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Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

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World Journal of Gastroenterology 2014年第13期20卷 3597-3608页

作者： Mio Kobayashi Yuko Kakuda Kenichi Harada Yasunori Sato Motoko sasaki Hiroko Ikeda mitsuhiro Terada Munenori Mukai Shuichi Kaneko Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 920-8640Japan Division of Pathology Kanazawa University HospitalKanazawa 920-8641Japan Department of Gastroenterology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Pathology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Gastroenterology Kanazawa University Graduate School of MedicineKanazawa 920-8640 Japan

AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH ***:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were *** activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored *** infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual ***:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in ***3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in *** degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in ***20+cells were mainly found in the portal tracts and,occasionally,at the interface in both *** AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in *** correlation existed between autoantibodies and inflammatory cell infiltration in PBC or *** most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with ***:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with inte

关键词： Primary biliary cirrhosis Autoimmune hepa-titis Interface hepatitis Lobular hepatitis Plasma cell subclass

Effects of hydraulic oil and lubricant additives on dynamic friction properties under various reciprocating sliding conditions

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Friction 2020年第2期8卷 471-480页

作者： Shinji KATO Shinya sasaki Engineering Headquarters Automotive ComponentsKYB Corporation2548DolaKani-shiGifu 509-0298Japan Department of Mechanical Engineering Faculty of Engineering Division ITokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan

The friction characteristics of a shock absorber are very complex because the reciprocating motion is not always *** this study,a device was developed and used to analyze the dynamic friction characteristics under various reciprocating sliding conditions to determine the sliding materials and hydraulic oils that improve the shock absorber *** study describes the influence of hydraulic oil additive on the fine reciprocating friction characteristics of steel and copper *** oils were prepared by blending a paraffinic mineral oil with zinc dithiophosphate(ZnDTP)and polyhydric alcohol ester as *** results show that the dynamic frictional characteristics vary mainly depending on the additive concentration.A specific additive formulation induces a unique amplitude-dependent friction *** addition,the influence of different additives on the lubrication mechanism is investigated based on the instrumental analysis of the friction surface.

关键词： shock absorber dynamic friction reciprocating friction additive zinc dithiophosphate(ZnDTP)

HYPERGAMES AND BAYESIAN GAMES:A THEORETICAL COMPARISON OF THE MODELS OF GAMES WITH INCOMPLETE INFORMATION

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Journal of Systems Science & Complexity 2012年第4期25卷 720-735页

作者： Yasuo sasaki Kyoichi KIJIMA Graduate School of Decision Science and Technology Tokyo Institute of Technology

The present study discusses the relationships between two independently developed models of games with incomplete information, hypergames （Bennett, 1977） and Bayesian games （Harsanyi, 1967）. The authors first show that any hypergame can naturally be reformulated in terms of Bayesian games in an unified way. The transformation procedure is called Bayesian representation of hypergame. The authors then prove that some equilibrium concepts defined for hypergames are in a sense equivalent to those for Bayesian games. Furthermore, the authors discuss carefully based on the proposed analysis how each model should be used according to the analyzer＇s purpose.

关键词： Bayesian game Bayesian representations of hypergame hypergame incomplete information."

Hierarchical Hypergames and Bayesian Games:A Generalization of the Theoretical Comparison of Hypergames and Bayesian Games Considering Hierarchy of Perceptions

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Journal of Systems Science & Complexity 2016年第1期29卷 187-201页

作者： sasaki Yasuo KIJIMA Kyoichi School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1AsahidaiNomiIshikawaJapan Department of Value and Decision Science Tokyo Institute of Technology 2-12-1OokayamaMeguro-kuTokyoJapan

This paper discusses the relationship of two independently developed models of games with incomplete information,hierarchical hypergames and Bayesian *** can be considered as a generalization of the previous study on the theoretical comparison of simple hypergames and Bayesian games(sasaki and Kijima,2012) by taking into account hierarchy of perceptions,i.e.,an agent's perception about the other agents' perceptions,and so *** authors first introduce the general way of transformation of any hierarchical hypergames into corresponding Bayesian games,which was called as the Bayesian representation of hierarchical *** authors then show that some equilibrium concepts for hierarchical hypergames can be associated with those for Bayesian games and discuss implications of the results.

关键词： Bayesian games game theory hierarchy of perceptions hypergames incomplete information

Candida-associated gastric ulcer relapsing in a different position with a different appearance

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World Journal of Gastroenterology 2012年第32期18卷 4450-4453页

作者： Kenji sasaki Department of Internal Medicine Tome Municipal Hospital of ToyosatoTomeMiyagi 987-0364Japan

An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the *** showed Candida tropicalis but not Helicobacter pylori(***).She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs(NSAIDs),diagnosed with Candida-associated gastric *** cured of the lesion,she developed another ulcer in a different position,in which Candida was demonstrated but *** was *** is the first case of recurrent Candida-associated gastric ulcer in the *** in both the original and recurrent lesions in an ***-negative patient with no antecedent ulcers who had not taken NSAIDs,Candida is considered,contrary to the prevailing opinion,to play an etiologic role in ulcer formation.

