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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

Contribution of hydro energy production,economic complexity and technological innovation in achieving an environmentally sustainable Asia

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Geoscience Frontiers 2024年第5期15卷 515-528页

作者： Farah Rana Bilal Hussain Abdelmohsen A.Nassani Ayesha Hussain mohamed Haffar Syed Asif Ali Naqvi Department of Economics Government College UniversityFaisalabadPakistan Government Graduate College Gojra Toba Tek SinghPakistan Department of Management College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh 11587Saudi Arabia Department of Home Economics Government College Women University FaisalabadPakistan Department of Management Birmingham Business SchoolUniversity of BirminghamUnited Kingdom

The impact of hydro energy production,economic complexity,urbanization,technological innovation and financial development on environmental sustainability between 1995 and 2017 is examined for a panel of thirteen Asian economies using two environmental proxies—their ecological footprint and CO_(2)*** non-parametric Driscoll-Kraay standard error method and the Dumitrescu-Hurlin panel causality test are applied to the *** findings show that hydro energy production and technological innovation have a significant negative impact on the environment,thus promoting environmental *** complexity significantly lowers environmental sustainability while the non-linear effect of economic complexity favors environmental sustainability;this confirms the existence of an economic-complexity-based inverted-U-shaped environmental Kuznets curve ***,urbanization and financial development significantly decrease environmental *** results of our study confirm the feedback causality between hydro energy production and carbon dioxide *** recommend expansionary policies regarding hydro energy production that are beneficial for substituting fossil fuel *** paves a path towards environmental sustainability in this era of global boiling.

关键词： Hydro energy production Environmental sustainability Global boiling Economic complexity Asian countries Panel corrected standard error

Multi-Objective Optimization Algorithm for Grouping Decision Variables Based on Extreme Point Pareto Frontier

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Computers, Materials & Continua 2024年第4期79卷 1281-1299页

作者： JunWang Linxi Zhang Hao Zhang Funan Peng Mohammed A.El-Meligy mohamed Sharaf Qiang Fu College of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China Key Laboratory of Intelligent Technology for Chemical Process Industry of Liaoning Province Shenyang University of Chemical TechnologyShenyang110142China Industrial Engineering Department College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

The existing algorithms for solving multi-objective optimization problems fall into three main categories:Decomposition-based,dominance-based,and *** multi-objective optimization problemsmainly focus on objectives,treating decision variables as a total variable to solve the problem without consideringthe critical role of decision variables in objective *** seen,a variety of decision variable groupingalgorithms have been ***,these algorithms are relatively broad for the changes of most decisionvariables in the evolution process and are time-consuming in the process of finding the Pareto *** solvethese problems,a multi-objective optimization algorithm for grouping decision variables based on extreme pointPareto frontier(MOEA-DV/EPF)is *** algorithm adopts a preprocessing rule to solve the Paretooptimal solution set of extreme points generated by simultaneous evolution in various target directions,obtainsthe basic Pareto front surface to determine the convergence effect,and analyzes the convergence and distributioneffects of decision *** the later stages of algorithm optimization,different mutation strategies are adoptedaccording to the nature of the decision variables to speed up the rate of evolution to obtain excellent individuals,thusenhancing the performance of the *** validation of the test functions shows that this algorithmcan solve the multi-objective optimization problem more efficiently.

关键词： Multi-objective evolutionary optimization algorithm decision variables grouping extreme point pareto frontier

Effect of lanthanide contraction on a series of "sulfate-templated" transition-rare-earth metal clusters:Synthesis,structures and magnetic properties

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Journal of Rare Earths 2024年第11期42卷 2150-2155页

作者： Kaipeng Bai Pengfei Sun mohamed Saber Lassoued Caihong Fan Chang Huang Yanzhen Zheng Weipeng Chen Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentXi'an Key Laboratory of Electronic Devices and Materials ChemistrySchool of ChemistryXi'an Jiaotong University Instrument Analysis Center of Xi'an Jiaotong University

Twelve novel transition-rare-earth metal clusters,formulated as [Ni18Pr14（μ3OH）14（dmpa）10（mmt）10（SO4）4（CH3COO）16]·9CH3OH·5H2O（1,H3dmpa=dimethylolpropionic acid,and Hmmt=2-me rcapto-5-methyl-1,3,4-thiadiazole） [Ni36RE102（OH）138（mmt）18（Hdmpa）30（H2dmpa）12（CH3COO）72（NO3）36（SO4）18（H2O）30]·Br6(RE=Nd（2）,Sm（3）,Eu（4） and Gd（5）)[Ni12RE10（μ3-OH）10（dmpa）8（mmt）8(S（4）2（CH3COO）8（H2O）4]·8CH3OH·7H2O(RE = Tb（6）,Dy（7）,Ho（8）,Er（9） and Y（10）) [Ni8Pr8（μ3-OH）8（mmt）8（Hdpga）16（CH3COO）8]·8CH3OH（11,H2dpga=diphe nyl-glycolic acid）,and [Ni16Tb6（μ3-OH）24（mmt）8（Hdpga）4（dpga）4（CH3COO）2（NO3）4（H2O）2]·12CH3OH·5H2O（12）,were synthesized solvothermally by using different ligand combinations and rare earth nitrates.X-ray crystal structure analyses reveal that complexes 1 and 12 possess sandwich-like *** 2-5 are isostructural and feature a hexagonal structure,shaped like a "Star of David".Isostructural 6-10 present ring-like structure,as well as the cluster *** structural variations of these complexes can be attributed to the effect of lanthanide ***,the template effect of SO42-anion derived from the slow decomposition of Hmmt ligand also plays a significant role in the formation of cluster *** insitu mechanism for the generation of sulfate anion is briefly ***,the magnetic properties of complexes 2-11 were studied which show typical antiferromagnetic interactions.

