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World Journal of Gastroenterology 2017年第28期23卷 5253-5256页

作者： Masaya Uesato Tsuguaki Kono Yasunori Akutsu Kentarou Murakami Akiko Kagaya Yorihiko Muto Akira Nakano mizuho aikawa Tomohide Tamachi Hiroyuki Amagai Takahiro Arasawa Yasuhide Muto Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine

A 65-year-old man with c T1 b N0M0 stage Ⅰ middle thoracic esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the posterior mediastinal route after preoperative carbon-ion radiotherapy and chemotherapy in a clinical trial. Anastomotic leakage occurred,but it spontaneously improved. At six months after the operation,he was rehospitalized with a cough and dysphagia. An esophago-bronchiole fistula and stenosis of the gastric tube were observed. He first underwent stent placement in the gastric tube. Two weeks later,the syringeal epithelium was burned by argon plasma coagulation after stent removal. Endoscopic occlusion was then performed for the fistula with two guidewire-assisted silicone spigots. Two weeks later,he was discharged on an oral diet,and he has not developed recurrence of the fistula or cancer for three years. This is the first report of endoscopic occlusion with a guidewire-assisted silicone spigot through the esophagus.

关键词： Endobronchial Watanabe 塞子 Guidewire 管漏 Esophagectomy 食道的癌症内视镜的吸藏

Predictor of respiratory disturbances during gastric endoscopic submucosal dissection under deep sedation

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World Journal of Gastrointestinal Endoscopy 2020年第10期12卷 378-387页

作者： mizuho aikawa Masaya Uesato Ryuma Urahama Koichi Hayano Reiko Kunii Yohei Kawasaki Shiroh Isono Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of MedicineChiba 260-8670Japan Staff of Clinical Laboratory Seirei Sakura Citizen HospitalChiba 285-8765Japan Biostatistics Section Clinical Research CenterChiba University HospitalChiba 260-8677Japan Department of Anesthesiology Chiba University Graduate School of MedicineChiba 260-8670Japan

BACKGROUND Sedation is commonly performed for the endoscopic submucosal dissection(ESD)of early gastric *** hypoxemia occasionally occurs due to the respiratory depression during *** To establish predictive models for respiratory depression during sedation for *** Thirty-five adult patients undergoing sedation using propofol and pentazocine for gastric ESDs participated in this prospective observational ***,a portable sleep monitor and STOP questionnaires,which are the established screening tools for sleep apnea syndrome,were *** during sedation was assessed by a standard polysomnography technique including the pulse oximeter,nasal pressure sensor,nasal thermistor sensor,and chest and abdominal respiratory motion *** apnea-hypopnea index(AHI)was obtained using a preoperative portable sleep monitor and polysomnography during ESD.A predictive model for the AHI during sedation was developed using either the preoperative AHI or STOP questionnaire *** All ESDs were completed successfully and without *** patients(49%)had a preoperative AHI greater than 5/*** intraoperative AHI was significantly greater than the preoperative AHI(12.8±7.6 events/h vs 9.35±11.0 events/h,P=0.049).Among the potential predictive variables,age,body mass index,STOP questionnaire score,and preoperative AHI were significantly correlated with AHI during *** linear regression analysis determined either STOP questionnaire score or preoperative AHI as independent predictors for intraoperative AHI≥30/h(area under the curve[AUC]:0.707 and 0.833,respectively)and AHI between 15 and 30/h(AUC:0.761 and 0.778,respectively).CONCLUSION The cost-effective STOP questionnaire shows performance for predicting abnormal breathing during sedation for ESD that was equivalent to that of preoperative portable sleep monitoring.

