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Effects of natural compounds in treatment and prevention ofhepatotoxicity and hepatocellular carcinoma

Hepatoma Research 2015年第1期1卷 111-118页

作者： mohamed a.hamzawy Ezzeldein S.M.El-Denshary Mosaad A.Abdel-Wahhab Department of Pharmacology and Toxicology College of PharmacyMisr University for Science and Technology6th of October City 15525Egypt Department of Pharmacology and Toxicology Faculty of PharmacyCairo UniversityCairo 11562Egypt Department of Food Toxicology and Contaminants National Research CentreDokkiCairo 12622Egypt

Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis,fi brosis,cirrhosis,and hepatocellular carcinoma(HCC).Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases in *** researches have been reported numerous natural and phytochemical compounds that may counteract or prevent the hepatic injury and primary liver *** conservative treatment of liver toxicity and HCC may face awkward challenges in chemotherapy such as therapeutic failure or drug ***,there is an actual need for safe and effective therapeutic and preventive modalities for liver *** present review aims to focus on the potential protective and therapeutic effects of natural compounds in the prevention and treatment of hepatotoxicity and *** also demonstrates the mechanism of the natural products in enzymatic regulation of antioxidants and its role in apoptosis and proliferation of cancerous lesions of ***,it highlights the promising role of natural bioactive compounds and provides the rational for further transitional researches,and emphasize on the scientifi c validation of natural compounds for therapeutic portfolio for clinical use in liver diseases.

关键词： Antioxidant hepatocellular carcinoma hepatotoxicity liver natural compounds

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Efficacy of Organo-Modified Nano Montmorillonite to Protect against the Cumulative Health Risk of Aflatoxin B<sub>1</sub>and Ochratoxin A in Rats

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Soft Nanoscience Letters 2015年第2期5卷 21-35页

作者： Mosaad A. Abdel-Wahhab Ezzeldein S. El-Denshary Aziza A. El-Nekeety Khaled G. Abdel-Wahhab mohamed A. hamzawy mohamed F. Elyamany Nabila S. Hassan Fathia A. Mannaa mohamed N. Q. Shaiea Reda A. Gado Mahmoud F. Zawrah Food Toxicology and Contaminants Department National Research Center Cairo Egypt Department of Pharmacology and Toxicology Faculty of Pharmacy Cairo University Cairo Egypt Medical Physiology Department National Research Center Cairo Egypt Department of Pharmacology and Toxicology College of Pharmacy Misr University for Science and Technology 6th October City Egypt Pathology Department National Research Center Cairo Egypt Ceramics Department-Center of Excellence for Advanced Sciences National Research Center Cairo Egypt

The aim of the current study was to prepare organo-modified nano montmorillonite (OMNM) and to evaluate its chemopreventive effects against the hapatonephrotoxicity induced by aflatoxin B1 (AFB1) and ochratoxin A (OA) singly or in combination in rats. OMNM was prepared using Cetyltrimethylammoniumbromide (CTAB) as organic modifier. Eighty male Sprague Dawley were divided into 8 groups and treated for 8 weeks as follow: the control group;the group treated orally with AFB1 (80 μg/kg b.w.);the group treated with OA (100 μg/kg b.w.);the group treated with AFB1 plus OA, the group treated with OMNM (5 g/kg diet) and the groups treated with AFB1 and/or OA plus OMNM. At the end of treatment period, blood and tissue samples were collected from all animals for biochemical and histological analysis. The results revealed that the expansion in the basal spacing of the montmorillonite due to the intercalation of CTAB was 7.20?Å and the average particle size of OMNM was 120 nm. The in vivo results indicated that treatment with both AFB1 and OA singly or in combination resulted in a significant increase in liver and kidney function parameters, oxidative stress and tumor markers accompanied with a significant decrease in antioxidant enzyme activities and significant histological changes in liver and kidney tissues. These changes were severe in the group received the combined treatment of AFB1 and OA. OMNM alone did not show any toxic effect and it succeeded to prevent or at least diminish the toxic effects and the histological changes in liver and kidney. It can be concluded that treatment with AFB1 and OA has a synergistic toxic effects and OMNM is safe and it is a promise candidate as an additive to protect against the exposure to multi-mycotoxins in high risk population.

关键词： Modified Montmorillonite Nanoparticles Aflatoxin Ochratoxin Mycotoxins Oxidative Stress

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