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World Journal of Clinical Oncology 2016年第5期7卷 414-419页

作者： Yoshihiro Matsumoto Tomoya Matsunobu Katsumi Harimaya Kenichi Kawaguchi mitsumasa hayashida Seiji Okada Toshio Doi Yukihide Iwamoto Department of Orthopaedic Surgery Graduate School of Medical Sciences Kyushu University Department of Orthopaedic Surgery Kyushu University Beppu Hospital

AIM To study the clinical findings and characteristic features in sciatic notch dumbbell tumors(SNDTs).METHODS We retrospectively reviewed the clinical outcomes and characteristic features of consecutive cases of SNDTs(n = 8). RESULTS Buttock masses occurred in three patients with SNDT(37.5%). Severe buttock tenderness and pain at rest were observed in seven patients with SNDTs(87.5%). Remarkably, none of the patients with SNDTs experienced back pain. Mean tumor size was 8.4 ± 2.0 cm(range, 3.9 to 10.6 cm) and part of the tumor mass was detected in 2 patients in the sagittal view of lumbar magnetic resonance imaging(MRI).CONCLUSION The clinical information regarding to SNDTs is scarce. The authors consider that above mentioned characteristic findings may facilitate the suspicion of pelvic pathology and a search for SNDT by MRI or computed tomography should be considered in patients presenting with sciatica without evidence of spinal diseases.

关键词： Sciatic notch Dumbbell masses Sciatica Differential diagnosis Bone and soft tissue tumor

Analysis of shopping behavior characteristics in the Keihanshin metropolitan area in Japan based on a person trip survey

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Geo-Spatial Information Science 2020年第4期23卷 305-315页

作者： Takashi Yamada Takumi hayashida Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityKinokawaWakayamaJapan

This study analyzed weekday shopping behavior from a home base to a destination using data from the 4th Keihanshin metropolitan area person trip *** first analyzed the relationships between occupation and transportation means,transportation means and travel time,and transportation means and duration of time at the *** of a chi-square test,residual analysis,and correspondence analysis confirmed that employed persons tend to travel by cars while unemployed persons tend to travel by bus or *** relationship between travel time and duration of time at the destination was also revealed according to transportation *** of a cluster analysis then classified shopping behaviors to expose four ***,multiple regression analyzed the degree to which certain variables were related to duration of time at the *** confirmed a strong relationship between duration of time at the destination and travel *** degree of this factor’s influence on other variables was also *** value of these findings is that the relationship between travel time by means of transportation and the duration of time at the destination was clarified using statistical *** then found a highly accurate equation that estimates the duration of time at a destination from the travel *** the duration of time at a destination can be estimated,it may be possible to more accurately develop the structure of rest facilities,the number of parking lots,the degree of congestion,and so on,which can be associated with the customer’s usage behavior in a shopping *** research in this paper contributes to the field of urban analysis and marketing by presenting a new effective method for person trip survey and analysis.

关键词： Person trip survey shopping behavior transportation means travel time duration of time at a destination

Surgical treatment algorithms for post-burn contractures

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Burns & Trauma 2017年第1期5卷 1-8页

作者： Kenji hayashida Sadanori Akita Division of Plastic and Reconstructive Surgery Department of DermatologyFaculty of MedicineShimane University Hospital89-1Enya-choIzumoShimane693-0021Japan Department of Plastic Surgery Wound Repair andRegenerationFukuoka UniversityFukuokaJapan.

Burn contractures produce restrictions in motion and unacceptable aesthetic results, frequently with persistent wounds. Proper planning and tissue selection are essential to minimize donor site morbidity optimizing outcomes. The principle of burn reconstructive surgery requires that the defects after release should be replaced with donor tissues which have matching texture and color as well as enough pliability. Autologous skin grafting or flap surgeries meet these criteria to replace scar tissues and resurface the subsequent to post-released scar defects. Despite the benefits, the use of flaps is often limited in burn patients for many reasons. If a surgeon intends to release completely and reconstruct in one-stage operation, a large defect may result in large donor site morbidity, necessitating flap surgery including free flap surgery. A lot of different methods and procedures are available for resurfacing the defects, and these are reviewed. In this article, algorithms for the release of burn contractures and reconstructive methods are presented. These treatment algorithms should aid in achieving significant improvement in both joint motions and aesthetic deformities.

