silico Biological Examination against Severe Acute Respiratory Syndrome Coronavirus 2

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 121-136页

作者： T.H.mohamed Ahadu Shareef Mmohamed Divan Masood Irfan Navabshan MSaiyad Musthafa Department of Chemistry The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia School of Computer Applications B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Crescent School of Pharmacy B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Department of Zoology The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia

Background:Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no *** herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing South Asian *** traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(COVID-19).Aims and Objectives:This research article aimed at conducting phytochemistry,antimicrobial activity,COVID-19 docking and some spectroscopic(Infrared,Ultraviolet,13C-Nuclear Magnetic Resonance(13C-NMR),1H-NMR,and Mass Spectra)characterizations of the polyherbal drugs were carried ***,In-vitro and In-silico analyses were performed to measure activity against *** Performance-Liquid Chromatography(HPLC),Gas Chromatography-Mass Spectrometry(GC-MS),antimicrobial,and docking studies were carried *** preliminary phytochemical assay and bioactive compounds were screened using HPLC and *** study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(SARS-Co V-2).Materials and Methods:The extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely Streptococcus oralis,Staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal Candida albicans,Aspergillus fumigatus,and Aspergillus *** docking study evaluates the pharmacological activity of bioactive chemical compounds with SARS-Co V-2 NSP5(PDB ID:7nxh)and SARS-Co V-2 Omicron spike protein with human angiotensin-converting enzyme 2(ACE-2)(PDB ID:7wk6).Results:In this study,for the first time,we at

关键词： Antimicrobial herbal drug Omicron and coronavirus disease 2019 phytochemicals spectroscopic

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Synergistic Swarm Optimization Algorithm

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2557-2604页

作者： Sharaf Alzoubi Laith Abualigah mohamed Sharaf Mohammad Sh.Daoud Nima Khodadadi Heming Jia Faculty of Computer Sciences and Informatics Amman Arab UniversityAmman11953Jordan Computer Science Department Al Al-Bayt UniversityMafraq25113Jordan Department of Electrical and Computer Engineering Lebanese American UniversityByblos13-5053Lebanon Hourani Center for Applied Scientific Research Al-Ahliyya Amman UniversityAmman19328Jordan MEU Research Unit Middle East UniversityAmman11831Jordan Applied Science Research Center Applied Science Private UniversityAmman11931Jordan School of Computer Sciences Universiti Sains MalaysiaPulau Pinang11800Malaysia School of Engineering and Technology Sunway University MalaysiaPetaling Jaya27500Malaysia Department of Industrial Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia College of Engineering Al Ain UniversityAbu Dhabi112612United Arab Emirates Department of Civil and Architectural Engineering University of MiamiCoral Gables1251USA School of Information Engineering Sanming UniversitySanming365004China

This research paper presents a novel optimization method called the Synergistic Swarm Optimization Algorithm(SSOA).The SSOA combines the principles of swarmintelligence and synergistic cooperation to search for optimal solutions efficiently.A synergistic cooperation mechanism is employed,where particles exchange information and learn from each other to improve their search *** cooperation enhances the exploitation of promising regions in the search space while maintaining exploration ***,adaptive mechanisms,such as dynamic parameter adjustment and diversification strategies,are incorporated to balance exploration and *** leveraging the collaborative nature of swarm intelligence and integrating synergistic cooperation,the SSOAmethod aims to achieve superior convergence speed and solution quality performance compared to other optimization *** effectiveness of the proposed SSOA is investigated in solving the 23 benchmark functions and various engineering design *** experimental results highlight the effectiveness and potential of the SSOA method in addressing challenging optimization problems,making it a promising tool for a wide range of applications in engineering and *** codes of SSOA are available at:https://***/matlabcentral/fileexchange/153466-synergistic-swarm-optimization-algorithm.

