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An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

An Enhanced Lung Cancer Detection Approach Using Dual-Model Deep Learning Technique

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 835-867页

作者： Sumaia mohamed Elhassan Saad mohamed Darwish Saleh Mesbah Elkaffas Department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt College of Computing and Information Technology Arab Academy for ScienceTechnology and Maritime TransportAlexandriaP.O.Box 1029Egypt

Lung cancer continues to be a leading cause of cancer-related deaths worldwide,emphasizing the critical need for improved diagnostic *** detection of lung tumors significantly increases the chances of successful treatment and ***,current diagnostic methods often fail to detect tumors at an early stage or to accurately pinpoint their location within the lung ***-model deep learning technologies for lung cancer detection,while beneficial,cannot capture the full range of features present in medical imaging data,leading to incomplete or inaccurate ***,it may not be robust enough to handle the wide variability in medical images due to different imaging conditions,patient anatomy,and tumor *** overcome these disadvantages,dual-model or multi-model approaches can be *** research focuses on enhancing the detection of lung cancer by utilizing a combination of two learning models:a Convolutional Neural Network(CNN)for categorization and the You Only Look Once(YOLOv8)architecture for real-time identification and pinpointing of *** automatically learn to extract hierarchical features from raw image data,capturing patterns such as edges,textures,and complex structures that are crucial for identifying lung ***8 incorporates multiscale feature extraction,enabling the detection of tumors of varying sizes and scales within a single *** is particularly beneficial for identifying small or irregularly shaped tumors that may be challenging to ***,through the utilization of cutting-edge data augmentation methods,such as Deep Convolutional generative Adversarial Networks(DCgAN),the suggested approach can handle the issue of limited data and boost the models’ability to learn from diverse and comprehensive *** combined method not only improved accuracy and localization but also ensured efficient real-time processing,which is crucial for practical clinical applicati

关键词： Lung cancer detection dual-model deep learning technique data augmentation CNN YOLOv8

Present status and future directions:Apexification

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World Journal of Methodology 2025年第1期15卷 26-32页

作者： Sachin Chauhan Radha Chauhan Prashant Bhasin Bhavna g Sharaf Department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia Department of Prosthodontics and Crown and Bridge and Oral Implantology Mahatma Gandhi Dental College&HospitalJaipur 302022RajasthanIndia Department of Pedodontics and Preventive Dentistry Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia

The success rate of apexification is primarily determined by multiple factors,including the material used,the size of the open apex compared to the length of the root,and the technique used in each *** main objective of this review was to provide an update on the present management of open apex to identify factors and circumstances that may influence the success of apexification using different materials and *** research on apexification should focus on how to treat open apices with wide periapical lesions without ***,the predictability of these parameters with non-surgical procedures was uncertain,but now,with the use of a dental operating microscope,it has become more *** reason could be that extra visits are no longer required due to major advances in the armamentarium and materials used for apexification.

关键词： Bioceramics Magnification Biodentine Mineral trioxide aggregate Apexification Open apex

Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan K Tirpack Danyaal g Buttar Mandeep Kaur Department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States Department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia Magnetic resonance imaging Biomarkers Neurotransmitters Psychiatric disorders

Radioactivity and mineralogy of the altered granites of the Wadi ghadir shear zone, South Eastern Desert, Egypt

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Chinese Journal Of geochemistry 2012年第1期31卷 30-40页

作者： mohamed F.Raslan mohamed g.El-Feky Nuclear Materials Authority El Maadi P.O.Box 530CairoEgypt

Quartz-diorite, gneissose granodiorites, two-mica granite and perthite leucogranie are the main rock units cropping out in the Wadi ghadir area, South Eastern Desert of Egypt. Along the NNE-SSW mega-faults, a broad brittle shear zone is developed in the ghadir two-mica granite. Brittle deformation is manifested by severe myloniti-zation and alteration of these granites. These sheared altered granites are characterized by the presence of radioactive mineralization, associated with alteration features such as silicification, hematization and kaolinitization. Radioelement measurements revealed that the unaltered and altered two-mica granites are considered as uraniferous granites. The average uranium and thorium contents in the unaltered two-mica granites are 12.29×10-6 and 19.81×10-6, respectively, and the average Th/U ratio is 1.62. The altered granites exhibit higher concentrations of U (averaging 97.949), but have lower Th and Th/U ratios (13.83 and 0.16, respectively), which indicates uranium enrichment in the granites. Binary relations of eTh/eU against either eU or eTh and eU with eTh in the studied gran-ites suggest that the distribution of radioactive elements not only magmatic (positive correlation between eU and eTh), but also due to hydrothermal redistribution of radioelements (weak correlation between eU and eTh/eU). The magmatic U and Th are indicated by the presence of uraninite, thorite, zircon and monazite whereas the evidence of hydrothermal mineralization is the alteration of rock-forming minerals such as feldspar and the forma-tion of secondary minerals such as uranophane and pyrite. Microscopic, XRD and scanning electron microscopic studies revealed the presence of uraninite, uranophane, thorite, Ce-monazite and zircon, in addition to phlogopite-fluor mica in the studied altered granites of the Wadi ghadir shear zone.

关键词：二云母花岗岩放射性元素脆性剪切带蚀变特征矿物学沙漠埃及扫描电子显微镜