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N-Butylpyridoquinoxa.ine 1,4-dioxide (NBPQD) a. a.new potent for tumor ima.ing a.d thera.y

Na.ura. Science 2012年第12期4卷 1074-1084页

作者： Sa.em a. Ha.ib Isma.l T. Ibra.im mohamed a. abd-eldaye Ma.douh M. El-Sheshta.ey Heba.M. Wa.y a.omic Energy a.thority Cairo Egypt Biochemistry Depa.tment Faculty of Pharmacy Mansoura University Mansoura Egypt Biochemistry Division Faculty of Science Damietta University Damietta Egypt Pha.ma.ology depa.tment Faculty of Veterinary medicine Ismailia University Ismailia Egypt

The development of new a.d effective a.titumor a.ents is one of the ma.n goa.s of medicina. a.d biochemica. resea.ch a. present. The present study is concerned with the eva.ua.ion of the previously synthesized N-Butylpyridoquinoxa.ine 1,4-dioxide (NBPQD) a. a. a.titumor a.ent a.a.nst Ehrlich a.cites ca.cinoma.(Ea.). The first pa.t of the study (tumor ima.ing) wa. to investiga.e the biodistribution of NBPQD in the orga.s of Ea.-bea.ing mice using iodine-125 isotope stressing on its distribution in the ma.n orga.s (stoma.h, liver, spleen, kidney) in a.dition to blood a.d a.cetic fluid. The second pa.t wa. the a.sessment of the a.titumor a.tivity of NBPQD by estima.ing the tumor volume a.d the contents of tota. protein, tota. lipid, DNa.a.d RNa.in liver tissues. In a.dition, liver function tests a.d the redox sta.us were a.sessed. Tumor volume a.d DNa. RNa. urea.a.d ma.ondia.dehyde (MDa. levels a.d the liver enzymes a.tivity were highly significa.tly increa.ed (P a.ed Ea.-bea.ing mice compa.ed to control. However, tota. lipid a.d tota. protein in liver tissues in a.dition to serum a.bumin, glucose, reduced gluta.hione (GSH) a. well a. a.tivities of gluta.hione reducta.e (GSH-R) a.d superoxide dismuta.e (SOD) a.l were highly significa.tly decrea.ed in untrea.ed Ea.-bea.ing mice compa.ed to controls. a.l these decrea.ed pa.a.eters were highly significa.tly restored to their norma. levels in NBPQD trea.ed mice compa.ed to the untrea.ed Ea.-bea.ing mice. The surviva. time of the NBPQD trea.ed mice wa. longer tha. tha. of the untrea.ed ones. It is thus, evident tha. NBPQD ha. a.rema.ka.le a.titumor a.tivity a.a.nst Ea. in Swiss a.bino mice.

关键词： Ehrlich a.cites Ca.cinoma SOD MDA 125I-NBPQD GSH-R GSH

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Correction:a.Lightweight a.proa.h for Skin Lesion Detection through Optima. Fea.ures Fusion

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Computers, Ma.eria.s & Continua 2025年第1期82卷 1459-1459页

作者： Kha.ija.Ma.zoor Fia. Ma.eed a.sa. Siddique Ta.ha.Mera. Ha.iz Ta.ya. Ra.f Moha.med a.El-Meligy mohamed Sha.a. abd Ela.ty E.abd Elga.a. Depa.tment of Informa.ion Technology University of GujratGujrat50700Pakistan Depa.tment of Softwa.e Engineering University of GujratGujrat50700Pakistan Depa.tment of Computer Science COMSATS University Islamabad-Wah CampusWah Cantt47040Pakistan Independent Resea.cher BradfordBD80HSUK a.va.ced Ma.ufa.turing Institute King Saud UniversityRiyadh11421Saudi Arabia Depa.tment of Industria. Engineering College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

In the a.ticle“a.Lightweight a.proa.h for Skin Lesion Detection through Optima. Fea.ures Fusion”by Kha.ija.Ma.zoor,Fia. Ma.eed,a.sa. Siddique,Ta.ha.Mera.,Ha.iz Ta.ya. Ra.f,Moha.med ***-Meligy,mohamed Sha.a.,abd Ela.ty *** Elga.a. Computers,Ma.eria.s&Continua.2022,Vol.70,No.1,pp.1617–***:10.32604/cmc.2022.018621,URL:https://***/cmc/v70n1/44361,there wa. a. error rega.ding the a.filia.ion for the a.thor Ha.iz Ta.ya. *** of“Centre for Sma.t Systems,a. a.d Cybersecurity,Sta.fordshire University,Stoke-on-Trent,UK”,the a.filia.ion should be“Independent Resea.cher,Bra.ford,BD80HS,UK”.

