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Hepatoprotective effect of Opuntia dillenii seed oil on CCl_4 induced acute liver damage in rat

Asian Pacific Journal of Tropical Biomedicine 2018年第5期8卷 254-260页

作者： mohamed Bouhrim Hayat Ouassou mohamed Choukri Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz mohamed bnouham Laboratory of Physiology Genetics and EthnopharmacologyDepartment of BiologyFaculty of SciencesUniversity Mohamed Ist Faculty of Medicine and Pharmacy Biochemistry Laboratory Central Laboratory Service-CHU

Objective:To investigate the hepatoprotective effect of Opuntia dillenii seed oil(ODSO)on CCl_4 provoked liver injury in ***:Animals were treated orally with ODSO at a concentration of 2 mL/kg,once daily for one week before the first intraperitoneal injection of CCl_4,and thereafter the administration of the oil was continued for 7 days until the introduction of the second injection of CCl_*** hours after the last dose of CCl_4,rats were sacrificed,and the relative liver weight,weight gain,alkaline phosphatase,aspartate amino transferase,alanine aminotransferase,direct bilirubin,total bilirubin,triglycerides,total cholesterol,very low density lipoprotein,low density lipoprotein,high density lipoprotein,plasmatic glucose,urea,creatinine,acid uric and malondialdehyde were ***:The significant increase was found in relative liver weight and plasma levels of alanine aminotransferase,aspartate amino transferase,alkaline phosphatase,total bilirubin,direct bilirubin,triglycerides,very low-density lipoprotein,urea,uric acid and ***,the significant decrease was indicated in the weight gain and the level of glucose plasmatic,and high-density lipoprotein levels in CCl_4 produced liver injury in rats were re-established to normal levels when treated with ***,no change was observed in the total cholesterol,low-density lipoprotein and creatinine in all ***:We conclude that the ODSO has a protective effect on CCl_4-mediated liver ***,we suggest its inclusion as a preventive control of liver disorders.

关键词： Opuntia dillenii seed oil Hepatotoxicity Carbon tetrachloride Biochemical parameters

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Evaluation of protective effect of cactus pear seed oil(Opuntia ficusincida L. MILL.) against alloxan-induced diabetes in mice

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 530-535页

作者： Berraaouan Ali Ziyyat Abderrahim Mekhfi Hassane Legssyer Abdelkhaleq Aziz Mohammed bnouham mohamed Laboratory of Physiology and Ethnopharmacology-URAC40 Mohammed First UniversityFaculty of Sciences

Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro antioxidant effect of CPSO was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. The preventive effect was conducted on Swiss albino mice treated with CPSO(2 m L/kg, per os), before and after a single intraperitoneal alloxan administration(100 mg/kg). Survival rate, body weight and fasting blood glucose were measured and histopathological analysis of pancreas was performed to evaluate alloxaninduced tissue injuries. Results: CPSO exhibited an antioxidant effect in DPPH scavenging assay. Moreover, the administration of CPSO(2 m L/kg) significantly attenuated alloxaninduced death and hyperglycemia(P<0.001) in treated mice. Morphometric study of pancreas revealed that CPSO significantly protected islets of langerhans against alloxan induced-tissue alterations. Conclusions: Based on theses results, CPSO can prevent alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells.

关键词： Antioxidant effect Alloxan prevention Cactus pear seed oil Diabetes mellitus Opuntia ficus-indica Oxidative stress

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Antidiabetic effect of Opuntia dillenii seed oil on streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2019年第9期9卷 381-388页

作者： mohamed Bouhrim Hayat Ouassou El Hassania Loukili Mohammed Ramdani Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz mohamed bnouham Faculty of Sciences University Mohamed first

Objective: To assess the antidiabetic effect of Opuntia dillenii seed oil on rats with diabetes mellitus. Methods: A rat diabetes model was established by intraperitoneal injection of rats with 50 mg/kg streptozotocin. Thirty albino Wistar rats were divided into five groups: the diabetic control group and normal control group were treated only with distilled water, two diabetic groups received 1 and 2 m L/kg of oil per day, respectively, for 30 days and one diabetic group received 2 mg/kg of glibenclamide. In addition, blood glucose was determined weekly. Body weight, average daily food, water intake and urinary volume of each animal were determined before and after the treatment period. After the treatment period, hepatic glycogen was determined using the anthrone reagent, and glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid were estimated using common clinical diagnostic kits. Results: Oral intake of the oil at 1 and 2 m L/kg for the diabetic animals significantly diminished blood glucose, glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid, accompanied by a noticeable elevation in the amount of hepatic glycogen in comparison with the diabetic control group. Similarly, Opuntia dillenii seed oil significantly increased the food intake and decreased the urinary volume per day in treated rats of the same groups in comparison with the period before the treatment intervention and attenuated body weight loss in the diabetic rats. Moreover, this effect of the oil was dose dependent. On the other hand, the oil did not affect their need for water. Conclusions: The results show that Opuntia dillenii seed oil has a very important antidiabetic effect on streptozotocin-induced diabetic rats. Hence, we suggest it as a preventive control of diabetes mellitus.

关键词： Opuntia dillenii seeds oil Streptozotocin Diabetes Rats Biochemical parameters

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Risk Factors and Diabetes Related Complications Frequency in the Population of the Northeastern Morocco

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Open Journal of Epidemiology 2018年第3期8卷 164-185页

作者： Jamila Hammoudi Hassana Dahmani Nourel Houda Bouanani Hamid Nouayti Hassane Mekhfi Abdelkhaleq Legssyer mohamed bnouham Abderrahim Ziyyat Laboratoire de Physiologie Génétique et Ethnopharmacologie Faculté des Sciences Université Mohammed 1<sup>er</sup> Oujda Morocco Centre de Référence de Diabétologie et des Maladies Chroniques Oujda Morocco

Objectives: Diabetes is one of the most challenging health problems in the 21st century that brings a considerable economic burden on worldwide healthcare resources. Indeed, people with diabetes have a higher lifetime healthcare expenditure due to the long-term complications, which include micro and macrovascular complications. This study sought to estimate the frequency of diabetes complications, and to investigate the associated risk factors. Methodology: Data were obtained from the medical records of 2401 diabetic patients followed at the Reference Center of Diabetes and Chronic Diseases (RCD) in Oujda (Morocco) during the period 2006-2011. Results: Our sample of 2401 diabetic patients include 64.7% women. 32% of patients have one or more complications;retinopathy is the most frequent complication (16.8%), followed by nephropathy (12.4%), cardiovascular diseases (5.4%), neuropathy (3.6%) and diabetes foot (2%). Logistic regression in univariate followed by multivariate analysis has showed that age, duration of diabetes and high albuminuria are the major risk factors for the development of diabetic complications in both type 1 and type 2 diabetes. Conclusions: Nearly one third of diabetic patients were affected by at least one diabetic complication;retinopathy is the most common complication in these patients. Strengthening programs to improve diabetes management and to reduce the risk of these complications should be a high priority in order to control the cost of treatment.

关键词： Diabetic Complications Retinopathy Nephropathy North-Eastern Morocco Risk Factors

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