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Combined liver-kidney transplantation for rare diseases

World Journal of Hepatology 2020年第10期12卷 722-737页

作者： mladen knotek Rafaela Novak Alemka Jaklin-Kekez Anna Mrzljak Department of Medicine Tree Top HospitalHulhumale 23000Maldives Department of Medicine Merkur University HospitalZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Clinic for Pediatric Diseases Helena Zagreb 10000Croatia

Combined liver and kidney transplantation(CLKT)is indicated in patients with failure of both organs,or for the treatment of end-stage chronic kidney disease(ESKD)caused by a genetic defect in the *** aim of the present review is to provide the most up-to-date overview of the rare conditions as indications for *** are major indications for CLKT in ***,in some of them(e.g.,atypical hemolytic uremic syndrome or primary hyperoxaluria),CLKT may be required in adults as *** hyperoxaluria is divided into three types,of which type 1 and 2 lead to *** has been proven effective in renal function replacement,at the same time preventing recurrence of the *** is associated with liver fibrosis in 5%of cases and these patients are candidates for *** alpha 1-antitrypsin deficiency,hereditary C3 deficiency,lecithin cholesterol acyltransferase deficiency and glycogen storage diseases,glomerular or tubulointerstitial disease can lead to chronic kidney *** transplantation as a part of CLKT corrects underlying genetic and consequent metabolic *** atypical hemolytic uremic syndrome caused by mutations in the genes for factor H,successful CLKT has been reported in a small number of ***,for this indication,CLKT has been largely replaced by eculizumab,an anti-C5 *** has been well established to provide immune protection of the transplanted kidney against donor-specific antibodies against class I HLA,facilitating transplantation in a highly sensitized recipient.

关键词： Combined liver-kidney transplantation Methylmalonic aciduria Hereditary complement C3 deficiency Glycogen storage diseases Homozygous protein C deficiency Primary hyperoxaluria Atypical hemolytic uremic syndrome Sensitization Donorspecific antibodies

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Pre-and intraoperative predictors of acute kidney injury after liver transplantation

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World Journal of Clinical Cases 2020年第18期8卷 4034-4042页

作者： Anna Mrzljak Lucija Franusic Jadranka Pavicic-Saric Tomislav Kelava Zeljka Jurekovic Branislav Kocman Danko Mikulic Ivan Budimir-Bekan mladen knotek Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia General Hospital Dubrovnik Dubrovnik 20000Croatia Department of Anesthesiology and Intensive Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Laboratory for Molecular Immunology Croatian Institute for Brain ResearchUniversity of ZagrebSchool of MedicineZagreb 10000Croatia Department of Medicine Merkur University HospitalZagreb 10000Croatia Department of Surgery Merkur University HospitalZagreb 10000Croatia

BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and *** factors for AKI after LT still need to be *** To identify the predictors of acute kidney injury after liver *** The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in *** was defined according to the Kidney Disease:Improving Global Outcomes *** Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage *** 5.38%of patients required renal replacement therapy after *** majority of patients(82.8%)developed AKI within the first two days after the *** logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term *** pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors.

关键词： Acute kidney injury Liver transplant Body mass index Red blood cell Survival

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Electrochemical hydriding performance of Mg-TM-Mm (TM=transition metals,Mm=mischmetal) alloys for hydrogen storage

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Transactions of Nonferrous Metals Society of China 2013年第7期23卷 2047-2059页

作者： V.knotek D.VOJTECH Department of Metals and Corrosion Engineering Institute of Chemical TechnologyPrague Technická 5166 28 Prague 6Czech Republic

