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Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies

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World Journal of Gastroenterology 2006年第44期12卷 7136-7142页

作者： Mohammed Ibrahim Aleem A Khan Santosh K Tiwari Mohammed Aejaz Habeeb mn khaja CM Habibullah Centre for Liver Research and Diagnostics Deccan college of Medical Sciences and Allied Hospitals Kanchanbagh Hyderabad India

AIM： To evaluate the antibacterial activity of Sapindus mukorossi （S. mukorossl） and Rheum emodi （R. emodl）. METHODS： Powders of S. mukorossi and R. emodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. The disk diffusion method was used for in vitro studies and in vivo studies were performed on male Wister rats. Thirty resistant clinical isolates of H pylon, as determined by their antibiotic sensitivity patterns by E-test, along with two Gram ＋ve （S. aureus, B. subtilis） and two Gram -ve （E. coli, P. vugaris） organisms were screened for their susceptibility patterns against these extracts. RESULTS： In our screening, all 30 resistant isolates and the other four organisms （two Gram ＋ve S. aureus, B. subtilis and two Gram -ve, E. coli, P. vugaris） were sensitive to the test compounds. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited Hpylori at very low concentrations, In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations （10 μg/mL） for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi （2.5 mg/mL） and R. emodi （3.0 mg/mL） given orally for seven days. CONCLUSION： We can conclude from this study that the extracts of S. mukorossi and R. emodi inhibited the growth of pylori in vitro and, in in vivo studies, the H pylori infection cleared within seven days at very low concentrations. We also found that H pylori did not acquire resistance against these herbal extracts even after 10 consecutive passages.

关键词： H pylori Sapindus mukorossi Rheum emodi

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Ternary MOF‑Based Redox Active Sites Enabled 3D‑on‑2D Nanoarchitectured Battery‑Type Electrodes for High‑Energy‑Density Supercapatteries

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Nano-Micro Letters 2021年第1期13卷 319-336页

作者： Goli Nagaraju SChandra Sekhar Bhimanaboina Ramulu Skkhaja Hussain DNarsimulu Jae Su Yu Institute for Wearable Convergence Electronics Department of Electronic EngineeringKyung Hee University1732 Deogyeong‑daeroGihung‑guYongin‑siGyeonggi‑do 17104Republic of Korea Department of Chemical Engineering College of EngineeringKyung Hee University1732 Deogyeong‑daeroGihung‑guYongin‑siGyeonggi‑do 17104Republic of Korea

Designing rationally combined metal-organic frameworks(MOFs)with multifunctional nanogeometries is of significant research interest to enable the electrochemical properties in advanced energy storage ***,we explored a new class of binderfree dual-layered Ni-Co-mn-based MOFs(NCM-based MOFs)with three-dimensional(3D)-on-2D nanoarchitectures through a polarityinduced solution-phase method for high-performance *** hierarchical NCM-based MOFs having grown on nickel foam exhibit a battery-type charge storage mechanism with superior areal capacity(1311.4μAh cm^−2 at 5 mA cm^−2),good rate capability(61.8%;811.67μAh cm^−2 at 50 mA cm^−2),and an excellent cycling *** superior charge storage properties are ascribed to the synergistic features,higher accessible active sites of dual-layered nanogeometries,and exalted redox chemistry of multi metallic guest species,*** bilayered NCM-based MOFs are further employed as a battery-type electrode for the fabrication of supercapattery paradigm with biomass-derived nitrogen/oxygen doped porous carbon as a negative electrode,which demonstrates excellent capacity of 1.6 mAh cm^−2 along with high energy and power densities of 1.21 mWh cm^−2 and 32.49 mW cm^−2,***,the MOF-based supercapattery was further assembled with a renewable solar power harvester to use as a self-charging station for various portable electronic applications.

关键词： Metal-organic frameworks Dual layers Redox chemistry Supercapattery Renewable energy

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Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies

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World Journal of Gastroenterology 2008年第16期14卷 2566-2571页

作者： Mohammed Ibrahim Mohammed Nane khaja Anjum Aara Aleem Ahmed Khan Mohammed Aejaz Habeeb Yalavarthy Prameela Devi Mangamoori Lakshmi Narasu Chitoor Mohammed Habibullah Centre for Liver Research and Diagnostics Deccan college of Medical Sciences and Allied Hospitals Kanchanbagh Nizam Institute of Pharmacy Deshmukhi pochampally (Mandal) Near Ramoji Film City Centre for Biotechnology Jawaharlal Nehru Technological University Kukatpally

AIM: To study the hepatoprotective capacity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi) extracts in CCl4 treated male rats. METHODS: The dried powder of S. mukorossi and R. emodi was extracted successively with petroleum ether, benzene, chloroform, and ethanol and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extract of the fruit pericarp of S. mukorossi and the rhizomes of R. emodi was analyzed in liver injured CCl4-treated male rats. RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with CCl4 and extracts of S. mukorossi & R. emodi. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo : extracts of the fruit pericarp of S. mukorossi (2.5 mg/mL) and rhizomes of R. emodi (3.0 mg/mL) were found to have protective properties in rats with CCl4 induced liver damage as judged from serum marker enzyme activities. CONCLUSION: The extracts of S. mukorossi and R. emodi do have a protective capacity both in vitro on primary hepatocytes cultures and in in vivo in a rat model of CCl4 mediated liver injury.

关键词： Hepatoprotective activity Sapindus mukorossr Rheum emodi

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