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Traditional medical uses of Drimia species in terms of phytochemistry,pharmacology and toxicology

Journal of Traditional Chinese Medicine 2017年第1期37卷 124-139页

作者： Mahbubeh Bozorgi Gholamreza.amin Maryam Shekarchi Roja Rahimi Department of Traditional Pharmacy School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Teh-ran University of Medical SciencesTehran ***Iran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Food and Drug Laboratory Research Center and Food and Drug Control Laboratories MOH and METehran ***Iran

Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications,skin disorders, epilepsy and cancer. Toxic properties of some Drimia species also were noted by ancient scientists and these plants have been traditionally used for rat control. Bufadienolides have been identified as the main constituents in the genus of Drimia. Phenolics, sterols, protein and some of other phytochemicals have been also isolated from these plants. Pharmacological and clinical studies have strongly approved their effect on cardiovascular system. Extracts and compounds isolated from Drimia species showed biological activities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory and insecticidal effects throughseveral in vivo and in vitro studies. Moreover, cytotoxic and antitumor activities which may be related to bufadienolide content of these plants have been considered by many researchers. Traditional therapeutic values of these plants for treating respiratory and rheumatic ailments as well as skin disorders are needed to be validated through more researches. Toxic effects of these plants and isolated compounds have been investigated through several in vivo studies. Drimia plants and their isolated compounds have narrow therapeutic index, so patients should be prohibited from applying these plants without medical supervision and should be informed about the main intoxication symptoms before starting treatment. Moreover, interaction of Drimia plants with other constituents of traditional herbal mixtures as well as chemical and biological modalities for reducing toxicity of bufadienolide compounds can be subjected for future studies.

关键词： Urginea Ethnopharmacology Toxicolo-gy Cardiac glycosides

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Finger Printing and Quantitative Analysis of <i>Cuscuta chinensis</i>Flavonoid Contents from Different Hosts by RP-HPLC

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Food and Nutrition Sciences 2014年第10期5卷 914-921页

作者： Maryam Shekarchi Babak Mokhtari Kondori Homa Hajimehdipoor Leila Abdi mohsen Naseri Mojgan Pourfarzib Gholamreza.amin Clinical Trial Research Center of Traditional Medicine Shahed University Tehran Iran Department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Department of Traditional Medicine Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Department of Traditional Medicine Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran Food and Drug Control Laboratories and Food and Drug Laboratory Research Center MOH and ME Tehran Iran Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

Background: Cuscuta spp. known as dodders, have been used as traditional medicines in eastern and southern Asian countries for many disorders such as gastrointestinal, respiratory, endocrine, skin and neurological diseases (Drug of mania). Flavonoids are the main biologically active constituents in Cuscuta genus especially in C. chinensis. Our aim in this study was to identify and discriminate between C. chinensis samples which were collected from different hosts, by using the pattern recognition aided fingerprint analysis and comparison of the content of four major flavonoids (hyperoside, rutin, isorhamnetin, kaempferol). Material and methods: Samples were collected from nine different plants in the same time and place, dried, grinded and extracted with methanol (80%) by repeated maceration. Extractions were evaluated by high performance liquid chromatography analysis and fingerprinting. Results: Beside chromatographic fingerprint using similarity index, we compared the content of 4 major flavonoids (hyperoside, rutin, isorhamnetin, kaempferol) of C. chinensis samples on different hosts. Coclusion: The results showed that there were significant differences between the content of four major flavonoids of nine C. chinensis samples, but chromatographic fingerprint by similarity index of more than 0.88, showed that the sample consistency was similar. So, it was suggested that combination of chromatographic fingerprint and the content determination of major flavonoids could be used to evaluate the quality control of C. chinensis from different hosts.

关键词： Cuscuta chinensis Fingerprint Flavonoids Hosts Similarity

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