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Enteric neuropathy in diabetes:Implications for gastrointestinal function

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World Journal of Gastroenterology 2024年第22期30卷 2852-2865页

作者： Mona mohamed ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes,commonly known for its metabolic effects,also critically affects the enteric nervous system(ENS),which is essential in regulating gastrointestinal(GI)motility,secretion,and *** development of diabetes-induced enteric neuropathy can lead to various GI dysfunctions,such as gastroparesis and irregular bowel habits,primarily due to disruptions in the function of neuronal and glial cells within the ENS,as well as oxidative stress and *** editorial explores the pathophysiological mechanisms underlying the development of enteric neuropathy in diabetic ***,it discusses the latest advances in diagnostic approaches,emphasizing the need for early detection and intervention to mitigate GI complications in diabetic *** editorial also reviews current and emerging therapeutic strategies,focusing on pharmacological treatments,dietary management,and potential neuromodulatory ***,this editorial highlights the necessity of a multidisciplinary approach in managing enteric neuropathy in diabetes,aiming to enhance patient quality of life and address a frequently overlooked complication of this widespread disease.

关键词： Diabetic neuropathy Gastrointestinal Insulin resistance Diabetes Enteric nervous system Enteric neuropathy

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

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World Journal of Diabetes 2024年第7期15卷 1430-1447页

作者： Mona mohamed ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence *** studies have indicated a possible link between DM and an increased risk of developing ***,while primarily known for its role in regulating blood sugar,also plays a vital role in protecting brain *** resistance(IR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's *** insulin signalling becomes dysfunctional,it can negatively affect various brain functions,making individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein *** research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to *** review aims to explore the relationship between DM and AD,with a focus on the role of *** also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target *** IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关键词： Alzheimer's disease Insulin resistance Obesity Dementia Diabetes Metabolic syndrome

A Practical Study of Intelligent Image-Based Mobile Robot for Tracking Colored Objects

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Computers, Materials & Continua 2024年第8期80卷 2181-2197页

作者： Mofadal Alymani mohamed Esmail Karar Hazem ibrahim Shehata College of Computing and Information Technology Shaqra UniversityShaqra11961Saudi Arabia Faculty of Electronic Engineering Menoufia UniversityMenouf32952Egypt Faculty of Engineering Zagazig UniversityZagazig44519Egypt

Object tracking is one of the major tasks for mobile robots in many real-world ***,artificial intelligence and automatic control techniques play an important role in enhancing the performance of mobile robot *** contrast to previous simulation studies,this paper presents a new intelligent mobile robot for accomplishing multi-tasks by tracking red-green-blue(RGB)colored objects in a real experimental ***,a practical smart controller is developed based on adaptive fuzzy logic and custom proportional-integral-derivative(PID)schemes to achieve accurate tracking results,considering robot command delay and tolerance *** design of developed controllers implies some motion rules to mimic the knowledge of experienced *** scenarios of three colored object combinations have been successfully tested and evaluated by using the developed controlled image-based robot *** PID control failed to handle some tracking scenarios in this *** proposed adaptive fuzzy PID control achieved the best accurate results with the minimum average final error of 13.8 cm to reach the colored targets,while our designed custom PID control is efficient in saving both average time and traveling distance of 6.6 s and 14.3 cm,*** promising results demonstrate the feasibility of applying our developed image-based robotic system in a colored object-tracking environment to reduce human workloads.

关键词： Mobile robot autonomous systems fuzzy logic control real-time image processing

Advancing diabetes management: Exploring pancreatic beta-cell restoration’s potential and challenges

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World Journal of Gastroenterology 2024年第40期30卷 4339-4353页

作者： Mona mohamed ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus,characterized by chronic hyperglycemia due to insulin deficiency or resistance,poses a significant global health *** to its pathogenesis is the dysfunction or loss of pancreatic beta cells,which are res-ponsible for insulin *** advances in beta-cell regeneration research offer promising strategies for diabetes treatment,aiming to restore endogenous insulin production and achieve glycemic *** review explores the physiological basis of beta-cell function,recent scientific advan-cements,and the challenges in translating these findings into clinical *** highlights key developments in stem cell therapy,gene editing technologies,and the identification of novel regenerative *** the potential,the field faces hurdles such as ensuring the safety and long-term efficacy of regen-erative therapies,ethical concerns around stem cell use,and the complexity of beta-cell differentiation and *** review highlights the importance of interdisciplinary collaboration,increased funding,the need for patient-centered approaches and the integration of new treatments into comprehensive care strategies to overcome these *** continued research and collab-oration,beta-cell regeneration holds the potential to revolutionize diabetes care,turning a chronic condition into a manageable or even curable disease.