关键词： Deep sedation Respiratory depression Polysomnography Endoscopic submucosal dissection Sleep apnea syndrome STOP questionnaire

Polysomnographic assessment of respiratory disturbance during deep propofol sedation for endoscopic submucosal dissection of gastric tumors

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World Journal of Gastrointestinal Endoscopy 2018年第11期10卷 340-347页

作者： Ryuma Urahama Masaya Uesato mizuho aikawa Yukiko Yamaguchi Koichi Hayano Tomoaki Matsumura Makoto Arai Reiko Kunii Shiroh Isono Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine Department of Gastroenterology Chiba University Graduate School of Medicine Department of Medical Oncology Chiba University Graduate School of Medicine Staff of Clinical Laboratory Chiba University Hospital Department of Anesthesiology Chiba University Graduate School of Medicine

AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry *** This prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection(ESD) under propofol sedation. Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired. The primary hypothesis was tested by comparing the apnea hypopnea index(AHI), defined as the number of apnea and hypopnea instances per hour during sedation, with and without hypoxemia; hypoxemia was defined as the reduction in oxygen saturation by ≥ 3% from *** Polysomnography(PSG) detected 207 respiratory disturbances in the 10 patients. PSG yielded a significantly greater AHI(10.44 ± 5.68/h) compared with pulse oximetry(1.54 ± 1.81/h, P < 0.001), thus supporting our hypothesis. Obstructive AHI(9.26 ± 5.44/h) was significantly greater than central AHI(1.19 ± 0.90/h, P < 0.001). Compared with pulse oximetry, PSG detected the 25 instances of respiratory disturbances with hypoxemia 107.4 s earlier on *** Compared with pulse oximetry, PSG can better detect respiratory irregularities and thus provide superior AHI values, leading to avoidance of fatal respiratory complications during ESD under propofol-induced sedation.

关键词： Polysomnography Hypoxemia Propofol Endoscopic submucosal dissection Pulse oximetry Sedation

生物质和塑料加氢脱氧制备燃料和化学品的双金属催化剂研究进展

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Chinese Journal of Catalysis 2024年第7期62卷 1-31页

作者：刘露杰刘奔中川善直刘斯宝王亮藪下瑞帆冨重圭一浙江大学化学工程与生物工程学院生物质化工教育部重点实验室浙江杭州310027 日本东北大学(Tohoku University)工学部应用化学系仙台日本福建师范大学环境与资源学院聚合物资源绿色循环利用教育部工程研究中心福建省污染控制与资源循环利用重点实验室福建福州350007 日本东北大学(Tohoku University)材料科学高等研究所仙台日本复旦大学化学系上海200433

在全球致力于实现碳中和的大背景下,生物质和废弃塑料的高值化利用已成为科研领域的研究热点.加氢脱氧反应(HDO),作为实现这一目标的重要途径之一,通过精准解离C-O/C-C键,为生产燃料和化学品提供了有效方法.在HDO过程中,C-O键的氢解及... 详细信息

