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Comparative study on pharmacokinetics and toxicity of intravitreal and sub-Tenon injection of triamcinolone acetonide in ocular tissues

引用

International Journal of Ophthalmology(English edition) 2020年第12期13卷 1864-1871页

作者： Yuko Arie Hiroko Miyai Ayako Suzuki Takeshi Okabe mitsuyo takashima Mayumi Takata Takashi Kurasawa Masaki Ito Reijiro Arakawa Yuichiro Ogura Akira Naito Sagami Research Laboratories Wakamoto Pharmaceutical Corporation Ltd.Kanagawa 2580018Japan Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoya 4678601Japan

AIM:To compare the differences in kinetics,distribution,and toxicity of triamcinolone acetonide(TA)between the injection methods,sub-Tenon and intravitreal injections in rabbit ocular ***:TA was injected into the vitreous or the sub-Tenon in *** pharmacokinetic study,rabbits were sacrificed periodically and then TA in blood and ocular tissues(retina/choroids,vitreous,and aqueous humor)were measured over 91 *** toxicological study,clinical signs,slit-lamp microscopic examination,ophthalmological test were *** eyeballs and surrounding tissues were collected and fixed with glutaraldehyde-formalin solution,and then paraffin embedded for histological ***:Higher levels of TA were distributed in the intraocular tissues when injected into the vitreous compared to the ***,TA level was remarkably lower in the rabbits which received intravitreal TA injections than those treated with sub-Tenon injection throughout the study period in *** discharge probably caused by systemic circulation of TA was observed by receiving sub-Tenon TA ***,technicassociated toxicological ocular symptoms and findings were more frequently observed in intravitreal injection than in sub-Tenon ***:There are significant differences in kinetics and distribution of TA in vitreous body,aqueous humor and plasma,between the two injection *** further study is needed to explain the species difference between human and rabbit,it is assumed that the difference in the frequency of intraocular pressure elevation and cataract formation by TA between the two injection methods are directly related to the TA concentrations in aqueous humor and vitreous body in each injection *** toxicity and technic-associated toxicity are also closely related to kinetics of TA in plasma and each injection method itself,respectively.

关键词： corticosteroid(s) pharmacokinetics injection ophthalmic drug delivery toxicity

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