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Calculus bovis in hepatocellular carcinoma:Tumor molecular basis,Wnt/β-catenin pathway role,and protective mechanism

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World Journal of Gastroenterology 2024年第35期30卷 3959-3964页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research and Clinical Studies InstituteNational Research CentreGiza 12622Egypt

In this editorial,we comment on the recent article by Huang et *** editorial focuses specifically on the molecular mechanisms of hepatocellular carcinoma(HCC),mechanism of Wnt/β-catenin pathway in HCC,and protective mechanism of Calculus bovis(CB)in *** cancer is the fourth most common cause of cancer-related deaths *** most prevalent kind of primary liver cancer,HCC,is typically brought on by long-term viral infections(hepatitis B and C),non-alcoholic steatohepatitis,excessive alcohol consumption,and other conditions that can cause the liver to become chronically inflamed and *** is a wellknown traditional remedy in China and Japan and has been used extensively to treat a variety of diseases,such as high fever,convulsions,and *** in lipid metabolism,cholesterol metabolism,bile acid metabolism,alcohol metabolism,and xenobiotic detoxification lead to fatty liver disease and liver ***,which is a tricarboxylic acid cycle intermediate,is vital to energy production and mitochondrial *** is also thought to be a signaling molecule in metabolism and in the development and spread of liver *** Wnt/β-catenin pathway is made up of a group of proteins that are essential for both adult tissue homeostasis and embryonic *** is frequently caused by the dysregulation of the Wnt/β-catenin signaling *** HCC liver carcinogenesis,Wnt/β-catenin signaling is activated by the expression of downstream target *** between the liver and the gut exists via the portal vein,biliary tract,and systemic ***"gutliver axis"controls intestinal *** of the main factors contributing to the development,progression,and treatment resistance of HCC is the abnormal activation of the Wnt/β-Catenin signaling ***,understanding this pathway is essential to treating *** ingredients of CB,particularly oleanolic acid,ergosterol,and ursolic acid,have anti-p

关键词： Hepatocellular carcinoma MicroRNAs Wnt/β-catenin pathway Calculus bovis Apoptosis

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Childhood asthma biomarkers including zinc: An exploratory crosssectional study

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World Journal of Clinical Pediatrics 2024年第1期13卷 31-40页

作者： Hoda Atef Abdelsattar Ibrahim Mona Mohsen Boles Salep Aziz Hanna Dina Mahmoud khaled mohamed Abdelhamid El-Khashab Pediatric Clinical Nutrition Unit Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Pediatrics Faculty of MedicineCairo UniversityCairo 12613Egypt Department of Clinical Pathology Faculty of MedicineCairo UniversityCairo 12613Egypt

BACKGROUND Childhood bronchial asthma(BA)is a chronic inflammatory respiratory *** conditions,including zinc deficiency,can affect such allergic *** To outline the difference in serum zinc levels between asthmatic children and healthy *** A cross-sectional study was carried out at Children’s Hospital,Cairo University,investigating serum zinc levels in children with BA(n=40)and healthy children(n=21).Other markers included serum ferritin,iron,hemoglobin(Hb),and immunoglobulin E(IgE)*** t-tests and Mann-Whinny tests were used for *** Kruskal-Wallis test was applied to compare serum ferritin and IgE levels with regard to asthma ***'s rank correlation was performed to explore the relationship between serum ferritin levels and both iron and Hb levels in asthmatic *** Children with BA had higher levels of zinc,yet the difference was not significant(P=0.115).Serum ferritin and IgE levels were significantly higher in asthmatic children(P=0.006 and 0.001,respectively),yet their levels did not differ significantly by severity(P=0.623 and 0.126,respectively).There was a nonsignificant weak correlation between serum ferritin levels and both serum iron and Hb *** Serum zinc levels do not seem to differ between asthmatic children and healthy *** ferritin levels may be a marker of asthma *** IgE levels are not markers of asthma severity.