在全球致力于实现碳中和的大背景下,生物质和废弃塑料的高值化利用已成为科研领域的研究热点.加氢脱氧反应(HDO),作为实现这一目标的重要途径之一,通过精准解离C-O/C-C键,为生产燃料和化学品提供了有效方法.在HDO过程中,C-O键的氢解及不饱和键的氢化是主要步骤,而C-C键的氢解则是需要避免的副反应.与简单的氢化反应相比,HDO过程需要具有双功能特性的催化剂,特别是当目标产物为含氧化合物时,催化剂的区域选择性至关重要.近年来,双金属催化剂在生物质及其衍生物以及含氧塑料废弃物和聚合物的HDO过程中的应用受到广泛关注.通过深入理解金属纳米颗粒与金属氧化物之间的协同作用和强相互作用,双金属催化剂的理性设计取得了显著进展.特别是,部分金属氧化物(如ReO_(x),WO_(x),MoO_(x),FeO_(x))与贵金属(如Ir,Pt,Ru)之间存在的强相互作用,不仅促进了C-O键的断裂,还有效保留了C-C键,为催化剂的高活性和高选择性奠定了基础.通过调整催化剂组成、使用小比表面积的载体等方法,可以进一步优化催化剂性能.本综述聚焦于金属氧化物改性的贵金属催化剂在HDO反应中的最新研究进展,特别是总结了Ir、Pt和Ru基催化剂在HDO反应中的应用.由于这类催化剂的结构和性能能够精确控制,并且每种催化剂都具备独特的选择性,因此被广泛应用于生物质衍生物和塑料废弃物的HDO过程中.本文总结了双金属催化剂的结构特点、HDO反应机制、催化剂结构与催化性能之间的关联,以及这些催化剂在高附加值化学品生产中的实际应用.我们以甘油和1,2-丙二醇的氢解为模型反应,深入探讨了基于Ir、Pt和Ru的双金属催化剂的催化性能、结构特点和催化机理.这些催化剂在温和条件下实现了高效的氢脱氧反应,有效抑制了C-C键的断裂,并优化了化学选择性和区域选择性.双金属催化剂在生物质精炼和塑料/聚合物转化方面展现出广泛的适用性.本文还介绍了其在木质纤维素衍生原料、羰基化合物以及聚碳酸酯等塑料中的应用.然而,双金属催化剂的稳定性在实际应用中仍面临挑战,如金属烧结、浸出、积碳及金属-金属氧化物界面的重构等问题.因此,未来的研究重点是开发高效的再生方法和高度稳定的催化剂.综上所述,金属氧化物改性的贵金属催化剂在HDO反应中展现出巨大潜力.通过深入研究和优化,有望为生物质和塑料的高值化利用提供有效解决方案.本文旨在为双金属催化剂的理性设计和优化提供参考,以期推动生物质和塑料的高值化利用技术的进一步发展和应用.

关键词：加氢脱氧氢解双金属催化剂生物质衍生物塑料废弃物

Mutant p53 in colon cancer

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Journal of Molecular Cell Biology 2019年第4期11卷 267-276页

作者： mizuho Nakayama Masanobu Oshima Division of Genetics Cancer Research Institute Kanazawa University Kanazawa 920-1192 Japan WPI-Nano Life Science Institute Kanazawa University Kanazawa 920-1192 Japan

The accumulation of genetic alterations in driver genes is responsible for the development and malignant progression of colorectal cancer. Comprehensive genome analyses have revealed the driver genes, including APC, KRAS, TGFBR2, and TP53, whose mutations are frequently found in human colorectal cancers. Among them, the p53 mutation is found in ~60% of colorectal cancers, and a majority of mutations are missense-type at ‘hot spots’, suggesting an oncogenic role of mutant p53 by ‘gain-of-function’ mechanisms. Mouse model studies have shown that one of these missense-type mutations, p53 R270H (corresponding to human R273H), causes submucosal invasion of intestinal tumors, while the loss of wild-type p53 has a limited effect on the invasion process. Furthermore, the same mutant p53 promotes metastasis when combined with Kras activation and TGF-β suppression. Importantly, either missense-type p53 mutation or loss of wild-type p53 induces NF-κB activation by a variety of mechanisms, such as increasing promoter accessibility by chromatin remodeling, which may contribute to progression to epithelial–mesenchymal transition. These results indicate that missense-type p53 mutations together with loss of wild-type p53 accelerate the late stage of colorectal cancer progression through the activation of both oncogenic and inflammatory pathways. Accordingly, the suppression of the mutant p53 function via the inhibition of nuclear accumulation is expected to be an effective strategy against malignant progression of colorectal cancer.

