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Peeling a giant ileal lipoma with endoscopic unroofing and submucosal dissection

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World Journal of Gastroenterology 2010年第13期16卷 1676-1679页

作者： Takashi Morimoto Kuang-I Fu Hironori Konuma yuko Izumi Syujirou Matsuyama Kanako Ogura Akihisa miyazaki Sumio Watanabe Department of Gastroenterology Juntendo University Nerima Hospital Department of Pathology Juntendo University Nerima Hospital Department of Gastroenterology Juntendo University School of Medicine

Lipoma is relatively common in the colon but is less often in the small intestine. Most lipomas are incidentally detected at endoscopy and are usually small and asymptomatic. However, some of them can present with obstruction and/or intussusceptions. Surgical resection is commonly recommended to remove such significant lipomas with a limited pedicle and larger than 2 cm in size, as endoscopic resection may result in unfavorable complications such as intestinal perforations. We report a case of 62-year-old man presenting with hematochezia. Colonoscopy showed a submucosal tumor, about 50 mm in size, in the terminal ileum. A clinical diagnosis of lipoma was established based on the findings of colonoscopy and abdominal computed tomography (CT). As the patient complained of hematochezia and mild iron deficiency anemia associated with repeated tumor prolapse, we decided to remove his lipoma. Consequently, the lesion was completely removed en bloc . Although abdominal CT immediately after removal of the lesion showed a small amount of free air, conservative treatment was successfully carried out for the perforation. Histologically, the removed lesion was a lipoma.

关键词： Lipoma Endoscopic submucosal dissection Endoscopic unroofing Perforation

Alcohol,postprandial plasma glucose,and prognosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第1期19卷 78-85页

作者： Hiroshi Abe yuta Aida Haruya Ishiguro Kai yoshizawa Tamihiro miyazaki Munenori Itagaki Satoshi Sutoh yoshio Aizawa Division of Gastroenterology and Hepatology Department of Internal MedicineJikei University School of Medicine Katsushika Medical CenterTokyo 125-8506Japan

AIM:To identify factors associated with prognosis of hepatocellular carcinoma(HCC) after initial ***:A total of 377 HCC patients who were newly treated at Katsushika Medical Center,Japan from January 2000 to December 2009 and followed up for > 2 years,or died during follow-up,were *** factors related to survival were first analyzed in 377 patients with HCC tumor stage T1-T4 using multivariate Cox proportional hazards regression analysis.A similar analysis was performed in 282 patients with tumor stage ***,factors associated with the period between initial and subsequent therapy were examined in 144 patients who did not show local ***,214 HCC stage T1-T3 patients who died during the observation period were classified into four groups according to their alcohol consumption and postprandial glucose levels,and differences in their causes of death were ***:On multivariate Cox proportional hazards regression analysis,the following were significantly associated with survival:underlying liver disease stage [non-cirrhosis/Child-Pugh A vs B/C,hazard ratio(HR):0.603,95% CI:0.417-0.874,P = 0.0079],HCC stage(T1/T2 vs T3/T4,HR:0.447,95% CI:0.347-0.576,P y(y(no vs yes,HR:0.641,95% CI:0.469-0.877,P = 0.0055) was significant in addition to underlying liver disease stage(non-cirrhosis/Child-Pugh A vs B/C,HR:0649,95% CI:0.476-0.885,P = 0.0068),HCC stage(T1 vs T2/T3,HR:0.788,95% CI:0.653-0.945,P = 0.0108),and mean postprandial plasma glucose after initial therapy(y for newly emerging HCC was significantly longer in the "postprandial glucose within 200 mg/dL group" than the "postprandial

关键词： Hepatocellular carcinoma Prognosis Alcohol consumption Diabetes mellitus Postprandial plasma glucose level Initial therapy Local recurrence Survival

Appropriate Heart Rate in a Patient with Repaired Tetralogy of Fallot

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Congenital Heart Disease 2022年第6期17卷 647-652页

作者： Aya miyazaki Hideki Uemura yasuyo Takeuchi Junya Tomida yasuo Ono yoshifumi Fujimoto Norie Mitsushita Akio Ikai Department of Transitional Medicine Division of Congenital Heart DiseaseShizuoka General HospitalShizuokaJapan Congenital Heart Disease Center Nara Medical UniversityKashiharaJapan Department of Cardiology Shizuoka General HospitalShizuokaJapan Department of Clinical Engineering Shizuoka General HospitalShizuokaJapan

Appropriate heart rate in a failing pulmonary ventricle remains unknown, particularly in congenital heart diseasewith unique hemodynamics. A 71-year-old male with repaired tetralogy of Fallot and a pacemaker for a sinusnode dysfunction suffered from heart failure symptoms with preserved left ventricular function. Simply changingthe pacemaker’s lower rate from 60 to 75 bpm, New york Heart Association classification improved from III to II,and hemodynamic parameters drastically improved. We regarded this case as informative. Appropriate heart ratecould be higher in congenital patients with failing right and non-failing left ventricles than in adults with malfunctioningLV.