关键词： BurnContracture Algorithm Donor site morbidity Perforator flap Surgical treatment

Advances in surgical applications of growth factors for wound healing

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Burns & Trauma 2019年第1期7卷 85-97页

作者： Sho Yamakawa Kenji hayashida Division of Plastic and Reconstructive Surgery Shimane University Faculty of Medicine89-1 Enya-choIzumoShimane 693-8501Japan

Growth factors have recently gained clinical importance for wound *** of recombinant growth factors has been shown to mimic cellmigration,proliferation,and differentiation in vivo,allowing for external modulation of the healing *** drug delivery systems can enhance the biological activity of these growth factors,which have a very short in vivo half-life after topical *** the basic mechanisms of these growth factors are well understood,most have yet to demonstrate a significant impact in animal studies or small-sized clinical *** this review,we emphasized currently approved growth factor therapies,including a sustained release system for growth factors,emerging therapies,and future research possibilities combined with surgical *** seeking to understand wound healing at a systemic level are currently ***,further research and consideration in surgery will be needed to provide definitive confirmation of the efficacy of growth factor therapies for intractable wounds.

关键词： Wound healing Growth factor Surgical application

Topical odour management in burn patients

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Burns & Trauma 2021年第1期9卷 311-317页

作者： Kenji hayashida Sho Yamakawa Division of Plastic and Reconstructive Surgery Shimane University Faculty of Medicine89-1 Enya-choIzumoShimane693-0021Japan

Preventing microbial colonization or infections that cause offensive smells may lead to odor *** both anaerobic and aerobic bacteria cause the release of malodor from wounds,the most direct way of avoiding or eliminating wound odor is to prevent or eradicate the responsible infection through the debridement of necrotic ***,some burn patients with malodorous wounds are unable to undergo debridement due to systemic conditions,especially in the acute ***,the optimal drug doses and dressings to ensure the efficacy and cost-effectiveness of odorous burn wound management is *** purpose of this commentary is to outline the odor management options available for burn patients,focusing on topical *** potential therapies for treating odorous wounds after burn injuries are suggested.

关键词： Odour Wounds Topical management Burns Natural substance

Strategies to prevent hypertrophic scar formation:a review of therapeutic interventions based on molecular evidence

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Burns & Trauma 2020年第1期8卷 433-440页

作者： Eri Shirakami Sho Yamakawa Kenji hayashida Division of Plastic and Reconstructive Surgery Shimane University Faculty of Medicine89-1 Enya-choIzumoShimane 693-8501Japan

Once scar tissues mature,it is impossible for the surrounding tissue to regenerate normal dermal ***,it is essential to understand the fundamental mechanisms and establish effective strategies to inhibit aberrant scar *** scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound ***,the underlying mechanisms of hypertrophic scar development are poorly *** purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation,focusing on strategies excluding therapeutic agents of internal *** aimed at molecular targets,including cytokines,will be future options to prevent and treat hypertrophic *** basic studies and clinical trials,including combination therapy,are required to investigate the mechanisms and prevent hypertrophic scar formation.

关键词： Hypertrophic scar Therapy Intervention Cytokines

Atomic force microscopy imaging of dialyzed single-walled carbon nanotubes dispersed with sodium dodecyl sulfate

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International Journal of Smart and Nano Materials 2013年第2期4卷 119-127页

作者： Shigeyuki Hirayama Takuya hayashida Kazuo Umemura Biophysics Section Department of PhysicsFaculty of ScienceTokyo University of Science1-3 KagurazakaShinjukuTokyo 1628601Japan

The existence of excess sodium dodecyl sulfate(SDS)molecules in a single-walled carbon nanotube(SWNT)solution dispersed by hybridization with SDS leads to unstable atomic force microscopy(AFM)*** this study,we demonstrate sequential dialysis against pure water in order to remove excess SDS molecules from an SDS-SWNT hybrid dispersion.A 1:102 volume ratio of SDS-SWNT dispersion to water in the dialysis was found to be effective in realizing stable AFM observations of the SDS-SWNT hybrids despite imperfect filtering of SDS via *** the other hand,the SDS-SWNT hybrids were stable even when this volume ratio was 1:***,the SDS-SWNT hybrids were present in the solution even when the dialyzed samples were stored for 14 *** results reveal that dialysis under optimal conditions enables improved handling of SDS-SWNT hybrids,particularly for stable AFM observations.

