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Prevalence and Correlates of Obesity and Overweight in Tunisian Bipolar I Patients

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Neuroscience & Medicine 2013年第3期4卷 181-187页

作者： Asma Ezzaher Anwar Mechri Dhouha Haj Mouhamed Wahiba Douki Lotfi Gaha mohamed fadhel najjar Biochemistry and Toxicology Laboratory Monastir University Hospital Monastir Tunisia Research Laboratory “Vulnerability to Psychotic Disorders LR 05 ES 10” Department of Psychiatry Monastir University Hospital Monastir Tunisia.

Objective: We aim to determine the prevalence of obesity and overweight in bipolar I patients, and to examine their associations with the demographic, clinical and therapeutic characteristics of this population. Patients and Methods: Our study included 120 bipolar I patients (79 men and 41 women, mean age = 39.5 ± 11.9 years). Weight and height were evaluated by body mass index (BMI). Obesity was defined when BMI ≥ 30 kg/m2 and overweight when BMI ≥ 25 kg/m2. Results: The prevalence of obesity and overweight was respectively 32.5% and 30.8%. Obesity was significantly more frequent in women than men. The illness duration was significantly longer in obese patients than in those with normal weight. Moreover, the family history of medical disorders and concomitant medical disorders was significantly more frequent in obese patients than in those with normal weight. However, any significant association between therapeutic characteristics and obesity or overweight was found. Conclusions: Obesity and overweight were frequent in bipolar I patients. Obesity was significantly frequent in women and significantly associated with illness duration, medical disorders, and concomitant medical disorders. These results emphasized the need for specific treatment strategies and programs for weight control for these patients.

关键词： Bipolar I Disorder Obesity Overweight

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

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Journal of Coastal Life Medicine 2017年第12期5卷 540-546页

作者： Sana Chakroun Intissar Grissa Lobna Ezzi Oumaima Ammar Fadoua Neffati Emna Kerkeni mohamed fadhel najjar Zohra Haouas Hassen Ben Cheikh Laboratory of Histology and Cytogenetic(Research Unit of Genetic Genotoxicity and Childhood Illness UR12ES10)Faculty of MedicineUniversity of MonastirStreet AvicenneMonastir 5019Tunisia Laboratory of Biochemistry and Toxicology Fattouma Bourguiba UniversityHospital of MonastirMonastirTunisia

Objective: To investigate the potential adverse effects of imidacloprid on biochemical parameters, oxidative stress and liver damage induced in the rat by oral sub-chronic imidaclopride exposure. Methods: Rats received three different doses of imidacloprid (1/45, 1/22 and 1/10 of LD50) given through gavage for 60 days. Two dozen of male Wistar rats were randomly divided into four experimental groups. Liver damage was determined by measuring aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase leakages. The prooxidant-antioxydant status in hepatic tissue homogenate was evaluated by measuring the degree of lipid peroxidation, the antioxidant enzymes activities such as catalase, superoxide dismutase and glutathione peroxidase (GPx). Results: The relative liver weight was significantly higher than that of control and other treated groups at the highest dose 1/10 of LD50 of imidacloprid. Additionally, treatment of rats with imidacloprid significantly increased liver lipid peroxidation (P ≤ 0.05 or 0.01) which went together with a significant decrease in the levels of superoxide dismutase and catalase activities. Parallel to these changes, imidacloprid treatment enhanced liver damage as evidence by sharp increase in the liver enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase. These results were also confirmed by histopathology. Conclusions: In light of the available data, it is our thought that after imidacloprid sub-chronic exposure, depletion of antioxidant enzymes is accompanied by induction of potential oxidative stress in the hepatic tissues that might affect the function of the liver which caused biochemical and histopathological alteration.

关键词： Imidacloprid Biochemical parameters Hepatotoxicity Oxidative stress Neonicotinoids

A Genetic Algorithm to Minimize the Makespan in a Two-Machine Cross-Docking Flow Shop Problem

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Journal of the Operations Research Society of China 2020年第3期8卷 457-476页

作者： Imen Hamdi mohamed fadhel Tekaya High Institute of Transport and Logistics University of SousseSousseTunisia MODILS lab Faculty of Economics and ManagementUniversity of SfaxSfaxTunisia

We consider the problem of two-machine cross-docking flow shop scheduling where each job on the second machine cannot be processed unless a job or a set of jobs have been completed on the first *** aim is to find a feasible schedule that minimizes the *** the problem is shown to be strongly NP-hard,we propose a genetic algorithm to solve small and large size *** test different types for each genetic operator where new ideas are introduced,which leads to propose six versions of the genetic *** then evaluate their effectiveness through an extensive computational experiments by using many instances generated randomly and by determining the percentage deviation from a lower bound from the literature.