关键词： Heart rate repaired tetralogy of Fallot failing right ventricle pacemaker lower rate the right-left ventricular interaction

740 Gbit/s (37 x 20 Gbit/s) DWDM Transmission Experiment Using Er^(3+)-Doped Tellurite Fiber Amplifiers and Distributed Raman Amplification

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光学学报 2003年第S1期23卷 569-570页

作者： Hiroyuki Toda Maoki Suzuki Ryo Takami Tetsuya miyazaki Takeshi Makino Fumito Kubota Graduate School of Engineering Osaka University 2-1 Yamada-Oka Suita Osaka 565-0871 Japan Communications Research Laboratory 4-2-1 Nukui-Kitamachi Koganei Tokyo 184-8795 Japan

We demonstrate 740 Gbit/s (37 x 20 Gbit/s) DWDM recirculating transmission experiment with 59 nm continuous bandwidth over 300 km by employing Er3+-doped tellurite fiber amplifiers. The use of Raman amplification is e... 详细信息

关键词： Raman Amplification transmission bandwidth Raman amplification fiber amplifiers

Broadband IP Stream Transmission Experiments over Global and Long Distance Networks

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光学学报 2003年第S1期23卷 527-528页

作者： Kimio Oguchi Tetsuro Fujii Atsushi Takahara Toshiaki miyazaki Kazuo Hagimoto Sadayasu Ono NTT Network Innovation Laboratories 1-1 Hikari-no-oka Yokosuka 239-0847 JapanNTT Network Innovation Laboratories 1-1 Hikari-no-oka Yokosuka 239-0847 JapanNTT Network Innovation Laboratories 1-1 Hikari-no-oka Yokosuka 239-0847 JapanNTT Network Innovation Laboratories 1-1 Hikari-no-oka Yokosuka 239-0847 JapanNTT Network Innovation Laboratories 1-1 Hikari-no-oka Yokosuka 239-0847 JapanNTT Network Innovation Laboratories 1-1 Hikari-no-oka Yokosuka 239-0847 Japan

Super High Definition (SHD) movies were successfully transmitted as streaming contents at about 300 Mbps for the first time over a long distance IP network (more than 3,000 km), in conjunction with the experimental ve... 详细信息

关键词： IP on over Broadband IP Stream Transmission Experiments over Global and Long Distance Networks

Enhanced thermoelectric performance in MnTe due to doping and insitu nanocompositing effects by Ag2S addition

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Journal of Materiomics 2021年第3期7卷 577-584页

作者： Jinfeng Dong Jun Pei Kei Hayashi Wataru Saito Hezhang Li Bowen Cai yuzuru miyazaki Jing-Feng Li State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Department of Applied Physics Graduate School of EngineeringTohoku UniversitySendai980-8579Japan

Extremely low lattice thermal conductivity is always the pursuit of thermoelectric materials *** this work,we reported an exceptional effect of Ag2S addition in MnTe,an emerging promising midtemperature thermoelectric material,to enable the realization of minimum lattice thermal conductivity,namely-0.4 Wm^(-1) K^(-1).Such a low lattice thermal conductivity is guaranteed by the incorporation of in-situ formed Ag rich phase(Ag2Te)with ultralow lattice thermal conductivity and further scattering of phonons from the partial doping effects induced point defects and boundaries between various *** from the dramatically decreased lattice thermal conductivity,the partial doping of Ag and S simultaneously enhance the electrical conductivity,further contributing to enhanced thermoelectric ***,an inverse sign of Seebeck and Hall coefficient was observed and rationalized by the influence of highly electron-conductive Ag_(2)Te *** to the synergetic modulation of electrical and thermal transport properties by in-situ formed composite,a high ZT value of 1.1 was achieved in MnTe based thermoelectric materials,which also demonstrates the importance of compositing approaches to design state-of-the-art thermoelectric materials.

