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Protective effect of alcohol consumption for fatty liver but not metabolic syndrome

World Journal of Gastroenterology 2012年第2期18卷 156-167页

作者： Masahide Hamaguchi Takao Kojima Akihiro Ohbora Noriyuki Takeda Michiaki Fukui takahiro Kato Immunology Frontier Research Center Osaka UniversityOsaka 565-0871Japan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityGifu 500-8523Japan Department of Endocrinology and Metabolism Murakami Memorial HospitalAsahi UniversityGifu 500-8523Japan Department of Endocrinology and Metabolism Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan

AIM:To investigate the effect of alcohol on the metabolic syndrome (MS) and fatty liver in Japanese men and ***:A cross-sectional study was conducted in a medical health checkup program at a general *** study involved 18 571 Japanese men and women,18-88 years of age,with a mean body mass index of 22.6 kg/m 2.A standardized questionnaire was *** total amount of alcohol consumed per week was calculated,and categorized into four *** liver was examined by ultrasound modified criteria of the revised National Cholesterol Educa-tion Program Adult Treatment Panel Ⅲ and the new International Diabetes ***:The prevalence of fatty liver decreased in men and women with light to moderate alcohol consumption,whereas the prevalence of MS was not so *** prevalence of fatty liver of any grade in men was lower than that in those with no or minimal alcohol *** women with light to moderate alcohol consumption,prevalence of fatty liver was lower than that in women with no or minimal alcohol *** logistic regression analysis,the odds ratio (OR) for MS in women with light alcohol consumption was decreased to < 1.0,but this change was not clear in *** OR for fatty liver was clearly < 1.0 in men with any level of alcohol consumption and in women with light to moderate ***:Light to moderate alcohol consumption has a favorable effect for fatty liver,but not for MS in Japanese men and women.

关键词： Alcoholic hepatitis Epidemiology Fatty liver Metabolic syndrome Alcohol consumption

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Adaptive Resources Allocation Algorithm Based on Modified PSO for Cognitive Radio System

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China Communications 2019年第5期16卷 83-92页

作者： Yi Yang Qinyu Zhang Ye Wang takahiro Emoto Masatake Akutagawa Shinsuke Konaka School of Electronic and Information Engineering Harbin Institute of Technology (Shenzhen)Shenzhen 518055China Department of Electrical and Electronic Engineering Tokushima UniversityTokushima770-8506Japan Shenzhen Cyberspace Laboratory (Pengcheng Laboratory) Shenzhen 518055China

Radio spectrum has become a rare resource due to the rapid development of wireless communication technique. Cognitive radio is one of important techniques to deal with this radio spectrum problem. But the resource allocation in cognitive radio also has its own issues, such as the flexibility of the allocation algorithm, the performance of resource allocation, and so on. In order to increase the flexibility of the allocation algorithm for cognitive radio, more and more researches are focusing on the evolutionary algorithms, such as genetic algorithm(GA), particle swarm optimization(PSO). Evolutionary algorithm can greatly improve the flexibility of the allocation algorithm for cognitive radio system in different communication scenarios, but the performances are relatively lower than the original mathematical methods. So in this paper, we proposed an adaptive resource allocation algorithm based on modified PSO for cognitive radio system to solve these problems. Modified particle swarm optimization(Modified PSO) has both genetic algorithm(GA) and particle swarm optimization(PSO)’s updating processes which makes this modified PSO overcame PSO’s own disadvantages and keep advantages. Simulation results showed our proposed algorithm has enough flexibility to meet cognitive radio systems’ requirements, and also has a better performance than original PSO.

关键词： cognitive radio particle swarm optimization genetic algorithm performance analysis flexibility

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Upconversion time-stretch infrared spectroscopy

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Light(Science & Applications) 2023年第3期12卷 465-474页

作者： Kazuki Hashimoto Takuma Nakamura takahiro Kageyama Venkata Ramaiah Badarla Hiroyuki Shimada Ryoich Horisaki Takuro Ideguchi Institute for Photon Science and Technology The University of TokyoTokyo113-0033Japan Department of Physics The University of TokyoTokyo113-0033Japan Graduate School of Information Science and Technology The University of TokyoTokyo113-8656Japan

