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Correlation between IL28B/TLR4 genetic variants and HCC development with/without DAAs treatment in chronic HCV patients

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Genes & Diseases 2020年第3期7卷 392-400页

作者： Ghada M.Salum Reham M.Dawood Mai Abd el-Meguid Noha e.ibrahim Ashraf O.Abdel Aziz Mostafa K.el Awady Department of Microbial Biotechnology Genetic Engineering DivisionNational Research Centre33 EL Bohouth St.(former El Tahrir St.)DokkiGizaP.O.12622Egypt Department of Tropical Medicine Faculty of MedicineCairo UniversityGizaP.O.12622Egypt

In egypt,Sofosbuvir(SOF)in combination with Dataclasvir(DCV)is the broadly used DAAs with excellent therapeutic *** study is designed to explore the relation between IL28B/TLR4 genetic variants and each of the followings;HCC development post SOF/DCV treatment,progression to HCC in naı¨ve patients and SOF/DCV therapy outcome.A total of 493 blood samples were collected(controls(n = 70);HCV patients treated with SOF/DCV(n = 252)of whom 65 patients developed HCC,187 patients didn’t develop HCC(125 responders,62 relapsers);naı¨ve HCV patients(n = 171)had early(n = 48),late liver fibrosis(n = 21)and HCC(n = 102)).Both SNPs were genotyped using a TaqMan 50 allelic discrimination *** IL28B rs12979860 SNP,the C allele was significantly correlating with the response rate more than T allele(OR 1.9,95%CI 1.29e2.9,p=0.004),while at TLR4 rs4986791 SNP,no association was found(OR 6.5,95%0.57e75.28,p = 0.09).Both SNPs couldn’t detect the probability for HCC emergence after *** naı¨ve patients,the protective alleles were detected in their lowest frequency in HCC patients(p = 0.1,for rs12979860 and,p = 0.001 for rs4986791).SOF/DCV combination improved SVR rates in HCV genotype 4a infected patients regardless of IL28B genotype,with the best rates in those lacking the T allele.

关键词： DAAs DCV HCV HCC IL28B SOF TLR4

Geology and geochemistry of the granitic rocks and associated dykes,east Gabal Nuqra,South eastern Desert,egypt

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Chinese Journal Of Geochemistry 2012年第4期31卷 376-389页

作者： ibrahim H.ibrahim Mostafa e.Darwish Nuclear Material Authority 530 P.O.El MaadiCairoEgypt

A crescent-shape granitic stock and associated dykes is located to the east Gabal Nuqra at the extreme western part of Wadi Natash,South eastern Desert,*** examined granites are classified as alkali-feldspar granites and mainly consist of quartz,potash feldspars,plagioclases,and ***,zircon,apatite and allanite are accessories representing the source of Y,U,Th and Rees in these *** granites are characterized by high K2O,Na2O and Zn contents and Rb/Sr ***,they are highly enriched in high field strength elements(HFSe),especially Zr(1529×10-6),Nb(100×10-6),Hf(91×10-6) and Y(624×10-6) and light rare-earth elements(LRee,141×10-6) concentrations and strongly depleted in Ca,Mg,Sr and eu *** features suggest that they are similar to A-type granites(type-2).The rhyolite dykes and granites have similar geochemical characteristics whereas the chondrite-normalized Ree patterns show a LRee enriched feature with strong negative eu-anomaly,whereas the Ree pattern of trachydacites show slightly fractionated pattern with no *** is suggested that the trachydacites were generated by small degree of partial-melting deep-seated basic *** liquid,when subjected to fractional crystallization involving separation of plagioclases as residue,generated the alkali-feldspar *** further fractional crystallization gave rise to the alkali *** igneous rock suite originated from metaluminous to alkaline trachytic magma,and was developed in a within-plate tectonic *** extension caused by NW-Se right-lateral shear in area led to the emplacement of the alkali-feldspar *** later extrusion of the alkali rhyolite and trachydacite dykes was due to cauldron subsidence.

