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非小细胞肺癌p63基因的表达与3q27-q29变化的关系研究

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中国肺癌杂志 2004年第5期7卷 419-422页

作者：余永伟 mitchell e.garber Karsten Schlens Manuela Pacyna-Gengelbach Iver Petersen 第二军医大学长海医院病理科上海200433 美国加尼福尼亚斯坦福大学医学院遗传研究所德国柏林洪堡大学病理研究所

目的　研究p63基因在非小细胞肺癌中的蛋白表达水平及与 3号染色体长臂 3 q2 7 3 q2 9区域改变的关系。方法　采用组织芯片技术构建 12 2例原发性非小细胞肺癌石蜡包埋标本组织芯片 ,并应用免疫组织化学方法检测 p63基因蛋白表达情况。... 详细信息

目的　研究p63基因在非小细胞肺癌中的蛋白表达水平及与 3号染色体长臂 3 q2 7 3 q2 9区域改变的关系。方法　采用组织芯片技术构建 12 2例原发性非小细胞肺癌石蜡包埋标本组织芯片 ,并应用免疫组织化学方法检测 p63基因蛋白表达情况。应用比较基因组杂交 (CGH)技术分析 70例原发性肺鳞癌和肺腺癌标本染色体的改变。同时分析p63基因的蛋白表达与 3号染色体长臂末端改变的关系。结果　 12 2例非小细胞肺癌 p63免疫组化染色结果显示 :5 9例鳞癌中 5 1例 ( 86.44 % ) p63免疫组化染色为阳性 ;3例大细胞肺癌中 2例 ( 66.66% )为阳性 ;60例腺癌仅有 1例 ( 1.67% )为阳性。p63蛋白的阳性表达率与患者的年龄、性别、肿瘤的分级、肿瘤的转移以及预后生存率无关 (P >0 .0 5 )。 70例非小细胞肺癌CGH分析结果发现有3 2例 3 q2 7 q2 9区域出现DNA扩增 ,3 0例鳞癌中 2 4例出现 3 q2 7 q2 9区域DNA拷贝数目的增加 ,40例腺癌仅 8例发现 3q2 7 q2 9区域DNA获得。p63免疫组化阳性率与 3q2 7 q2 9区域的改变比较分析结果显示 :2 4例鳞癌 p63阳性者中 ,2 3例 ( 95 .83 % ) 3 q2 7 q2 9区域有显著的获得 ,1例 p63基因蛋白表达呈阳性的腺癌患者的 3 q2 7 q2 9区域有DNA拷贝数目的增加。结论　研究结果提示 p63免疫组化阳性?

关键词：非小细胞肺癌 p63 组织芯片比较基因组杂交

非小细胞肺癌p63基因的表达及其与3号染色体位点变化的关系

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临床与实验病理学杂志 2004年第6期20卷 650-653页

作者：余永伟 mitchell e garber Karsten Schlns Manuela Pacyna-Gengelbach Iver Petersen 第二军医大学长海医院病理科上海200433 Department of Genetics Stanford University Institute of Pathology Humboldt University Charitè Medical School

目的　探讨非小细胞肺癌 p6 3基因的蛋白表达水平及其与定位在 3号染色体 2 7～ 2 9区域改变的关系。方法　应用比较基因组杂交 (CGH)技术对 70例原发性肺鳞状细胞癌和肺腺癌标本进行染色体不平衡性分析。采用组织芯片技术构建12 2例... 详细信息

目的　探讨非小细胞肺癌 p6 3基因的蛋白表达水平及其与定位在 3号染色体 2 7～ 2 9区域改变的关系。方法　应用比较基因组杂交 (CGH)技术对 70例原发性肺鳞状细胞癌和肺腺癌标本进行染色体不平衡性分析。采用组织芯片技术构建12 2例原发性非小细胞肺癌石蜡包埋标本组织芯片 ,并采用免疫组织化学方法检测p6 3蛋白表达情况。比较 p6 3蛋白表达及其与 3号染色体末端改变的关系。结果　CGH分析结果发现 ,30例鳞状细胞癌 2 4例出现 3q2 7～ 2 9区域DNA拷贝数目的增加 ,4 0例腺癌仅 8例发现 3q2 7～ 2 9区域DNA获得。p6 3免疫组化染色结果显示 :5 0例 (84 75 % )鳞状细胞癌免疫组化染色为阳性 ;3例大细胞肺癌中 2例 (6 6 6 6 % )为阳性反应 ;腺癌中仅有 1例 (1 6 7% )为阳性。p6 3蛋白的阳性表达率与患者的年龄、性别、肿瘤的分级、肿瘤的转移以及生存率无关 (P >0 0 5 )。p6 3免疫组化阳性率与 3q2 7～ 2 9区域的改变比较结果显示 :p6 3免疫组化阳性反应与 3号染色体长臂 2 7～ 2 9区域的DNA扩增呈正相关 (P <0 0 1)。结论　p6

