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World Journal of Gastroenterology 2014年第33期20卷 11850-11855页

作者： Katsutoshi Sugimoto Hisashi Oshiro Saori Ogawa mitsuyoshi honjo Takeshi Hara Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo 160-0023 Japan Department of Pathology Tokyo Medical University Tokyo 160-0023 Japan Department of Intelligent Image Information Gifu University Graduate School of Medicine Gifu 501-1193 Japan

AIM: To evaluate the usefulness of three-dimensional (3D) shear-wave elastography (SWE) in assessing the liver ablation volume after radiofrequency (RF) ablation.

关键词： Radiofrequency ablation Liver Ultrasound Shear-wave elastography Three-dimensional

Real-time virtual sonography visualization and its clinical application in biliopancreatic disease

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World Journal of Gastroenterology 2013年第42期19卷 7419-7425页

作者： Atsushi Sofuni Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka mitsuyoshi honjo Shuntaro Mukai Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

AIM:To evaluate the usefulness of real-time virtual sonography(RVS)in biliary and pancreatic ***:This study included 15 patients with biliary and pancreatic *** can be used to observe an ultrasound image in real time by merging the ultrasound image with a multiplanar reconstruction computed tomography(CT)image,using pre-scanned CT volume *** ultrasound used was EUB-8500with a convex probe *** RVS images were evaluated based on 3 levels,namely,excellent,good and poor,by the displacement in ***:By combining the objectivity of CT with free scanning using RVS,it was possible to easily interpret the relationship between lesions and the surrounding organs as well as the position of vascular *** resulting evaluation levels of the RVS images were12 excellent(pancreatic cancer,bile duct cancer,cholecystolithiasis and cholangiocellular carcinoma)and 3 good(pancreatic cancer and gallbladder cancer).Compared with conventional B-mode ultrasonography and CT,RVS images achieved a rate of 80%superior visualization and 20%better ***:RVS has potential usefulness in objective visualization and diagnosis in the field of biliary and pancreatic diseases.

关键词： Biliary and pancreatic disease Computed tomography-multiplanar reconstruction image Navigation Real-time ultrasound image Real-time virtual sonography

Evaluation of novel slim biopsy forceps for diagnosis of biliary strictures: Single-institutional study of consecutive 360 cases(with video)

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World Journal of Gastroenterology 2017年第35期23卷 6429-6436页

作者： Kenjiro Yamamoto Takayoshi Tsuchiya Takao Itoi Shujiro Tsuji Reina Tanaka Ryosuke Tonozuka mitsuyoshi honjo Shuntaro Mukai Kentaro Kamada Mitsuru Fujita Yasutsugu Asai Yukitoshi Matsunami Yuichi Nagakawa Hiroshi Yamaguchi Atsushi Sofuni Department of Gastroenterology and Hepatology Tokyo Medical University Third Department of Surgery Tokyo Medical University Department of Pathology Tokyo Medical University

AIM To evaluate the feasibility and reliability of endoscopic transpapillary bile duct biopsy for the diagnosis of biliary *** A total of 360 patients(241 men) who underwent endoscopic retrograde cholangiopancreatography for biliary strictures with biopsy from April 2012 to March 2016 at Tokyo Medical University Hospital were retrospectively reviewed. This study was approved by our Institutional Review Board(No. 3516). Informed consent was obtained from all individual participants included in this study. The biopsy specimens were obtained using a novel slim biopsy forceps(Radial Jaw 4P, Boston Scientific, Boston, MA, United States).RESULTS The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 69.6%, 100%, 100%, 59.1%, and 78.8%, respectively. The sensitivity was 75.6% in bile duct cancer, 64% in pancreatic cancer, 61.1% in gallbladder cancer, and 57.1% in metastasis. In bile duct cancer, a lower sensitivity was observed for perihilar bile duct stricture(68.7%) than for distal bile duct stricture(83.1%). In terms of the stricture lengths of pancreatic cancer, gallbladder cancer, and metastasis, a longer stenosis resulted in a better sensitivity. In particular, there was a significant difference between pancreatic cancer and gallbladder cancer(P < 0.05). One major complication was perforation of the extrahepatic bile duct with bile leakage. CONCLUSION Endoscopic transpapillary biopsy alone using novel slim biopsy forceps is feasible and reliable, but restrictive. Biopsy should be performed in consideration of the stricture level, stricture length, and cancer type.

关键词： Endoscopic transpapillary biopsy Biopsy forceps Biliary stricture Bile duct cancer Endoscopic retrograde cholangiography

Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer

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World Journal of Gastroenterology 2014年第28期20卷 9570-9577页

作者： Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka mitsuyoshi honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi Department of Gastroenterology and Hepatology Tokyo Medical University

AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or *** consent was *** study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at *** were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,*** after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care *** events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in ***,no severe adverse events occurred in this ***:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC.

关键词： High-intensity focused ultrasound Pancreatic cancer Safety trial Tumor ablation Ultrasonography