关键词： Cross-docking Flow shop Scheduling Makespan Genetic algorithm

Comparison of Mineral Contents in Three Different Tobacco Formulations

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Biomedical and Environmental Sciences 2017年第1期30卷 52-58页

作者： HOUAS Ikram TEYEB Hassen Arancha ROCHINA-MARCO DOUKI Wahiba najjar mohamed fadhel GAHA Lotfi CERVERA MariaLuisa DE LA GUARDIA Miguel Research Laboratory 'Vulnerability to Psychotic Disorders LR 05 ES 10' Department of Psychiatry Faculty of Medicine University of Monastir Monastir 5000 Tunisia Biochemistry and Toxicology Laboratory Monastir University Hospital Monastir 5000 Tunisia Department of Analytical Chemistry University of Valencia Burjassot 46100 Spain

We identified and quantified a variety of mineral elements in 18 tobacco samples purchased from a Tunisian market. In total, 25 mineral elements have been measured in cigarettes, water pipe tobacco, and smokeless tobacco using inductively coupled plasma-optical emission spectroscopy following microwave-assisted digestion. Statistical analyses were performed using SPSSTM, version 18.0. The lowest concentrations of all studied elements were observed in water pipe tobacco. Significantly higher concentrations of Al, Fe, Mg, Na, Ca, Cr, and Co were found in smokeless tobacco, while cigarettes brands contained the highest concentrations of K, Mn, Ni, Ba, and Sr. There was no significant difference between the mineral contents of local and foreign cigarettes and conventional and light cigarettes. Our findings demonstrated that local smokeless tobacco appears to be the most hazardous tobacco type. The concentration of minerals in light cigarettes was not significantly different from the concentration in conventional cigarettes.

关键词： Comparison of Mineral Contents in Three Different Tobacco Formulations

Are biopsies during endoscopic ultrasonography necessary for a suspected esophageal leiomyoma?Is laparoscopy always feasible?

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World Journal of Clinical Cases 2023年第9期11卷 2116-2118页

作者： Hazem Beji mohamed fadhel Chtourou Slim Zribi Yassine Kallel Mahdi Bouassida Hassen Touinsi Department of General Surgery Hospital mohamed Taher Maamouri Nabeul University of Tunis El Manar-Faculty of Medicine of TunisNabeul 8000Tunisia

The present letter to the editor is related to the work entitled“Large leiomyoma of lower esophagus diagnosed by endoscopic ultrasonography-fine needle aspiration:A case report.”Although endoscopic ultrasonography seems necessary in a suspected leiomyoma of the esophagus,the performance of biopsies via fine needle aspiration is controversial as it increases the risk of complications such as bleeding,infection,and intraoperative *** is the best treatment strategy for small *** with tumor enucleation or esophageal resection can be considered in large leiomyomas.

关键词： Esophageal Leiomyoma Endoscopic ultrasonography Biopsy Surgical resection

Characterization of the Dominant Bacterial Communities Associated with Terrestrial Isopod Species Based on 16S rDNA Analysis by PCR-DGGE

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Open Journal of Ecology 2018年第9期8卷 495-509页

作者： Delhoumi Majed Zaabar Wahiba Bouslama mohamed fadhel Achouri mohamed Sghaier Laboratory of Bio-Ecology and Evolutionary Systematics Department of Biology Faculty of Sciences of Tunis University of Tunis El Manar Tunis Tunisia

From the marine environment, woodlice gradually colonized terrestrial areas benefiting from the symbiotic relationship with the bacterial community that they host. Indeed, they constitute the only group of Oniscidea suborder that has succeed to accomplish their lives in terrestrial even desert surfaces. Herein they play an important role in the dynamic of ecosystems and the decomposition of litter. So to enhance our understanding of the sea-land transition and other process like decomposition and digestion of detritus, we studied the bacterial community associated with 11 specimens of terrestrial isopods belonging to six species using a Culture independent approach (DGGE). Bands sequencing showed that the cosmopolitan species Porcellionides pruinosus has the most microbial diversity. Screening demonstrated the predominance of Proteobacteria followed by members from Actinobacteria, Firmicutes and Cyanobacteria phyla. In fact we detected some symbionts like Wolbachia, Mycoplasma and Spiroplasma for the first time in a terrestrial isopod species.

关键词： Microbial Community PCR-DGGE Terrestrial Isopod Symbiont

An unusual cause of gastric outlet obstruction in a young girl: Trichobezoar

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Open Journal of Gastroenterology 2012年第4期2卷 206-208页

作者： Mahdi Bouassida Hédi Charrada mohamed fadhel Chtourou Lamine Hamzaoui mohamed Monji Mighri mohamed Msaddak Azzouz Hassen Touinsi Sadok Sassi Department of Gastrology Mohamed Tahar Maamouri Hospital Nabeul Tunisia Department of Reanimation Mohamed Tahar Maamouri Hospital Nabeul Tunisia Department of Surgery Mohamed Tahar Maamouri Hospital Nabeul Tunisia

Trichobezoars are an infrequent form of bezoars formed from ingested hair. They are more common in adolescent females with history of trichotillomania. Exceptionally, it can occur in young children making the diagnosis difficult. We report the case of a 6-year-old girl with a history of abdominal pain, distension, weight loss, and attacks of vomiting. Upper gastrointestinal endoscopy revealed a trichobezoar occupying almost the whole gastric cavity. The gastric bezoar was removed by surgery. Gastric trichobezoar is exceptional in young children and can lead to stunting and gastric outlet obstruction. After definitive surgical or endoscopic treatment, pediatric psychiatric consultation should be opted for any mental disorder and for prevention of further recurrence.

关键词： Trichobezoar Young Children Gastric Outlet Obstruction Trichotillomania

An unusual cause of gastric outlet obstruction in a young girl: Trichobezoar

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