关键词：蛋白质 p63 组织芯片免疫组织化学比较基因组杂交非小细胞肺癌

Systematic review of giant gastric lipomas reported since 1980 and report of two new cases in a review of 117110 esophagogastroduodenoscopies

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World Journal of Gastroenterology 2017年第30期23卷 5619-5633页

作者： mitchell S Cappell Charlton e Stevens Mitual Amin Department of Gastroenterology and Hepatology William Beaumont Hospital Oakland University William Beaumont School of Medicine San Antonio Military Medical Center Department of Pathology William Beaumont Hospital

To systematically review the syndrome of giant gastric lipomas, report 2 new illustrative *** systematically reviewed using PubMed for publications since 1980 with following medical subject heading/keywords: (“giant lipoma”) AND (“gastric”) OR [(“lipoma”) and (“gastric”) and (“bleeding”)]. Two authors independently reviewed literature, and decided by consensus which articles to incorporate. Computerized review of pathology/endoscopy records at William Beaumont Hospitals, Royal Oak and Troy, Michigan, January 2005-December 2015, revealed 2 giant gastric lipomas among 117110 consecutive esophagogastroduodenoscopies (eGDs), which were thoroughly reviewed, including re-review of original endoscopic photographs, radiologic images, and pathologic slides.

关键词： esophagogastroduodenoscopy Lipoma Gastric Giant Melena Upper gastrointestinal bleeding Systematic review

explicit and Parameterized episodes of Warm-Season Precipitation over the Continental United States

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Advances in Atmospheric Sciences 2006年第1期23卷 91-105页

作者： mitchell W. MONCRIeFF John D. TUTTLe Richard e. CARBONe National Center for Atmospheric Research BoulderColorado 80307-3000U. S. A.

This paper describes explicit and parameterized simulations of midsummer precipitation over the continental United States for two distinct episodes： moderate large-scale forcing and weak forcing. The objective is to demonstrate the capability of explicit convection at currently affordable grid-resolution and compare it with parameterized realizations. Under moderate forcing, 3-kin grid-resolution explicit simulations represent rainfall coherence remarkably well. The observed daily convective generation near the Continental Divide and the subsequent organization and propagation are reproduced qualitatively. The propagation speed, zonal extent and duration of the rainfall streaks compare favorably with their observed counterparts, although the streak frequency is underestimated. The simulations at -10-km grid-resolution applying conventional convective parameterization schemes also replicate reasonably well the diurnal convective regeneration in moderate forcing. The performance of the 3-km grid-resolution model demonstrates the potential of -1-km-resolution explicit cloud-resolving models for the prediction of warm season precipitation for moderately forced environments. In weak forcing conditions, however, predictions of precipitation coherence and diurnal variability are much poorer. This suggests that an even finer resolution explicit model is required to adequately treat convective initiation and upscale organization typical of the warm season over the continental U.S.

关键词： warm-season precipitation explicit simulation convective parameterization

An Awareness-Adoption Matrix for Strategic Decision Making in Agricultural Development Projects: A Case Study in Yunnan Province, China

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Journal of Integrative Agriculture 2009年第9期8卷 1112-1119页

作者： M Subedi T J Hocking M A Fullen A R McCrea e Milne D J mitchell School of Applied Sciences The University of Wolverhampton Wolverhampton WV1 1LY UK Department of Geography University of Leicester Leicester LE1 7RH UK