关键词： Fusion Skin Fea.ure

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Effects of P301L-Ta. on post-tra.sla.iona. modifica.ions of microtubules in huma. iPSC-derived cortica. neurons a.d Ta. tra.sgenic mice

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2348-2360页

作者： mohamed a.hya. a. Ka.ba.i Christoph Köhler Ha.s Zempel Institute of Huma. Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecula. Medicine Cologne(CMMC) University of CologneCologneGermany Center a.a.omy Department ⅡMedical FacultyUniversity of CologneCologneGermany

Ta. is a.microtubule-a.socia.ed protein tha. promotes microtubule a.sembly a.d sta.ility in the *** is missorted a.d a.grega.ed in a. a.ra. of disea.es known a. *** a.e essentia. for neurona. function a.d regula.ed via.a.complex set of post-tra.sla.iona. modifica.ions,cha.ges of which a.fect microtubule sta.ility a.d dyna.ics,microtubule intera.tion with other proteins a.d cellula. structures,a.d media.e recruitment of microtubule-severing *** impa.rment of microtubule dyna.ics ca.ses neurona. dysfunction,we hypothesize cognitive impa.rment in huma. disea.e to be impa.ted by impa.rment of microtubule *** therefore a.med to study the effects of a.disea.e-ca.sing muta.ion of Ta.(P301L)on the levels a.d loca.iza.ion of microtubule post-tra.sla.iona. modifica.ions indica.ive of microtubule sta.ility a.d dyna.ics,to a.sess whether P301L-Ta. ca.ses sta.ility-cha.ging modifica.ions to *** investiga.e Ta. loca.iza.ion,phosphoryla.ion,a.d effects on tubulin post-tra.sla.iona. modifica.ions,we expressed wild-type or P301L-Ta. in huma. Ma.T-KO induced pluripotent stem cell-derived neurons(i Neurons)a.d studied Ta. in neurons in the hippoca.pus of mice tra.sgenic for huma. P301L-Ta.(p R5 mice).Huma. neurons expressing the longest Ta. isoform(2N4R)with the P301L muta.ion showed increa.ed Ta. phosphoryla.ion a. the a.8,but not the p-Ser-262 epitope,a.d increa.ed polygluta.yla.ion a.d a.etyla.ion of microtubules compa.ed with endogenous Ta.-expressing neurons.P301L-Ta. showed pronounced soma.odendritic presence,but a.so successful a.ona. enrichment a.d a.simila. a.odendritic distribution compa.a.le to exogenously expressed 2N4R-wildtype-Ta..P301L-Ta.-expressing hippoca.pa. neurons in tra.sgenic mice showed prominent missorting a.d ta.opa.hy-typica. a.8-phosphoryla.ion of Ta. a.d increa.ed polygluta.yla.ion,but reduced a.etyla.ion,of microtubules compa.ed with non-tra.sgenic *** sum,P301L-Ta. results in cha.ges in micr

关键词： huma. induced pluripotent stem cell microtubules P301L pR5 mice Ta. ta.opa.hy tubulin code

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Effect of different meta. sulfa.e precursors on structura. a.d ca.a.ytic performa.ce of zirconia.in dehydra.ion of metha.ol to dimethyl ether

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燃料化学学报 2018年第1期46卷 67-74页

作者： abd El-a.iz a.Sa.d mohamed abd El-a.l Chemistry Depa.tment Faculty of ScienceAssiut University71516 AssiutEgypt

ZrO_2 wa. trea.ed with 10% SO_4^(2-) from different meta. sulfa.e precursors for metha.ol dehydra.ion to dimethyl *** the sa.ples exhibited tetra.ona. pha.e a.d no diffra.tion pea.s corresponding to meta. sulfa.es or meta. oxides were *** FT-IR results revea.ed tha. there were different intera.tions between sulfa.e a.d ZrO_2,a.d this ha. a.grea. effect on the surfa.e a.ea.of the *** ca.a.ytic a.tivity wa. mea.ured over the ca.a.ysts in the tempera.ure ra.ge of 100-300 ℃.The results revea.ed tha. sulfa.ed zirconia.with CuSO_4·5 H_2O a.d a._2(SO_4)_3·16 H_2O showed the best ca.a.ytic *** ma.imum yield of DME ≈87% wa. obta.ned over CuSZ a. a.rea.tion tempera.ure of 275 ℃.Moreover,the ca.a.ytic a.tivity of the ca.a.ysts wa. correla.ed well with their surfa.e a.idity tha. mea.ured by dehydra.ion of isopropa.ol.

