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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli ali mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Anti-wear properties evaluation of frictional sliding interfaces in automobile engines lubricated by copper/graphene nanolubricants

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Friction 2020年第5期8卷 905-916页

作者： mohamed Kamal Ahmed ali Xianjun HOU mohamed AAABDELKAREEM Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Automotive and Tractors Engineering Department Faculty of EngineeringMinia UniversityEl-Minia 61111Egypt Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China

Owing to the significance of improving fuel economy, reducing emissions, and extending the durability of engine components, this study focused on the tribological performance of nano-additives. In this study, copper (Cu) and graphene (Gr) nanomaterials were dispersed in a fully formulated engine oil (5W-30) with different concentrations. The tribological trials were investigated under various speeds and loads, utilizing a reciprocating tribometer to mimic the ring/liner interfaces in the engine. The frictional surface morphologies were com-prehensively analyzed using electron probe X-ray microanalysis (EPMA), field emission scanning electron microscopy (FESEM), energy dispersive spectrometer (EDS), and three dimensional (3D) surface profilometry to explore the mechanisms responsible for improving the tribological performance of the frictional sliding parts in the engine. The tribological test results illustrated that lubrication by nano-additives reduced the wear rate (WR) and friction coefficient (COF) by 25%–30% and 26.5%–32.6%, respectively, as compared with 5W-30. The results showed that this is a promising approach for increasing the durability and lifespan of frictional sliding components and fuel economy in automobile engines.

关键词： engine tribology nanomaterial nanolubricant friction wear tribofilm

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Machine learning-based seismic assessment of framed structures with soil-structure interaction

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 205-223页

作者： mohamed NOURELDIN Tabish ali Jinkoo KIM Department of Global Smart City Sungkyunkwan UniversitySuwon 16419Korea

The objective of the current study is to propose an expert system framework based on a supervised machine learning technique(MLT)to predict the seismic performance of low-to mid-rise frame structures considering soil-structure interaction(SSI).The methodology of the framework is based on examining different MLTs to obtain the highest possible accuracy for *** the MLT,a sensitivity analysis was conducted on the main SSI parameters to select the most effective input *** limit state criteria were used for the seismic evaluation within the process.A new global seismic assessment ratio was introduced that considers both serviceability and strength aspects by utilizing three different engineering demand parameters(EDPs).The proposed framework is novel because it enables the designer to seismically assess the structure,while simultaneously considering different EDPs and multiple limit ***,the framework provides recommendations for building component design based on the newly introduced global seismic assessment ratio,which considers different levels of seismic *** proposed framework was validated through comparison using non-linear time history(NLTH)*** results show that the proposed framework provides more accurate results than conventional ***,the generalization potential of the proposed framework was tested by investigating two different types of structural irregularities,namely,stiffness and mass *** results from the framework were in good agreement with the NLTH analysis results for the selected case studies,and peak ground acceleration(PGA)was found to be the most influential input parameter in the assessment process for the case study models *** proposed framework shows high generalization potential for low-to mid-rise structures.

关键词： seismic hazard artificial neural network soil-structure interaction seismic analysis

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Robust Output Practical Stability of Time-Varying Nonlinear Control Systems via Indefinite Lyapunov Functions

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Journal of Systems Science & Complexity 2024年第6期37卷 2595-2613页

作者： DAMAK Hanen ABOTHHER Amal HAMMAMI mohamed ali Department of Mathematics University of SfacPreparatory Engineering Institute of SfaxSfax 3047Tunisia Department of Mathematics University of ZawiaFaculty of education Abu EssaZawia 16418Libya Department of Mathematics University of SfacFaculty of Sciences of SfaxSfax 3047Tunisia

This paper focuses on studying the problem of robust output practical stability of timevarying nonlinear control systems. The main innovation lies in the fact that the proposed approach for stability analysis allows for the computation of bounds that characterize the asymptotic convergence of solutions to a small ball centered at the origin using a Lyapunov method with a definite *** different conditions on the perturbation, the authors demonstrate that the system can be globally robustly asymptotically output stable by designing a candidate feedback controller. Finally, three examples are given to illustrate the practical implications and significance of the theoretical results.

