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Journal of Life Sciences 2015年第2期9卷 51-64页

作者： Marguerite Simo Kamdem modeste lambert sameza Pierre Michel Jazet Dongmo Fabrice Fekam Boyom Issakou Bakargna-Via Jean Baptiste Hzounda Fokou Ide Flavie Kenfack Tsague Elisabeth Zeuko'o Menkem Paul Henri Amvam Zollo Chantal Menut Department of Biochemistry Faculty of Science University of Yaounde I Yaounde P. O Box 812 Cameroon Department of Biochemistry Faculty of Science University of Douala Douala P.O Box 24157 Cameroon ENSAL University of Ngaoundere Ngaoundere P.O Box 455 Cameroon IBMM Montpellier-UMR 5247 Faeulte de Pharmaeie 15 Avenue Charles Flahault Montpellier 34093 France

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浙江省某县县域医共体抗菌药物管理案例研究

中国社会医学杂志 2024年第4期41卷 391-396页

作者：邓子如董晓莲王伟马聪付朝伟 Helen lambert 王娜严非复旦大学公共卫生学院国家卫健委卫生技术评估重点实验室上海200032 德清县疾病预防与控制中心浙江湖州313200 英国布里斯托大学人口健康科学系布里斯托BS82PS

目的探究浙江省某县县域医共体内部抗菌药物管理政策和措施实施中的经验和问题。方法研究团队于2019年10月及2020年7月赴浙江省某县开展现场调查,通过目的性抽样收集医共体内两家医疗机构的抗菌药物相关数据进行描述性分析,并对四家医... 详细信息

目的探究浙江省某县县域医共体内部抗菌药物管理政策和措施实施中的经验和问题。方法研究团队于2019年10月及2020年7月赴浙江省某县开展现场调查,通过目的性抽样收集医共体内两家医疗机构的抗菌药物相关数据进行描述性分析,并对四家医疗机构中的15名关键知情人进行访谈,了解医共体内抗菌药物管理制度与抗菌药物使用状况。结果案例县县域医共体内机构已成立架构清晰的抗菌药物管理系统;设有前置审方、事后点评、绩效奖惩等管理措施;近年来抗菌药物使用相关指标总体呈下降趋势,县医院门诊、住院抗菌药物使用率均达到国家标准,但县医院住院患者抗菌药物使用强度、乡镇卫生院门诊抗菌药物使用率仍高于国家标准。结论案例县依托县域医共体制度优势,促进医疗机构抗菌药物自上而下管理,管理组织架构清晰,措施较为全面,注重过程管理,动态调整考核指标;但仍需加大对临床药师等专业技术人员的培养,完善抗菌药物管理信息系统。

关键词：抗菌药物管理县域医共体案例研究

A Review on TSO-DSO Data Exchange,CIM Extensions and Interoperability Aspects

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 309-315页

作者： Arsim Bytyqi Siddhesh Gandhi Eric lambert Nejc Petrovic European Network of Transmission System Operators(ENTSO-E) BrusselsBelgium Electricite de France(EDF) ParisFrance Elektro Gorenjska LjubljanaSlovenia

The exchange of information between transmission system operators(TSOs)and distribution system operators(DSOs)is a common ***,the evolution of the regulatory frameworks in Europe has increased the need for enhancing TSO-DSO data exchange and *** paper provides an overview of the TSO-DSO data exchanges and demonstrates the best practices using International Electrotechnical Commission(IEC)common information model(CIM),including the implementation of IEC common grid model exchange standard(CGMES),and discussion of the corresponding advantages,disadvantages,and ***,this paper evaluates and reports the activities already carried out within European projects,with particular focus on TSO-DSO ***,this paper concludes the need for TSOs and DSOs to rely on standard-based solutions when performing TSO-DSO data exchange,which enables the efficient operation and development of the future power systems.