Eighteen as-cast binary Mg-Ni, Mg-Mm and ternary Mg-Ni-Mm and Mg-Ni-TM （TM=transition metals （Cu, Zn, Mn and Co）; Mm = mischmetal containing Ce, La, Nd and Pr） alloys were hydrided by an electrochemical process to determine the alloys with the most potential for electrochemical hydrogen storage. The alloys were hydrided in a 6 mol/L KOH solution at 80 °C for 480 min and at 100 A/m2. To assess the electrochemical hydriding performance of alloys, maximum hydrogen concentrations, hydrogen penetration depths and total mass of absorbed hydrogen in the alloys were measured by glow discharge spectrometry. In addition, the structures and phase compositions of the alloys both before and after hydriding were studied by optical and scanning electron microscopy, energy dispersive spectrometry and X-ray diffraction. It was determined that the highest total amount of hydrogen was absorbed by the Mg-25Ni-12Mm and Mg-26Ni （mass fraction, %） alloys. The maximum hydrogen concentrations in the Mg-25Ni-12Mm and Mg-26Ni alloys were 1.0% and 1.6%, respectively. The main hydriding product was the binary MgH2 hydride, and the ternary Mg2NiH4 hydride was also detected in the Mg-25Ni-12Mm alloy. The electrochemical hydriding parameters achieved are discussed in relation to the structures of alloys, alloying elements and hydriding mechanisms.

关键词： hydrogen storage magnesium nickel rare earths electrochemical hydriding

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Electrochemical hydriding and thermal dehydriding properties of nanostructured hydrogen storage MgNi26 alloy

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Transactions of Nonferrous Metals Society of China 2016年第8期26卷 2136-2143页

作者： V.knotek O.EKRT M.LHOTKA D.VOJTěCH Department of Metals and Corrosion Engineering University of Chemistry and Technology Prague Department of Inorganic Technology University of Chemistry and Technology Prague

The MgNi26 alloy was prepared by three different methods of gravity casting (GC), mechanical alloying (MA) and rapid solidification (RS). All samples were electrochemically hydrided in a 6 mol/L KOH solution at 80 °C for 240 min. The structures and phase compositions of the alloys were studied using optical microscopy and scanning electron microscopy, energy dispersive spectrometry and X-ray diffraction. A temperature-programmed desorption technique was used to measure the absorbed hydrogen and study the dehydriding process. The content of hydrogen absorbed by the MgNi26-MA (approximately 1.3%, mass fraction) was 30 times higher than that of the MgNi26-GC. The MgNi26-RS sample absorbed only 0.1% of hydrogen. The lowest temperature for hydrogen evolution was exhibited by the MgNi26-MA. Compared with pure commercial MgH2, the decomposition temperature was reduced by more than 200 °C. The favourable phase and structural composition of the MgNi26-MA sample were the reasons for the best hydriding and dehydriding properties.

关键词： magnesium alloy hydrogen storage electrochemical hydriding mechanical alloying melt spinning

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在工具上涂覆硬质材料的可能性

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国外稀有金属 1992年第3期 32-38页

作者： knotek,O 郭奥湘

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钛、锆、铝的二元、三元和四元氮化物工业镀膜

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真空与低温 1989年第4期8卷 51-55页

作者： O.knotek 张振厚

用于高速钢和渗碳硬质合金基体上的(Ti、Al)N、(Ti、Zr)N 和(Ti、Al、V)N 涂层,同化学气相沉积(CVD)和物理气相沉积(PVD)的 TiN 涂层相比,发现其耐磨性有所改进。用 Ti:Al 50:50%(重量比)的靶在高速钢钻头上制备(Ti、Al)N 涂层,在某些... 详细信息

用于高速钢和渗碳硬质合金基体上的(Ti、Al)N、(Ti、Zr)N 和(Ti、Al、V)N 涂层,同化学气相沉积(CVD)和物理气相沉积(PVD)的 TiN 涂层相比,发现其耐磨性有所改进。用 Ti:Al 50:50%(重量比)的靶在高速钢钻头上制备(Ti、Al)N 涂层,在某些情况下,其性能比常规的 TiN 离子镀刀具提高到了3倍,而渗碳硬质合金基体上的涂层,能大大改进刀具的后刀面和月牙洼的磨损,根据切削条件,同 CVD 的 TiN/TiC 相比,其性能也提高到3倍。证实了新的多元硬质涂层制备工艺和涂层性能的基本关系,用平面磁控源和粉末冶金靶研制和试验了工业生产的离子镀沉积工艺。首先介绍了新涂层材料的基本研究和进展。其次描述了双阴极磁控源的溅射离子镀工艺的批炉型和直线型 PVD 涂层的工业应用。最后,通过对不同条件下涂层刀具的磨损试验,展现了多元新涂层的优异的耐磨性。

关键词：真空镀膜氮化物

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