关键词： Control theory global robust practical asymptotic output stability(GRPAOS) Lyapunov method time-varying control systems

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A Multi-Level Selective Maintenance Strategy Combined to Data Mining Approach for Multi-Component System Subject to Propagated Failures

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Journal of Systems Science and Systems Engineering 2022年第3期31卷 313-337页

作者： mohamed ali Kammoun Zied Hajej Nidhal Rezg Universite de Lorraine LGIPMF-57000 MetzFrance Ecole poly technique du Groupe Honoris United Universities-Tunisia

In several industrial fields like air transport,energy industry and military domain,maintenance actions are carried out during downtimes in order to maintain the reliability and availability of production *** such a circumstance,selective maintenance strategy is considered the reliable solution for selecting the faulty components to achieve the next mission without *** this paper,a novel multi-level decision making approach based on data mining techniques is investigated to determine an optimal selective maintenance *** the first-level,the age acceleration factor and its impact on the component nominal age are used to establish the local *** first decision making employed K-means clustering algorithm that exploited the historical maintenance *** on the first-level intervention plan,the remaining-levels identify the stochastic dependence among components by relying upon Apriori association rules algorithm,which allows to discover of the failure occurrence *** addition,at each decision making level,an optimization model combined to a set of exclusion rules are called to supply the optimal selective maintenance plan within a reasonable time,minimizing the total maintenance cost under a required reliability *** illustrate the robustness of the proposed strategy,numerical examples and a FMS real study case have been solved.

关键词： Selective maintenance stochastic dependence age acceleration factor data mining flexible manufacturing system

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Thermal degradation of diethanolamine at stripper condition for CO2 capture: Product types and reaction mechanisms

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Chinese Journal of Chemical Engineering 2019年第12期27卷 2900-2908页

作者： Idris mohamed Saeed Brahim Si ali badrul mohamed Jan Wan Jefrey Basirun Shaukat ali Mazari Ibrahim ali Obid Birima Department of Chemistry Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Department of Chemical Engineering Faculty of EngineeringDawood University of Engineering and TechnologyMA Jinnah RoadKarachi 74800Pakistan

Amine-based absorption/stripping is one of the promising technology for CO2 capture from natural and industrial gas *** the process,amines and CO2 undergo irreversible reactions to produce undesired compounds,which cause corrosion,foaming,increased viscosity and breakdown of equipment,ultimately contributing to the economic loss and environmental *** this study,the thermal degradation of aqueous diethanolamine in the presence and absence of dissolved CO2 was *** experiments were performed in stainless steel *** results show that thermal degradation in the absence of CO2 was a slow process;triethanolamine,and tris(2-aminoethyl)amine were only the degradation products identified in the mixture In addition,the rate of degradation was very low,only 3%degradation was observed after 4 *** in the presence of CO2,sixteen degradation products were identified,nine of which were new degradation products reported for the first time in this *** 3-(2-hydroxyethyl)-2-oxazolidinone,1,4-bis(2-hydroxyethyl)piperazine and triethanolamine were the most abundant degradation *** remaining DEA concentration after 4 weeks was about 20%of the total amine *** most probable degradation reactions and their mechanisms are also proposed.

关键词： Diethanolamine CO2 capture Degradation Mechanism

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Exploration of structural,optical,and photoluminescent properties of (1-x)NiCo_(2)O_(4)/xPbS nanocomposites for optoelectronic applications

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Chinese Physics B 2022年第6期31卷 663-670页

作者： Zein K Heiba mohamed Bakr mohamed Noura M Farag ali badawi Physics Department Faculty of ScienceAin Shams UniversityCairoEgypt Physics Department Faculty of ScienceTaibah UniversityAl-Madina al MunawarahSaudi Arabia Department of Physics College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Physics University College of TurabahTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

The(1-x)NiCo_(2)O_(4)/x PbS(0≤x≤0.2)nanocomposite samples are synthesized using the hydrothermal and thermolysis *** different phases developed in the obtained nanocomposite samples are accurately determined using the x-ray diffraction technique equipped with a *** percentage of the formed phases(NiCo_(2)O_(4)(NCO),PbS,PbSO_(4)),structural and microstructure parameters are determined using Rietveld quantitative phase *** transmission electron microscope(TEM)images and Rietveld analysis reveal almost isotropic particle size in the nano range with a very narrow size *** obtained phase percentage of PbS and PbSO4are smaller than nominated values(x)suggesting dissolving of some Pb and S ions into NCO which is then confirmed by the analysis of Fourier-transform infrared(FTIR)spectra of nanocomposite *** absorption spectra are modified upon doping NCO with *** optical band gaps of the nanocomposites increase as the amount of PbS *** effect of alloying on extinction coefficient,refractive index,dielectric constant,optical conductivity,the intensity,and emitted color from the photoluminescence of the nanocomposite samples are also *** refractive index value of NCO and NCO-PbS nanocomposite samples exhibit normal *** photoluminescent measurements reveal that the NCO-PbS nanocomposites can emit a violet *** improvement in the values of the nonlinear optical(NLO)parameters of pristine NCO at high frequencies or the nanocomposite samples at low frequencies,are made them used in NLO photonic devices.