Significant achievements have been made in generating sustainable agricultural technologies in developing countries. Usually, these new technologies have been more effective in increasing production and productivity than existing technologies. However, many new technologies considered ‘effective’ have not been successful in alleviating the associated sustainability problems, due to poor adoption by targeted users. Success of any novel technical intervention should be judged on the basis of how widespread adoption is in the target area by targeted users. In this context, a case study identified the factors affecting farmers’ adoption of improved technologies extended by an agricultural development project in a rural Village in Yunnan Province, China. Initial adoption/adaptation of project technologies was influenced by farmers’ awareness of the technology. Farmers were more aware of polythene mulch, contour cultivation, intercropping and tree planting technologies than others. This led to a comparatively high initial uptake of polythene mulch, contour cultivation, sweet chestnut, and intercropping technologies. Farmers had inadequate knowledge about some Project technologies, the adoption of which was particularly low. This reveals the need for increasing farmers’ awareness about the rationale for Project technologies to achieve greater adoption/adaptation of project technologies by farmers over wider areas. Farmers’ testing of the technology leads to better adoption/adaptation compared to mere awareness. However, considerable time and resources are required for testing/trying technologies. This justifies the usefulness of comparatively quick and less resource demanding options for awareness creation. Development of effective cropping technologies is important for sustainable agricultural development. The success of any agricultural development project, especially in terms of improving sustainability, depends on how widely those improved technologies are adopted/adap

关键词： awareness-adoption matrix sustainable agriculture China

Habitat restoration is the greatest challenge for population recovery of Hainan gibbons(Nomascus hainanus)

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Integrative Zoology 2023年第4期18卷 630-646页

作者： Qingqing He Shasha YAN Paul A.garber Baoping ReN Xvming QI Jiang ZHOU School of Karst Science Guizhou Normal UniversityGuiyangChina Department of Anthropology University of IllinoisUrbanaIllinoisUSA Ministry of education Key Laboratory for ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikouChina Bawangling Branch Hainan Tropic Rainforest National Park AdministrationChina

Hainan gibbons are among the world’s most critically endangered primates,with a remaining population of only 35 individuals distributed across 5 social groups in the Bawangling Branch of the Hainan Tropical Rainforest National Park,*** conversion and forest fragmentation over the past 40 years have reduced their geographical distribution by 95%.In the absence of a quantitative assessment of the availability of remaining suitable habitat,it is unclear whether this species can survive to the end of this *** used behavioral observations,ArcGIS,remote sensing,stereo optical imagery,and Maxent modeling to identify patterns of Hainan gibbon range use and compare changes in the distribution of suitable forest types and areas of forest fragmentation over the past 20 years(2000–2020).The results indicate that the combined range of the 5 extant Hainan gibbon groups totaled 14.89 *** home range of the smallest group(Group e,3 individuals)was 1.51 km2,which likely represents the minimum home range size for this *** remaining area of highly suitable and moderately suitable habitat totals 26.9 ***,habitat connectivity across the gibbon range is very low(less than 0.5),limiting the ability of Hainan gibbons to move between forest *** results of this study indicate that the availability of suitable habitat in Bawangling is insufﬁcient to allow for future Hainan gibbon population ***,immediate action must be taken to restore,reforest,and establish ecological corridors to reconnect areas of suitable habitat for these critically endangered gibbons.

关键词： conservation Hainan gibbon home range area landscape management Maxent modeling

Modern treatment of gastric gastrointestinal stromal tumors

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World Journal of Gastroenterology 2012年第46期18卷 6720-6728页

作者： Kevin K Roggin mitchell C Posner Department of Surgery Pritzker School of Medicine University of Chicago

Gastrointestinal stromal tumors (GIST) are rare mesenchymal smooth muscle sarcomas that can arise anywhere within the gastrointestinal tract. Sporadic mutations within the tyrosine kinase receptors of the interstitial cells of Cajal have been identified as the key molecular step in GIST carcinogenesis. Although many patients are asymptomatic, the most common associated symptoms include: abdominal pain, dyspepsia, gastric outlet obstruction, and anorexia. Rarely, GIST can perforate causing life-threatening hemoperitoneum. Most are ultimately diagnosed on cross-sectional imaging studies (i.e., computed tomography and/or magnetic resonance imaging in combination with upper endoscopy. endoscopic ultrasonographic localization of these tumors within the smooth muscle layer and acquisition of neoplastic spindle cells harboring mutations in the c-KIT gene is pathognomonic. Curative treatment requires a complete gross resection of the tumor. Both open and minimally invasive operations have been shown to reduce recurrence rates and improve long-term survival. While there is considerable debate over whether GIST can be benign neoplasms, we believe that all GIST have malignant potential, but vary in their propensity to recur after resection and metastasize to distant organ sites. Prognostic factors include location, size (i.e., > 5 cm), grade (> 5-10 mitoses per 50 high power fields and specific mutational events that are still being defined. Adjuvant therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to reduce the risk of recurrence after one year of therapy. Treatment of locally-advanced or borderline resectable gastric GIST with neoadjuvant imatinib has been shown to induce regression in a minority of patients and stabilization in the majority of cases. This treatment strategy potentially reduces the need for more extensive surgical resections and increases the number of patients eligible for curative therapy. The modern surgical treatment of

