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Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

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World Journal of Gastroenterology 2017年第19期23卷 3488-3495页

作者： Yasushi Adachi Masanori Nojima mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai Kiyomi Sakata Akiko Tamakoshi Division of Gastroenterology Department of Internal MedicineSapporo Shirakaba-dai Hospital Department of Gastroenterology Sapporo Medical University The Institute of Medical Science Hospital The University of Tokyo Department of Public Health Sapporo Medical UniversitySchool of Medicine Department of Preventive Medicine Nagoya UniversityGraduate School of Medicine Department of Hygiene and Preventive Medicine Iwate Medical University School of Medicine Department of Public Health Hokkaido University School of Medicine

To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal *** assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 ***-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95%CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150).CONCLUSIONThe free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence.

关键词： Esophageal cancer Insulin-like growth factor Insulin-like growth factor binding protein Nested case-control study Odds ratio

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Mn^(2+)与聚N-异丙基丙烯酰胺相互作用的光谱研究

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光谱学与光谱分析 2005年第10期25卷 1591-1594页

作者：郭绍芬陈明清陆天虹黄晓华 mitsuru Akashi 江南大学化学与材料工程学院江苏无锡214036 南京师范大学化学与环境科学学院鹿儿岛大学工学院应用化学系

合成了聚N-异丙基丙烯酰胺(PNIPAAm)与Mn2+的配合物,并用荧光光谱、紫外-可见光谱及FTIR进行了初步表征。光谱数据说明Mn2+与PNIPAAm羰基氧发生了配位键合作用。由于Mn2+的发射光谱与PNIPAAm激发光谱部分重叠及Mn2+位于561 nm的发射峰在... 详细信息

合成了聚N-异丙基丙烯酰胺(PNIPAAm)与Mn2+的配合物,并用荧光光谱、紫外-可见光谱及FTIR进行了初步表征。光谱数据说明Mn2+与PNIPAAm羰基氧发生了配位键合作用。由于Mn2+的发射光谱与PNIPAAm激发光谱部分重叠及Mn2+位于561 nm的发射峰在Mn2+-PNIPAAm体系发射光谱中消失,说明发生了较好的F rster能量传递。Mn2+-PNIPAAm配合物体系在307 nm紫外区荧光强度比PNIPAAm增强了314%。

关键词： Mn^2+ 聚N-异丙基丙烯酰胺能量传递光谱重叠

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Effect of Polyacrylamide integrated with other soil amendments on runoff and soil loss:Case study from northwest Ethiopia

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International Soil and Water Conservation Research 2022年第3期10卷 487-496页

作者： Birhanu Kebede Atsushi Tsunekawa Nigussie Haregeweyn mitsuru Tsubo Temesgen Mulualem Amrakh I.Mamedov Derege Tsegaye Meshesha Enyew Adgo Ayele Almaw Fenta Kindiye Ebabu Tsugiyuki Masunaga Bahir Dar Institute of Technology Bahir Dar UniversityP.O.Box 26Bahir DarEthiopia Arid Land Research Center Tottori University1390 HamasakaTottori680-0001Japan International Platform for Dry Land Research and Education Tottori University1390 HamasakaTottori680-0001Japan College of Agriculture and Environmental Sciences Bahir Dar UniversityP.O.Box 1289Bahir DarEthiopia Faculty of Life and Environmental Science Shimane UniversityShimane Matsue690-0823Japan

Anionic polyacrylamide(PAM)has the potential to reduce soil erosion through soil ***,a comprehensive study about its effectiveness especially when applied combined with other amendments have rarely been conducted in the tropical highland climatic conditions,such as in *** study assessed the effectiveness of PAM(P=40 kg ha^(-1))alone or integrated with other soil amendments such as gypsum(G=5 t ha^(-1)),lime(L=4 t ha^(-1))and biochar(B=8 t ha^(-1))on runoff and soil loss at Aba Gerima watershed in the Upper Blue Nile basin,northwest of Ethiopia,where there is high erosion-caused soil degradation.A total of 79 daily runoff and sediment data were collected from eight runoff plots(1.3m×4m)with three replications planted with teff(Eragrostis tef)crop for two years(2018&2019)rainy *** changes in soil physicochemical properties and crop growth parameters were *** reduced seasonal runoff by 12–39%and soil loss by 13–53%.The highest reduction in runoff was observed from P+B and PAM treatments while the highest reduction in soil loss was observed from that of P+L and PAM *** PAM with other amendments improved soil structural stability,moisture content,soil pH(P+L)and organic matter(P+B),leading to favorable environment for crop growth(biomass yield)and reduced runoff and soil *** PAM,biochar and lime amendments may need more time after application to be more *** continuing the field experiment and studying physico-chemical mechanisms for extended period will better elucidate their single or combined effectiveness over time.