High-speed measurement confronts the extreme speed limit when the signal becomes comparable to the noise *** the context of broadband mid-infrared spectroscopy,state-of-the-art ultrafast Fourier-transform infrared spectrometers,in particular dual-comb spectrometers,have improved the measurement rate up to a few MSpectra s^(-1),which is limited by the signal-to-noise ***-stretch infrared spectroscopy,an emerging ultrafast frequency-swept mid-infrared spectroscopy technique,has shown a record-high rate of 80 MSpectra s^(-1) with an intrinsically higher signal-to-noise ratio than Fourier-transform spectroscopy by more than the square-root of the number of spectral ***,it can measure no more than~30 spectral elements with a low resolution of several ***,we significantly increase the measurable number of spectral elements to more than 1000 by incorporating a nonlinear upconversion *** one-to-one mapping of a broadband spectrum from the mid-infrared to the near-infrared telecommunication region enables low-loss time-stretching with a single-mode optical fiber and low-noise signal detection with a high-bandwidth *** demonstrate high-resolution mid-infrared spectroscopy of gas-phase methane molecules with a high resolution of 0.017 cm^(-1).This unprecedentedly high-speed vibrational spectroscopy technique would satisfy various unmet needs in experimental molecular science,e.g.,measuring ultrafast dynamics of rreversible phenomena,statistically analyzing a large amount of heterogeneous spectral data,or taking broadband hyperspectral images at a high frame rate.

关键词： spectroscopy noise resolution

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Removal of competitive native species combined with tree planting can accelerate the initial afforestation process: an experiment in an old field in Japan invaded by dwarf bamboo and kudzu

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Journal of Forestry Research 2015年第3期26卷 581-588页

作者： Yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi Yamaguchi takahiro Ara Nobukazu Nakagoshi Biodiversity Division National Institute for Agro-Environmental Sciences 3-1-3 Kannondai TsukubaIbaraki 305-8604 Japan Ecosystem Informatics Division National Institute for Agro-Environmental Sciences 3-1-3 Kannondai TsukubaIbaraki 305-8604 Japan Experimental Farm Management Division National Institute for Agro-Environmental Sciences 3-1-3 KannondaiTsukuba Ibaraki 305-8604 Japan Graduate School for International Development and Cooperation Hiroshima University 1-5-1 KagamiyamaHigashi-Hiroshima 739-8529 Japan

Restoring natural forests after field abandon- ment is a land management objective that fosters the re- covery of forest biodiversity. We performed seeding and transplanting of native tree species 40 years after the abandonment of an arable field that became dominated by a dwarf bamboo （Pleioblastus chino （Franch. et Sav.） Makino） and by kudzu （Pueraria lobata （Willd.） Ohwi）. By permutation tests, the removal of competing vegetation （gap creation） significantly increased the survival of three seeded species of Fagaceae and of eight transplanted spe- cies. In contrast, intact vegetation prevented most indi- viduals of all species from surviving for 1 year after planting. The lack of natural recruitment of Fagaceae in the nonseeded subplots indicated that seed limitation was a cause of the slow afforestation. Although litter accumula- tion in gaps at the time of seeding slightly increased sur- vival for late-germinating Quercus myrsinifolia Blume andCastanopsis sieboldii （Makino） Hatus. ex T. Yamaz. et Mashiba, the effect was not consistent among plots and was not statistically significant. Our results suggest that for successful afforestation using native trees in abandoned fields, it will be necessary to remove competitive native species to avoid severe limitations on microsite availability and that simultaneous tree establishment by seeding or transplanting should be implemented to accelerate the establishment of native tree species.

关键词： Farmland abandonment - Micrositelimitation Pleioblastus chino Pueraria lobata Treeseedling

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Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from nonneoplasia for colorectal diminutive polyps(≤ 5 mm)

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World Journal of Gastrointestinal Oncology 2018年第4期10卷 96-102页

作者： takahiro Utsumi Yasushi Sano Mineo Iwatate Hironori Sunakawa Akira Teramoto Daizen Hirata Santa Hattori Wataru Sano Noriaki Hasuike Kazuhito Ichikawa takahiro Fujimori Gastrointestinal Center and Institute of Minimally Invasive Endoscopic Care (iMEC) Sano Hospital Department of Pathology Shinko Hospital

AIM To clarify the diagnostic performance of endocytoscopy for differentiation between neoplastic and nonneoplastic colorectal diminutive *** Patients who underwent endocytoscopy between October and December 2016 at Sano Hospital were prospectively recruited. When diminutive polyps(≤5 mm) were detected, the lesions were evaluated by endocytoscopy after being stained with 0.05% crystal violet and 1% methylene blue. The diminutivepolyps were classified into five categories(EC 1 a, 1 b, 2, 3 a, and 3 b). Endoscopists were asked to take a biopsy from any lesion diagnosed as EC1 b(indicator of hyperplastic polyp) or EC2(indicator of adenoma). We have assessed the diagnostic performance of endocytoscopy for EC2 and EC1 b lesions by comparison with the histopathology of the biopsy specimen. RESULTS A total of 39 patients with 63 diminutive polyps were analyzed. All polyps were evaluated by endocytoscopy. The mean polyp size was 3.3 ± 0.9 mm. Among the 63 diminutive polyps, 60 were flat and 3 were pedunculated. The mean time required for EC observation, including the time for staining with crystal violet and methylene blue, was 3.0 ± 1.9 min. Histopathologic evaluation showed that 13 polyps were hyperplastic and 50 were adenomas. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of EC2 for adenoma compared with EC1 b for hyperplastic polyp were 98.0%, 92.3%, 96.8%, 98.0% and 92.3%, respectively. There were only two cases of disagreement between the endoscopic diagnosis made by endocytoscopy and the corresponding histopathological *** Endocytoscopy showed a high diagnostic performance for differentiating between neoplastic and non-neoplastic colorectal diminutive polyps, and therefore has the potential to be used for "real-time histopathology".