关键词： Candida-associated gastric ulcer Gastric candidiasis Helicobacter pylori-negative gastric ulcer Non-steroidal anti-inflammatory drugs-induced gastric ulcer Recurrent gastric ulcer

Population synthesis of planet formation using a torque formula with dynamic effects

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Geoscience Frontiers 2017年第2期8卷 215-222页

作者： Takanori sasaki Toshikazu Ebisuzaki Department of Astronomy Kyoto University RIKEN

Population synthesis studies into planet formation have suggested that distributions consistent with observations can only be reproduced if the actual Type Ⅰ migration timescale is at least an order of magnitude longer than that deduced from linear *** past studies considered the effect of the Type I migration of protoplanetary embryos,in most cases they used a conventional formula based on static torques in isothermal disks,and employed a reduction factor to account for uncertainty in the mechanism ***,in addition to static torques,a migrating planet experiences dynamic torques that are proportional to the migration *** dynamic torques can impact on planet migration and predicted planetary *** this study,we derived a new torque formula for Type Ⅰ migration by taking into account dynamic *** formula was used to perform population synthesis simulations with and without the effect of dynamic *** many cases,inward migration was slowed significantly by the dynamic *** the static torque case,gas giant formation was effectively suppressed by Type I migration;however,when dynamic effects were considered,a substantial fraction of cores survived and grew into gas giants.

关键词： Planetary formation Population synthesis Type Ⅰ migration

Highly active and stable supported Pd catalysts on ionic liquidfunctionalized SBA-15 for Suzuki–Miyaura cross-coupling and transfer hydrogenation reactions

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Green Energy & Environment 2019年第2期4卷 180-189页

作者： Etty N.Kusumawati Takehiko sasaki Department of Chemistry Graduate School of Science The University of Tokyo Institute for Catalysis Hokkaido University Department of Complexity Science and Engineering Graduate School of Frontier Sciences The University of Tokyo

Highly dispersed palladium nanoparticles were synthesized in the presence of immobilized ionic liquid on mesoporous silica ***(2.4 nm)_me-Im@SBA-15 catalyst was prepared by the reduction using NaBH_4 as the reducing agent with controlled feed rate and has been investigated as ligand-free catalyst for Suzuki–Miyaura cross-coupling reaction at room temperature in aqueous solution under *** catalyst was also prepared in situ from PdCl4_me-Im@SBA-15 during the reaction and demonstrated high activity and stability towards nitrobenzene hydrogenation at high temperature. Both catalysts were reusable at least for four recycle processes without significant loss in activity with simple procedure. The catalysts were characterized by TEM, EXAFS, FTIR and XPS.

关键词： Palladium nanoparticle Ionic liquid SBA-15 Suzuki–Miyaura cross-coupling Hydrogenation

BO_(2)-F^(+)Centers in the Radiation-damaged YCOB Crystals

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Chinese Physics Letters 2000年第12期17卷 896-898页

作者： RUAN Yong-Feng Hiroshi NAKAO Takatomo sasaki Department of Physics Tianjin UniversityTianjin 300072 Department of Electrical Engineering Osaka UniversityOsaka 565-0871Japan

An intense paramagnetic EPR signal generated from x-ray-irradiated,powdered YCOB crystals was observed at the liquid nitrogen temperature for the first *** peaks,located at the positions where the effective g factor equals to 1.992,1.986,1.980,1.974 and 1.965,labeled as A,B,C,D and E respectively,were *** is believed that the peaks A,B,C and D generated from the BO_(2)-F^(+)center which is a single electron trapped in an oxygen vacancy which was originally occupied by an O^(2-)ion bonded to a(BO3)^(3-)anion *** peak E is thought of coming from Y2+ions that are formed by the Y^(3+) ions trapping *** mechanism for the formation of the radiation-induced defects in the YCOB crystals is suggested.

关键词： Crystal occupied trapping

Fibroblasts, an inconspicuous but essential player in colon cancer development and progression

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World Journal of Gastroenterology 2016年第23期22卷 5301-5316页

作者： Naofumi Mukaida Soichiro sasaki Division of Molecular Bioregulation Cancer Research InstituteKanazawa University

Tumor microenvironments have a crucial role in cancer initiation and progression, and share many molecular and pathological features with wound healing process. Unless treated, tumors, however, do not heal in contrast to wounds that heal within a limited time framework. Wounds heal in coordination of a myriad of types of cells, particularly endothelial cells, leukocytes, and fibroblasts. Similar sets of cells also contribute to cancer initiation and progression, and as a consequence, anti-cancer treatment strategies have been proposed and tested by targeting endothelial cells and/or leukocytes. Compared with endothelial cells and leukocytes, less attention has been paid to the roles of cancer-associated fibroblasts(CAFs), fibroblasts present in tumor tissues, because their heterogeneity hinders the elucidation on them at cellular and molecular levels. Here, we will discuss the origin of CAFs and their crucial roles in cancer initiation and progression, and the possibility to develop a novel type of anti-cancer treatment by manipulating the migration and functions of CAFs.

关键词： Angiogenesis Drug resistance Extracellular matrix Immune evasion Transforming growth factor-β Invasion Metastasis