关键词： Dryland Soil amendments Polyacrylamide Soil erosion Soil properties

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A durable complete response resulting from treatment with nivolumab plus ipilimumab for metastatic collecting duct carcinoma of the kidney

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Asian Journal of Urology 2023年第3期10卷 376-378页

作者： Keisuke Funajima Sei Naito Takanobu Kabasawa Hayato Nishida Tomoyuki Kato mitsuru Futakuchi Norihiko Tsuchiya Department of Urology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan Department of Pathology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan

Dear Editor,Collecting duct carcinoma(CDC)or Bellini carcinoma originates in the distal collecting *** is a markedly aggressive subtype of renal cell carcinoma and accounts for less than 1%of all renal cell carcinomas[1].We described a patient with CDC and psoriasis,who showed complete response(CR)after being treated with combination therapy of nivolumab and ipilimumab(NI).The study was conducted in accordance with and approved by the Ethics Committee of Yamagata University Faculty of Medicine(approval no.2019-35).The need for patient consent was waived by the same institutional review board;all the patients provided written informed consents.

关键词： markedly nivolumab approval

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Effects of Coronavirus Disease 2019 and Frailty on Delirium in the Intensive Care Unit: A Propensity Score Analysis

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Open Journal of Anesthesiology 2023年第2期13卷 23-31页

作者： Takayuki Yamanaka mitsuru Ida Taich Kotani Masahiko Kawaguchi Department of Anesthesiology Nara Medical University Kashihara Nara Japan

Purpose: The association between frailty and delirium has emerged as a research topic. Neurological symptoms have been reported among patients with coronavirus disease 2019 (COVID-19), but its effects on delirium remain unclear. This study aimed to compare the incidence of delirium between patients with COVID-19 and those without COVID-19, and to evaluate the impact of COVID-19 and frailty on delirium. Methods: This retrospective study included patients aged ≥ 20 years who were admitted to our intensive care unit (ICU) between January 2020 and February 2022. An inverse probability of treatment weighting using stabilized inverse propensity scores was adopted to minimize bias. After patient demographics were adjusted, the incidence of delirium, assessed using the Confusion Assessment Method for ICU, was compared between patients with COVID-19 and those without COVID-19. The effects of COVID-19 and the Clinical Frailty Scale score on delirium were analyzed by adjusting some covariates, including the sequential organ failure assessment (SOFA) score, using a generalized estimating equation. Results: Among 260 eligible patients, 226 patients were included. The weighted incidence of delirium was 56.9% and 61.9% in patients with and without COVID-19, respectively (p = 0.67). The generalized estimating equation revealed that the odds ratios (95% confidence interval) for COVID-19, the CFS score, and the SOFA score were 1.49 (0.62 - 3.57), 1.46 (1.11 - 1.91), and 1.22 (1.10 - 1.36), respectively. Conclusion: CFS and SOFA scores on ICU admission may be associated with delirium, with no significant difference between patients with COVID-19 and those without COVID-19.

关键词： COVID-19 Delirium Frailty Intensive Care Unit SARS-CoV-2

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Tillage and crop management impacts on soil loss and crop yields in northwestern Ethiopia

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International Soil and Water Conservation Research 2022年第1期10卷 75-85页

作者： Fekremariam Asargew Mihretie Atsushi Tsunekawa Nigussie Haregeweyn Enyew Adgo mitsuru Tsubo Kindiye Ebabu Tsugiyuki Masunaga Birhanu Kebede Derege Tsegaye Meshesha Wataru Tsuji Muluken Bayable Mulatu Liyew Berihun The United Graduate School of Agricultural Sciences Tottori University4-101 Koyama-MinamiTottori680-8553Japan Amhara Regional Agricultural Research Institute P.O.Box527Bahir DarEthiopia Arid Land Research Center Tottori University1390 HamasakaTottori680-0001Japan International Platform for Dryland Research and Education Tottori University1390 HamasakaTottori680-0001Japan College of Agriculture and Environmental Sciences Bahir Dar UniversityP.O.Box 1289Bahir DarEthiopia Faculty of Life and Environmental Science Shimane UniversityShimaneJapan Faculty of Civil and Water Resource Engineering Bahir Dar Institute of TechnologyBahir Dar UniversityP.O.Box252Bahir DarEthiopia Faculty of Agriculture Tottori UniversityTottoriJapan

