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Different timing for abdominal paracentesis catheter placement and drainage in severe acute pancreatitis complicated by intraabdominal fluid accumulation

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 134-142页

作者： Rui Chen Hua-Qiang Chen Rui-Die Li Hui-min Lu Department of General Surgery Chengdu Sixth People’s HospitalChengdu 610058Sichuan ProvinceChina West China center of exelle.ce.for pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest ChinaDivision of Pancreatic SurgeryDepartment of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina HospitalSichuan University

BACKGROUND Non-surgical methods such as percutaneous drainage are crucial for the treatment of patients with severe acute pancreatitis(SAp).However,there is still an ongoing debate regarding the optimal timing for abdominal paracentesis catheter place-ment and *** To explore the influe.ce.of different timing for abdominal paracentesis catheter placement and drainage in SAp complicated by intra-abdominal fluid *** Using a retrospective approach,184 cases of SAp complicated by intra-abdominal fluid accumulation were enrolled and categorized into three groups based on the timing of catheter placement:group A(catheter placement within 2 d of symptom onset,n=89),group B(catheter placement between days 3 and 5 after symptom onset,n=55),and group C(catheter placement between days 6 and 7 after symptom onset,n=40).The differe.ce. in progression rate,mortality rate,and the number of cases with organ dysfunction were compared among the three *** The progression rate of group A was significantly lower than those in groups B and groups C(2.25%vs 21.82%and 32.50%,per,the proportion of patients with at least one organ dysfunction in group A was significantly lower than those in groups B and groups C(41.57%vs 70.91%and 75.00%,pe mortality rates in group A,group B,and group C were similar(p>0.05).At postoperative day 3,the levels of C-reactive protein(55.41±19.32 mg/L vs 82.25±20.41 mg/L and 88.65±19.14 mg/L,pprocalcitonin(1.36±0.51 ng/mL vs 3.20±0.97 ng/mL and 3.41±0.98 ng/mL,pecrosis factor-alpha(15.12±6.63 pg/L vs 22.26±9.96 pg/L and 23.39±9.12 pg/L,perleukin-6(332.14±90.16 ng/L vs 412.20±88.50 ng/L and 420.08±87.65ng/L,perleukin-8(415.54±68.43 ng/L vs 505.80±66.90 ng/L and 510.43±68.23ng/L,perum amyloid A(270.06±78.49 mg/L vs 344.41±81.96 mg/L and 350.60±80.42 mg/L,pere significantly lower in group A compared to those in groups B and group *** length of hospit

关键词： Abdominal paracentesis catheter drainage Timing Severe acute pancreatitis Intra-abdominal fluid Application value

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Advancing early Detection of Colorectal Adenomatous polyps via Genetic Data Analysis: A Hybrid Machine Learning Approach

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Journal of Computer and Communications 2024年第7期12卷 23-38页

作者： Ahmed S. Maklad mohamed A. Mahdy Amer Malki Noboru Niki Abdallah A. mohamed Computer Scie.ce.Department College of Computer Science and Engineering in Yanbu Taibah University Medina Saudi Arabia Information Systems Department Faculty of Computers and Artificial Intelligence Beni-Suef University Beni-Suif Egypt Computer Scie.ce.Department Faculty of Computers and Artificial Intelligence Beni-Suef University Beni-Suif Egypt Institute of Advanced Scie.ce.and Technology Tokushima University Tokushima Japan Information Systems Department College of Computer Science and Engineering in Yanbu Taibah University Medina Saudi Arabia Mathematics and Computer Scie.ce.Department Faculty of Science Menoufia University Menoufia Egypt

In this study, a hybrid machine learning (HML)-based approach, incorporating Genetic data analysis (GDA), is proposed to accurately identify the prese.ce.of adenomatous colorectal polyps (ACRp) which is a crucial early detector of colorectal cancer (CRC). The present study develops a classification ensemble model based on tuned hyperparameters. Surpassing accuracy pe.ce.tages of early detection approaches used in previous studies, the current method exhibits e.ce.tional performance in identifying ACRp and diagnosing CRC, overcoming limitations of CRC traditional methods that are based on error-prone manual examination. particularly, the method demonstrates the following CRp identification accuracy data: 97.7 ± 1.1, precision: 94.3 ± 5, recall: 96.0 ± 3, F1-score: 95.7 ± 4, specificity: 97.3 ± 1.2, average AUC: 0.97.3 ± 0.02, and average p-value: 0.0425 ± 0.07. The findings underscore the potential of this method for early detection of ACRp as well as clinical use in the development of CRC treatment planning strategies. The advantages of this approach are highly expected to contribute to the prevention and reduction of CRC mortality.