关键词： Rare earths Transition-rare-earth metal clusters Mixed-ligand strategy Sulfate-templated Lanthanide contraction Exchange coupling

Effect of stress-dependent microannulus aperture on well leakage

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1967-1976页

作者： Meng Meng Luke P.Frash J.William Carey mohamed Mehana Wenfeng Li Bailian Chen Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNMUSA

Debonding at the cement-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in *** detachment gives rise to a microannulus,which notably possesses greater permeability than undamaged cement,undermining its sealing ***,the permeability of the microannulus is regarded as a uniform value throughout the ***,fundamentally,a microannulus is one type of fracture,and its gap or aperture size is affected by the effective *** this work,we developed a unique experimental *** equipment facilitates the curing of cement inside a steel casing,the formation of a microannulus between the casing and the cement,and the investigation of the fluid flow dynamics along the microannulus under laboratory-replicated in situ *** microannulus was formed by injecting fluid from one end of the setup,and receiving similar amount of fluid on the other end signified the development of the leakage ***,strain gauges affixed to the casing’s external surface yielded key information on the microannulus’s opening and *** observed a noticeable decline in microannulus hydraulic aperture(or permeability)in relation to effective stress and an exponential equation fits their *** findings also indicate a distinct behavior when comparing liquid CO_(2) with ***,it is easier for liquid CO_(2) to create the ***,the hydraulic aperture range for this microannulus(0.7-6 mm)is considerably smaller than that created by water flow(2-17 mm).Finally,we integrated the stressdependent microannulus aperture size into the combined analysis of well mechanical integrity and well *** outcomes consistently demonstrated that when factoring in the stress-dependent aperture sizes,the leakage rates are 3e5 times compared to a fixed aperture *** traditional assumption of a constant aperture significantly underestimates fluid leakage risks.

关键词： Microannulus Leakage assessment Aperture size Triaxial experiment Carbon sequestration

Chemical-assisted MMP reduction on methane-oil systems:Implications for natural gas injection to enhanced oil recovery

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Petroleum 2024年第1期10卷 101-108页

作者： mohamed Almobarak Matthew B.Myers Colin D.Wood Yongbing Liu Ali Saeedi Quan Xie Discipline of Petroleum Engineering WA School of Mines:MineralsEnergy and Chemical EngineeringCurtin UniversityWestern AustraliaAustralia Commonwealth Scientific and Industrial Research Organization Kensington6151Australia Curtin University Oil and Gas Innovation Centre Management Kensington6151Australia State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation No.8 Xindu AvenueXindu DistrictChengdu 610500PR China

***,the main challenge in this process is the high minimum miscibility pressure(MMP)between natural gas and crude oil,which limits its application and recovery factor,especially in hightemperature ***,we present a novel investigation to quantify the effect of chemicalassisted MMP reduction on the oil recovery ***,we measured the interfacial tension(IFT)of the methane-oil system in the presence of chemical or CO_(2) to calculate the MMP reduction at a constant temperature(373K)using the vanishing interfacial tension(VIT)***,we performed three coreflooding experiments to quantify the effect of MMP reduction on the oil recovery factor under different injection *** interfacial tension measurements show that adding a small fraction(1.5 wt%)of the tested surfactant(SOLOTERRA ME-6)achieved 9%of MMP reduction,while adding 20 wt%of CO_(2) to the methane yields 13%of MMP ***,the coreflooding results highlight the significance of achieving miscibility during gas injection,as the ultimate recovery factor increased from 65.5%under immiscible conditions to 77.2%using chemical-assisted methane,and to 79%using gas mixture after achieving near miscible *** results demonstrate the promising potential of the MMP reduction to signifi-cantly increase the oil recovery factor during gas ***,these results will likely expand the application envelop of the miscible gas injection,in addition to the environmental benefits of utilizing the produced gas by re-injection/recycling instead of flaring which contributes to reducing the greenhouse gas emissions.