关键词： Diabetes therapies Beta cell regeneration Regenerative medicine Stem cell therapy Gene editing Molecular therapeutics

Gastroesophageal reflux after per-oral endoscopic myotomy:Management literature

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World Journal of Gastroenterology 2024年第23期30卷 2947-2953页

作者： Ahmed Tawheed ibrahim Halil Bahcecioglu Mehmet Yalniz mohamed El-Kassas Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Gastroenterology Faculty of MedicineFirat UniversityElazig 23119Türkiye Liver Disease Research Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

In this editorial,we respond to a review article by Nabi et al,in which the authors discussed gastroesophageal reflux(GER)following peroral endoscopic myotomy(POEM).POEM is presently the primary therapeutic option for achalasia,which is both safe and effective.A few adverse effects were documented after POEM,including *** diagnostic criteria were not clear enough because approximately 60%of patients have a long acid exposure time,while only 10%experience reflux *** predictors of high disease incidence have been identified,including old age,female sex,obesity,and a baseline lower esophageal sphincter pressure of less than 45 *** technical steps during the procedure,such as a lengthy or full-thickness myotomy,may further enhance the *** pump inhibitors are currently the first line of *** voices are increasingly advocating for the routine combining of POEM with an endoscopic fundoplication method,such as peroral endoscopic fundoplication or transoral incisionless ***,more research is necessary to determine the safety and effectiveness of these procedures in the long term for patients who have undergone them.

关键词： Achalasia Per-oral endoscopic myotomy Gastroesophageal reflux disease Transoral incisionless fundoplication Peroral endoscopic fundoplication

Thermal performance of domed roof in air-conditioned spaces

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Energy and Built Environment 2024年第2期5卷 270-287页

作者： ibrahim Reda Raouf N.AbdelMessih mohamed Steit Ehab M.Mina Mechanical Power Engineering Faculty of EngineeringAin Shams University1 El-Sarayat St.Cairo 11517Egypt Architectural Engineering Faculty of EngineeringAin Shams UniversityCairoEgypt

Due to their thermal performance,domed roofs are one of the passive solutions that affect energy consumption in *** thermal performance of domed roofs has been investigated in many naturally ventilated ***,few studies have discussed their performance in conditioned ***,this study introduces a computational comparison between domed and flat roofs to investigate their impact on thermal comfort inside a conditioned *** an earlier stage,field measurements were carried out inside a Bahraini mosque to acquire its indoor air conditions during the summer period of 2021,in addition to validating the computational *** findings of this study confirm that,under mechanical cooling conditions,the flat roof offers a lower indoor temperature than the domed roof by 0.4℃and 0.1℃for open and closed doors,***,the air velocity is lower by approximately 0.01 m/s for both door *** overall PMV values of the flat roof are also lower by 0.07 and 0.01,while the PPD values are lower by 0.20,and 0.34 for open and closed doors,*** on these small differences,it can be concluded that the thermal performance of both roofing systems behaves equally in conditioned ***,the air patterns are substantially different,the overall thermal performance is *** similarity drives building designers to rethink the thermal performance of the domed roofs in air-conditioned spaces with such a hot climate,regardless of their aesthetic and acoustical behaviour.

关键词： Thermal comfort Computational fluid dynamics(CFD) Predicted mean vote(PMV)and predicted percentage dissatisfied(PPD) Domed roof Flat roof

Distribution characteristics and removal rate of antibiotics and antibiotic resistance genes in different treatment processes of two drinking water plants

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 143-152页

作者： Jun Wang Mingtao Huang Bolin Li Hassan ibrahim mohamed Huanjie Song Gezi Li Ying Yu Han Zhang Weimin Xie School of Resource and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Wuhan Lingang Economic and Technological Development Zone Service Industry Development Investment Group Co.Ltd. Wuhan 430040China Civil Engineering Department Faculty of EngineeringAssiut UniversityAssiut 71516Egypt Changjiang Basin Ecology Environment and Monitoring and Scientific Research Center Changjiang Basin Ecology and Environment AdministrationMinistry of Ecological EnvironmentWuhan 430010China