Lack of appropriate agronomic practices is one of the major causes for soil erosion and low yields in teff(Eragrostis tef[Zucc.])production in Ethiopia.A 3-yr study was conducted at the Aba Gerima watershed in northwestern Ethiopia,to investigate the effects of two tillage practices(reduced tillage[RT]and conventional tillage[CT]),two planting methods(row planting[RP]and broadcast planting[BP]),and two compaction options(with[+T]and without[-T]trampling)on soil loss and teff yields in a split-split plot *** concentration ranged from 0.01 to 5.37 g L^(-1)(mean,0.25 g L^(-1))in our ***,the estimated total(August-October)soil loss ranged from 0.2 to 0.5 t ha^(-1)(mean,0.3 t ha^(-1)).The sediment concentration and total soil loss were significantly influenced(P<0.05)by tillage,planting methods,and trampling only in the third monitoring *** reduced soil loss by 19% relative to that of CT,whereas RP resulted in a 13%reduction in soil loss over ***-T plots showed a 15%reduction in soil loss as compared to+T *** revealed significant increase in soil total carbon and nitrogen in RT *** soil loss and greater teff grain yield were obtained in plots with improved agronomic practices(RT and RP)compared to conventional ones(CT and BP).Based on our findings we conclude that the use of RT,RP,and-T practices can effectively minimize soil loss without any crop yield penalty.

关键词： Drought-resistance Grain yield Reduced tillage Row planting Soil erosion Teff

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Basic Characteristics of the Hydraulic-Driven Forceps for Force Feedback

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Journal of Mechanics Engineering and Automation 2015年第9期5卷 519-524页

作者： Tohru Sasaki Yasuyuki Mito mitsuru Jindai Yusuke Ikemoto Graduate School of Science and Engineering for Research University of Toyama Toyama 930-8555 Japan Graduate School of Science and Engineering for Education University of Toyama Toyama 930-8555 Japan

A surgical manipulator has widely been used for laparoscopic surgery. It has been chosen mainly for the use in supporting human operations and in robot systems like the da Vinci surgical system. These manipulator systems are suitable for careful work, but they have a few problems. One of the problems is that the manipulator is not equipped with haptic sensing functions. Therefore, the operator must know the advanced techniques for visually detecting the physical contact state during surgical operations. These haptic sensing functions thus need to be incorporated into a surgical manipulator. We have developed hydraulic-driven forceps with a micro bearing and a bellows tube that can convey haptic sense to the operator. This system can measure the small forces acting on the tips of the forceps using Pascal＇s principle. A model of the system is provided from the relationship between the internal pressure of the bellows tube and the refraction angles of the forceps. It was confirmed using this model that the developed system makes it possible to estimate both the strength and the direction of the external force applied to the forceps by measuring the internal pressure of the bellows tube. An operator using a three-dimensional haptic device was able to feel the force response during an experiment in which they used the forceps to hold a blood vessel. This report describes the most appropriate method for letting the operator feel the force conveyed by using our system.

关键词： Hydraulic-driven forceps force feedback surgical manipulator.

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聚N-异丙基丙烯酰胺-丙烯酸共聚微凝胶与Tb(Ⅲ)相互作用的研究

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高分子学报 2005年第3期15卷 458-462页

作者：肖雨亭陈明清陆天虹 mitsuru Akashi 黄晓华江南大学化学与材料工程学院南京师范大学化学与环境科学学院材料科学重点实验室中国科学院长春应用化学研究所长春130022 大阪大学工学部分子化学系南京师范大学化学与环境科学学院材料科学重点实验室南京210097

聚N-异丙基丙烯酰胺(PNIPAM)微凝胶是一类具有独特的温度响应性,即具有最低临界溶解温度(LCST)的高分子化合物.由于具有了LCST性能,当PNIPAM微凝胶受热时,在较窄的温度范围内,溶胀于微凝胶内的溶剂被挤出[1],从而导致微凝胶的粒子尺寸[2... 详细信息