关键词： Synergistic swarm optimization algorithm optimization algorithm metaheuristic engineering problems benchmark functions

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MOALG: A Metaheuristic Hybrid of Multi-Objective Ant Lion Optimizer and Genetic Algorithm for Solving Design Problems

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Computers, Materials & Continua 2024年第3期78卷 3489-3510页

作者： Rashmi Sharma Ashok Pal Nitin Mittal Lalit Kumar Sreypov Van Yunyoung Nam mohamed Abouhawwash Department of Mathematics Chandigarh UniversityGharuanMohali140413India Deaprtment of Industry 4.0 Shri Vishwakarma Skill UniversityPalwal121102India Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea Department of Computational Mathematics Science and Engineering(CMSE)College of EngineeringMichigan State UniversityEast LansingMI 48824USA Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt

This study proposes a hybridization of two efficient algorithm’s Multi-objective Ant Lion Optimizer Algorithm(MOALO)which is a multi-objective enhanced version of the Ant Lion Optimizer Algorithm(ALO)and the Genetic Algorithm(GA).MOALO version has been employed to address those problems containing many objectives and an archive has been employed for retaining the non-dominated *** uniqueness of the hybrid is that the operators like mutation and crossover of GA are employed in the archive to update the solutions and later those solutions go through the process of MOALO.A first-time hybrid of these algorithms is employed to solve multi-objective *** hybrid algorithm overcomes the limitation of ALO of getting caught in the local optimum and the requirement of more computational effort to converge *** evaluate the hybridized algorithm’s performance,a set of constrained,unconstrained test problems and engineering design problems were employed and compared with five well-known computational algorithms-MOALO,Multi-objective Crystal Structure Algorithm(MOCryStAl),Multi-objective Particle Swarm Optimization(MOPSO),Multi-objective Multiverse Optimization Algorithm(MOMVO),Multi-objective Salp Swarm Algorithm(MSSA).The outcomes of five performance metrics are statistically analyzed and the most efficient Pareto fronts comparison has been *** proposed hybrid surpasses MOALO based on the results of hypervolume(HV),Spread,and *** primary objective of developing this hybrid approach has been achieved *** proposed approach demonstrates superior performance on the test functions,showcasing robust convergence and comprehensive coverage that surpasses other existing algorithms.

关键词： Multi-objective optimization genetic algorithm ant lion optimizer metaheuristic

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Thermal performance of domed roof in air-conditioned spaces

Energy and Built Environment

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Energy and Built Environment 2024年第2期5卷 270-287页

作者： Ibrahim Reda Raouf N.AbdelMessih mohamed Steit Ehab M.Mina Mechanical Power Engineering Faculty of EngineeringAin Shams University1 El-Sarayat St.Cairo 11517Egypt Architectural Engineering Faculty of EngineeringAin Shams UniversityCairoEgypt

Due to their thermal performance,domed roofs are one of the passive solutions that affect energy consumption in *** thermal performance of domed roofs has been investigated in many naturally ventilated ***,few studies have discussed their performance in conditioned ***,this study introduces a computational comparison between domed and flat roofs to investigate their impact on thermal comfort inside a conditioned *** an earlier stage,field measurements were carried out inside a Bahraini mosque to acquire its indoor air conditions during the summer period of 2021,in addition to validating the computational *** findings of this study confirm that,under mechanical cooling conditions,the flat roof offers a lower indoor temperature than the domed roof by 0.4℃and 0.1℃for open and closed doors,***,the air velocity is lower by approximately 0.01 m/s for both door *** overall PMV values of the flat roof are also lower by 0.07 and 0.01,while the PPD values are lower by 0.20,and 0.34 for open and closed doors,*** on these small differences,it can be concluded that the thermal performance of both roofing systems behaves equally in conditioned ***,the air patterns are substantially different,the overall thermal performance is *** similarity drives building designers to rethink the thermal performance of the domed roofs in air-conditioned spaces with such a hot climate,regardless of their aesthetic and acoustical behaviour.