关键词： MSO 4/ZrO2 甲醇脱水 DME

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Wea. properties of copper a.d copper composites powders consolida.ed by high-pressure torsion

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Friction 2020年第2期8卷 433-450页

作者： mohamed Ibra.im abd El a.L Mecha.ica. Engineering Depa.tment College of EngineeringPrince Sattam Bin Abdulaziz UniversityWadi Addawaser 11991Saudi Arabia Mecha.ica. Design&Production Depa.tment Faculty of EngineeringZagazig UniversityZagazig 44519Egypt

The wea. cha.a.teristics of Cu a.d Cu-SiC composite microsize powders consolida.ed by cold compa.tion combined with sintering or high-pressure torsion(HPT)were *** HPT processed(HPTed)sa.ples with bimoda. a.d trimoda. microstructures a.d fine Cu gra.ns a.d SiC pa.ticle sizes ha.e superior ha.dness,rea.ona.le ductility level,a.d high wea. *** wea. ma.s loss a.d coefficient of friction of HPTed sa.ples were rema.ka.ly lower tha. tha. of cold-compa.ted a.d sintered sa.ples a. well a. tha. of micro a.d na.o Cu a.d Cu-SiC composites from previous *** sa.ple fa.rica.ion method ha. a. a.pa.ent influence on the wea. *** wea. mecha.ism wa. converted from a.hesive,dela.ina.ion,three-body mecha.ism,grooves(ta.e off the SiC pa.ticles),a.d cra.ks into a.ra.ive wea. a.ter *** ca. be considered a.domina.t wea. mecha.ism in a.l *** worn surfa.e morphology a.d a.a.ysis support the rela.ionship between wea. mecha.ism a.d cha.a.teristics.

关键词： Cu-SiC composite powders high-pressure torsion(HPT) fine a.d coa.se gra.ns wea. cha.a.teristics worn surfa.e morphology

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Ore Controls a.d Meta.logenesis of a.-a. Deposits a. a.a.la.Mine,Centra. Ea.tern Desert of Egypt

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a.ta.Geologica.Sinica.English Edition) 2020年第5期94卷 1451-1470页

作者： mohamed abd EL MONSEF Geology Depa.tment Faculty of ScienceTanta UniversityTanta 31527Egypt Institute of Geologica. Sciences Faculty of ScienceMasaryk UniversityBrnoCzech Republic

Gold-silver deposits in the a.a.la.a.ea.occur a. hydrotherma. qua.tz veins in NE–SW pre-existing fra.tures within the a.a.la.gra.itic *** orienta.ion of such qua.tz veins ha. been a.tributed to extensiona. beha.ior rela.ed to the a.a.la.Shea. Zone(a.Z).The a.a.la.a.ea.is covered by a.va.iety of lithologies tha. a.e(from oldest to youngest):meta.edimenta.y rocks,meta.olca.ic rocks,ophiolite a.sembla.e(serpentinites/ta.c-ca.bona.es),a.a.la.gra.ite a.d Dokha. volca.ic ***,a.a.la.gra.ite ra.ges in composition from gra.odiorite to *** geochemistry constra.ns the ca.c-a.ka.ne a.finity of the a.a.la.gra.ite tha. wa. intruded within a. orogenic(syncollision)tectonic *** ore minera.s a.e represented by gold/silver(electrum),pyrite(Py1&Py2),a.senopyrite,pyrrhotite,spha.erite,cha.copyrite,ga.ena.covellite a.d *** tempera.ure of ore forma.ion ra.ges from 240 to 285℃a.d the estima.ed fluid pressure is in the ra.ge of 20–100 *** on the geologica. setting,ore textures a.d fluid cha.a.teristics;the a.a.la.a.-a. deposits a.e considered to be orogenic in na.ure,formed from a.continenta. collision(~653-590 Ma.,synchronous with the empla.ement of ca.c-a.ka.ine ma.ma.ism during the evolutiona.y history of the a.a.ia. Nubia. Shield(a.S).The initia. ore-forming fluid wa. prima.ily derived from a.meta.orphic source rela.ed to ophiolitic-serpentinite rocks under deep regiona. conditions of greenschist-a.phibolite fa.ies,where the a.a.la.gra.itic eruption provided the required tempera.ure conditions for the meta.orphic process to ta.e *** such conditions,the tra.sporta.ion of ore meta.s a. bisulfide complexes is *** deposition of ore minera.s wa. triggered by fluidwa.lrock intera.tion through fra.ture pa.hwa.s in conjunction with a.tempera.ure-pressure drop tha. is likely to ha.e been rela.ed to uplift into the crusta. levels.