聚N-异丙基丙烯酰胺(PNIPAM)微凝胶是一类具有独特的温度响应性,即具有最低临界溶解温度(LCST)的高分子化合物.由于具有了LCST性能,当PNIPAM微凝胶受热时,在较窄的温度范围内,溶胀于微凝胶内的溶剂被挤出[1],从而导致微凝胶的粒子尺寸[2]、粒子形态[3,4],、亲水性[5]、胶体稳定性[6]以及微凝胶分散液的粘度、电泳流动性[7]发生较大改变的现象.因此,近年来受到了人们的广泛关注.自从1986年Pelton[8]首次报道合成了PNIPAM微凝胶以来,不断有报道用类似方法[9]和其他方法[10]合成了PNIPAM微凝胶,也有用苯乙烯[1]或丙烯酸类衍生物[12,13]和PNIPAM合成了共聚微凝胶.……

关键词：聚N-异丙基丙烯酰胺微凝胶 Tb(Ⅲ) 相互作用丙烯酸共聚高分子化合物临界溶解温度 PNIPAM 温度响应性胶体稳定性 LCST 温度范围粒子尺寸粒子形态亲水性分散液流动性

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A Modified Eigenvector Method for Blind Deconvolution of MIMO Systems Using the Matrix Pseudo-Inversion Lemma

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Circuits and Systems 2011年第1期2卷 7-13页

作者： mitsuru Kawamoto Kiyotaka Kohno Yujiro Inouye Koichi Kurumatani 不详

Recently we have developed an eigenvector method (EVM) which can achieve the blind deconvolution (BD) for MIMO systems. One of attractive features of the proposed algorithm is that the BD can be achieved by calculating the eigenvectors of a matrix relevant to it. However, the performance accuracy of the EVM depends highly on computational results of the eigenvectors. In this paper, by modifying the EVM, we propose an algorithm which can achieve the BD without calculating the eigenvectors. Then the pseudo-inverse which is needed to carry out the BD is calculated by our proposed matrix pseudo-inversion lemma. Moreover, using a combination of the conventional EVM and the modified EVM, we will show its performances comparing with each EVM. Simulation results will be presented for showing the effectiveness of the proposed methods.

关键词： Blind Signal Processing Blind Deconvolution Eigenvector Methods Super-Exponential Mthods MIMO Systems Matrix Pseudo-Inversion Lemma

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Transcatheter arterial embolization for traumatic injury to the pharyngeal branch of the ascending pharyngeal artery:Two case reports

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World Journal of Clinical Cases 2022年第32期10卷 12015-12021页

作者： Daisuke Yunaiyama Yuki Takara Takehiro Kobayashi Mika Muraki Taro Tanaka mitsuru Okubo Toru Saguchi Motoki Nakai Kazuhiro Saito Kiyoaki Tsukahara Yuri Ishii Hiroshi Homma Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023Japan Department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University HospitalShinjuku-ku 160-0023Japan Department of Emergency and Critical Care Medicine Tokyo Medical University HospitalShinjuku-ku 160-0023Japan

BACKGROUND The ascending pharyngeal artery(APhA)comprises the pharyngeal trunk(PT)and neuromeningeal *** PT feeds the nasopharynx and adjacent tissue,which potentially connects with the sphenopalatine artery(SPA),branched from the internal maxillary artery(IMA).Due to its location deep inside the body,the PT is rarely injured by ***,we present two cases that underwent transcatheter arterial embolization(TAE)of the PT of the APhA due to trauma and iatrogenic *** SUMMARY Case 1 is a 49-year-old Japanese woman who underwent transoral endoscopy under sedation for a medical *** nasal airway was inserted as glossoptosis occurred during *** from the nasopharynx was observed during the endoscopic *** the bleeding continued,the patient was referred to our hospital for further ***-enhanced computed tomography(CT)demonstrated extravasation in the nasopharynx originating from the right Rosenmuller *** was performed and the extravasation disappeared after *** 2 is a 28-year-old Japanese woman who fell from the sixth floor of a building and was transported to our *** CT demonstrated a complex facial fracture accompanying extravasation in the left pterygopalatine fossa to the *** demonstrated an irregular third portion of the *** angiography after TAE of the IMA demonstrated extravasation from the PT of the APhA,additional TAE to the artery was *** bleeding stopped after the *** Radiologists should be aware that the PT of the APhA can be a bleeding source,which has a potential connection with the SPA.

关键词： Arteries Catheters Hemorrhage Injury Trauma Case report

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