关键词： colon cancer missense-type mutant p53 gain-of-function mouse model NF-κB multistep tumorigenesis organoids

Reductive Conversion of Biomass-Derived Furancarboxylic Acids with Retention of Carboxylic Acid Moiety

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Transactions of Tianjin University 2021年第3期27卷 165-179页

作者： Yoshinao Nakagawa mizuho Yabushita Keiichi Tomishige Department of Applied Chemistry School of EngineeringTohoku University6-6-07 AobaAramakiAoba-kuSendai 980-8579Japan Research Center for Rare Metal and Green Innovation Tohoku University468-1AobaAramakiAoba-kuSendai 980-0845Japan

Catalytic reduction systems of 2-furancarboxylic acid(FCA)and 2,5-furandicarboxylic acid(FDCA)with H 2 without reduction of the carboxyl groups are *** and FDCA are produced from furfural and 5-hydroxymethylfurfural which are important platform chemicals in biomass *** ring hydrogenation to tetrahydrofuran-2-carboxylic acid(THFCA)and tetrahydrofuran-2,5-dicarboxylic acid(THFDCA)easily proceeds over Pd *** of one C–O bond in the furan ring produces 5-hydroxyvaleric acid(5-HVA)and 2-hydroxyadipic acid.2-Hydroxyvaleric acid is not produced in the reported systems.5-HVA can be produced as the lactone form(δ-valerolactone;DVL)or as the esters depending on the *** reactions proceed over Pt catalysts with good yields(~70%)at optimized *** of two C–O bonds in the furan ring produces valeric acid and adipic acid,the latter of which is a very important chemical in industry and its production from biomass is of high *** acid from FDCA can be produced directly over Pt-MoO_(x) catalyst,indirectly via hydrogenation and hydrodeoxygenation as one-pot reaction using the combination of Pt and acid catalysts such as Pt/niobium oxide,or indirectly via two-step reaction composed of hydrogenation catalyzed by Pd and hydrodeoxygenation catalyzed by iodide ion in acidic *** the two-step method can give good yield of adipic acid at present.

关键词： Biomass Hydrogenolysis Furanic compound Carboxylic acid

Experimental Study of Heating Fluid between Two Concentric Cylinders with Cavities

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Journal of Thermal Science 2008年第2期17卷 175-180页

作者： Hiromitsu HAMAKAWA Hiroyuki MORI Makoto IINO Masaaki HORI mizuho YAMASAKI Toshiaki SETOGUCHI Department of Mechanical Engineering Oita University EBARA Kyushu Co. Ltd. Fanuc LTD Kawasaki Heavy Industries Ltd. Department of Mechanical Engineering Saga University

在这篇论文，我们在在有洞的内部柱体被旋转的二同心柱体之间的环隙涉及加热液体，外部柱体在休息。加热液体和成穴行为上的内部柱体的洞的效果被检验。我们测量了流动率，转子的旋转速度，磨擦转矩，温度上升和压力在这台设备的入口和... 详细信息

在这篇论文，我们在在有洞的内部柱体被旋转的二同心柱体之间的环隙涉及加热液体，外部柱体在休息。加热液体和成穴行为上的内部柱体的洞的效果被检验。我们测量了流动率，转子的旋转速度，磨擦转矩，温度上升和压力在这台设备的入口和插头之间落下。水的流动率从 0.42 × 1 0 −4 到 4.59 × 1 在入口的 0 −4 m 3/s。磨擦转矩和有洞的内部柱体的热的数量比没有洞的盒子大，并且当内部柱体的旋转速度增加了，他们增加了。当内部柱体的旋转速度增加了，效率接近了大约 1。在内部柱体的表面上的洞的成穴的行为被讨论。

关键词：剪切流同心环状物摩擦性能热处理

Field-deployable rapid multiple biosensing system for detection of chemical and biological warfare agents

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Microsystems & Nanoengineering 2018年第1期4卷 498-508页