关键词： Colorectal Adenoma Detection Colorectal Cancer Diagnosis Hybrid Machine Learning Genetics Analysis

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probing atomic-scale structure of dielectric ceramics with scanning transmission electron microscopy

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Journal of Advanced Dielectrics 2024年第3期14卷 1-10页

作者： min Zhang Rui Wei Jinquan Zeng Yuan-Hua Lin State Key Laboratory of New ceramics and Fine processing School of Materials Scie.ce.and engineering Tsinghua University BeijingP.R.China

High performance dielectric capacitors are ubiquitous components in the modern electronics industry,owing to the highest power density,fastest charge-discharge rates,and long ***,the wide application of dielectric capacitors is limited owing to the low energy *** the past decades,multiscale structures of dielectric ceramics have been extensively explored and many exciting developments have been *** the rapid development of energy storage properties,the atomic structure of dielectric materials is rarely *** this paper,we present a brief overview of how scanning transmission electron microscopy(STeM)is used as a tool to elucidate the morphology,local structure heterogeneity,atomic resolution structure phase evolution and the correlation with energy storage properties,which provides a powerful tool for rational design and synergistic optimization.

关键词： Atomic-scale structure dielectric ceramics STeM energy storage

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Intermolecular Acid-Base-pairs Containing poly(p-Terphenyl-co-Isatin piperidinium) for High Temperature proton exchange Membrane Fuel cells

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energy & environmental Materials 2024年第3期7卷 410-418页

作者： Xiaofeng Hao Zhen Li min Xiao Zhiheng Huang Dongmei Han Sheng Huang Wei Liu Shuanjin Wang Yuezhong Meng The Key Laboratory of Low-carbon Chemistry & energy Conservation of Guangdong province State Key Laboratory of Optoelectronic Materials and TechnologiesSchool of Materials Science and EngineeringSun Yat-sen University School of Chemical engineering and Technology Sun Yat-sen University Institute of Chemistry Henan Provincial Academy of Sciences Research center of Green Catalysts College of ChemistryZhengzhou University

How to optimize and regulate the distribution of phosphoric acid in matrix,and pursuing the improved electrochemical performance and service lifetime of high temperature proton exchange membrane （HT-peMs） fuel cell are significant ***,bifunctional poly （p-terphenyl-co-isatin piperidinium） copolymer with tethered phosphonic acid （t-pA） and intrinsic tertiary amine base groups are firstly prepared and investigated as *** distinctive architecture of the copolymer provides a well-designed platform for rapid proton *** not only transports through the hydrogen bond network formed by the adsorbed free phosphoric acid （f-pA）anchored by the tertiary amine base groups,but also rely upon the proton channel constructed by the ionic cluster formed by the t-pA *** the design of the structure,the bifunctional copolymers with lower pA uptake level （play prominent proton conductivities and peak power densities (99 mS cm-1,812 mW cm-2at 160℃),along with lower pA leaching and higher voltage stability,which is a top leading result in disclosed *** results demonstrate that the design of intermolecular acid-base-pairs can improve the proton conductivity without sacrificing the intrinsic chemical stability or mechanical property of the thin membrane,realizing win-win demands between the mechanical robustness and electrochemical properties of HT-peMs.

关键词： bifunctional copolymer high temperature proton exchange membrane intermolecular acid–base-pairs phosphonic acid retention phosphonic acid uptake level

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Assessment the effect of Dapoxetine and/or Acetaminophen in rats;neurochemicals and oxidative stress biomarkers evaluation

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Brain Scie.ce.Advances 2024年第1期10卷 57-71页

作者： Gehan S.Georgy Ibrahim M.Ibrahim Laila mohamed e.Amer ebtehal Mohammad F. pharmacology Department Egyptian Drug Authority(EDA)Giza P.O.29Egypt Molecular Drug evaluation Department Egyptian Drug Authority(EDA)Giza P.O.29Egypt Histology Department Faculty of MedicineAl-Azhar UniversityDamietta P.O.11651Egypt

Dapoxetine is a newer anti-depressant that is used for severe forms of depression via selective serotonin reuptake inhibition *** aimed to evaluate the effect of different doses of dapoxetine lonely or with acetaminophen(AMp).Seven groups of albino rats were used where dapoxetine was administered orally at the doses of 3,5,and 8 mg/kg body weight for a period of 14 days in groups 2,4,and 6,***(67.5 mg/kg body weight)was co-administered with dapoxetine(3,5,and 8 mg/kg body weight)for 14 days in groups 3,5 and 7,*** in mid and high dose plus AMp increased body weight and hematological *** and rearing were declined with mid and high doses of dapoxetine+AMp,contrary to *** was decreased with high doses of dapoxetine+*** dose of dapoxetine+AMp induced lowering of serotonin and dopamine as well as increasing of *** derived neurotrophic factor was decreased in all *** stress biomarkers were augmented with high dose of dapoxetine+*** doses of dapoxetine and/or AMp induced loss of the purkinje.ce.l layer at *** high dose of dapoxetine+AMp denotes behavioral,histopathological and neurochemical alterations,even though no serotonin syndrome occurs.