关键词： Children Asthma Zinc Ferritin

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Interest of Cardiac Rehabilitation in Patients with Heart Disease in a Cardiology Department in Senegal

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World Journal of Cardiovascular Diseases 2024年第4期14卷 217-227页

作者： Awa Ba-Diop Abdou Khadir Sow Rim mohamed khaled Mor Diaw Mame Saloum Coly Fulgence Abdou Faye Amadou Ndiadé Bamba Gaye Abdoulaye Ba Abdoulaye Samb Laboratory of Physiology and Functional Explorations Department of Medicine Alioune Diop University of Bambey Bambey Senegal IRL3189 Environment Health Societies CNRS-UCAD Dakar Senegal The African Research Network Noncommunicable Diseases Dakar Senegal Laboratory of Physiology and Functional Explorations FMPOS UCAD Dakar Senegal Laboratory of Physiology and Functional Explorations UFR Sant&#233 UAS of Thi&#232s Thi&#232s Senegal INSERM U970 Team 4 Paris France

Cardiac rehabilitation helps improve the prognosis and quality of life for patients with heart disease. To show its interest in the African context, in the management of heart disease, a prospective study was carried out. Its objective was to evaluate the effects of physical rehabilitation on cardiac function. Methods: Patients were evaluated at the beginning and at the end of cardiovascular rehabilitation by cardiovascular, biological, and echocardiographic parameters including the size of the heart chambers, the kinetics of the walls, and the systolic function of the ventricles. Results: The study involved 12 patients, 67% of whom were men. After cardiac rehabilitation, the mean hemodynamic constants had not been significantly modified. However, a significant decrease in Total-Cholesterol, LDL-Cholesterol and triglyceride levels was noted. Mean fasting blood sugar decreased from 1.25 ± 0.48 g/L to 0.92 ± 0.18 g/L and glycated hemoglobin from 7.72% ± 0.01% to 6.45% ± 0.008%. The echocardiographic parameters studied showed an improvement in the dilation of the heart chambers in 8.33% of the patients, the normalization of the ejection fraction of the left ventricle in 16% patients, the improvement of the kinetic disorders in 16% of patients and recovery of right ventricular systolic function in all patients. Conclusion: Cardiac rehabilitation as a secondary preventive measure for cardiovascular disease has contributed significantly to improving the clinico-biological parameters of the disease.

关键词： Cardiac Rehabilitation Heart Disease Cardiovascular Disease

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A coal rib monitoring study in a room-and-pillar retreat mine

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International Journal of Mining Science and Technology 2021年第1期31卷 127-135页

作者： Gamal Rashed khaled mohamed Robert Kimutis GCB/PMRD//NIOSH/CDC PittsburghPA 15236USA

The National Institute for Occupational Safety and Health(NIOSH)conducted a comprehensive monitoring program in a room-and-pillar mine located in Southern *** deformation and the stress change in an instrumented pillar were monitored during the progress of pillar retreat mining at two sites of different geological conditions and depths of *** main objectives of the monitoring program were to better understand the stress transfer and load shedding on coal pillars and to quantify the rib deformation due to pillar retreat mining;and to examine the effect of rib geology and overburden depth on coal rib *** instrumentation at both sites included pull-out tests to measure the anchorage capacity of rib bolts,load cells mounted on rib bolts to monitor the induced loads in the bolts,borehole pressure cells(BPCs)installed at various depths in the study pillar to measure the change in vertical pressure within the pillar,and roof and rib extensometers installed to quantify the vertical displacement of the roof and the horizontal displacement of the rib that would occur during the retreat mining *** outcome from the monitoring program provides insight into coal pillar rib support optimization at various depths and geological ***,this study contributes to the NIOSH rib support database in U.S coal mines and provides essential data for rib support design.

关键词： Coal rib performance Coal rib design Coal rib monitoring Coal rib failure Load transfer Retreat mining

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Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19:A review

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World Journal of Gastroenterology 2021年第1期27卷 37-54页

作者： khaled mohamed mohamed Koriem Medical Physiology Department Medical Research DivisionNational Research CentreDokki 12622CairoEgypt

The term lipidome is mentioned to the total amount of the lipids inside the biological *** lipid enters the human gastrointestinal tract through external source and internal *** absorption pathway of lipids in the gastrointestinal tract has many ways;the 1st way,the lipid molecules are digested in the lumen before go through the enterocytes,digested products are re-esterified into complex lipid *** 2nd way,the intracellular lipids are accumulated into lipoproteins(chylomicrons)which transport lipids throughout the whole *** lipids are re-synthesis again inside the human body where the gastrointestinal lipids are:(1)Transferred into the endoplasmic reticulum;(2)Collected as lipoproteins such as chylomicrons;or(3)Stored as lipid droplets in the *** lipids play an important role in many stages of the viral replication *** specific lipid change occurs during viral infection in advanced viral replication *** are 47 lipids within 11 lipid classes were significantly disturbed after viral *** virus connects with blood-borne lipoproteins and apolipoprotein E to change viral *** viral interest is cholesterol-and lipid raft-dependent *** conclusion,lipidome is important in gastrointestinal fat absorption and coronavirus disease 2019(COVID-19)infection so lipidome is basic in gut metabolism and in COVID-19 infection success.