关键词：碱长花岗岩地球化学特征堤坝沙漠埃及轻稀土元素碱性流纹岩元素富集特征

Approximate analytical solutions and mean energies of stationary Schrodinger equation for general molecular potential

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Chinese Physics B 2021年第7期30卷 116-131页

作者： eyube e S Rawen B O ibrahim N Department of Physics School of Physical SciencesModibbo Adama University of TechnologyP M B 2076 YolaAdamawa StateNigeria Directorate of Basic and Remedial Studies Abubakar Tafawa Balewa University(ATBU)P M B 750001BauchiBauchi StateNigeria Department of Physics Faculty of ScienceP M B 1069MaiduguriBorno StateNigeria

The Schrodinger equation is solved with general molecular potential via the improved quantization *** for bound state energy eigenvalues,radial eigenfunctions,mean kinetic energy,and potential energy are obtained in compact *** modeling the centrifugal term of the effective potential,a Pekeris-like approximation scheme is ***,we use the Hellmann–Feynman theorem to derive the relation for expectation *** state energy eigenvalues,wave functions and meanenergies of Woods–Saxon potential,Morse potential,Mobius squared and Tietz–Hua oscillators are deduced from the general molecular *** addition,we use our equations to compute the bound state energy eigenvalues and expectation values for four diatomic molecules viz.H_(2),CO,HF,and O_(2).Results obtained are in perfect agreement with the data available from the literature for the potentials and *** also show that as the vibrational quantum number increases,the mean kinetic energy for the system in a Tietz–Hua potential increases slowly to a threshold value and then *** in a Morse potential,the mean kinetic energy increases linearly with vibrational quantum number increasing.

关键词： general molecular potential Schrodinger equation improved quantization rule

exact Solutions of Nonlinear evolution equations in Mathematical Physics Using the Modified Simple equation Method

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Chinese Physics Letters 2012年第6期29卷 1-4页

作者： e.M.e.Zayed S.A.Hoda ibrahim Department of Mathematics Faculty of ScienceZagazig UniversityP.O.Box 44519ZagazigEgypt

The modified simple equation method is employed to construct the exact solutions involving parameters of nonlinear evolution equations via the (1+1)-dimensional modified KdV equation,and the (1+1)-dimensional reaction-diffusion *** these parameters are taken to be special values,the solitary wave solutions are derived from the exact *** is shown that the proposed method provides a more powerful mathematical tool for solving nonlinear evolution equations in mathematical physics.

关键词： equation. exact equation

Flow computations past a triangular boattailed projectile

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Defence Technology（防务技术） 2020年第3期16卷 712-719页

作者： e.elawwad A.ibrahim A.elshabkaa A.Riad Armed Forces Research Center(ARC) Cairo11765Egypt Military Technical College(MTC) Cairo11766Egypt

This paper presents a computational study of the air flow past a triangular boattailed *** study shows that there is a single normal shock wave impinges the projectile at transonic *** supersonic speeds,the formed shock waves are smeared compared to a conical boattailed ***,there is a reduction of the wake region behind the triangular base and the rear stagnation point is nearer to the projectile base resulting in base drag ***,there is an improvement of the stability of the triangular boattailed projectile since a lower overturning moment is incurred.

关键词： Triangular base Boattailed projectile Drag reduction Range extension

exact Solutions of Kolmogorov-Petrovskii-Piskunov equation Using the Modified Simple equation Method

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Acta Mathematicae Applicatae Sinica 2014年第3期30卷 749-754页

作者： e.M.e.Zayed S.A.Hoda ibrahim Mathematics Department Faculty of ScienceZagazig University

The modified simple equation method is employed to find the exact solutions of the nonlinear Kolmogorov-Petrovskii-Piskunov （KPP） equation. When certain parameters of the equations are chosen to be special values, the solitary wave solutions are derived from the exact solutions. It is shown that the modified simple equation method provides an effective and powerful mathematical tool for solving nonlinear evolution equations in mathematical physics.

关键词： modified simple equation method Kolmogorov-Petrovskii-Piskunov equation exact solutions solitary wave solutions

In Vitro Antimicrobial Activity of Summer Squash(Cucurbita pepo L.)

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In Vitro Antimicrobial Activity of Summer Squash(Cucurbita p...