关键词： acetaminophen dapoxetine neurotransmitters oxidative stress biomarkers

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The effect and Mechanism of Fructus lycii on Improvement of exercise Fatigue Using a Network pharmacological Approach with in vitro experimental Verification

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Biomedical and environmental Scie.ce. 2024年第1期37卷 42-53页

作者： JI Xiao Ning LIU Zhao ping ZHANG Chao Zheng CHeN min LIANG Jiang LU Jiang ZHANG Lei National Resource.ce.ter for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China China National center for Food Safety Risk Assessment Beijing 100022China Chinese.ce.ter for Disease Control and prevention Beijing 102206China

Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise *** A network pharmacological approach was used to explore potential mechanisms of action of Fructus *** muscle C2C12 cells and immunofluore.ce.ce were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological *** Six potential active components,namely que.ce.in,β-sitosterol,stigmasterol,7-Omethylluteolin-6-C-beta-glucoside_qt,atropine,and glycitein,were identified to have potency in improving exercise fatigue via multiple pathways,such as the pI3K-Akt,neuroactive ligand-receptor interaction,IL-17,TNF,and MApK signaling *** immunofluore.ce.ce results indicated that que.ce.in,a significant active component in Fructus lycii,increased the mean staining area of 2-NBDG,TMRM,and MitoTracker,and decreased the area of cellRox compared to the ***,the protein expression levels of p-38 MApK,p-MApK,p-JNK,p-pI3K,and p-AKT markedly increased after que.ce.in *** Fructus lycii might alleviate exercise fatigue through multiple components and *** these,que.ce.in appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative *** pI3K-AKT and MApK signaling pathways also appear to play a role in this process.

关键词： Fructus lycii exercise fatigue Network pharmacology

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Treg Immunomodulation Contributes to the Anti-atherosclerotic effects of Huxin Formula in Apoe^(-/-)Mice

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Chinese Journal of Integrative Medicine 2024年第10期30卷 896-905页

作者： OU Xiao-min CAI Jing HU Xiao-yue ZeNG Qiao-huang LAN Tao-hua JIANG Wei The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510405China Department of Cardiology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510020China Guangdong provincial Key Laboratory of Chinese Medicine for prevention and Treatment of Refractory Chronic Diseases Guangzhou510020China

Objective:To explore the effects of Huxin formula(HXF)in curtailing atherosclerosis and its underlying ***:According to random number table method,24 specific pathogen free male Apoe^(-/-)mice were randomly divided into model group,HXF low-dose(HXF-L)group(8.4 g/kg daily),HXF high-dose(HXF-H)group(16.8 g/kg daily),and pravastatin(8 mg/kg daily)group in experimentⅠ(n=6 per group).C57BL/6J mice served as the control group(n=6).Apoe^(-/-)mice in HXF-L,HXF-H,pravastatin groups were fed a Western diet and administered continuously by gavage for 12 weeks,while C57BL/6J mice in the control group were fed conventional lab mouse chow for 12 ***,Tregs were depleted by weekly intraperitoneal injection of purified anti-mouse CD25 antibody(pC61,250μg per mouse)for 4 weeks in experimentⅡ(n=6 per group).Oil Red O and Masson staining were used to evaluate the plaque area and aortic root *** CD4^(+)CD25^(+)Foxp3^(+)Treg counts in the lymph nodes and spleen cells were detected using flow cytometric *** transforming growth factor-β1(TGF-β1),interleukin(IL)-10,and IL-6 serum levels were examined by MILLIpLeX?MAp *** real-time reverse transcription pCR(qRT-pCR)and Western blot were utilized to assess the expression of TGF-βmRNA and protein in the *** expression of CD4^(+)T lymphocytes,macrophages and smooth muscle.ce.ls in the aortic root were detected by immunofluore.ce.ce ***:HXF reduced plaque area in Apoe^(-/-)mice(peased the Treg counts in the lymph nodes and spleen cells(ppeover,HXF alleviated inflammatory response via elevating IL-10 and TGF-β1 serum levels(pe decreasing the IL-6 serum levels in Apoe^(-/-)mice(p>0.05).Also,HXF upregulated the expression of TGF-βmRNA and protein in the aorta(penuated CD4^(+)T lymphocytes,macrophages and smooth muscle.ce.ls in aortic root plaque(permore,the depletion of Tregs with CD25