关键词： Endocytoscopy Diagnostic performance Diminutive polyp Endocytoscopic classification Realtime histopathology

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A laboratory acoustic emission experiment and numerical simulation of rock fracture driven by a high-pressure fluid source

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第1期8卷 27-34页

作者： Xinglin Lei takahiro Funatsu Shengli Ma Liqiang Liu Geological Survey of Japan National Institute of Advanced Industrial Science and Technology State Key Laboratory of Earthquake Dynamics Institute of Geology China Earthquake Administration Western Australian School of Mines Curtin University

In order to improve our understanding of rock fracture and fault instability driven by high-pressure fluid sources, the authors carried out rock fracture tests using granite under a confining pressure of 80 MPa with fluid injection in the laboratory. Furthermore, we tested a number of numerical models using the FLAC;modeling software to find the best model to represent the experimental results. The high-speed multichannel acoustic emission（AE） waveform recording system used in this study made it possible to examine the total fracture process through detailed monitoring of AE hypocenters and seismic *** experimental results show that injecting high-pressure oil into the rock sample can induce AE activity at very low stress levels and can dramatically reduce the strength of the rock. The results of the numerical simulations show that major experimental results, including the strength, the temporal and spatial patterns of the AE events, and the role of the fluid can be represented fairly well by a model involving（1） randomly distributed defect elements to model pre-existing cracks,（2） random modification of rock properties to represent inhomogeneity introduced by different mineral grains, and（3）macroscopic inhomogeneity. Our study, which incorporates laboratory experiments and numerical simulations, indicates that such an approach is helpful in finding a better model not only for simulating experimental results but also for upscaling purposes.

关键词： Laboratory experiment Acoustic emission(AE) Fracture Numerical simulation Fluid injection

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Skeletal muscle mass and quality before preoperative chemotherapy influence postoperative long-term outcomes in esophageal squamous cell carcinoma patients

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 621-633页

作者： Daichi Ichinohe takahiro Muroya Harue Akasaka Kenichi Hakamada Department of Gastroenterological Surgery Hirosaki University Graduate School of MedicineHirosaki 0368562AomoriJapan

BACKGROUND Previous reports have focused on muscle mass as a prognostic factor in esophageal *** To investigate how preoperative body type influences the prognosis of patients with esophageal squamous cell carcinoma who underwent neoadjuvant chemotherapy(NAC)and *** The subjects were 131 patients with clinical stage Ⅱ/Ⅲ esophageal squamous cell carcinoma who underwent subtotal esophagectomy after *** muscle mass and quality were calculated based on computed tomography images prior to NAC,and their statistical association with long-term outcomes was examined retrospectively in this case-control *** The disease-free survival rates in the low psoas muscle mass index(PMI)group vs the high PMI group were 41.3%vs 58.8%(P=0.036),*** the high intramuscular adipose tissue content(IMAC)group vs the low IMAC group,the disease-free survival rates were 28.5%vs 57.6%(P=0.021),*** overall survival(OS)rates for the low PMI group vs the high PMI group were 41.3%vs 64.5%(P=0.008),respectively,and for the high IMAC group vs the low IMAC group,they were 29.9%vs 61.9%(P=0.024),*** of the OS rate revealed significant differences in patients aged 60 years or older(P=0.018),those with pT3 or above disease(P=0.021),or those with lymph node metastasis(P=0.006),aside from PMI and *** analysis demonstrated that pT3 or above hazard ratio(HR):1.966,95%confidence interval(CI):1.089-3.550,(P=0.025),lymph node metastasis(HR:2.154,95%CI:1.118-4.148,P=0.022),low PMI(HR:2.266,95%CI:1.282-4.006,P=0.005),and high IMAC(HR:2.089,95%CI:1.036-4.214,P=0.022)were significant prognostic factors for esophageal squamous cell *** muscle mass and quality before NAC in patients with esophageal squamous cellcarcinoma are significant prognostic factors for postoperative OS.