关键词： Gold-silver a.senopyrite geothermometry fluid inclusions orogenic deposits a.a.la.Shea. Zone(a.Z)

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Dyna.ic Intera.tion a.a.ysis of Coupled a.ia.-Torsiona.-La.era. Mecha.ica. Vibra.ions in Rota.y Drilling Systems

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Structura. Dura.ility & Hea.th Monitoring 2025年第1期19卷 77-103页

作者： Sa.rina.Medda. Sid a.med Ta.jer abdelha.im Idir Kong Fa. Tee mohamed Zinela.idine Doghma.e Ma.jid Kidouche a.plied a.toma.ion La.ora.ory Faculty of Hydrocarbons and ChemistryUniversity of BoumerdesBoumerdes35000Algeria Institute of Electrica. a.d Electronic Engineering(IGEE) University of BoumerdesBoumerdes35000Algeria La.ora.ory of the Electrifica.ion of Industria. Enterprises University of BoumerdesBoumerdes35000Algeria Electrica. Engineering Depa.tment Mohamed Boudiaf University of M’silaM’sila28000Algeria Depa.tment of Civil a.d Environmenta. Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplina.y Resea.ch Center for Construction a.d Building Ma.eria.s King Fahd University of Petroleum&Minerals(KFUPM)Dhahran31261Saudi Arabia

Ma.nta.ning the integrity a.d longevity of structures is essentia. in ma.y industries,such a. a.rospa.e,nuclea.,a.d *** a.hieve the cost-effectiveness of la.ge-sca.e systems in petroleum drilling,a.strong empha.is on structura. dura.ility a.d monitoring is *** study focuses on the mecha.ica. vibra.ions tha. occur in rota.y drilling systems,which ha.e a.substa.tia. impa.t on the structura. integrity of drilling *** study speciﬁca.ly investiga.es a.ia.,torsiona.,a.d la.era. vibra.ions,which might lea. to nega.ive consequences such a. bit-bounce,cha.tic whirling,a.d high-frequency *** events not only hinder the efﬁciency of drilling but a.so lea. to exha.stion a.d ha.m to the system’s components since they a.e difﬁcult to be detected a.d controlled in rea. *** study investiga.es the dyna.ic intera.tions of these vibra.ions,speciﬁca.ly in their high-frequency modes,usingﬁeld da.a.obta.ned from mea.urement while ***ﬁndings ha.e demonstra.ed the effect of strong coupling between the high-frequency modes of these vibra.ions on drilling sys-tem *** obta.ned results highlight the importa.ce of considering the interconnected impa.ts of these vibra.ions when designing a.d implementing robust control ***,integra.ing these compo-nents ca. increa.e the dura.ility of drill bits a.d drill strings,a. well a. improve the a.ility to monitor a.d detect ***,by exploiting theseﬁndings,the a.sessment of structura. resilience in rota.y drilling systems ca. be ***,the study demonstra.es the ca.a.ity of structura. hea.th monitoring to improve the qua.ity,dependa.ility,a.d efﬁciency of rota.y drilling systems in the petroleum industry.

关键词： Rota.y drilling systems mecha.ica. vibra.ions structura. dura.ility dyna.ic intera.tion a.a.ysis ﬁeld da.a.a.a.ysis

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Optima. sea.ching for a.Helix ta.get motion

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Science China.Ma.hema.ics 2015年第4期58卷 749-762页

作者： mohamed abd a.la. El-Ha.idy Depa.tment of Ma.hema.ics Faculty of Science Tanta University

This pa.er discusses a.sea.ch problem for a.Helix ta.get motion in which a.y informa.ion of the ta.get position is not a.a.la.le to the sea.chers. There exist three sea.chers sta.t sea.ching for the ta.get from the origin. The purpose of this pa.er is to formula.e a.sea.ch model a.d finds the conditions under which the expected va.ue of the first meeting time between one of the sea.chers a.d the ta.get is finite. a.so, the existence of the optima. sea.ch pla. tha. minimizes the expected va.ue of the first meeting time is shown. Furthermore,this optima. sea.ch pla. is found. The effectiveness of this method is illustra.ed by using a. exa.ple with numerica. results.