关键词： Transmission system operator(TSO) distribution system operator(DSO) data exchange interoperability standardization common information model(CIM) common grid model exchange standard(CGMES)

Tidal triggering of seismicity in the region of Palu, Central Sulawesi, Indonesia

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Geodesy and Geodynamics 2023年第4期14卷 377-384页

作者： Ibnu Nurul Huda Sebastien lambert Jean Souchay Research Center for Computing National Research and Innovation AgencyBogorIndonesia Department of Astronomy and Bosscha Observatory FMIPAInstitut Teknologi BandungBandungIndonesia SYRTE Observatoire de ParisUniversité PSLCNRSSorbonne UniversitéLNEParisFrance

This paper investigates the correlation between tidal stress and earthquakes for periods ranging from hours to months in the limited zone of the Palu region(Central Sulawesi,Indonesia).Through Schuster and binomial tests,we examined the relation between the seismicity(time density of seismic events)and tidal potential arising from the Moon and Sun,using all tidal components simultaneously and focusing on the estimation of specific *** results show significant correlations between the seismicity and tidal potential for S2(0.5 d)and O1(1.075 d)tidal components in the case of solely isolated earthquake events,particularly for shallow ***,there is a strong relationship between aftershocks and tidal components larger than the Mf period(13.661 d).Finally,the analysis of the temporal variation of the earthquake-tide relation reveals an optimal correlation for about six years before the 2018 great Palu *** correlation becomes insignificant afterwards.

关键词： Tidal triggering Earth tides Palu region Statistical test

Neurocognitive Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in Kinshasa in the Dolutegravir Era, Democratic Republic of Congo

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Neuroscience & Medicine 2024年第1期15卷 1-22页

作者： Candide About Kabamba Berry Ikolango Bongenya Jocelyn Ewuti Nonga lambert Omombo Losenga Noëlla Maketi Dikati Thérèse Kasaka Ntumba Grace Ipaya Booto Rosalie Djamba Dembo Stéphanie Mauwa Selenge Benoit Obel Kabengele Guy Makila Mabe Bumoko Marie-Thérèse Ayane Safi Sombo Erick Ntambwe Kamangu Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo “Focus HIV/AIDS” Research Group Kinshasa Democratic Republic of Congo Department of Internal Medicine University Clinic of Kinshasa Kinshasa Democratic Republic of Congo Molecular Biochemistry Department Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Context: Antiretroviral therapies improve the prognosis of NeuroAIDS contrasting with a high frequency of Minor Neurocognitive Disorders (MND) even in aviremic subjects. Objective: The objective of this study is to present the neurological and cognitive profile of People Living with HIV (PLHIV) initiating antiretroviral treatment in Kinshasa in the era of Dolutegravir (DTG). Methods: This is a multicenter, cross-sectional study with a descriptive aim carried out in 16 HIV Outpatient Treatment Centers (OTC) in Kinshasa from October 4, 2021 to February 15, 2022. The International HIV Dementia Scale (IHDS) correlated with the Activities of Daily Living (IADL) scale facilitated the categorization of NeuroCognitive Disorders (NCD) of PLHIV evaluated after carrying out a summary neurological examination. Results: Of the 96 patients recruited, 56.3% were women with a sex ratio of 0.68. The average age was 40.1 ± 12.1 years. The secondary education level was the majority at 64.6%. Malaria (44.8%) and tuberculosis (32.3%) were more common as opportunistic infections. They were alcoholics in (30.2%). Their history was heart disease (15.6%), high blood pressure (18.8%);drug abuse (10.4%). The IHDS score was light in 55.2% of cases. The correlation between IHDS/IADL watches asymptomatic neurocognitive impairments (ANI) in 77.1%, almost all of subjects are found with normal overall functioning (94.8%) and a disturbed neurological examination in 53.1% of cases with a predominance of motor impairments in 79.1%. Conclusion: In view of these results, early and systematic screening of NCD and associated factors remains necessary in our context. .

关键词： IHDS Dolutegravir Initiation Kinshasa Neurological Profile PLHIV

Sensory Phenotypic and Molecular Identification of Aromatic Rice Accessions Cultivated in Benin

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Advances in Bioscience and Biotechnology 2024年第3期15卷 195-206页

作者： Chimène Nadège Mahoussi Nanoukon Koffi David Montcho Hambada Deless Edmond Fulgence Thiémélé Bignon Meyrix Pamela Franzel Loumedjinon Babatoundé Franel Carel Wenceslas Affolabi Amed Sèmèvo Havivi Kéllya Laurinzo Déguénon Grâce Finagnon Vitoekpon Arielle Bankole lambert Gustave Djedatin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Bio-technologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Biotechnologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Plant Horticultural and Forestry Sciences National University of Agriculture Kétou Benin Genetics Teaching and Research Unit Department of Biochemistry-Genetics Peleforo GON COULIBALY University Korhogo C&#244te d’Ivoire