关键词： Lipidome Gastrointestinal tract Fat metabolism COVID-19 Viral infection Future therapy

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Multiple sclerosis: New insights and trends

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 429-440页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research DivisionNational Research Centre

Multiple sclerosis(MS) is the most famous autoimmune disease attacking the central nervous system. It attacks people from age 20–50 years old and the females' attacks double than males' attacks. MS is an autoimmune disease affecting principally the central nervous system that cause nerve sheath demyelination followed by axon damage and paralysis. MS symptoms include muscle weakness, weak reflexes, muscle spasm, difficult in move, miss-coordination and unbalance with others. There are many factors may be responsible for MS: microbial, viral, smoking, stress, environmental toxins, contaminated diet, and gout. MS is wide spread in the populations in North Europe and this related to lack of vitamin D due to decrease of sunlight exposure. MS biomarkers include nitric oxide, interleukin-6, nitric oxide synthase, fetuin-A and osteopontin. MS is not a genetic disease where MS occurs when human leukocyte antigen system related genes are changed in chromosome 6. The physiology of MS is monitored by activation of immuneinflammatory, oxidative, and nitrosative stress pathways. MS is including two main steps:(1) myelin sheath destruction and formation of lesions and,(2) inflammation. Four types of MS can be distinguished: relapsing-remitting, primary progressive, secondary progressive and progressive relapsing. Nine treatments have been accepted for relapsingremitting MS type: interferon b-1a, interferon b-1b, mitoxantrone, natalizumab, glatiramer acetate, fingolimod, dimethyl fumarate, teriflunomide, and alemtuzumab, however,the only treatment used is mitoxantrone for progressive MS but many of MS treatments side effects are recorded. Complementary treatments also used in MS treatments such as:vitamin D, Yoga, medicinal plants, oxygen therapy, acupuncture and reflexology.

关键词： Multiple sclerosis Diagnosis Genetics Physiology Treatments

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Protective effect of natural products and hormones in colon cancer using metabolome:A physiological overview

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 957-966页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research DivisionNational Research CentreDokkiCairoEgypt

Globally, the third cause of males cancer and the fourth cause of females cancer is colon cancer(CC). In Egypt, high CC percentage occurs in children and in individuals below 40 years of age. The complete loss of biological enzyme function is the main cause of CC and consequently CC increased in smoking and pollution exposure. The aim of this review is to focus on the application of metabolome as a physiological tool that can play an important role in preventing CC incidence by natural products and hormones. The dietary factors, intestinal micro-flora and endogenously produced metabolites are the main three causes that produce free radicals in the colon. A correlation occurs between the enzyme activity and CC polymorphisms or property. Nowadays metabolome is applied with the progress of different analytical methods, data bases and tools for cancer predication and stimulation especially in CC cases. Metabolism is defined as intracellular chemical reactions that produce chemical substances and energies sustaining life. Metabolic pathway networks are also composed of links that are defined as transformation of chemical structures between two metabolites and an enzyme reaction. The most important advantage of metabolome is its ability to analyze metabolites from any source, regardless of origin, where the application of liquid chromatography combined with mass spectra in metabolome analysis to a series of cancer cell lines that were progressively more tumorigenic due to the induction of 1,2,3 or 4 oncogenes to cell lines could be a metabolome example application. In conclusion, natural products and hormones are very important in preventing CC in humans and animal models where both natural products and hormones play a significant and important effect in regulating physiological process especially in CC cases. In this situation, metabolome must increase in its application in the future for the diagnosis of CC cases.

关键词： Colon cancer Metabolome Physiology Natural products Hormones

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A lipidomic concept in infectious diseases

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 265-274页

作者： khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research Division National Research CentreDokki Cairo Egypt