关键词： Helix motion optima. sea.ch pla. first meeting time proba.ility mea.ure multiobjective nonlinea. progra.ming problem

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Ma.netoresistive properties of Ni-doped La.(0.7)Sr_(0.3)MnO_3 ma.ga.ites

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Ra.e Meta.s 2016年第7期35卷 551-558页

作者： a.med mohamed a.med abd El-Moez a.med mohamed Medha. abdelra.y abdella.eef Ha.sa. a.med abd El-Gha.ny Physics Depa.tment Faculty of ScienceSohag University

La..7Sr0.3Mnl_xNixO3 （x = 0, 0.025, 0.050 a.d 0.075） cera.ics were prepa.ed by the conventiona. solid-sta.e rea.tion method. The pa.tia. substitution of Mn by Ni2＋ lea.s to a.decrea.e in cell volume a. well a. a.structura. tra.sition from the rhombohedra. to the orthorhombic structure. Ni2＋ doping increa.es the electrica. resistivity, decrea.es the semiconductor-meta. tra.sition tempera.ure （Tms） a.d rela.ively enha.ces the room tempera.ure ma.netoresista.ce （MR）, especia.ly in x = 0.025 a.d a.ound Tins. With respect to conduction mecha.ism, the sma.l pola.on hopping （SPH） a.d the va.ia.le ra.ge hopping （VRH） models were used to ex- a.ine conduction in the semiconducting region.

关键词： Ma.ga.ites X-ra. diffra.tion Structure Electrica. resistivity Ma.netoresista.ce

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Neoproterozoic Tectonic Events of Egypt

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a.ta.Geologica.Sinica.English Edition) 2021年第4期95卷 1366-1405页

作者： mohamed abd EL-Wa.ED Za.a.ia.Ha.IMI Geology Depa.tment Faculty of ScienceTanta UniversityTanta 31527Egypt Depa.tment of Geology Faulty of ScienceBen ha UniversityBenha 13518Egypt

The Egyptia. Nubia. Shield(ENS)represents the northwestern pa.t of the a.a.ia.-Nubia. Shield a.d the northern extension of the Ea.t a.rica. *** ENS is rega.ded a. being formed due to northwa.d-directed esca.e *** is cha.a.terized by mild a.cretion a.d suture zones domina.ed by ma.or strike-slip zones with a.commonly sinistra. sense of movement;some shea. zones displa. a.dextra. sense of *** is domina.ed by gneisses a.d migma.ites in the south,a.c volca.icla.tic meta.ediments a.d highly dismembered ophiolites in the centra. pa.ts,wherea. its northern pa.t is domina.ed by la.e-to post-tectonic *** southern Sina.,the Neoproterozoic rocks a.e grouped into four complexes,na.ely Feira.–Sola.,Sa.a.–Za.hra.Kid a.d *** ENS ophiolites were formed between 730–750 Ma.ma.nly in a.supra.subduction zone *** ENS ha. undergone a.Neoproterozoic deforma.ion history involving three successive pha.es:(1)Ea.ly N–S shortening pha.e(D1),(2)Syn-a.cretiona.y pha.e(D2)a.d(3)Post-a.cretiona.y pha.e(D3).The initia. isla.d-a.c sta.e(780–730 Ma.is a.N–S shortening pha.e initia.ed by collision between the Ea.tern Desert tectonic terra.e to the north with both the Gebeit a.d Ga.ga.a.terra.es to the south(830–720 Ma..During the a.c-splitting a.d ba.k-a.c sprea.ing sta.e(730–620),voluminous syn-tectonic gra.itoids intruded into the ENS(750–610 Ma..The E–W-directed compressiona./tra.spressiona. pha.e(620–450 Ma.led to the overa.l uplift of the centra. pa.t of the ENS a.d consequently the development a.d exhuma.ion of the core complexes in oblique convergent *** E–W intense shortening deforma.ion resulted a.so in the forma.ion of NW-a.d NE-striking sinistra. a.d dextra. strike-slip shea. zones,*** la.est periods of the E–W-directed compressiona./tra.spressiona. regime were cha.a.terized by deposition of the mola.se-type Ha.ma.a. Sediments unconforma.ly over the Dokha. Volca.ics,or interbedded with *** combined thrusting,folding a.d sin

关键词： Neoproterozoic deforma.ion N–S shortening syn-a.cretiona.y pha.e post-a.cretiona.y pha.e Egyptia. Nubia. Shield

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