关键词： Thermal comfort Computational fluid dynamics(CFD) Predicted mean vote(PMV)and predicted percentage dissatisfied(PPD) Domed roof Flat roof

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Intravesical instillation of platelet-rich plasma for treatment of interstitial cystitis/bladder pain syndrome:A pilot study

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Current Urology 2024年第1期18卷 49-54页

作者： Ahmed S.El Hefnawy mohamed Attya Ahmed Hasan Esam El Sawy mohamed Abdel-Razik Nasr El-Tabey Mansoura Urology and Nephrology Center Faculty of MedicineMansoura UniversityMansouraEgypt

Objective:The aim of this study was to evaluate the feasibility of intravesical instillation of platelet-rich plasma(PRP)to treat interstitial cystitis/bladder pain syndrome(IC/BPS).Materials and methods:Twenty PRP samples were tested in vitro for stability after exposure to urine samples with different pH.A pilot study involving 21 female patients with IC/BPS was conducted,and 6 weekly doses of autologous PRP(50 mL)were *** were followed up at the 2nd,4th,8th,and 12th weeks after terminating *** primary endpoint was the visual analog scale(VAS)for pain,and the secondary endpoints included the IC symptom index,IC problem index of the O'Leary-Sant questionnaire and global response assessment,urine culture,and *** was defined as a reduction in VAS by 30%or more compared with basal level,and adverse events were ***:The mean±SD of VAS was significantly reduced compared with basal level(4.4±2.6 vs.8.8±1.1,respectively,p=0.001).Meanwhile,80%of cases were considered successful,with a 50.1%reduction in the mean score compared with the basal *** mean±SD of IC symptom index and IC problem index significantly improved compared with the basal *** response assessment was markedly,moderately,and slightly improved in 2(10%),10(50%),and 5(25%)patients,respectively,and showed no change in 3(15%).Three patients had positive urine cultures at follow-up,but 1 withdrew after 2 sessions because of a lack of ***:Repeated intravesical instillation of PRP could be considered an effective and safe approach for treating IC/BPS.

关键词： Bladder pain syndrome Interstitial cystitis Platelet-rich plasma

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The effectiveness of physical activity interventions on blood pressure in children and adolescents:A systematic review and network meta-analysis

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Journal of Sport and Health Science 2024年第5期13卷 699-708页

作者： mohamed A.Hassan Wanjiang Zhou Mingyi Ye Hui He Zan Gao School of Kinesiology University of Minnesota-Twin CitiesMinneapolisMN 55455USA Department of Methods and Curriculum Physical Education College for MenHelwan UniversityCairo 12552Egypt China Institute of Sport and Health Science Beijing Sport UniversityBeijing 100084China Department of Kinesiology Recreationand Sport StudiesUniversity of TennesseeKnoxvilleTN 37996USA

Background:High blood pressure(BP)is a major contributor to mortality and cardiovascular *** the known benefits of exercise for reducing BP,it is crucial to identify the most effective physical activity(PA)*** systematic review and network meta-analysis(NMA)aimed to evaluate the available evidence on the effectiveness of various PA interventions for reducing BP and to determine their hierarchy based on their impact on ***:A search of PubMed,SPORTDiscus,PsycINFO,Web of Science,CINAHL,Cochrane,and Eric databases was conducted up to December 2022 for this systematic review and *** controlled trials and quasi-experimental studies targeting healthy children and adolescents aged 6-12 years old were included in this *** studies that compared controlled and intervention groups using PA or exercise as the major influence were *** followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)*** independent investigators performed the literature screening,data extraction,and risk of bias *** used Bayesian arm-based NMA to synthesize the *** primary outcomes were systolic BP and diastolic *** calculated the mean differences(MDs)in systolic BP and diastolic BP before and after *** treatment differences were estimated using NMA and random-effect ***:We synthesized 27 studies involving 15,220 children and *** combined with nutrition and behavior change was the most effective intervention for reducing both systolic BP and diastolic BP(MD=-8.64,95%credible interval(95%CI):-11.44 to-5.84;MD=-6.75,95%CI:-10.44 to-3.11),followed by interventions with multiple components(MD=-1.39,95%CI:-1.94 to-0.84;MD=-2.54,95%CI:-4.89 to-0.29).Conclusion:Our findings suggest that PA interventions incorporating nutrition and behavior change,followed by interventions with multiple components,are most effective for reducing both systolic BP and diastolic BP

关键词： Children Diastolic blood pressure Physical activity Systolic blood pressure

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