作者： Masato Saito Natsuko Uchida Shunsuke Furutani mizuho Murahashi Wilfred Espulgar Naoki Nagatani Hidenori Nagai Yuki Inoue Tomohiko Ikeuchi Satoshi Kondo Hirotaka Uzawa Yasuo Seto Eiichi Tamiya Department of Applied Physics Graduate School of EngineeringOsaka University2-1YamadaokaSuitaOsaka 565-0871Japan Advanced Photonics and Biosensing Open Innovation Laboratory(PhotoBIO-OIL) National Institute of Advanced Industrial Science and Technology(AIST)Photonics Center Osaka University P3 Bldg2-1 Yamada-OkaSuitaOsaka 565-0871Japan Nanomaterials Research Institute National Institute of Advanced Industrial Science and Technology(AIST)1-1-1 HigashiTsukuba 305-8565Japan Health Research Institute National Institute of Advanced Industrial Science and Technology(AIST)1-8-31 MidorigaokaIkedaOsaka 563-8577Japan Department of Applied Chemistry Graduate School of EngineeringOkayama University of Science1-1Ridai-choKita-kuOkayama-shi 700-0005Japan National Research Institute of Police Science 6-3-1 KashiwanohaKashiwaChiba 277-0882Japan

The threat of biological and chemical terror acts remains a growing worldwide *** is therefore a need to develop appropriate technology for the detection of chemical and biological warfare agents,with early identification intended for use by first ***,we disclose the developed autonomous air sampling and detection system for evaluation of the presence of chemical and biological warfare agents that can be harmful to the *** current device utilizes the designed mist generator-assisted air collection system(338 l min^(−1))and biosensing chip technologies,such as electrochemical measurement,Au nanoparticle-based localized surface plasmon resonance,and rapid microfluidic chip PCR for detection of minute concentrations lower than the mean lethal dose(LD_(50))of nerve gases(sarin and VX),toxic proteins(BTX/A/Hc and ricin),and pathogens(anthrax simulant).An operation time of only 5–15 min is needed for the collection and detection;sample preparation is already integrated into the system without the need for direct human *** addition to the system’s sensitivity and ease of use,its portability makes it highly beneficial for first responders,which could aid in immediate risk assessment and mitigation of on-site events.

关键词： biological and chemical agents biosensing electrochemical detection LSPR PCR rapid detection

Classification of Emphysema Subtypes: Comparative Assessment of Local Binary Patterns and Related Texture Features

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Advances in Computed Tomography 2015年第3期4卷 47-55页

作者： mizuho Nishio Hisanobu Koyama Yoshiharu Ohno Kazuro Sugimura Division of Functional and Diagnostic Imaging Research Department of Radiology Kobe University Graduate School of Medicine Kobe Japan Advanced Biomedical Imaging Research Center Kobe University Graduate School of Medicine Kobe Japan Division of Radiology Department of Radiology Kobe University Graduate School of Medicine Kobe Japan

The purpose of this study was to assess usefulness of local binary patterns (LBP) and related texture features, namely completed local binary patterns (CLBP) and local ternary patterns (LTP), for the classification of emphysema subtypes on low-dose CT images. Fifty patients (34 men and 16 women;age, 67.5 ± 10.1 years) who underwent low-dose CT (60 mAs) were included. They were comprised of 17 never smokers, 13 smokers without COPD, and 20 smokers with COPD. By consensus reading of low-dose CT images from these patients, two radiologists selected 3681 nonoverlapping regions of interest (ROIs) and annotated them as one of the following three classes: normal tissue, centrilobular emphysema, and paraseptal emphysema. From these ROIs, histogram of CT densities, LBP, CLBP, and LTP were calculated, and the 3 types of texture histograms were concatenated with the CT density histogram. These 3 types of histograms (referred to as combined LBP, combined CLBP, and combined LTP) were used to classify ROI using linear support vector machine. For each type of the combined histogram, the accuracy of classification was determined by patient-based 10-fold cross validation. The best accuracy of combined LBP, combined CLBP, and combined LTP were 81.36%, 82.99%, and 83.29%, respectively. Compared to the classification accuracies obtained with combined LBP, those with combined LTP or combined CLBP were consistently improved. In conclusion, the results of this study suggest that, on low-dose CT, LTP and CLBP were more useful for the classification of emphysema subtypes than LBP.

关键词： Emphysema COPD Texture Analysis Low-Dose CT

Photomechanical Effect of Azobenzene Liquid-Crystalline Elastomers

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Photomechanical Effect of Azobenzene Liquid-Crystalline Elas...