Infectious diseases resemble a great threat to the human health according to World Health Organization where about 17% of all deaths(z9.2 million deaths) in 2013 recorded are related to infectious diseases. The pathogenic microorganisms such as bacteria, viruses,fungi and parasites are the principle causes of infectious diseases. Ebola, AIDS, dengue,hepatitis, malaria, tuberculosis and schistosomiasis are among 216 infectious diseases found where the immunity represents the first line defense in infection. Lipidomic includes examination of different biological lipids in the biological cell. The lipidomic research covers all aspects of individual lipid molecule including its structure, function,connection with other cell constituents such as protein, lipid, and metabolite in both health and disease conditions. Details of cell biology obtained from different pathogens(viruses, bacteria, and parasites) provide a great data on molecular structure of hostpathogen relation and consequently on infection process. The lipids here play a very important role in many processes involved in host-pathogen relations. The role of lipid in host-pathogen link includes many processes in(1) structural host constituents,(2) host recognition,(3) intracellular transferring, and(4) energy and resource homeostasis during pathogen duplication. There are many lipid phosphatases, kinases, and lipases molecules that greatly involved in these processes and controlling pathogen expression and infection progress. The cell lipid metabolism depends on an adequate energy stores that push the infection to be accelerated and disease symptoms to be appeared. Consequently, future lipidomics studies are the basic for detecting the lipid role in host-pathogen relations which help in therapy advances and biomarkers development.

关键词： Lipidomics Virus Bacteria Parasite Membrane trigger

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Loading characteristics of mechanical rib bolts determined through testing and numerical modeling

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International Journal of Mining Science and Technology 2020年第1期30卷 17-24页

作者： khaled mohamed Gamal Rashed Zorica Radakovic-Guzina Centers for Disease Control National Institute for Occupational Safety and HealthPittsburghPA 15236USA ITASCA Consulting Group MinneapolisMN 55401USA

Underground coal mines use mechanical bolts in addition to other types of bolts to control the rib deformation and to stabilize the yielded coal *** research has been conducted to understand the performance of the mechanical bolts in coal *** from the National Institute for Occupational Safety and Health(NIOSH)conducted this work to understand the loading characteristics of mechanical bolts(stiffness and capacity)installed in coal ribs at five underground coal *** pull-out tests were performed in this study to define the loading characteristics of mechanical rib *** installation torques were applied to the tested bolts based on the strength of the coal seam.A typical tri-linear load-deformation response for mechanical bolts was obtained from these *** was found that the anchorage capacity depended mainly on the coal *** for modeling mechanical bolts have been developed using the tri-linear load-deformation *** outcome of this research provides essential data for rib support design.

关键词： Coal rib Mechanical bolt Conventional bolt Tension bolt Point-anchored bolt Rib support Pull-out test Numerical modeling FLAC3D

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Do statins reduce the mortality rate in stroke patients treated with systemic thrombolysis in a 5-year single-center study?

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Neural Regeneration Research 2021年第9期16卷 1807-1812页

作者： Toralf Brüning mohamed Al-khaled Department of Neurology University Medical Center Schleswig-HolsteinCampus LübeckLübeckGermany

The present study investigated the association between pre-treatment with a cholesterol-lowering drug(statin) or new setting hereon and the effect on the mortality rate in patients with acute ischemic stroke who received intravenous systemic thrombolysis. During a 5-year period(starting in October 2008), 542 consecutive stroke patients who received intravenous systemic thrombolysis with recombinant tissue plasminogen activator(rt-PA) at the Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Germany, were included. Patients were characterized according to statins. The primary endpoint was mortality;it was assessed twice: in hospital and 3 months after discharge. The secondary outcome was the rate of symptomatic intracerebral hemorrhage. Of the 542 stroke patients examined(mean age 72 ± 13 years;51% women, mean National Institutes of Health Stroke Scale(NIHSS) score 11), 138 patients(25.5%) had been pretreated with statin, while in 190 patients(35.1%) statin therapy was initiated during their stay in hospital, whereas 193(35.6%) never received statins. Patients pre-treated with statin were older and more frequently had previous illnesses(arterial hypertension, diabetes mellitus and previous cerebral infarctions), but were comparably similarly affected by the stroke(NIHSS 11 vs. 11;P = 0.76) compared to patients who were not on statin treatment at the time of cerebral infarction. Patients pretreated with statin did not differ in 3-month mortality from those newly treated to a statin(7.6% vs. 8%;P = 0.9). Interestingly, the group of patients pretreated with statin showed a lower rate of in hospital mortality(6.6% vs. 17.0;P = 0.005) and 3-month mortality(10.7% vs. 23.7%;P = 0.005) than the group of patients who had no statin treatment at all. The same effect was seen for patients newly adjusted to a statin during the hospital stay compared to patients who did not receive statins(3-month mortality: 7.1% vs. 23.7%;P < 0.001). With a good funct

关键词： acute ischemic stroke hemorrhage mortality outcome secondary prophylaxis statins stroke systemic thrombolysis

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