Ballistic resistance and energy dissipation of woven-fabric composite targets:Insights on the effects of projectile shape and obliquity angle

中国科学院地质与地球物理研究所第十届(2010年度)学术年会

作者： Salwa e.ibrahim ibrahim F.Ahmed Osman Khalil el Badri A. Osman School of Life Science and Technology.Box 75 Beijing University of Chemical Technology Nol5 Bei San Huan Dong LuBeijing100029P.R.China Faculty of Pure and applied Science international University of AfricaSudan

The aim of this study was to screen and evaluate the antimicrobial activity of Summer squash(Cucurbita pepo L.) extracts,dissolved in dimethylsulfoxide,using the diffusion method,against four standard organisms(Bacillus subtilis,Staphylococcus aureus,escherichia coli, and Candida albicans).The methanol extract exhibited higher activity against bacteria and fungi than the petroleum ether extract,but its activity varied with different organs of the plant(***,stems, leaves,flowers and fruits).The aqueous extracts exhibited low activity against organisms tested than non-aqueous *** highest activity of methanolic fractions was obtained from ethyl acetate fraction followed by butanolic fraction,whereas the petroleum ether extract exhibited no activity on *** studies showed that the extracts contain sterols triterpens,saponins,carotenoids and reducing *** results showed that summer squash possesses high antimicrobial *** its activity varies with the nature of the solvent used forextraction,and the part of the plant used i.e.,roots, shoots and flowers.

关键词： Cucurbita pepo L. antimicrobial activity phytochemical screenin

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Defence Technology（防务技术） 2023年第3期21卷 14-32页

作者： ibrahim Goda UniversitéBourgogne Franche-Comté FEMTO-ST InstituteDépartement Mécanique Appliquée24 Rue de L’Épitaphe25000BesançonFrance

This study aims at investigating the ballistic resistance and energy absorption in woven e-glass composite panels,considering different projectile nose shapes and oblique incidence *** that scope,three-dimensional finite element(Fe)models of both projectiles and the laminated target are developed and numerical investigations are carried out using Abaqus explicit *** composite damage model’s constitutive law encompasses nonlinear material response,material properties degradation,progressive failure,and an element deletion *** cohesive surface technique is used to represent the interface between two adjacent plies in the laminate,and the traction-separation law is used to characterize the behaviors of interlaminar degradation and *** responses attributable to fiber rupture,matrix cracking,and plasticity caused by micro-matrix cracking due to shear loading are taken into account with suitable damage evolution *** computational framework is first validated against the experimental results reported in the literature by performing ballistic impact tests on the target laminate with conical,hemispherical and blunt-ended projectile,and the numerical results showed a good comparison in terms of residual *** the framework is explored in simulating more complex failure mechanisms,with particular emphasis on the influence of the impact angle of obliquity,a parameter that is not usually analyzed in the *** that regard,the effects of normal and oblique impact on the damage morphologies and ballistic behavior of the fabric composite target in terms of energy absorption,impact contact force,and projectile residual velocity are conducted and analyzed,*** findings showed that the ballistic impact behavior of target composite is substantially influenced by projectile nose shape and incidence angle obliquity.

关键词： resistance cracking composite

effect of Aging on the Toughness of Austenitic and Duplex Stainless Steel Weldments

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Journal of Materials Science & Technology 2010年第9期26卷 810-816页

作者： Omyma Hassan ibrahim ibrahim Soliman ibrahim Tarek Ahmed Fouad Khalifa Metallurgy Dept. Nuclear Research CentreAtomic Energy Authority(Egypt) Nuclear Safety Centre Atomic Energy Authority(Egypt) Shoubra Faculty of engineering Benha University

In the present study,the effect of aging heat treatment at 650,750,and 850？C on the impact toughness of 316L austenitic stainless steel,2205 duplex stainless steel and their weldments has been *** process was conducted using the TIG（tungsten inert gas） welding *** impact testing,at room temperature,was employed to determine the effect of aging treatment on the impact properties of investigated *** treatment resulted in degradation in the impact toughness as demonstrated by the reduction in the impact fracture energy and deformation parameters（strain hardening capacity,fracture deffection,and crack initiation and propagation energy）.The degree of embrittlement was more noticeable in duplex stainless steel parent and weld-metal than in 316L stainless steel and became greater with the increase of aging *** degradation in impact toughness was discussed in relation to the observed precipitation of the intermetallic sigma phase in the microstructure of the stainless steel weldments and the corresponding fracture surface morphology.

关键词： Austenitic and duplex stainless steels Aging Instrumented impact Toughness