关键词： Esophageal squamous cell carcinoma Muscle mass Muscle quality Neoadjuvant chemotherapy Body composition

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Diagnostic utility of endoscopic ultrasound-guided fineneedle aspiration biopsy for glomus tumor of the stomach

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World Journal of Gastroenterology 2015年第22期21卷 7052-7058页

作者： Shin Kato Kaoru Kikuchi Kenji Chinen takahiro Murakami Fumihito Kunishima Department of Gastroenterology Okinawa Prefectural Chubu Hospital Department of Surgery Okinawa Prefectural Chubu Hospital Department of Pathology Okinawa prefectural Chubu Hospital

A 52-year-old man was referred for further investigation of a gastric submucosal tumor on the greater curvature of the antrum. Endoscopic ultrasonography demonstrated a hypoechoic solid mass, which was primarily connected to the muscular layer of the stomach. We performed endoscopic ultrasoundguided fine-needle aspiration biopsy. The pathological examination showed proliferation of oval-shaped cells with nest formation, which stained strongly positive for muscle actin, and negative for c-kit, CD34, CD56,desmin, S-100, chromogranin, and neuron-specific enolase. Therefore, we performed laparoscopy and endoscopy cooperative surgery based on the preoperative diagnosis of glomus tumor of the stomach. The final histological diagnosis confirmed the preoperative diagnosis. Although preoperative diagnosis of glomus tumor of the stomach is difficult with conventional images and endoscopic biopsy, endoscopic ultrasoundguided fine-needle aspiration biopsy is an essential tool to gain histological evidence of glomus tumor of the stomach for early diagnosis.

关键词： Glomus tumor Endoscopic ultrasoundguidedfine-needle aspiration biopsy Stomach Preoperative diagnosis

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Multi-Strategy Dynamic Spectrum Access in Cognitive Radio Networks: Modeling, Analysis and Optimization

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China Communications 2019年第3期16卷 103-121页

作者： Yi Yang Qinyu Zhang Ye Wang takahiro Emoto Masatake Akutagawa Shinsuke Konaka School of Electronic and Information Engineering Harbin Institute of Technology (Shenzhen) Department of Electrical and Electronic Engineering Tokushima University

Dynamic spectrum access(DSA) based on cognitive radios(CR) technique is an effective approach to address the "spectrum scarcity" issue. However, traditional CR-enabled DSA system employs only single DSA strategy, which might not be suited to the dynamic network environment. In this paper, we propose a multi-strategy DSA(MS-DSA) system, where the primary and the secondary system share spectrum resources with multiple DSA strategies simultaneously. To analyze the performance of the proposed MS-DSA system, we model it as a continuous-time Markov chain(CTMC) and derive the expressions to compute the corresponding performance metrics. Based on this, we define a utility function involving the concerns of effective throughput, interference quantity on primary users, and spectrum leasing cost. Two optimization schemes, named as spectrum allocation and false alarm probability selection, are proposed to maximize the utility function. Finally, numerical simulations are provided to validate our analysis and demonstrate that the performance can be significantly improved caused by virtues of the proposed MS-DSA system.

关键词： cognitive radio networks dynamic spectrum access multi-strategy performance analysis optimization

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Three-dimensional virtual operations can facilitate complicated surgical planning for the treatment of patients with jaw deformities associated with facial asymmetry: a case report

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International Journal of Oral Science 2013年第3期5卷 176-182页

作者： Shingo Hara Masaharu Mitsugi takahiro Kanno Akihiko Nomachi Takehiko Wajima Yukihiro Tatemoto Hanarabi Orthodontic Dental Clinic Department of Oral and Maxillofacial Surgery Kochi Health Sciences Center Takamatsu Oral and Maxillofacial Surgery Clinic Department of Oral and Maxillofacial Surgery Shimane University Faculty of Medicine

This article describes a case we experienced in which good postsurgical facial profiles were obtained for a patient with jaw deformities associated with facial asymmetry,by implementing surgical planning with SimPlant *** this method,we conducted LF1 osteotomy,intraoral vertical ramus osteotomy（IVRO）,sagittal split ramus osteotomy（SSRO）,mandibular constriction and mandibular border *** only did we obtain a class I occlusal relationship,but the complicated surgery also improved the asymmetry of the frontal view,as well as of the profile view,of the *** virtual operation using three-dimensional computed tomography（3D-CT）could be especially useful for the treatment of patients with jaw deformities associated with facial asymmetry.

关键词： facial asymmetry mnandibular constriction transverse discrepancy of the dental arch width virtual operation

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