Emerging pollutants,such as antibiotics and antibiotic-resistance genes,are becoming increasingly important sources of safety and health *** water safety,which is closely related to human health,should receive more attention than natural water body ***,minimal research has been performed on the efficacy of existing treatment processes in water treatment plants for the removal of antibiotics and antibiotic resistance *** address this research gap,this study detected and analyzed six main antibiotics and nine antibiotic resistance genes in the treatment processes of two drinking water plants in *** were collected over three months and then detected and analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry and fluorescence *** total concentrations of antibiotics and antibiotic resistance genes in the influent water of the two water plants were characterized as December>March>*** precipitation and filtration processes of the Zou Maling Water Plant and Yu Shidun Water Plant successfully removed the *** ozone-activated carbon process increased the removal rate of most antibiotics to 100%.However,a large amount of antibiotic resistance gene residues remained in the effluents of the two water *** experiments demonstrated that the existing ozone-activated carbon processes could not effectively remove antibiotic resistance *** study provides a reference for the optimization of drinking water treatment processes for antibiotics and antibiotic resistance gene removal.

关键词： Antibiotics Antibiotics resistance genes Water treatment process unit Spatiotemporal distribution Removal efficacy

Quantification of Silicon (SI) and Silicon Dioxide (SiO₂) from the Nafud Desert-Al-Qassim Region, Kingdom of Saudi Arabia Using XRD Analysis

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Advances in Materials Physics and Chemistry 2024年第5期14卷 67-75页

作者： Nagwa ibrahim mohamed Department of Physics College of Science Qassim University Buraydah Saudi Arabia

This research was conducted in the Qassim region, Kingdom of Saudi Arabia. The goal of this research is to determine the percentage of silicon in the Rub al-Khali desert. Samples were collected from four cities located in the Al-Qassim Region of Saudi Arabia (Uyun Al-Jawa, Al-Fuwailiq, Al-Sulaibiya, and Al-Qawara), from three distinct depths (the earth’s surface, 50 cm, and 100 cm). The percentages of silicon in these places vary between the highest value for silicon dioxide, which is 74.47 m/m%, and 34.8 m/m% for silicon in Al-Qawara city at a depth of 100 cm. We used an x-ray fluorescence (XRF) instrument to evaluate the samples. There are high percentage of both silica and silicon in the Nafud desert. Studies have shown that these ratios can help investors benefit from an element of Silicon and silicon dioxide, so the sands of the Nafud desert is sufficient for extracting Silicon and silica in huge quantities. This may transform the Kingdom into a leading country in the global computer technology industry that depends on silicon extracted from the desert sands, the most important of which are microcomputer data processing devices.

关键词： Silica Sand Dispersive X-Ray Fluorescence (EDXRF) Analyzer Solar Cells Nafud Desert Al-Qawwarh

Enhancing Wireless Sensor Network Efficiency through Al-Biruni Earth Radius Optimization

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Computers, Materials & Continua 2024年第6期79卷 3549-3568页

作者： Reem ibrahim Alkanhel Doaa Sami Khafaga Ahmed mohamed Zaki Marwa M.Eid Abdyalaziz A.Al-Mooneam Abdelhameed ibrahim S.K.Towfek Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer Science and Intelligent Systems Research Center BlacksburgVirginia24060USA Delta Higher Institute for Engineering and Technology Mansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Artificial Intelligence and Computational Intelligence Research Center MeridenConnecticut06450USA School of ICT Faculty of EngineeringDesign and Information&Communications Technology(EDICT)Bahrain PolytechnicP.O.Box 33349Isa TownBahrain

The networks of wireless sensors provide the ground for a range of applications,including environmental moni-toring and industrial *** the networks can overcome obstacles like power and communication reliability and sensor coverage is the crux of network *** infrastructure planning should be focused on increasing performance,and it should be affected by the detailed data about node *** work recommends the creation of each sensor’s specs and radius of influence based on a particular geographical location,which will contribute to better network planning and *** using the ARIMA model for time series forecasting and the Al-Biruni Earth Radius algorithm for optimization,our approach bridges the gap between successive terrains while seeking the equilibrium between exploration and *** implementing adaptive protocols according to varying environments and sensor constraints,our study aspires to improve overall network *** compare the Al-Biruni Earth Radius algorithm along with Gray Wolf Optimization,Particle Swarm Optimization,Genetic Algorithms,and Whale Optimization about performance on real-world *** the most efficient in the optimization process,Biruni displays the lowest error rate at *** two other statistical techniques,like ANOVA,are also useful in discovering the factors influencing the nature of sensor data and network-specific *** to the multi-faceted support the comprehensive approach promotes,there is a chance to understand the dynamics that affect the optimization outcomes better so decisions about network design can be *** delivering better performance and reliability for various in-situ applications,this research leads to a fusion of time series forecasters and a customized optimizer algorithm.

关键词： Wireless sensor networks optimization ARIMA model BER algorithm metaheuristic algorithms