关键词： Gas injection Enhanced oil recovery Miscibility Coreflooding

Investigating and predicting the role of photovoltaic, wind, and hydrogen energies in sustainable global energy evolution

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Global Energy Interconnection 2024年第4期7卷 429-445页

作者： Mahmood Swadi Dheyaa Jasim Kadhim mohamed Salem Firas Mohammed Tuaimah Ammar Sabri Majeed Ali Jawad Alrubaie Department of Electrical Engineering College of EngineeringUniversity of BaghdadBaghdad 10001Iraq Libyan Authority for Scientific Research Tripoli 80045Libya School of Electrical and Electronic Engineering Universiti Sains Malaysia(USM)Nibong Tebal 14300PenangMalaysia Continuing Education Center University of BaghdadBaghdad 10001Iraq Al-Furat Al-Awsat Technical University AL-Mussaib Technical CollegeBabylonIraq

The global shift toward next-generation energy systems is propelled by the urgent need to combat climate change and the dwindling supply of fossil *** review explores the intricate challenges and opportunities for transitioning to sustainable renewable energy sources such as solar,wind,and *** transition economically challenges traditional energy sectors while fostering new industries,promoting job growth,and sustainable economic *** transition to renewable energy demands social equity,ensuring universal access to affordable energy,and considering community *** environmental benefits include a significant reduction in greenhouse gas emissions and a lesser ecological *** study highlights the rapid growth of the global wind power market,which is projected to increase from$112.23 billion in 2022 to$278.43 billion by 2030,with a compound annual growth rate of 13.67%.In addition,the demand for hydrogen is expected to increase,significantly impacting the market with potential cost reductions and making it a critical renewable energy source owing to its affordability and zero *** 2028,renewables are predicted to account for 42%of global electricity generation,with significant contributions from wind and solar photovoltaic(PV)technology,particularly in China,the European Union,the United States,and *** developments signify a global commitment to diversifying energy sources,reducing emissions,and moving toward cleaner and more sustainable energy *** review offers stakeholders the insights required to smoothly transition to sustainable energy,setting the stage for a resilient future.

关键词： Next energy Renewable energy Sustainability Environmental benefits Economic opportunities

3D reservoir characterization of the Mangahewa Formation,Mangahewa Field,Taranaki Basin,New Zealand

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Energy Geoscience 2024年第2期5卷 152-170页

作者： Dk Nurulnazihah Pg Norsahminan Md Aminul Islam Surya Tejasvi Thota mohamed Ragab Shalaby Department of Geosciences Faculty of ScienceUniversiti Brunei DarussalamJalan Tungku LinkGadong BE1410Brunei Darussalam

The Mangahewa Formation is the primary reservoir target in the Mangahewa Field in the Taranaki Basin,New *** formation is distinguished by its marginal marine substantial tight-sand reservoir,having thickness exceeding 800 *** aim of this study is to assess the reservoir properties of the Mangahewa Formation through 3D reservoir modeling,employing 3D seismic data,core data,and well data from the Mangahewa *** variance attributes,the faults and horizons have been identified successfully within the *** majority of the interpreted faults exhibit dip angles exceeding 60°,with a maximum displacement of 118 *** detect direct hydrocarbon indicators,root-mean-square amplitude seismic attribute,envelope,and generalized spectral decomposition techniques have been ***,four lithofacies,comprising 78.3%sandstone,9.2%siltstone,9.5%claystone,and 3.0%coal have been established by utilizing the Sequential Indicator Simulation(SIS)algorithm to create a lithofacies model.A property model has been generated using the Sequential Gaussian Simulation(SGS)*** evaluation indicates that the Mangahewa Formation exhibits reservoir qualities ranging from fair to good,with porosity levels between 8%and 11%,permeability averaging up to 10 mD,variable shale volumes,and hydrocarbon saturation in the range of 40%-50%.This study's methodologies and findings can serve as a valuable foundation for similar investigations in other tightsand gas fields located in different regions.

关键词： Marginal marine Tight-sand reservoir Mangahewa formation Mangahewa gas-condensate field Northern taranaki basin

Estimation of monthly global solar radiation over twelve major cities of Libya

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Energy and Built Environment 2024年第1期5卷 46-57页

作者： Alhassan Ali Teyabeen Najeya B.Elhatmi Akram A.Essnid F.mohamed Libyan Center for Solar Energy Research and Studies TripoliLibya Libyan Authority of Scientific Research TripoliLibya

This study aims to estimate monthly averaged daily horizontal global solar *** climatological data collected at twelve major cities located across Libya’s map were used to establish 7 different empirical *** empirical coefficients of the models were calculated using the least square *** accuracy of the models was evaluated using different statistical criteria such as Taylor diagram,mean absolute percentage error,MAPE,and root mean square error,*** results indicated that the sunshine duration-based models are more accurate than air temperature-based models,and the best performance was obtained by the quadratic regression model for all twelve Libyan ***,this regression model can be used for the prediction of monthly mean horizontal global solar radiation at a specific site across Libya’s regions with minimum ***,the results of the global solar irradiance produced by this method can be used for designing solar systems applications.

关键词： Monthly global solar radiation Clearness index Empirical models Performance evaluation Taylor diagram Libya