关键词： Gastrointestinal stromal tumors Laparoscopic resections of gastrointestinal stromal tumors Imatinib mesylate Gastrectomy

An evaluation of the Introduction of Modified Cropping Practices in Yunnan Province,China,Using Surveys of Farmers’ Households

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Agricultural Sciences in China 2009年第2期8卷 188-202页

作者： M Subedi T J Hocking M A Fullen A R McCrea e Milne D J mitchell WU Bo-zhi School of Applied Sciences University of Wolverhampton Wulfruna Street Wolverhampton WV1 1LY UK The Macaulay Institute Craigiebuckler Aberdeen AB15 8QH UK Yunnan Agricultural University Kunming 650201 P.R.China

Problems associated with land degradation are serious in China. Sloping land in South China has experienced a decline in crop productivity by 30-60% due to soil erosion and it has been predicted that most topsoil will be lost within the next 100 years if current erosion rates continue. Considering these situations, an agro-environmental research and development project （Sustainable Highland Agriculture in South-east Asia- SHASeA） was conducted in a catchment in Yunnan Province, China, to address the objectives of increasing crop productivity in sustainable and environmentally-friendly ways. A range of cropping practices was developed and implemented in a rural upland catchment （Wang Jia）. At the end of the project, farmers were surveyed to evaluate project effectiveness. All farmers from Wang Jia Catchment, who were involved in project implementation, were surveyed. A sample of farmers working in an adjacent catchment （not associated with the project） was surveyed for comparative purposes. Farmers had different perceptions of the cropping practices employed. Contour cultivation was preferred and likely to be adopted. Others practices such as straw mulching and intercropping were seen as less appropriate and unlikely to be adopted. Polythene mulch was recognized as effective, but likely to be adopted only if financial returns were favourable. The availability of relevant information had an important impact on the extent of technology testing by farmers and their willingness to adopt the practices in the future.

关键词： cropping practices farmers' perceptions household survey Yunnan China

Verification of the 2019 GloSea5 Seasonal Tropical Cyclone Landfall Forecast for east China

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Journal of Meteorological Research 2020年第5期34卷 917-925页

作者： Joanne CAMP Philip e.BeTT Nicola GOLDING Chris D.HeWITT Timothy D.mitchell Adam A.SCAIFe Met Office Hadley Centre Exeter EX 13PBUK University of Southern Queensland Toowoomba QLD 4350Australia College of engineering Mathematics and Physical SciencesUniversity of ExeterDevon EX44QFUK

A prototype climate service was developed and trialled in early 2019 to provide seasonal forecast of the June–July–August(JJA) tropical cyclone(TC) landfall risk for the east China region ahead of the forthcoming typhoon *** forecasts were produced in both March and April 2019 and a final forecast was released to the China Meteorological Administration(CMA) on 1 May 2019. The trial service was produced by using the Met Office Global Seasonal forecast system(GloSea5), and a forecast of the western Pacific subtropical high(WPSH) index was used to infer the TC landfall risk based on a simple linear regression between historical model WPSH indices and observed TC landfalls in east China. The forecast method shows significant skill for forecasting the JJA TC landfall risk in east China with up to three-month lead time, with the greatest skill for predictions initialized in May. The 2019 forecast provided good guidance of the near-average TC activity observed in east China in JJA 2019. Success of the forecast adds confidence to an improved climate service ahead of the 2020 typhoon season.

关键词： seasonal forecasting typhoons tropical cyclones(TCs) landfall risk east China western Pacific subtropical high(WPSH)