关键词： carbon nanotube atomic force microscopy sodium dodecyl sulfate dialysis

Dorsal hand reconstruction with radial artery perforator-based adipofascial flap

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Plastic and Aesthetic Research 2020年第5期7卷 15-25页

作者： Sho Yamakawa Kenji hayashida Division of Plastic and Reconstructive Surgery Shimane University HospitalIzumoShimane 693-8501Japan

Reconstruction of dorsal hand soft tissue defects after severe injury is challenging for *** on the degree of defect,extensor tendon reconstruction may also be *** reconstruction methods are commonly performed to cover dorsal hand defects,such as skin grafting and distant,free,or local *** them,free vascularized flap transplantation is an ideal procedure because the major vessels that feed the local flap may have been damaged,and the affected limb can be reconstructed using a flow-through *** free flap surgery has advanced,few surgeons can choose this option due to its technical difficulty and *** the other hand,distant flaps have been commonly used for the reconstruction of dorsal hand defects,and local flaps,such as reverse forearm flaps and retrograde posterior interosseous flaps,do not require microvascular ***,they have some problems;distant flaps require at least two surgeries,reverse forearm flaps sacrifice major vessels and leave a scar at the donor site,and retrograde posterior interosseous flaps require meticulous dissection of the vascular *** radial artery perforator-based adipofascial flap is a versatile flap that is safe and easy to elevate without sacrificing the radial *** addition,elevating it as an adipofascial flap enables surgeons to avoid an unacceptable donor *** present two cases,demonstrating the usefulness of this pedicled perforator flap.

关键词： Perforator dorsal hand reconstruction adipofascial flap hand replantation color Doppler ultrasonography

Improving conditional random field model for prediction of protein-RNA residue-base contacts

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Frontiers of Electrical and Electronic Engineering in China 2018年第2期6卷 155-162页

作者： Morihiro hayashida Noriyuki Okada Mayumi Kamada Hitoshi Koyano Department of Electrical Engineering and Computer Science National Institute of Technology Matsue College Shimane 690- 8518 Japan Graduate School of Medicine Kyoto University Kyoto 606-8507 Japan Riken Quantitative Biology Center Hyogo 650-0047 Japan

Background： For understanding biological cellular systems, it is important to analyze interactions between protein residues and RNA bases. A method based on conditional random fields （CRFs） was developed for predicting contacts between residues and bases, which receives multiple sequence alignments for given protein and RNA sequences, respectively, and learns the model with many parameters involved in relationships between neighboring residue-base pairs by maximizing the pseudo likelihood function. Methods： In this paper, we proposed a novel CRF-based model with more complicated dependency relationships between random variables than the previous model, but which takes less parameters for the sake of avoidance of overfitting to training data. Results： We performed cross-validation experiments for evaluating the proposed model, and took the average of AUC （area under receiver operating characteristic curve） scores. The result suggests that the proposed CRF-based model without using Ll-norm regularization （lasso） outperforms the existing model with and without the lasso under several input observations to CRFs. Conclusions： We proposed a novel stochastic model for predicting protein-RNA residue-base contacts, and improved the prediction accuracy in terms of the AUC score. It implies that more dependency relationships in a CRF could be controlled by less parameters.

关键词： protein-RNA interaction residue-base contact conditional random field

The neck burn scar contracture:a concept of effective treatment

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Burns & Trauma 2017年第3期5卷 140-147页

作者： Sadanori Akita Kenji hayashida Satoshi Takaki Yoshihisa Kawakami Takuto Oyama Hiroyuki Ohjimi Department of Plastic Surgery Wound Repair and Regeneration School of Medicine Fukuoka University 7-45-1 Nanakuma Jonan ku Fukuoka 8140180 Japan Section of Plastic Surgery School of Medicine Shimane University Shimane Japan Department of Plastic Surgery School of Medicine Fukuoka University Fukuoka Japan

A neck scar contracture can severely and negatively affect the function of mastication, phonic, or breathing and result in neck pain and issues with esthetics. The best way is of course to avoid such contracture by means of non-surgical treatment such as use of a growth factor. The basic fibroblastic growth factor is clinically well proven in decreasing scar formation and improving healing. There are numerous reconstructive methods for neck contracture, especially when the lesions are relatively limited in part of the neck. However, a very severe and full circumferential scar contracture requires extensive reconstruction. The thin groin flap is one of the answers and well matches with the tissue texture and maintains the flexibility. Even with extensive burns and delayed reconstructions due to resuscitation first, the groin area is well preserved and can be safely harvested by dual vasculature systems of the superficial circumflex iliac artery and superficial epigastric artery, which warrant more reliability compared to the perforator flaps in this area. More demanding and stringent forms of the neck burn scar contracture are the sequelae of radiation. A radiation burn or radiation injury can be progressing and hard to heal. Adipose-derived stem cells can reverse the scar contracture as the surrounding tissue is softened and can accelerate wound healing. In this review, different types of neck burn scar contracture and reconstructive methods are summarized, including innovative use of bFGF and ADSCs in the management of difficult wound healing and scar contracture.

关键词： Neck scar contracture Anatomical locations Prophylaxis Severe scar contracture Thin groin flap Radiation injury Adipose-derived stem cell