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Therapeutic application of mesenchymal stem cells-derived extracellular vesicles in colorectal cancer

BIOCELL 2023年第3期47卷 455-464页

作者： mohadeseh nemati YOUSEF RASMI JAFAR REZAIE Department of Biochemistry School of MedicineUrmia University of Medical SciencesUrmiaIran Solid Tumor Research Center Cellular and Molecular Medicine InstituteUrmia University of Medical SciencesUrmiaIran

Colorectal cancer(CRC)is the third most common cancer and the leading cause of cancer death *** to therapy is a challenge for CRC *** stem cells(MSCs)have become one of the furthermost effective approaches for tumor treatment due to their specific feature;however,their therapeutic function is ***,extracellular vesicles(EVs)derived from MSCs(MSCs-EVs)have attracted extensive research attention due to their promising role in CRC *** are cell-derived vesicles that transfer different biomolecules between cells,contributing to intracellular ***-EVs can suppress CRC by delivering therapeutic agents to tumor *** studies indicate that MSCs-EVs can serve as a drug delivery system for the treatment of different *** methods are used to modify(engineer)MSCs-EVs for loading therapeutic *** MSCs-EVs have improved specificity,targeting ability,and immunogenicity compared to synthetic ***,CRC-EVs participate in regulating different cells,such as immune cells,fibroblasts,and endothelial cells,promoting ***-EVs-based therapy indicates a high potential in the treatment of cancer;however,the majority of studies have been conducted in the pre-clinical,and their clinical applications need further *** this review,we describe the biogenesis of EVs,focusing on the effect of MSCs-EVs on CRC cells and CRC-derived EVs on other ***,MSCs-EVs as a drug delivery system for cancers is also reviewed,and perspectives regarding the therapeutic application of MSCs-EVs are discussed.

关键词： Colorectal cancer Cancer therapy MSCs Extracellular vesicles

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Evaluation of Serum Iron, Zinc and Their Relationships with Glycemic Control Status in Iranian Elderly Women with Type 1 Diabetes Mellitus

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Journal of Pharmacy and Pharmacology 2015年第9期3卷 411-416页

作者： Mahshid Mohammadian Attabak Toofani Milani Mohammad Reza Hassas Siamak Rashidi Elmira Roshani Asl Sadegh Rostaminasab mohadeseh nemati Farid Javandust Narmin Mokarizadeh Farhad fathi younesi Department of Biochemistry Urmia University of Medical Sciences Urmia 57147 West Azerbaij'an Iran Aria Medical Laboratory Urmia University of Medical Sciences Sanandaj *** Kurdistan Iran Department of Medicine Urmia University of Medical Sciences Urmia 5 714 7 West Azerbaijan Iran Department of Biochemistry Faculty of Medicine Shahid Beheshti University of Medical Sciences Tehran *** Tehran Iran

It seems that defects on micro-minerals levels have an etiologic role involved in type 1 diabetes mellitus pathogenicity. The aim of our study were to evaluate the serum levels of zinc and iron and investigate their possible relationship between these biochemical parameters with demographic conditions and glycemic control in patients with type 1 diabetes mellitus disorder. In this case-control based study, 68 female with type 1 diabetes mellitus with a mean age of 52.2 ±2 as case group and 122 healthy women as a control group with a mean age of 49/4 ±3/2 were investigated .for biochemical analysis ,10 mL fasting venous blood sample were obtained from each subjects. FBS （fasting blood glucose）, fructosamine （glycemic control parameter） were determined （spectrophotometry method, （pars azmoon, Iran）, nitroblue tetrazoline method respectively）.serum zinc level with colorimetric method （Biorex-UK） and serum iron with photometric method （pars azmoon, Iran） were determined. Statistical analysis using SPSS software performed. Significant levels considered as P 〈 0.05. According to this study there is statistically significant difference between serum levels of iron and zinc in patients with type 1 diabetes compared to controls .indeed serum level of iron and zinc had lower level in patient group toward controls. In patients group, there are a positive correlation between age and decreased level of serum zinc （P 〈 0.05）. Also there was a significant negative correlation between the glycemic control status and serum zinc. Other studied parameters concluded BMI （body mass index）, Weight and height have not significant difference between groups. The decrease in serum iron and zinc level in women with type 1 diabetes may be related to low dietary intake or increased excretion of micro minerals or the presence of confounding factors that require more extensive intervention studies to confirm it.

关键词： Typel diabetes mellitus Iron Zinc glycemic control Iran.

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