Rice is one of the most widely cultivated cereals in the world, and its aroma is increasingly in demand. With the advancement of research, a major rice flavor gene has been identified on rice chromosome 8. It encodes non-functional betaine aldehyde dehydrogenase leading to the accumulation of 2-acetyl-1-pyrroline which is the major olfactory compound that confers the fragrant character to rice. The aroma of rice is considered a special trait of enormous economic importance that determines the prime price in world trade. To satisfy the needs of the population and reduce rice imports into Benin, we conducted this study to identify aromatic rice accessions grown in Benin. Seventy-two rice accessions collected across Benin were PCR amplified with three SSR markers RM 7049, Aro 7, and RM 223, linked to the fgr (fragrance of rice) aroma gene. Molecular analysis revealed that 12 of the 72 accessions, namely Bagou 19, Bagou 22, Tchaka 34, Foun 15, Tchaka 41, Nana 32, Kan 61, Kung 69, Kung 67, Bagou 20, Agbab 101 and Koum 55 possess the fgr gene and can be considered as aromatic rice accessions. A sensory phenotypic test using KOH was carried out on rice accessions carrying fgr gene. Of the twelve positives, only one had the smell of aromatic rice, like the Azucena control. These results show that Benin also has aromatic rice varieties that can be sold on national and international markets.

关键词： Aromatic Rice 2-Acetyl-1-Pyrroline SSR Markers Benin

The pikas of China: a review of current research priorities and challenges for conservation

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Integrative Zoology 2023年第1期18卷 110-128页

作者： Joseph P.lambert Xiaozheng ZHANG Kun SHI Philip RIORDAN Wildlife Institute School of Nature ConservationBeijing Forestry UniversityBeijingChina Eco-Bridge Continental Haidian DistrictBeijingChina Marwell Wildlife WinchesterHampshireUK

Of the approximately 30 extant species of pika(Ochotona;Ochotonidae;Lagomorpha),at least 23 occur in *** these,8 are endemic,and 3 are classiﬁed as Endangered by the *** into most Chinese species is scarce,and there is much to learn about basic aspects of their *** reviewed the literature on the 23 Chinese Ochotona species,with the aim of highlighting knowledge gaps and biases in research ***ﬁcally,we identify(1)which pika species receive the most attention from researchers,(2)which topics are the most frequently studied,and(3)how well research satisﬁes conservation *** covered a total of 879 articles,most of which were written in English or *** 75%of all publications focused on the plateau pika Ochotona *** species were represented by 10 or fewer publications *** and endemic species were particularly poorly represented.204 papers treated pikas as a pest,while 13 studied conservation *** species were considered possible targets for pest control,including some poorly known *** make some recommendations on how research into Chinese Ochotona could be improved,including:(1)recognizing that the current species-level taxonomy may be an ineffective way to prioritize conservation research in Ochotona,(2)directing more research toward threatened and endemic species,subspecies,and populations,(3)researching the ecosystem engineering effects of pikas,(4)collecting basic data on natural history of the many understudied species,and(5)researching threats,including climate change and pest control campaigns.

关键词： conservation Lagomorpha Ochotona prioritization research allocation

The Relationship between Model Biases in East Asian Summer Monsoon Rainfall and Land Evaporation

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Advances in Atmospheric Sciences 2023年第11期40卷 2029-2042,I0004-I0013页

作者： Ruth GEEN Marianne PIETSCHNIG Shubhi AGRAWAL Dipanjan DEY FHugo lambert Geoffrey KVALLIS School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK Department of Mathematics and Statistics University of ExeterExeter EX44QJUK Department of Earth and Environmental Sciences Indian Institute of Science Education and ResearchBhopal 462066India School of Ocean and Earth Science University of SouthamptonSouthampton SO171BJUK