关键词： Manganese telluride Thermoelectric Thermal conductivity Composite

In-vitro proliferation assay with recycled ascitic cancer cells in malignant pleural mesothelioma: A case report

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World Journal of Clinical Cases 2019年第23期7卷 4036-4043页

作者： Takashi Anayama Mai Taguchi Takehiro Tatenuma Hironobu Okada Ryohei miyazaki KentaroHirohashi Motohiko Kume Keisuke Matsusaki Kazumasa Orihashi Department of SurgeryⅡ Kochi Medical SchoolKochi UniversityKochi 783-8505Japan Japanese CART Study Group Kaname Second ClinicKanamecho HospitalTokyo 171-0043Japan

BACKGROUND We report the first case,to the best of our knowledge,of massive ascites due to recurrent malignant pleural mesothelioma that was controlled using KM-cell-free and concentrated ascites reinfusion therapy(KM-CART).The tumor cells derived via KM-CART were utilized secondarily in an in vitro cell growth assay using the collagen gel droplet-embedded culture drug sensitivity test(CD-DST)to investigate anticancer drug *** SUMMARy A 56-year-old man presented with recurrent malignant mesothelioma with massive ascites;more than 4000 mL of ascitic fluid was removed,filtered,and concentrated using KM-CART,and the cell-free ascitic fluid was reinfused into the patient to improve quality of *** cells isolated secondarily in an in vitro proliferation assay using CD-DST exhibited low sensitivity to pemetrexed and high sensitivity to *** with gemcitabine maintained stable disease for 4 *** The combination of KM-CART and CD-DST may be a promising treatment option for malignant ascites associated with malignant mesothelioma.

关键词： Ascites Cancer Malignant Mesothelioma Pemetrexed Palliative therapy Case report

Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats

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World Journal of Gastroenterology 2005年第46期11卷 7254-7260页

作者： Hiroaki Shimizu Noboru Mitsuhashi Masayuki Ohtsuka Hiroshi Ito Fumio Kimura Satoshi Ambiru Akira Togawa Hiroyuki yoshidome Atsushi Kato Masaru miyazaki Department of General Surgery Graduate School of Medicine Chiba University Chiba 260-0856 Japan

AIM： To study the regulatory mechanisms of sinusoida regeneration after partial hepatectomy. METHODS： We invesldgated the expression of angiopoietin （Ang）-1, Ang-2, Tie-2, and vascular endothelial growth factor （VEGF） in regenerating liver tissue by quantitative reverse-transcription polymerase chain reaction （RT- PCR） using a LightCycler （Roche Diagnostics） and also immunohistochemical staining after 70% hepatectomy in rats. In the next step, we isolated liver cells （hepatocytes, sinusoidal endothelial cell （SEC）, Kupffer cell, and hepatic stellate cells （HSC）） from regenerating liver tissue by in situ collagenase perfusion and counterflow elutriation, to determine potential cellular sources of these angiogenic factors after hepatectomy. Proliferation and apoptosis of SECs were also evaluated by proliferating cell nuclear antigen （PCNA） staining and the terminal deoxynucleotidyl transferase d-uridine triphosphate nick end labeling （TUNEL） assay, respectively. RESULTS： VEGF mRNA expression increased with a peak at 72 h after hepatectomy, decreasing thereafter. The expression of Ang-1 mRNA was present at detectable levels before hepatectomy and increased slowly with a peak at 96 h. Meanwhile, Ang-2 mRNA was hardly detected before hepatectomy, but was remarkably induced at 120 and 144 h. In isolated cells, VEGF mRNA expression was found mainly in the hepatocyte fraction. Meanwhile, mRNA for Ang-1 and Ang-2 was found in the SEC and HSC fractions, but was more prominent in the latter. The PCNA labeling index of SECs increased slowly, reaching a peak at 72 h, whereas apoptotic SECs were detected between 120 h and 144 h. CONCLUSION： Ang-Tie system, together with VEGF, plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy. However, the VEGF system plays a more important role in the early phase of sinusoidal regeneration than angiopoietin/Tie system.

关键词： Vascular endothelial cell growth factor Angiopoietin Sinusoidal endothelial cell Hepatectomy Liver regeneration

Human Acyl-CoA:cholesterol Acyltransferase (ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis

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Acta Biochimica et Biophysica Sinica 2006年第3期38卷 151-156页

作者： Catherine CHANG Ruhong DONG Akira miyazaki Naomi SAKASHITASecond Department of Pathology,Kumamoto University School of Medicine,Kumamoto,Japan Jay LIU Michael GUO Department of Biochemistry Dartmouth Medical SchoolHanoverNew Hampshire 03755 USA Department of Biochemistry Showa University School of MedicineTokyoJapan

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl estersfrom cholesterol and long-chain fatty-acyl-coenzyme *** the single-cell level,ACAT serves as a regulatorof intracellular cholesterol *** addition,ACAT supplies cholesteryl esters for lipoproteinassembly in the liver and small *** pathological conditions,the accumulation of cholesterylesters produced by ACAT in macrophages contributes to foam cell formation,a hallmark of the earlystage of *** reviews addressing various aspects of ACAT and ACAT inhibitors areavailable [1-8].This review briefly outlines the current knowledge on the biochemical properties of humanACATs,and then focuses on discussing the merit of ACAT as a drug target for pharmaceutical interventionsagainst atherosclerosis.

关键词： acyl-CoA cholesterol acyltransferase cholesterol cholesteryl ester atherosclerosis