关键词： Co_(2)O_(4)and PbS nanocomposite FTIR optical photoluminescence

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ON A SECOND ORDER DISSIPATIVE ODE IN HILBERT SPACE WITH AN INTEGRABLE SOURCE TERM

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Acta Mathematica Scientia 2012年第1期32卷 155-163页

作者： Alain Haraux mohamed ali Jendoubi UPMC Univ Paris 06 UMR 7598Laboratoire Jacques-Louis Lions CNRS UMR 7598Laboratoire Jacques-Louis Lions Facult des Sciences de Bizerte Dpartement de Mathmatiques

Asymptotic behaviour of solutions is studied for some second order equations including the model casex（t）＋γx（t）＋ ↓△φb（x（t）） = h（t） with γ 〉 0 and h ∈ L1（O, ＋∞; H）, φ being continuouly differentiable with locally Lipschitz continuous gradient and bounded from below. In particular when φ is convex, all solutions tend to minimize the potential φ as time tends to infinity and the existence of one bounded trajectory implies the weak convergence of all solutions to equilibrium points.

关键词： dissipative dynamical system asymptotic behaviour gradient system heavyball with friction

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Investigation for Uranium Dispersion Adjacent to Cretaceous Phosphatic Outcrops in Al-Nassrieh Basin, Southern Palmyrides, Syria

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Journal of Earth Science 2016年第5期27卷 786-795页

作者： mohamed Al-Hilal Ahmad Al-ali Department of Geology the Atomic Energy Commission of Syria (AECS)

A detailed radiometric survey including soil gas radon measurements and field gammaray survey, in accordance with geochemical and geological investigations were carried out in AlNassrieh Basin（central Syria）, for the purpose of uranium exploration. Thirty-six samples were collected from various lithofacies of the survey area and analyzed by γ-ray spectrometric technique for determining the concentration values of major radioelements. The relationships between the concentrations of equivalent e U, e Th, and their ratios were examined in order to define their trend of variations and evaluate the degree of uranium remobilization and redistribution. Although the initial results indicate that uranium enrichment is mostly restricted to the Upper Cretaceous phosphate rocks, a considerable portion of uranium appeared to be leached out of the primary phosphatic source and dispersed in the adjacent recent sediments. Further, notable increases of radon level associated with relatively high values of uranium concentration and gamma count rates were found to be spatially correlated with the transition zone between the marine Paleogene and continental Neogene formations throughout the study basin. This observation demonstrates the importance of the concerned zone as a suitable geological environment for hosting probable uranium mineralization along a chemically reducing interface where surface water of terrestrial and marine origin mingled at depth and away from surficial conditions.

关键词： radiometric survey geochemistry uranium exploration AI-Nassrieh Basin Syria.

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Linearly and Quadratically Separable Classifiers Using Adaptive Approach

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Journal of Computer Science & Technology 2011年第5期26卷 908-918页

作者： mohamed Abdel-Kawy mohamed ali Soliman Rasha M.Abo-Bakr Department of Computer and Systems Engineering Faculty of EngineeringZagazig UniversityZagazigEgypt Departement of Mathematics Faculty of ScienceZagazig UniversityZagazigEgypt

This paper presents a fast adaptive iterative algorithm to solve linearly separable classification problems in R *** each iteration,a subset of the sampling data （n-points,where n is the number of features） is adaptively chosen and a hyperplane is constructed such that it separates the chosen n-points at a margin and best classifies the remaining *** classification problem is formulated and the details of the algorithm are ***,the algorithm is extended to solving quadratically separable classification *** basic idea is based on mapping the physical space to another larger one where the problem becomes linearly *** illustrations show that few iteration steps are sufficient for convergence when classes are linearly *** nonlinearly separable data,given a specified maximum number of iteration steps,the algorithm returns the best hyperplane that minimizes the number of misclassified points occurring through these *** with other machine learning algorithms on practical and benchmark datasets are also presented,showing the performance of the proposed algorithm.

关键词： linear classification quadratic classification iterative approach adaptive technique

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