The East Asian Summer Monsoon(EASM)provides the majority of annual rainfall to countries in East *** state-of-the-art models broadly project increased EASM rainfall,the spread of projections is large and simulations of present-day rainfall show significant climatological *** evapotranspiration biases occur locally over East Asia,and globally over land,in simulations both with and without a coupled *** study explores the relationship between evapotranspiration and EASM precipitation ***,idealized model simulations are presented in which the parameterization of land evaporation is modified,while sea surface temperature is *** results suggest a feedback whereby excessive evapotranspiration over East Asia results in cooling of land,a weakened monsoon low,and a shift of rainfall from the Philippine Sea to China,further fueling ***-model regressions against evapotranspiration over China indicate a similar pattern of behavior in Atmospheric Model Intercomparison Project(AMIP)*** causes of this pattern are *** feedback is not explained by an overly intense global hydrological cycle or by differences in radiative *** of land-only simulations indicates that evapotranspiration biases are present even when models are forced with prescribed *** are strengthened when coupled to the atmosphere,suggesting a role for land-model errors in driving atmospheric *** atmosphere-ocean models are shown to have similar evapotranspiration biases to those in AMIP over China,but different precipitation biases,including a northward shift in the ITCZ over the Pacific and Atlantic Oceans.

关键词： monsoon East Asia China evapotranspiration model bias

Supramolecular gating of guest release from cucurbit[7]uril using de novo design

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npj Computational Materials 2022年第1期8卷 172-179页

作者： Hugues lambert Alvaro Castillo Bonillo Qiang Zhu Yong-Wei Zhang Tung-Chun Lee Institute of High Performance Computing A*STAR1 Fusionopolis WayConnexis Tower138632SingaporeSingapore Department of Chemistry Christopher Ingold BuildingUniversity College London(UCL)20 Gordon StreetLondonWC1H 0AJUK Institute for Materials Discovery University College London(UCL)LondonUK Institute of Materials Research and Engineering A*STAR2 Fusionopolis WayInnovis Tower138634SingaporeSingapore

Herein we computationally explore the modulation of the release kinetics of an encapsulated guest molecule from the cucurbit[7]uril(CB7)cavity by ligands binding to the host *** uncovered a correlation between the ligand-binding affinity with CB7 and the guest residence time,allowing us to rapidly predict the release kinetics through straightforward energy minimization *** high-throughput predictions in turn enable a Monte-Carlo Tree Search(MCTS)to de novo design a series of cap-shaped ligand molecules with large binding affinities and boosting guest residence times by up to 7 orders of ***,halogenated aromatic compounds emerge as top-ranking *** modeling suggests the presence of halogen-bonding between the ligands and the CB7 ***,the binding of top-ranked ligands is supported by^(1)H NMR and 2D *** findings open up possibilities in gating of molecular transport through a nanoscale cavity with potential applications in nanopore technology and controlled drug release.

关键词： release kinetics straight

The ecological validity of traditional standing and novel bicycle balance and agility tests for predicting performance in mountain bikers

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Sports Medicine and Health Science 2022年第4期4卷 287-292页

作者： K.Buchholtz M.lambert T.L.Burgess Health Physical ActivityLifestyleand Sport(HPALS)Research CentreUniversity of Cape TownCape TownSouth Africa Department of Physiotherapy LUNEX International University of HealthExercise and SportsLuxembourg Division of Physiotherapy University of Cape TownAnzio RoadObservatoryCape TownSouth Africa Centre for Medical Ethics and Law Faculty of Medicine and Health SciencesStellenbosch UniversityCape TownSouth Africa

Falls are a common mechanism of injury in mountain biking and may be related to a loss of control of the ***,the components of bicycle control(balance and agility)are measured in standing and running,which may not reflect the skills required in mountain *** this paper,we present the validity of both traditional standing and novel bicycle-specific balance tests in mountain ***-nine male and female participants completed indoor laboratory tests and an outdoor downhill *** completed single-leg stance balance,Y-balance test,one static and four dynamic bicycle-specific balance tests,a bicycle agility test,and an outdoor downhill ***-leg stance balance and Y-balance tests with eyes open had poor validity when associated with bicycle *** static(r=-0.57,p=0.001)and four dynamic bicycle balance tests(r=-0.51 to-0.78,p=0.005 to 0.0001),and the bicycle agility test(r=0.87,p<0.0001)had moderate to strong relationships with the outdoor downhill ***-leg stance balance and Y-balance tests with eyes open are not valid measures of performance on a mountain bike,and should not be used to assess these *** novel bicycle balance tests have adequate validity to be used as measures of performance in mountain bikers.

关键词： Bicycling Control Proprioception