关键词： atherosclerosis Huxin Formula Tregs immune responses inflammation

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The impact of chemotherapy-naïve open radical cystectomy delay and perioperative transfusion on the recurre.ce.free survival: A perioperative parameters-based nomogram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： Ahmed M.Harraz Ahmed elkarta mohamed H.Zahran Ahmed Mosbah Atallah A.Shaaban Hassan Abol-enein Urology and Nephrology center Mansoura UniversityEgypt

Objective: To develop and internally validate a nomogram to predict recurre.ce.free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (pBT) as potential ***: patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (n=948) and validating (n=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nomogram. Discrimination, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On multivariate analysis, independent predictors were TTC (hazards ratio [HR] 1.07, 95% confide.ce.interval [CI] 1.05-1.08, ppBT (one unit: HR 1.40, 95% CI 1.03-1.90, p=0.03;two or more units: HR 1.72, 95% CI 1.29-2.29, peral hydronephrosis (HR 1.54, 95% CI 1.21-1.97, pcell carcinoma (HR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (HR 1.77, 95% CI 1.41-2.22, pph node status (HR 1.53, 95% CI 1.21-1.95, pphovascular invasion (HR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable corresponde.ce.between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nomogram with good discrimination, validation, and clinical utility was constructed utilizing TTC and pBT in addition to standard pathological criteria.

关键词： Radicalcystectomy Blood transfusion Time to radical cystectomy Survival Nomogram

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protein tyrosine phosphatases:emerging role in cancer therapy resistance

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Cancer Communications 2024年第6期44卷 637-653页

作者： min Zhao Wen Shuai Zehao Su ping Xu Aoxue Wang Qiu Sun Guan Wang Innovation center of Nursing Research Nursing Key Laboratory of Sichuan ProvinceDepartment of BiotherapyCancer Center and State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalWest China School of NursingSichuan UniversityChengduSichuanP.R.China West China Biomedical Big Data center Med-X Center for InformaticsSichuan UniversityChengduSichuanP.R.China emergency Department Zigong Fourth People’s HospitalChengduSichuanP.R.China

Background:Tyrosine phosphorylation of intracellular proteins is a posttranslational modification that plays a regulatory role in signal transduction during cellular *** of signal transduction proteins caused by protein tyrosine phosphatases(pTps)contributed their role as a convergent node to mediate cross-talk between signaling *** the context of cancer,pTp-mediated pathways have been identified as signaling hubs that enabled cancer cells to mitigate stress induced by clinical *** is achieved by the promotion of constitutive activation of growth-stimulatory signaling pathways or modulation of the immune-suppressive tumor *** evide.ce. suggested that anticancer drugs will release their greatest therapeutic potency when combined with pTp inhibitors,reversing drug resistance that was responsible for clinical failures during cancer *** covered:This review aimed to elaborate recent insights that supported the involvement of pTp-mediated pathways in the development of resistance to targeted therapy and immune-checkpoint *** opinion:This review proposed the notion of pTp inhibition in anticancer combination therapy as a potential strategy in clinic to achieve long-term tumor *** clinical trials are currently underway to assess the safety and efficacy of combination therapy in advanced-stage tumors.

关键词： cancer treatment combination therapy drug resistance protein tyrosine phosphatase

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effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： Chin-Heng Lu Hung-min Chang Kuang-Hsi Chang Yen-Chuan Ou Chao-Yu Hsu min-Che Tung Frank Cheau-Feng Lin Stella Chin-Shaw Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong Hsing Research center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Scie.ce. Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General education center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Scie.ce. China Medical UniversityTaichungTaiwanChina Department of post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

patients with suspected OSA were examined using *** were divided into two groups based on the prese.ce.of *** was defined as a patient who needed to void at least *** index(AHI)was employed to classify patients according to degrees of severity:AHIevents/h,5 events/hAHIevents/h,15 events/hAHIevents/h,and AHI30 events/h,defined as normal,mild OSA,moderate OSA,and severe OSA,*** variables,pSG parameters,International prostate Symptom Scores(IpSSs),and quality of life scores due to urinary symptoms were ***:In total 140 patients,114 patients had OSA(48 had mild OSA;34 had moderate OSA;and 32 had severe OSA)and 107 patients had *** total IpSS was significantly higher in nocturia patients in all groups e.ce.t the group of severe OSA *** the increasing severity of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxygenation saturation(p=0.046),and decreased AHI of non-rapid eye movement(p=0.047),AHI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(pe time(p=0.025),stage 1 sleep(p=0.033),and sleep latency(p=0.033),and decreased height(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea polysomnography Apneaehypopnea index International prostate Symptom Score

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